This paper examines the control design for parameter-dependent input-delay linear parameter-varying (LPV) systems with saturation constraints. A linear differential inclusion approach is implemented to formulate the saturation nonlinearity. Subsequently, a gain-scheduled dynamic output-feedback controller is structured to conform to the saturation representation. By means of a Lyapunov–Krasovskii functional, sufficient delay-dependent conditions are derived for the analysis and feedback control synthesis of the closed-loop system in the presence of uncertainties and exogenous disturbances. Disturbance rejection objectives following an induced -norm and an norm formulation are examined. Estimation of the domain of attraction with the parametrisation of the admissible LPV controllers is presented. Three different optimisation objectives with respect to disturbance rejection, disturbance tolerance, and domain of attraction expansion are formulated. The proposed design methodology is examined in the context of the air-fuel ratio (AFR) regulation in a spark ignition (SI) engine with a speed-dependent delay and model parameters in the presence of canister purge disturbances and AFR dynamics uncertainty. The injector is restricted in the amount of fuel it can deliver to the cylinder. The three-way catalytic converter's performance in terms of oxygen storage and emission reduction is taken into consideration. Closed-loop simulation results are provided to validate the methodology.