Oxide Solution Research Articles

Drag reducing performance and its influencing on natural yam mucilage

Yam mucilage is a novel environmentally friendly drag reducer. This study investigates drag reduction and degradation characteristics of Chinese yam mucilage, using an in-house rotor device. The effects of temperature, aging, and salts on the drag reduction rate (DR) of yam mucilage were also explored. Furthermore, the synergistic drag reduction properties of Chinese yam-polyethylene oxide (PEO) solution were investigated by blending Chinese yam mucilage with PEO. The rotational speed range of the rotor device was set at 200–700 r/min, corresponding to Reynolds numbers (Re) ranging from 30 396 to 106 385. The results demonstrated that the DR of yam mucilage initially increased, and then decreased at low concentrations, with increasing Re. Conversely, the DR of yam mucilage at high concentrations increased with increasing Re, albeit at a gradually slowing rate as concentration increased; however, the shear stability was gradually enhanced. Degradation testing revealed that yam slime exhibited semi-rigid, or rigid polymer characteristics, with notable shear stability. At a concentration of 2000 ppm and Re = 106 385, the maximum DR reached 44.1%. Prolonged heating and standing resulted in the reduced DR of yam mucilage. However, salt ions exerted dual effects on the DR of yam mucilage: Low concentrations of NaCl improved its effectiveness while Na2SO4 and high concentrations of NaCl diminished its efficacy. The addition of a small quantity of PEO was found to significantly enhance the drag reduction efficacy of yam mucilage, but no significant improvement in the shear stability of yam mucilage was observed. Yam mucilage exhibits promising potential as an environmentally friendly drag reducer with remarkable drag reduction capabilities.

Deformed graphene FET biosensor on textured glass coupled with dielectrophoretic trapping for ultrasensitive detection of GFAP

Numerous efforts have been undertaken to mitigate the Debye screening effect of FET biosensors for achieving higher sensitivity. There are few reports that show sub-femtomolar detection of biomolecules by FET mechanisms but they either suffer from significant background noise or lack robust control. In this aspect, deformed/crumpled graphene has been recently deployed by other researchers for various biomolecule detection like DNA, COVID-19 spike proteins and immunity markers like IL-6 at sub-femtomolar levels. However, the chemical vapor deposition (CVD) approach for graphene fabrication suffers from various surface contamination while the transfer process induces structural defects. In this paper, an alternative fabrication methodology has been proposed where glass substrate has been initially texturized by wet chemical etching through the sacrificial layer of synthesized silver nanoparticles, obtained by annealing of thin silver films leading to solid state dewetting. Graphene has been subsequently deposited by thermal reduction technique from graphene oxide solution. The resulting deformed graphene structure exhibits higher sensor response towards glial fibrillary acidic protein (GFAP) detection with respect to flat graphene owing to the combined effect of reduced Debye screening and higher surface area for receptor immobilization. Additionally, another interesting aspect of the reported work lies in the biomolecule capture by dielectrophoretic (DEP) transport on the crests of the convex surfaces of graphene in a coplanar gated topology structure which has resulted in 10 aM and 28 aM detection limits of GFAP in buffer and undiluted plasma respectively, within 15 min of application of analyte. The detection limit in buffer is almost four decades lower than that documented for GFAP using biosensors which is is expected to pave way for advancing graphene FET based sensors towards ultrasensitive point-of-care diagnosis of GFAP, a biomarker for traumatic brain injury.

Enthalpies of mixing for alloys liquid below room temperature determined by oxidative solution calorimetry

Enthalpies of mixing for alloys liquid below room temperature determined by oxidative solution calorimetry

In situ pulmonary mucus hydration assay using rotational and translational diffusion of gold nanorods with polarization-sensitive optical coherence tomography.

Assessing the nanostructure of polymer solutions and biofluids is broadly useful for understanding drug delivery and disease progression and for monitoring therapy. Our objective is to quantify bronchial mucus solids concentration (wt. %) during hypertonic saline (HTS) treatment in vitro via nanostructurally constrained diffusion of gold nanorods (GNRs) monitored by polarization-sensitive optical coherence tomography (PS-OCT). Using PS-OCT, we quantified GNR translational () and rotational () diffusion coefficients within polyethylene oxide solutions (0 to 3wt. %) and human bronchial epithelial cell (hBEC) mucus (0 to 6.4wt. %). Interpolation of and data is used to develop an assay to quantify mucus concentration. The assay is demonstrated on the mucus layer of an air-liquid interface hBEC culture during HTS treatment. In polymer solutions and mucus, and monotonically decrease with increasing concentration. is more sensitive than to changes above 1.5wt. % of mucus and exhibits less intrasample variability. Mucus on HTS-treated hBEC cultures exhibits dynamic mixing from cilia. A region of hard-packed mucus is revealed by measurements. The extended dynamic range afforded by simultaneous measurement of and of GNRs using PS-OCT enables resolving concentration of the bronchial mucus layer over a range from healthy to disease in depth and time during HTS treatment in vitro.

Fabrication of high-flux PTFE hollow fiber membranes through nonionic surfactant infiltration coupled with mussel-inspired chemistry coating

Polytetrafluoroethylene (PTFE) hollow fiber membrane holds tremendous potential for the treatment of complex wastewater due to its outstanding chemical and thermal stability. However, its treatment efficiency is often hindered by the low water permeate flux arising from the inherent hydrophobicity of PTFE. Here, we present a gentle and convenient hydrophilic modification method that involves immersion in a nonionic surfactant aqueous solution, followed by dopamine self-polymerization. The nonionic surfactant facilitated the penetration of the dopamine solution into the membrane, where dopamine self-polymerized to form a hydrophilic layer on the surface and inner pores of the membrane. The hydrophilicity-modified PTFE hollow fiber membranes demonstrated an impressive increase in water permeate flux, reaching 10231.4 L m−2 h−1, nearly ten times that of the original membrane. Even after prolonged exposure to a strong acid solution (pH = 1) or an oxidant solution (1000 mg L−1 NaClO) for two weeks, this membrane still maintained its favorable water permeability. Furthermore, the modified PTFE membranes also exhibited remarkable resistance to fouling by humic acid. These results showcased a straightforward method for designing a hydrophilic layer on PTFE hollow fiber membranes, underscoring their significant potential for real wastewater treatment applications.

Hydrophilic Modification of Polytetrafluoroethylene (PTFE) Capillary Membranes with Chemical Resistance by Constructing Three-Dimensional Hydrophilic Networks.

Polytetrafluoroethylene (PTFE) capillary membranes, known for the great chemical resistance and thermal stability, are commonly used in membrane separation technologies. However, the strong hydrophobic property of PTFE limits its application in water filtration. This study introduces a method whereby acrylamide (AM), N, N-methylene bisacrylamide (MBA), and vinyltriethoxysilane (VTES) undergo free radical copolymerization, followed by the hydrolysis-condensation of silane bonds, resulting in the formation of hydrophilic three-dimensional networks physically intertwined with the PTFE capillary membranes. The modified PTFE capillary membranes prepared through this method exhibit excellent hydrophilic properties, whose water contact angles are decreased by 24.3-61.2%, and increasing pure water flux from 0 to 1732.7-2666.0 L/m2·h. The enhancement in hydrophilicity of the modified PTFE capillary membranes is attributed to the introduction of hydrophilic groups such as amide bonds and siloxane bonds, along with an increase in surface roughness. Moreover, the modified PTFE capillary membranes exhibit chemical resistance, maintaining the hydrophilicity even after immersion in strong acidic (3 wt% HCl), alkaline (3 wt% NaOH), and oxidative (3 wt% NaClO) solutions for 2 weeks. In conclusion, this promising method yields modified PTFE capillary membranes with great hydrophilicity and chemical resistance, presenting substantial potential for applications in the field of water filtration.

Preparation, characterization, and the antimicrobial activity of PVA-PVP/ZnO nanofiber films via indigenous electrospinning setup

The study aimed to produce composite nanofibers (NFs) using the electrospinning method from Polyvinyl alcohol- Polyvinylpyrrolidone/Zinc oxide (PVA-PVP/ZnO) solutions. X-ray diffraction analysis confirmed that in the composite nanofibers, the relative intensity of the dominant crystal plane (101) associated with the wurtzite hexagonal structure of ZnO nanoparticles (NPs) decreased, and its broadness increased in the composite, indicating the presence of an amorphous part in the sample. The existence of functional groups from polymer systems was confirmed by Fourier-transform infrared spectroscopy (FTIR) spectral analysis. Field emission scanning electron microscope (FESEM) images revealed linear and branched uniform nanofiber structures with smooth surfaces of PVA-PVP/ZnO electrospun. The absorbance of PVA-PVP/ZnO NFs increased with the increase in ZnO NPs content, and an absorption band was observed in the ultra violet (UV) region at around 310 nm. The calculation of the optical energy gap using the absorption spectra fitting (ASF) approach roughly aligned with Tauc's model, ranging from 3.47 to 3.24 eV. The highest inhibition zone (14 and 15 mm) was observed at the ratios of 4 and 6 wt.% of ZnO NPs against gram-negative bacteria (Escherichia coli).

Memory and scission effects of polymers on the flow regime of polyethylene oxide solutions in continuous abrupt contraction–expansion microchannels with different cavity lengths

This study experimentally observes the flow regimes of polyethylene oxide solutions in continuous, abrupt contraction–expansion microchannels. In dilute solutions (0.5 × 10−3–1.5 × 10−3 wt. %), the effects of flow rate, concentration, and cavity length on flow characteristics in the contraction and expansion parts of each cavity are analyzed, including quantified calculations of normalized vortex lengths and extension rates. The results indicate that polymer memory and scission affect the flow transitions. Memory effects enhance vortex growth and scission weakens flow, and these effects occur continuously within the channel. Increased flow rates and cavity lengths intensify polymer scission, accelerating the transitions from elastic instability to corner vortex, lip vortex, and then to steady vortex-free flows in the contraction parts and from steady vortex-free flows to lip and corner vortices in the expansion parts. The flow-regime transitions for concentrations from 0.01 to 0.4 wt. % for dilute and unentangled semi-dilute solutions at various flow rates are summarized in the Reynolds and Weissenberg number spaces. Polymer chains tend to become entangled in higher-concentration solutions, rendering the solution rigid and inducing complex flow regimes.

Improvement of carbon fiber/phenolic composite properties by low-loading graphene oxide and SiO2 nanoparticles

As an ablative thermal protection material, the mechanical properties and ablative resistance of carbon fiber/phenolic (C-Ph) composite should be improved to meet the high requirements in deep space exploration. Herein, the properties of C-Ph composites were improved by the synergistic effect of low-concentration graphene oxide (GO) solution and low mass fraction of SiO2 nanoparticles. Compared to the unmodified C-Ph composite, the compressive strength of the modified composites was increased by 40.75 % and the linear and mass ablation rates were reduced by 17.78 % and 43.95 %, respectively. The introduction of GO effectively improved the interfacial bonding between the fiber and phenolic resin. Meanwhile, the uniformly dispersed SiO2 nanoparticles resisted the applied loads, thus synergistically enhancing the mechanical properties of the composites. In terms of improving ablation resistance, GO promoted the graphitization of fibers and enhanced the stability of the char layer. Concurrently, SiO2 nanoparticles reacted with the carbon matrix under high temperatures to form ablation-resistant SiC, thus synergistically enhancing the ablative properties of the composite.

Fabrication of advanced thin film for high performance display by nanoimprinting process via gallium oxide solution doped tin

Line pattern replication process through nanoimprint lithography (NIL) method has been used in numerous of research fields. NIL technology is not yet utilized for displays industry, and we propose an alignment layer of the sol-gel process using NIL. One-dimensionally nanopatterned by polydimethylsiloxane sheets cause surface changes in hybrid SnGaO thin films mixed in a 3:7 ratio, which aligns the liquid crystals (LCs) uniformly in the line pattern direction. These surface changes are confirmed through atomic force microscopy data analysis, and changes in surface shapes for different the curing temperatures in the furnace are analyzed. X-ray photoelectron spectroscopy shows that the chemical composition of the thin films changes according to curing temperatures, and the intensities of SnO and GaO increase exponentially at 200 °C compared to those at 50 °C. Through this, the van der Waals force increases between surface molecules, in the anisotropic direction to help align the LCs. Furthermore, we performed polarized optical microscopy and pre-tilt angle analysis confirm that the LCs are energized uniformly. Finally, the performance of an actual display device transmittance and electro-optical properties; the transmittance of SnGaO is 4.51p% higher than that of the currently commercialized PI-rubbing, and the voltage-transmittance curve is a perfect graph.

Characterization and Eco-Friendly Synthesis of Silver and Iron Nanoparticles Using Microalgae Extracts: Implications for Nanobiotechnology.

<b>Background and Objective:</b> The remarkable surface-to-volume ratio and efficient particle interaction capabilities of nanoparticles have garnered significant attention among researchers. Microalgal synthesis presents a sustainable and cost-effective approach to nanoparticle production, particularly noteworthy for its high metal uptake and ion reduction capabilities. This study focuses on the eco-friendly and straightforward synthesis of Silver (AgNPs) and Iron (FeNPs) nanoparticles by utilizing Spirulina (<i>Arthrospira platensis</i>) and <i>Chlorella pyrenoidosa</i> extract, devoid of any chemical reducing or capping agents. <b>Materials and Methods:</b> Following the mixing of 1 mM AgNO<sub>3</sub> and 1 mM iron oxide solution with the algal extract, the resulting filtrated solution underwent comprehensive characterization, including UV-visible absorption spectra analysis, observation of particle morphology, Zetasizer measurements and Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX) analysis. <b>Results:</b> The UV-visible spectroscopy revealed a maximum absorbance peak at 430-440 nm, confirming the successful green synthesis of AgNPs and FeNPs, as indicated by the distinct color change from transparent to dark reddish-yellow and brown to reddish-brown, respectively. The SEM-EDX analysis further elucidated the spherical morphology of the nanoparticles, with an average diameter of 93.71 nm for AgNPs and 6198 nm for FeNPs. The Zeta potential measurements indicated average values of -56.68 mV for AgNPs and 29.73 mV for FeNPs, with conductivities of 0.1764 and 0.6786 mS/cm, respectively. <b>Conclusion:</b> The observed bioaccumulation of silver and iron nanoparticles within the algal extract underscores its potential as an environmentally friendly and cost-effective method for nanoparticle synthesis. These findings suggested a promising avenues for the application of silver and iron nanoparticles in the field of nanobiotechnology. Future research endeavors could focus on optimizing preparation conditions and controlling nanoparticle size to further enhance their utility and effectiveness.

Detection of 238Pu at picogram quantities by laser resonance ionization mass spectrometry

Based on the laser resonance ionization mass spectrometry (LRIMS) developed in the laboratory, a preliminary method was established to determine Pu isotope ratios. A three-color-three-photon resonance ionization scheme was confirmed, and the laser wavelengths of each excitation/ionization step were λ1 = 586.654 nm, λ2 = 606.181 nm and λ3 = 642.722 nm. The selective ionization of 238Pu/238U was realized by testing the Pu and U mixed sample, a selectivity ratio of over 107 was obtained. More effective electrothermal atomization of Pu was implemented by loading graphene oxide solution on the Pu sample surface, and the total detection efficiency of ∼40 ng Pu sample was above 3 × 10−4, which was three orders of magnitude higher than the efficiency of the unloaded graphene oxide solution Pu sample. Results showed that the relative standard deviation of 238Pu/239Pu ratio was ∼0.20%, indicating that LRIMS could effectively avoid the isobaric interference of 238U faced by other commercial mass spectrometers such as TIMS and ICP-MS, and could achieve precise measurement of 238Pu/239Pu ratio.

Stability of the standard nitric oxide solution – The changes of UV–Vis spectrum over one year

The stability of standard nitric oxide solution can be observed by UV–Vis spectrometry; it is possible to observe changes over 365 days of storage but also over one day under air-equilibrated conditions. Nitrous acid tetrad appeared after one week and disappeared after three months; the peak of nitrate ions appeared after one month and grew for the next two months, it reached the maximum when the nitrous acid tetrad disappeared, and the spectrum of nitrate ions was stable for the rest of the year.

Technological solutions to landfill management: Towards recovery of biomethane and carbon neutrality

Inadequate landfill management poses risks to the environment and human health, necessitating action. Poorly designed and operated landfills release harmful gases, contaminate water, and deplete resources. Aligning landfill management with the Sustainable Development Goals (SDGs) reveals its crucial role in achieving various targets. Urgent transformation of landfill practices is necessary to address challenges like climate change, carbon neutrality, food security, and resource recovery. The scientific community recognizes landfill management's impact on climate change, evidenced by in over 191 published articles (1998–2023). This article presents emerging solutions for sustainable landfill management, including physico-chemical, oxidation, and biological treatments. Each technology is evaluated for practical applications. The article emphasizes landfill management's global significance in pursuing carbon neutrality, prioritizing resource recovery over end-of-pipe treatments. It is important to note that minimizing water, chemical, and energy inputs in nutrient recovery is crucial for achieving carbon neutrality by 2050. Water reuse, energy recovery, and material selection during manufacturing are vital. The potential of water technologies for recovering macro-nutrients from landfill leachate is explored, considering feasibility factors. Integrated waste management approaches, such as recycling and composting, reduce waste and minimize environmental impact. It is conclusively evident that the water technologies not only facilitate the purification of leachate but also enable the recovery of valuable substances such as ammonium, heavy metals, nutrients, and salts. This recovery process holds economic benefits, while the conversion of CH4 and hydrogen into bioenergy and power generation through microbial fuel cells further enhances its potential. Future research should focus on sustainable and cost-effective treatment technologies for landfill leachate. Improving landfill management can mitigate the adverse environmental and health effects of inadequate waste disposal.

Copolymerization of pyrrole and carbazole onto polyester textile.

The purpose of this study was the polymerization of carbazole (Cz), pyrrole (Py) and copolymerization of them onto polyester (PES) textile with chemical oxidative method by using FeCl3. First, in order to determine the optimum conditions, the effect of polymerization steps, the immersion order of the PES to the oxidant and monomer solutions, time, monomer, oxidant, and surfactant concentrations and types on the conductivities of PES/PCz composite were investigated and at this conditions, conductive composite, PES/P[Py-co-Cz] was obtained. The highest conductivities were obtained as 12.4 mS/cm and 9.0 mS/cm for PES/PCz and PES/P[Py-co-Cz], respectively. Further characterization of PES/P[Py-co-Cz] was performed by conductivity, FTIR, scanning electron microscopy (SEM), and dynamic mechanical analysis (DMA) measurements, and results were compared with PES/PCz and also PES/PPy. The presence of Py and Cz in the same polymer chain created synergy and improved the conductivity and mechanical properties of the composite.

Hybrid Electrolyte Based on PEO and Ionic Liquid with In Situ Produced and Dispersed Silica for Sustainable Solid-State Battery

This work introduces the synthesis of hybrid polymer electrolytes based on polyethylene oxide (PEO) and electrolyte solution bis(trifluoromethane)sulfonimide lithium salt/ionic liquid 1-ethyl-3-methyl-imidazolium bis(trifluoromethylsulfonyl)imide (LiTFSI/EMIMTFSI) with in situ produced and dispersed silica particles by the sol–gel method. Conventional preparation of solid polymer electrolytes was followed by desolvation of lithium salt in a polymer matrix of PEO, which, in some cases, additionally contains plasticizers. This one-pot synthesis is an alternative route for fabricating a solid polymer electrolyte for solid-state batteries. The presence of TFSI- reduces the crystallinity of the PEO matrix (plasticizing effect), increases the dissociation and solubility of LiTFSI in the PEO matrix because of a highly delocalized charge distribution, and reveals excellent thermal, chemical, and electrochemical stability. Tetraethylorthosilicate (TEOS) was chosen due to the slow reaction rate, with the addition of (3-glycidyoxypropyl)trimethoxysilane (GLYMO), which contributes to the formation of a silica network. FTIR studies confirmed the interactions between the silica, the polymer salt, and EMIMTFSI. Impedance spectroscopy measurements were performed in a wide range of temperatures from 25 to 70 °C. The electrochemical performance was explored by assembling electrolytes in LiCoO2 (LCO), NMC(811), and LiFePO4 (LFP) coin half-cells. The HPEf15 shows a discharge capacity of 143 mA/g for NMC(811) at 0.1 C, 134 mA/g for LCO, and 139 mA/g for LFP half-cells at 0.1 C and 55 °C. The LFP half-cell with a discharge capacity of 135 mA/g at 0.1 C (safety potential range of 2.8 to 3.8) obtained a cyclability of 97.5% at 55 °C after 100 cycles. Such a type of electrolyte with high safety and good electrochemical performance provides a potential approach for developing a safer lithium-ion battery.

Study of Electrical and Mechanical Properties of Polypyrrole-Coated Three-Dimensional Spacer Fabric

In this study, the liquid phase oxidative polymerization method was utilized to prepare polypyrrole conductive three-dimensional spacer fabrics. By controlling pyrrole solution, oxidant FeCl3 solution, dopant p-toluene sulfonic acid concentration and reaction time, the optimal process for the preparation of conductive spacer fabrics was obtained. This led to the best preparation process of polypyrrole-coated three-dimensional spacer conductive fabric (polypyrrole/three-dimensional spacer fabrics) being obtained. The results showed that the conductive properties of polypyrrole/three-dimensional spacer fabrics were the best when 0.10 mol/L pyrrole, 0.40 mol/L oxidant FeCl3 solution, and 0.40 mol/L dopant p-toluene sulfonic acid were prepared within a 2-h reaction time. The properties of polypyrrole/three-dimensional spacer fabrics were analyzed using the results from surface resistance, Fourier transform-infrared spectroscopy, mechanical properties, and stability tests. The results showed that polypyrrole was well attached to the three-dimensional spacer fabric surface, and the concentration of polypyrrole in the fabric exhibited an inverse correlation with changes in surface resistance. The mechanical properties of polypyrrole/three-dimensional spacer fabrics after treatment exhibit superior performance, with consistent changes in the meridional and zonal electrical properties during tensile testing and can maintain excellent long-term electrical stability in atmospheric environments.

Particle Size-Dependent Electrophoresis in Polymer Solutions.

It has long been known that the electrophoretic velocity of a charged particle is independent of its size under the thin-Debye-layer limit. This so-called Smoluchowski velocity is, however, valid only for Newtonian fluids. A couple of recent theoretical studies predict the rheology-induced particle size dependence of electrophoresis in non-Newtonian fluids. This work presents the first experimental demonstration of such dependence in viscoelastic poly(ethylene oxide) (PEO) solutions. Three different-sized particles are observed to travel at the same electrophoretic velocity in a Newtonian buffer through a rectangular microchannel. In contrast, their measured electrophoretic velocities in the PEO solution exhibit an increasing trend for larger particles, which is consistent with theoretical prediction. This particle size dependence is found to grow with an increasing concentration or length of the PEO polymer. Both trends are attributed to enhanced fluid elasticity, as characterized by the increasing elasticity number.

Molecularly Targeted Lanthanide Nanoparticles for Cancer Theranostic Applications

Injectable colloidal solutions of lanthanide oxides (nanoparticles between 10 and 100 nm in size) have demonstrated high biocompatibility and no toxicity when the nanoparticulate units are functionalized with specific biomolecules that molecularly target various proteins in the tumor microenvironment. Among the proteins successfully targeted by functionalized lanthanide nanoparticles are folic receptors, fibroblast activation protein (FAP), gastrin-releasing peptide receptor (GRP-R), prostate-specific membrane antigen (PSMA), and integrins associated with tumor neovasculature. Lutetium, samarium, europium, holmium, and terbium, either as lanthanide oxide nanoparticles or as nanoparticles doped with lanthanide ions, have demonstrated their theranostic potential through their ability to generate molecular images by magnetic resonance, nuclear, optical, or computed tomography imaging. Likewise, photodynamic therapy, targeted radiotherapy (neutron-activated nanoparticles), drug delivery guidance, and image-guided tumor therapy are some examples of their potential therapeutic applications. This review provides an overview of cancer theranostics based on lanthanide nanoparticles coated with specific peptides, ligands, and proteins targeting the tumor microenvironment.

Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput

Elasto-inertial microfluidic separation offers many advantages including high throughput and separation resolution. Even though the separation efficiency highly depends on precise control of the flow conditions, no concrete guidelines have been reported yet in elasto-inertial microfluidics. Here, we propose a dimensionless analysis for precise estimation of the microsphere behaviors across the interface of Newtonian and viscoelastic fluids. Reynolds number, modified Weissenberg number, and modified elastic number are used to investigate the balance between inertial and elastic lift forces. Based on the findings, we introduce a new dimensionless number defined as the width of the Newtonian fluid stream divided by microsphere diameter. The proposed dimensionless analysis allows us to predict whether the microspheres migrate across the co-flow interface. The theoretical estimation is found to be in good agreement with the experimental results using 2.1- and 3.2-μm-diameter polystyrene microspheres in a co-flow of water and polyethylene oxide solution. Based on the theoretical estimation, we also realize submicron separation of the microspheres with 2.1 and 2.5 μm in diameter at high throughput, high purity (>95%), and high recovery rate (>97%). The applicability of the proposed method was validated by separation of platelets from similar-sized Escherichia coli (E.coli).