The study of the patterns of change in the hydrodynamic parameters under the conditions of non-stationary flow at the entry of the cylindrical pipe and the initial arbitrary distribution of velocities in the entry section was conducted based on the boundary layer equations. A boundary problem was formed under the axisymmetric change conditions in the flow. The boundary conditions were chosen in accordance with the pattern of an arbitrary distribution of velocities in the entry section. A general solution of the approximating Navier-Stokes equations is presented depending on the initial conditions and the Reynolds number. In accordance with the type of flow, the boundary conditions of the problem are established, and the boundary-value problem is formulated. Regularities for the change in velocities lengthwise in the entrance region have been obtained for a constant and parabolic velocity distribution in the inlet cross-sections. Analytical solutions have been obtained, allowing to obtain patterns of changes in velocities and pressures toward flow at any section and at any time. For the mentioned cases, the composite graphs of velocity changes in different sections along the length of the entrance transition area were constructed by computer analysis, for different time conditions. With the obtained composite graphs, the patterns of change over the entire length of the transition area of the entrance region were constructed, enabling to obtain fluid flow velocity at any point of the section. The length of the transition zone can be estimated based on the condition of reaching a certain percentage (99%) of the maximum velocity of the flow. The proposed solutions create the conditions for correctly constructing separate units of hydromechanical equipment