Ozone Flow Rate Research Articles

Preparation and performance of catalyst for organic peroxide wastewater treatment

To improve the oxidation pretreatment efficiency of wastewater from organic peroxides, a catalyst (CeO2-C catalyst) was developed using the calcination method with ceramic particles as the support. The crystalline structure and elemental composition of the CeO2-C catalyst were characterized by Scanning Electron Microscope (SEM), Energy Dispersive Spectrometer (EDS), and X-ray diffraction (XRD). This study explored the effects of CeO2 mass ratio, calcination temperature, and calcination time on the performance of the catalyst. The optimal preparation conditions were established through orthogonal experiments. Additionally, the synergistic effect of the catalyst on the ozone oxidation treatment of peroxide wastewater was investigated. The results indicated that the optimal preparation parameters were a CeO2 mass ratio of 4 %, a calcination temperature of 500 °C, and a duration of 5 h, respectively. After five cycles of reuse, the catalytic activity slightly decreased but remained relatively stable. With an ozone flow rate of 6 L/min, the CeO2-C/ozone catalytic oxidation process achieved a Chemical Oxygen Demand (COD) removal rate of 28.11 % in wastewater, and the B/C (the ratio of BOD concentration to COD concentration) of wastewater improved from 0.093 to 0.152. The calcination method proved effective for preparing the CeO2-C catalyst, which demonstrated significant catalytic performance and held promising application prospects in the oxidation pretreatment of organic peroxide wastewater.

Degradation and mineralization of atrazine by ozonation: A toxicological prediction by QSAR toolbox

This work aims to investigate the atrazine (ATZ) mitigation by an advanced oxidative process. Atrazine is one an effective herbicide which has been detected in water sources, causing contamination problems. To address the persistent issue of contamination, ATZ degradation and mineralization were studied by ozonation. In addition, the eco-toxicity of the possible degradation byproducts was also evaluated by the Quantitative Structure-Activity Relationship (QSAR) OECD toolbox. To evaluate the influence and predict the optimum conditions of the ozonation process and the reaction time on the degradation of ATZ, as well as, the percentage of mineralization, an experimental design was performed based on factorial design 23 methodology with center-point analysis. Total organic carbon (TOC) analyses and High-Performance Liquid Chromatography (HPLC) were employed to evaluate the efficiency of ATZ mitigation. The optimal conditions were achieved at an ozone flow rate of 0.4 mL/min, oxidation time = 30 min, and pH=8 where 100 % of ATZ was degraded and the highest percentage of mineralization was obtained (25.61 %). The potential toxicity of the residual concentration of ATZ was obtained by comparing with the values predicted by the QSAR tool, by comparing the outcomes. It was possible to come to the conclusion that the approach had positive implications for environmental safety. The values obtained are below the values considered toxic in aquatic environments, in almost all experiments. Low-concentration byproduct formation suggests that the degradation routes lead to low-hazardous concentrations of compounds for the environment. This implies the ozone treatment strategy might offer a long-term remedy for the ATZ.

Can ozone mass transfer in water treatment be enhanced through independent pressurized ozonation?

The dissolved ozone equilibrium concentration is hard to improve by increasing the gas phase partial pressure due to the low initial pressure and difficulty in pressurization. In this study, a novel hydraulic pressurization technology was developed to reliably elevate the ozonation pressure and improve the solubility of ozone. It was located downstream of the ozone generator to avoid generator overpressure. Specifically, at the optimal pressure of 0.30 MPa with an initial ozone flow rate of 1–6 L min−1, the specific surface area of bubbles and turbulent dissipation rate in the ozonation reactor were up to 2.5- and 1.5-fold that of the atmospheric aeration. Meanwhile, the dissolved ozone equilibrium concentration, redox potential, and volumetric mass transfer coefficient were up to 2.4-, 1.6-, and 2.7-fold that of atmospheric aeration, respectively. The increase in bubble-specific surface area and turbulent dissipation rate, synergistically enhanced the mass transfer, contributing 83.2–94.4 % and 5.6–16.8 %, respectively. As the reactor pressure was increased from 0 to 0.30 MPa, the decolorization time of Acid Red 18 was shortened from 20 to 8 min, and the COD removal rate increased from 48.0 % to 85.0 %. This work provides an alternative approach coupled with a novel device that enhances the ozone mass transfer during water treatment.

Characterization of the ozone effect on a scraped off fouling sample

Fouling deposition on combustion system elements is a problem of interest to the industry. This experimental work analyzes the degradation of fouling using ozone as oxidizing agent. Two independent test benches were used for the experiments, a fouling test bench and an ozone test bench. The fouling generation tests are performed under controlled conditions to obtain characterized fouling. The ozone tests performed are divided into three groups: pre-tests, A-tests and B-tests. The pre-tests were used to determine the effect of different variables affecting the oxidation process. The A, B-tests were performed to characterize the oxidation process under different scenarios. During the ozone treatment tests, flow rate, ozone concentration, temperature and duration of the test were controlled to obtain the fouling mass loss measurement. Finally, an analytical expression was obtained that characterizes the sample mass variation as a function of the input variables, maximizing the reaction between the fouling and ozone.

Advanced oxidation of Arsenic(III) to Arsenic(V) using ozone nanobubbles under high salinity

Arsenic, a highly toxic element, is present in various water resources as As(III) and/or As(V). The removal of As(V) using adsorption is considered to be easier than the removal of As(III). In this work, we report the oxidation of As(III) to As(V) using ozone nanobubbles. Ozone has been widely used in the advanced oxidation process (AOP) to remove organics and inorganics in wastewater. The major advantage of ozone nanobubbles is their enhanced half-life, which leads to higher ozone solubility in water. In addition, the rate of mass transfer by using nanobubbles can be enhanced drastically. The effect of ozone flow rates, initial As(III) concentrations, pH levels, and the presence of salt is systematically studied in this work. The present results revealed that ozone nanobubbles positively impacted the oxidation of As(III) to As(V). AOP process based on O3 NBs (nanobubbles) was most efficient with 99 % oxidation rates of 1 ppm of As(III) within 20 minutes at 6.5 ppm ozone concentrations. An acidic pH of 3–7 promoted quick oxidation due to the high mass transfer coefficient of ozone nanobubbles. About ∼70 % degradation of As(III) to As(V) was achieved with 0.10854 min-1 rate constant at acidic (pH = 3) compared to ∼39 % degradation with 0.046 min-1 rate constant at pH =11. The presence of salt (∼50 mM) in the solution not only hindered the ozone mass transfer coefficient but also reduced the stability of nanobubbles. The detection of reactive oxygen species, particularly hydroxyl radical was unravelled by utilizing 2-propanol as a scavenger.

Low temperature (002)-oriented zinc oxide films prepared using ozone-based spatial atomic layer deposition

In this study, ZnO films are prepared at a low temperature of 150 °C by using spatial atomic layer deposition (sALD) with diethylzinc and ozone as precursor and oxidant. The ozone flow rate is varied to systematically investigate its effect on optical, structural and electrical properties. The experimental results show that the self-limiting surface reactions can occur at the low ozone flow rate of 200 sccm, confirming ALD growth mode. All the ozone flow rates lead to ZnO (002) crystalline orientation, which is difficult to be obtained for conventional water-based ALD ZnO films at the low temperature. The increased ozone flow rate results in an increased amount of oxygen vacancies, enhanced carrier concentration and a reduced stress. The resistivity and carrier concentration can be tuned in the range of 4.75–0.08 Ω-cm and (1.1–5.5) × 1018 cm−3. Finally, the sALD ZnO film on polyethylene terephthalate reveals a high stability in the film property against bending. This study is beneficial for the utilization of ZnO films in optoelectronic devices that demand the (002) preferred orientation, especially under low-temperature conditions.

A New Sight of Ozone Usage in Textile: Improving Flame Retardant Properties.

Ozone, widely recognized as an environmentally friendly gas, is extensively used in various textile industry applications. These include pre-treatment processes like bleaching and desizing, as well as creating pattern and vintage effects, wastewater clarification, and surface modification. This study focuses on ozone as a novel solution to a specific challenge: addressing the reduction in flame retardancy properties experienced by flame-retardant (FR) polyester fabrics during post-treatment processes in the production line. Experimentation involved subjecting the fabrics to ozonation and exploring different combinations of ozone flow rates and treatment durations. Mechanical and functional properties of the fabrics were examined, with flammability tested according to International Maritime Organization (IMO) standards. Notably, treatment with a 5 L/min ozone flow rate, a 7.01 g/h ozone concentration ratio, and a duration of 10 min showed significant improvements in IMO values, ensuring compliance with required standards. Furthermore, treated samples underwent comprehensive tests for fastness and strength, yielding results within acceptable ranges. Fourier-transform infrared (FT-IR) and thermogravimetric analysis (TGA) measurements were conducted to evaluate the impact of ozonation. FT-IR results indicated that the presence of C-H groups associated with dyestuff contributed to decreased flame retardancy in the original fabric post-dyeing. However, these groups were effectively eliminated through ozonation, thereby enhancing the fabric's flame retardancy.

Kinetics of catalytic ozonation of methylene blue in wastewater with Fe/Ce co-doped in attapulgite

In this study, the attapulgite (ATP) was modified by Fe and Ce with the method of impregnation-roasting, and the degradation of Methylene Blue (MB) in the presence of ozone was investigated. The results showed that the degradation rate of 80 mg/L MB wastewater could reach about 94%, when the ozone flow rate is 250 mL/min, the reaction temperature is 35 ℃, the catalyst is 0.4 g, and the initial pH of the solution is 7. The characterization results of the modified ATP showed that the Fe3+ and Ce4+ had been successfully loaded on the gravimetric clay. Finally, the degradation mechanism of MB was speculated, and the reaction kinetic equation was obtained. The model fit and reliability are good.

Ozone Assisted Photocatalytic Degradation of Textile Wastewater

In present research, photocatalytic degradation of textile wastewater was investigated through the combined effect of ozonation and photocatalysis processes. Catalytic acids in the nano-particle form under moderate reaction conditions were used for the successful disintegration of contaminants in textile wastewater which in turn increases the process efficiency. Moreover, the combined effect of the photocatalytic-ozonation process after secondary treatment of textile wastewater on discharge requirements of zero discharge hazardous chemicals (ZDHC) by Road to Zero was also studied. Different parameters were optimized like ozone flowrate, catalytic concentration, UV light intensity, and reaction time. Results revealed that overall process efficiency is influenced by ozone and reaction time. In contrast, an increased rate of degradation is attributed to the synthesized TiO2 (anatase) in nanoparticle form. The combined ozone-assisted photo-catalytic process showed the COD, BOD, and TSS removal efficiencies of 91.5%, 94%, and 86% at 25 and#176;C temperature and pH 7-9. The results were attained at optimum conditions like reaction time (140 min), Ozone concentration (2 g/hr), TiO2 concentration (2g/L), and UV energy (88 W), respectively. The study demonstrated the efficiency of an integrated process for the degradation of real textile wastewater. Thus, combined photocatalytic and ozonation processes are known to exhibit better responses than individual processes for pollutants removal from textile wastewater.

Enhancing the quality attributes of mint medicinal plant (Mentha spicata L.) through simultaneous combined ozone and infrared drying

AbstractMedicinal plants are widely used in various traditional and modern medical methods due to their therapeutic properties. Drying is a common method used to preserve the biochemical compounds of medicinal plants. Still, conventional drying methods can lead to the loss of active compounds due to exposure to high temperatures. This research aimed to design and construct an ozone generator for use in a combined dryer and evaluate the ozone, temperature, and hot air flow rate on the quality properties of mint (Mentha spicata L.). Drying experiments were conducted at varying temperatures, air flow speeds, and ozone levels. Results indicated that increasing temperature reduced total phenol and flavonoid content while increasing antioxidant capacity. Higher airflow speed positively influenced total phenol, total flavonoid content and antioxidant potency but reduced drying time. Ozone exposure increased total phenol, flavonoid content, antioxidant activity, and had minimal effect on drying time. Optimization revealed that a temperature of 52.47°C, air flow rate of 1.5 m/s, and 90.37% ozone concentration yielded favorable outcomes, including enhanced phenolic and flavonoid content, antioxidant power, and decreased energy consumption. Compared to other drying methods, the proposed ozone‐enhanced method proved superior in preserving bioactive compounds and maintaining a reasonable drying time. Overall, the research highlights the potential of ozone‐assisted drying for optimizing the quality of medicinal plants during preservation.Practical ApplicationThe paper introduces a novel and efficient method for preserving the quality of medicinal mint. By concurrently applying ozone and infrared drying techniques, this approach aims to capitalize on their synergistic effects in maintaining the plant's beneficial compounds. Ozone acts as a natural antimicrobial agent, preserving the plant's integrity, while infrared drying expedites the process without compromising the phytochemical profile. This innovative method not only ensures microbial safety and extended shelf life but also enhances the mint's aroma, flavor, and nutrient retention. The practical application of this combined technique holds promise for pharmaceutical and herbal industries, providing a valuable approach for optimizing the drying process and preserving the medicinal attributes of Mentha spicata L.

Treatment of oil-based drilling cuttings by floatation-advanced oxidation two-step process.

In this paper, a floatation-advanced oxidation two-step process was proposed for deep oil removal of oil-based drilling cuttings (OBDC). In the first stage, a novel and simple degreasing solution was prepared and most of the base oil contained by OBDC was removed by flotation; in the second stage, the oil content of OBDC was further reduced by combined ultrasound + ozone (US + O3) advanced oxidation. The recommended degreasing solution was a mixture of methanol, ammonium chloride, and water with a mass ratio of 1.48.1 : 0.25. The best flotation process was as follows: a mass ratio of OBDC to degreasing solution of 1 : 10, stirring speed of 400 rpm and N2 flotation with a flow rate of 400 mL min-1 for 60 min. The oil content of OBDC can be reduced from 14.57% to 1.42% after flotation treatment and the degreasing solution can be reused more than five times. The optimal process of US + O3 advanced oxidation was as follows: a mass ratio of OBDC to water of 1 : 10, ultrasonic power of 1000 W, and an ozone flow rate of 4.0 L min-1 for 100 min. The oil content of OBDC can be reduced from 1.42% to 0.14% after US + O3 treatment at room temperature. The results of this paper provide a new method and idea for OBDC treatment.

Hydrodynamic cavitation-assisted acid pretreatment and fed-batch simultaneous saccharification and co-fermentation for ethanol production from sugarcane bagasse using immobilized cells of Scheffersomyces parashehatae

A new alternative for hydrodynamic cavitation-assisted pretreatment of sugarcane bagasse was proposed, along with a simultaneous saccharification and co-fermentation (SSCF) process performed in interconnected columns. Influential variables in the pretreatment were evaluated using a statistical design, indicating that an ozone flow rate of 10 mg min−1 and a pH of 5.10 resulted in 86 % and 72 % glucan and xylan hydrolysis yields, respectively, in the subsequent enzymatic hydrolysis process. Under these optimized conditions, iron sulfate (15 mg L−1) was added to assess Fenton pretreatment, resulting in glucan and xylan hydrolysis yields of 92 % and 71 %, respectively, in a material pretreated for 10 min. In SSCF, ethanol volumetric productivities of 0.33 g L−1 h−1 and of 0.54 g L−1 h−1 were obtained in batch and fed-batch operation modes, achieving 26 g L−1 of ethanol in 48 h in the latter mode.

Light-assisted catalytic ozonation for efficient degradation of ciprofloxacin using NiO/MoS2 nanocomposite

In this study, the hydrothermal method was used to prepare NiO/MoS2 nanocomposite which was employed for the first time in the photocatalytic ozonation (PCO) process to degrade ciprofloxacin antibiotic. The synthesized nanocatalyst was analyzed with various characterization techniques. Response surface methodology (RSM) was utilized to conduct the statistical analysis and optimization of the influential parameters in the degradation process. The maximum efficiency for ciprofloxacin removal (100%) was attained at pH = 5.8, by employing 0.37 g L-1 of the NiO/MoS2 nanocatalyst, an ozone (O3) flow rate of 0.2 g L-1h−1 and duration of 12 min. The results indicated a significant synergistic effect in the analyzed system, which supports the proposal that utilizing the photocatalyst and ozone together through the PCO process is a more efficient method. Also, according to the kinetic analysis data, the PCO process conformed to obey the pseudo-first-order model. Furthermore, the nanocatalyst exhibited a high level of recyclability and stability, retaining 85.44% efficiency after undergoing five successive photocatalytic ozonation cycles. In conclusion, the obtained results confirm that the O3/Vis/NiO/MoS2 system is a promising approach for the treatment of wastewaters containing emerging pharmaceutical contaminants.

Advance oxidation processes of Rhodamine B under O3/UV using spent bleaching earth-ZnO composite: Performance in kinetics

Spent bleaching earth and ZnO composite (SBE/ZnO) was prepared as the catalyst for the advanced oxidation processes (AOPs) of rhodamine B (RB) under O3/UV. The photocatalytic ozonation process of RB was conducted at an ozone flow rate of 1 L/min by adjusting the variation of initial RB concentration, catalyst dosage, and reaction time. The RB removal efficiency of 96.7% was reached within 36 min at optimal operational conditions (initial concentration of 100 mg/L and catalyst dosage of 1.5 g). The kinetical analysis at this condition showed that the photocatalytic ozonation process of RB followed a pseudo-first-order reaction with a rate constant of 0.0975 min-1. Meanwhile, the effect of operational variables was evaluated using response surface methodology (RSM) and resulted in an optimized model for RB Removal following equation: RB Removal = 84.95 - 6.24A + 5.81B + 22.45C + 3.07AB + 13.14AC - 6.72BC + 0.1174A2 + 7.86B2 - 8.90C2, where A is the initial concentration of RB, B is catalyst dose and C is reaction time, with a high coefficient of determination R2 = 0.9432.

Investigation of spent caustic effluent treatment by electro-peroxone process; cost evaluation and kinetic studies

Spent caustic is an extremely polluted industrial wastewater with quite complex chemistry and various environmental negative impacts. Conventional wastewater treatment methods are not adequately efficient for the remediation of spent caustic. In the present work, for the first time, the treatment of spent caustic effluent was investigated by the Electro-Peroxone (EP) method as a subdivision of Advanced Oxidation Processes (AOPs). The Central Composite Design (CCD) was employed to optimize the operational parameters, including initial COD, applied current, pH, and ozone flow rate in the removal of COD. The statistical investigations showed an acceptable determination coefficient and a suitable second-order model. The predicted optimal circumstances were as the following: initial COD = 1076 mg. L-1, applied current = 0.79 A, pH = 7.9 and O3 flow rate = 1.68 L.min−1. At optimum points, the predicted and actual COD removal percentages were 96.3 and 95.0 %, respectively. The kinetic investigations showed that the removal of COD followed the first-order kinetic with the half-life and constant reaction rate at 18 min and 0.038 min−1, respectively. The specific energy consumption (SEC) value in the EP process was calculated at 33.96 kWh/Kg COD removal, showing that the combined EP process could be a cost-effective technique for the treatment of spent caustic effluent on an industrial scale.

Decolorization by Catalytic Ozonation USING Mn(II) Fe(II) and Fe(III)

The textile industry holds significant importance in Thailand. It has been estimated that 10-20% of dyes are lost during the dyeing process and subsequently released into wastewater. The high concentration of non-biodegradable substances in these wastewaters makes them challenging to treat using conventional methods. Therefore, this study aimed to assess the effectiveness of a catalytic ozonation process employing Mn(II), Fe(II), and Fe(III) for treating synthetic dye wastewater. The study also sought to optimize operational parameters such as pH and contact time. Both with and without catalytic ozonation, experiments were conducted in a batch reactor with a consistent ozone flow rate of 6 g/hr. Under the non-catalytic ozonation conditions, it was observed that more than 90% of decolorization occurred within 15 minutes at a pH of 9. The ozonation of the dye followed a first-order reaction mechanism at room temperature, with a rate constant (k) of 0.18 min-1. The catalytic ozonation used a concentration of 1.2 mM of Mn(II) was showed color removal of 90% in 8 min. For catalytic ozonation used Fe(II) and Fe(III) with concentrations of 0.6 mM showed color removal of 90% in 10 min. The highest rate constant (k) showed 0.29 min-1 for Mn(II) and 0.21 min-1 for Fe(II) and Fe(III). In conclusion, the study found that the inclusion of a catalyst substantially enhanced the degradation efficiency of the dye compared to ozonation without a catalyst.

Ozone pretreatment combined with partial denitrification-anammox process for efficient nitrogen removal from nanofiltration concentrate of landfill leachate

Treatment of nanofiltration concentrate (NFC) from landfill leachate is challenging due to its complex composition and high concentration of refractory organic matter. This study proposed a combined process of ozone pretreatment and partial denitrification/anammox (PD/A) for treating NFC, exploring the feasibility of using ozone-oxidized NFC as a carbon source for partial denitrification. The ozone oxidation process was employed to degrade the refractory organic compounds. With an ozone flow rate of 1.2 L/min and a reaction time of 50 min, the chemical oxygen demand (COD) removal efficiency of NFC was 20.83%, and the volatile fatty acid (VFA) content reached a maximum value of 104.37 mg/L. Meanwhile, the process significantly increased the ammonia and nitrate concentrations in the NFC. Then, PD/A process was applied to remove nitrogen from the NFC. Results showed that PD/A can effectively remove nitrogen from the NFC without additional carbon source. Using VFA produced in the ozone oxidation stage as carbon source, the reactor achieved a nitrogen removal efficiency of approximately 70%, resulting in an effluent with a total nitrogen below 40 mg/L, which satisfied the relevant standards in China. This study provides new insights into the application of ozone oxidation and PD/A in treating NFC from leachate.

Quick sterilization of Spirulina powder through dry ozonization for pharmaceutical preparations

Quick sterilization using dry ozonation technology had been developed to destroy total pathogenic microorganism contamination in Spirulina powder effectively. This technology is safe and environmentally friendly, with carbon dioxide (CO2) and water (H2O) as output. Quick sterilization applications are easy and inexpensive but provide results that meet the quality standards of pharmaceutical preparations according to government regulations. This work aimed to perform rapid sterilization and determine the microbial level contamination produced by the ozonation sterilization system. The variables of sterilization time, flow rate, and ozone dose differ in the application of the ozonized sterilization system. The sterilization process through an ozonation reaction is carried out by providing ozone at the flow rate of 1, 2, 3, and 4 liters per minute (LPM) and ozone concentrations of 1, 2, 3, and 4 ppm. Ozone was produced at a rate of 5 gr/hour from an ozone generator with a voltage of 30 kV. 40 gr Spirulina powder in a closed reactor with a volume of <50% (Spirulina/reactor volume) was ozonated at room temperature (27 °C) for 1, 2, 3, and 4 minutes. The optimum operating conditions of Spirulina platensis sterilization were an ozone flow rate of 2 LPM, sterilization time of 2 minutes, and ozone dose of 2 ppm. This system reduces the sterilization time from 60 minutes (UV light) to 2 minutes. This technology is a very attractive and potential choice in the large-scale production of Spirulina powder for pharmaceutical industry applications.

Ozonation for oxidation and transformation of pharmaceuticals in Arroio Diluvio River in Southern Brazil

ABSTRACT Pharmaceuticals are often found in the water environment and are not completely degraded by conventional treatment processes. There are some techniques, such as advanced oxidative processes (AOPs), which can promote, in addition to the total removal of contaminants, their mineralization, transforming them into CO2 and water. Thus, the objective of this work was to evaluate the mineralization capacity of the emerging pollutants caffeine and ampicillin, present in a real aqueous matrix, through ozonation. Factorial planning was carried out by Central Composite Design (CCD) under the Response Surface Methodology (RSM). Water samples were collected from Arroio Dilúvio, a river that cuts through the city of Porto Alegre (RS – Brazil), which receives domestic, hospital, and industrial effluents in nature. The experiments were conducted from the analysis of the influence of pH, time, and ozone flow rate variables. The ozonation system consisted of an oxygen concentrator, an ozone generator, and a gas washer bottle. With removals of caffeine and ampicillin around 100 and 99.7%, respectively, a mineralization of 30.8% was also obtained under conditions of pH 8, with an applied ozone dosage of 830 mg.L−1. In this process, the gas phase concentration was at 16.7 mg.L−1 when applied to 200 mL sample for 10 minutes and ozone flow rate of 1 L.min−1. A linear relationship was observed between the real and predicted values, and it has been shown that the relationship of the residual plot confirmed a sufficient approximation of the method for the optimization process. Finally, the desirability function showed adequate operating conditions for the mineralization of compounds by ozonation. Therefore, it is considered that this technique is effective for the mineralization of the pharmaceuticals studied, and can be applied as a way of treating a contaminated real matrix.

Adsorption/Ozonation integration for intensified ethyl acetate plant wastewater treatment: Process optimization and sensitivity analysis assessment

For the first time, the ethyl acetate production plant wastewater was treated using a batch adsorption/ozonation integrated process. The wastewater contained alcoholic pollutants (majorly, ethanol) and the discharge of this wastewater could result in serious risks to the environment. The operational variables including reaction time (10 to 60 min), temperature (20 to 60 °C), ozone flowrate (4 to 12 L/min) and granular activated carbon (GAC) dose (5 to 15 g) were optimized by applying response surface methodology, where the removal of chemical oxygen demand (COD) was aimed to be maximized as the target variable. The optimal conditions were obtained at the reaction time of 60 min, temperature of 60 °C, GAC dose of 10 g and ozone flowrate of 8 L/min, which resulted in COD removal of 98.5 %. Characterization analyses revealed that ozonation could support in-situ regeneration of the GAC and provide a synergistic effect on the COD removal enhancement. The separation kinetics of the integrated process was also assessed and found to be superior than those of the standalone operations. Sobol sensitivity analysis results uncovered that the reaction temperature by 85 % and the binary interaction of the reaction time and temperature by near 7 % impact shares were the most effective parameters on the COD removal. Isothermal studies showed that the adsorption of ethanol on GAC is physical, multilayer and heterogeneous. Consequently, the integrated adsorption/ozonation process has been approved as a potential method for the treatment of ethyl acetate plant wastewater.