The kinetics of degradation of pharmaceutical drugs is studied by ozonation in a fine bubble system. In the present experimental work, fine bubbles of ozone were used for degradation of pharmaceutical drugs soluble in water. The ozonation of pharmaceutical drugs by ozone bubbles was found to be very effective at high pH and high ozone flow rates. The apparent reaction rate constant was estimated at different pH of the solution. The axial variation of ozone concentration in solution in the reactor is analyzed by dispersion model. The volumetric mass transfer coefficients based on the ozonation of pharmaceutical drugs by fine bubble based are also enunciated in this present work. The results may be useful for removal of drug waste in water treatment process by advanced oxidation techniques.