Pathogenic microbial strains and specimens are crucial national and strategic biological resources. Preservation and management of the pathogenic microbial resources, as an integral component of biosafety, play an important role in the national biosafety system and in the overall framework of national security. Sound preservation and management rely on the effective designation of preservation institutions, strengthened operation and management of preservation institutions, standardized description and data specifications, establishment of preservation information management systems, and promotion of resource-sharing and utilization. Firm protection and efficient sharing and utility of pathogenic microbial resources are expected to make a unique contribution to the sustainable development of the national economy.