This investigation aimed to explore the bioactive compound potential in medicinal plants such as polyphenols and to test the total phenol content as well as the velocity of skin absorption and antioxidant activities of crude extracts from plants and fruits. albino rats and the Franz diffusion model was used for experimentation.Raphanus sativus proved to have the most substantial phenolic content following Beta vulgaris and Rosa indicat.Analyzed compounds led to skin permeation as Malus domestica had the highest absorbent value among all tested compounds. In addition to that, all extracts were potent DPPH radical scavengers and out of these Daucus carota oil was presented with the best antioxidant ability. The outcome of these experiments advocates for constant research and the growth of highly efficient transdermal delivery systems and aesthetic concoctions with the inherent healing from nature.