Oxide Nanocomposite Hydrogels Research Articles

Multifunctional Self-Assembled Block Copolymer/Iron Oxide Nanocomposite Hydrogels Formed from Wormlike Micelles.

This article reports the preparation of multifunctional magnetic nanocomposite hydrogels formed from wormlike micelles. Specifically, iron oxide nanoparticles were incorporated into a temperature responsive block copolymer, poly(glycerol monomethacrylate)-b-poly(2-hydroxypropyl methacrylate) (PGMA-b-PHPMA), and graphene oxide (GO) dispersion at a low temperature (∼2 °C) through high-speed mixing and returning the mixture to room temperature, resulting in the formation of nanocomposite gels. The optimal concentrations of iron oxide and GO enhanced the gel strength of the nanocomposite gels, which exhibited a strong magnetic response when a magnetic field was applied. These materials retained the thermoresponsiveness of the PGMA-PHPMA wormlike micelles allowing for a solid-to-liquid transition to occur when the temperature was reduced. The mechanical and rheological properties and performance of the nanocomposite gels were demonstrated to be adjustable, making them suitable for a wide range of potential applications. These nanocomposite worm gels were demonstrated to be relatively adhesive and to act as strain and temperature sensors, with the measured electrical resistance of the nanocomposite gels changing with applied strain and temperature sweeps. The nanocomposite gels were found to recover efficiently after the application of high shear with approximately 100% healing efficiency within seconds. Additionally, these nanocomposite worm gels were injectable, and the addition of GO and iron oxide nanomaterials seemed to have no significant adverse impact on the biocompatibility of the copolymer gels, making them suitable not only for 3D printing in nanocomposite engineering but also for potential utilization in various biomedical applications as an injectable magnetic responsive hydrogel.

Adsorption studies of toxic organic pesticides from aqueous medium by sodium alginate‐cl‐poly (allyl amine‐co‐acrylic acid)/copper oxide nanocomposite hydrogel: Isotherms, kinetics, and thermodynamics

AbstractThe sodium alginate (SAG) cross‐linked poly (allyl amine‐co‐acrylic acid)/copper oxide [SAG‐cl‐poly(AAM‐co‐AA)/CuO] nanocomposite hydrogel (SNCHG) was synthesized by using a free radical initiated cross‐linked copolymerization process in‐situ. Several characterization techniques namely FTIR, PXRD, FESEM with EDAX, TGA, and BET analysis were employed to characterize the synthesized SNCHG. Water swelling properties together with swelling kinetics of SNCHG were evaluated. The highest swelling (35% after 30 minutes) was found at pH 8. The adsorption property of the developed nanocomposite hydrogel (SNCHG) was evaluated in three pesticides' solution namely chlorpyrifos (CP), phosalone (PL), and 4,4'‐ dichloro diphenyl dichloro ethane (DD) in water medium. Several factors affecting the adsorption like solution pH, time of adsorption, amount of pesticides, etc. were evaluated. The maximum adsorption were found to be 96.9% for CP at pH 7, 95.85% for PL at pH 7, and 86.72% for DD at pH 4. Pseudo‐second order kinetics and both Freundlich and Dubinin–Radushkevich adsorption isotherms were followed in all the three cases. Maximum adsorption capacity (Qm) were found to be 507.61, 158.22, and 132.97 mg g−1 for CP, PL, and DD, respectively. The adsorption process was endothermic in nature and spontaneous.Highlights A novel CuO Nps embedded sodium alginate‐based hydrogel is developed. Increment of surface area and water swelling property are illustrated. The hydrogel exhibits excellent adsorption property towards pesticides. The observed affinity of adsorption is chemisorption.

Novel microbicide graphene oxide nanocomposite hydrogel against herpes simplex virus

Hydrogels are 3D network soft materials capable of swelling in water. Graphene oxide (GO) hydrogels have garnered attention due to their inherent biocompatibility, large surface area, bioavailability, and excellent mechanical properties. In this study, we report the synthesis and characterization of a novel hydrogel nanocomposite incorporating GO, chitosan nanoparticles (CS NPs), zinc oxide nanoparticles (ZnO NPs), and tannic acid (TA). TA acts as a green crosslinker for GO, a binder for ZnO NPs, and a material known for its antiviral and antimicrobial activity. GO sheets were used to stabilize ZnO NPs and prevent their agglomeration. We evaluated the antimicrobial and antiviral activity of the novel nanocomposite hydrogel against pathogenic microbes and the herpes simplex virus (HSV-1), which revealed strong inhibition effects.We demonstrated that the hydrogel nanocomposite incorporating TA, CS NPs,ZnO NPs, and GO sheets displays novel antimicrobial properties. The hydrogel nanocomposite presents a versatile framework for the integration of antibacterial activity against Gram-positive and Gram-negative bacteria, as well as antifungal and anti-Herpes virus (HSV-1) applications. Furthermore, this hydrogel exhibited superior antiviral activity against the HSV-1 virus, with nearly 86% inhibition. The hydrogels possess pH-responsive properties with no cytotoxic effects and represent an up-to-date strategy for improving antiviral surfaces, personal protective equipment (PPE), and sprays based on their excellent swelling properties.

Ultrasound-assisted adsorption of chlorpyrifos from aqueous solutions using magnetic chitosan/graphene quantum dot‑iron oxide nanocomposite hydrogel beads in batch adsorption column and fixed bed

Chlorpyrifos is a hazardous material that pollutes the environment and also poses risks to human health. Thus, it is necessary to remove chlorpyrifos from aqueous media. In this study, chitosan-based hydrogel beads with different content of iron oxide-graphene quantum dots were synthesized and used for the ultrasonic-assisted removal of chlorpyrifos from wastewater. The results of batch adsorption experiments showed that among the hydrogel beads-based nanocomposites, the chitosan/graphene quantum dot‑iron oxide (10) indicated a higher adsorption efficiency of about 99.997 % at optimum conditions of the response surface method. Fitting the experimental equilibrium data to different models shows that the adsorption of chlorpyrifos is well described by the Jossens, Avrami, and double exponential models. Furthermore, for the first time, the study of the ultrasonic effect on the removal performance of chlorpyrifos showed that the ultrasonic-assisted removal of chlorpyrifos significantly reduces the equilibration time. It is expected that the ultrasonic-assisted removal strategy can be a new method to develop highly efficient adsorbents for rapid removal of pollutants in wastewater. Also, the results of the fixed bed adsorption column showed that the breakthrough time and exhausting time of chitosan/graphene quantum dot‑iron oxide (10) were equal to 485 and 1099 min, respectively. And finally, the adsorption-desorption study showed the successful reuse of adsorbent for chlorpyrifos adsorption in seven runs without a significant decrease in adsorption efficiency. Therefore, it can be said that the adsorbent has a high economic and functional potential for industrial applications.

Graphene Oxide Nanocomposite Hydrogels Based on Mucilage Extracted from Ocimum basilicum Seeds Grafted by Acrylate Polymers; Assay on Physicochemical Properties

Graphene Oxide Nanocomposite Hydrogels Based on Mucilage Extracted from Ocimum basilicum Seeds Grafted by Acrylate Polymers; Assay on Physicochemical Properties

Phosphonated graphene oxide-modified polyacrylamide hydrogel electrolytes for solid-state zinc-ion batteries

Compared to rigid batteries using liquid electrolytes, solid-state batteries (SSBs) offer several advantages: flexibility, prevention of leakage, suppression of dendritic formation and hydrogen evolution, as well as minimization of cathode active material dissolution. For the materialization of real-life SSBs, gel polymer electrolytes (GPEs) are among promising candidates. However, development of GPEs with satisfying ionic conductivity and mechanical endurance is challenging. Herein, we report on the development of polyacrylamide (PAM)/phosphonated graphene oxide (PGO) nanocomposite hydrogel electrolytes for zinc-ion batteries; PGO acts as the filler through in-situ polymerization of acrylamide in an aqueous suspension of PGO. The synthesized PAM/PGO hydrogel exhibits high ionic conductivity of 31.0 mS/cm at 30 °C compared to that of PAM (13.8 mS/cm) and PAM-GO (20.8 mS/cm). The higher ionic conductivity of PAM-PGO can be attributed to its higher hydrophilicity and electrolyte storage capacity along with its lower activation energy for ionic conduction (7.2 KJ/mol K) in comparison with that of PAM (10.1 KJ/mol K) and PAM-GO (10.2 KJ/mol K). The interaction between water against PAM, PAM-GO and PAM-PGO is investigated via density-functional theory (DFT). The MnO2-based zinc-ion battery assembled using PAM-PGO as electrolyte shows high initial capacity of 240 mAh/g, losing only 4 and 15% of its capacity after 100 and 145 cycles, respectively. Results demonstrate promising potential of PAM-PGO as a solid-state electrolyte for flexible battery applications.

Cationic Dye Removal (Methylene Blue) from Aqueous Solution Using the Ecologically Friendly Alginate/Hydroxyapatite/Graphene Oxide Nanocomposite Hydrogel Beads

Cationic Dye Removal (Methylene Blue) from Aqueous Solution Using the Ecologically Friendly Alginate/Hydroxyapatite/Graphene Oxide Nanocomposite Hydrogel Beads

Super-strong and anti-tearing poly(vinyl alcohol)/graphene oxide nano-composite hydrogels fabricated by formation of multiple crosslinking bonding network structure

As load-bearing material in biomedical-applications as cartilage replacement, artificial meniscus and tendons, etc., poly(vinyl alcohol) (PVA)/graphene oxide (GO)-tannic acid (TA) nano-composite hydrogels with multiple-crosslinking network were fabricated by establishing freezing/thawing-annealing-swelling method. By TA anchoring, PVA molecules were grafted onto GO surface efficiently, and strong interfacial interaction led to exfoliation and uniform distribution of GO in matrix. By introducing annealing process, the crystallinity and crystallite size of PVA increased and introducing GO-TA led to more perfect and denser crystalline structure, while physical crosslinking network centered on GO-TA and hydrogen bond-abundant crystalline phase formed, resulting in increasing crosslinking density of hydrogel. By further swelling in CaCl2 aqueous solution, hydroxyl-Ca2+ coordination formed, and multiple-crosslinking network was constructed with high crosslinking density. The tensile strength and fracture toughness of composite hydrogel were remarkably improved, reaching 14.38 MPa/27.93 MJ/m3, approximately 11-/26-fold higher than those of neat PVA hydrogel, while tearing strength was significantly enhanced, attributed to high energy dissipation through unzipping multiple interactions.

Enhanced adsorption performance of chitosan/cellulose nanofiber isolated from durian peel waste/graphene oxide nanocomposite hydrogels

In this work, nanocomposite hydrogels were prepared from cellulose nanofiber (CNF) isolated from durian peel waste combined with chitosan (CS) and graphene oxide (GO) with glutaraldehyde as a cross-linking agent. The morphology, structure and thermal properties of the nanocomposites were investigated using Scanning electron microscopy, Fourier-transform infrared spectroscopy, Raman spectroscopy, X-ray diffraction and thermogravimetric analysis techniques. Accordingly, the nanocomposite hydrogels was used for the removal of methylene blue (MB) dye and levofloxacin hemihydrate (LFX) antibiotics pollutant. It was found that the presence of GO in the matrix further enhances the adsorption capacities of 32.05 and 11.01 mg/g for MB and LFX, respectively obtained from pseudo-second order kinetic model. In addition, the removal percentage for both MB and LFX were achieved > 85 % for CS/CNF/GO (6 mg/mL) hydrogels due to the strong electrostatic interaction with MB and LFX. This study revealed that the addition of GO into nanocomposites hydrogel effectively remove MB and LFX in aqueous solution with low cost processing, facile preparation, thus promising for future wastewater treatment.

Green synthesis, characterization, photocatalytic activity, and biological applications of gelatin-sodium alginate zinc oxide nanocomposite

The present study stated a green approach for synthesizing zinc oxide nanoparticles using Oldenlandia umbellata (Rubiaceae) plant extract, which was used as the biological reducing agent for synthesizing zinc oxide nanoparticles from zinc nitrate hexahydrate. The synthesized ZnO nanoparticles were loaded with Gelatin-Sodium alginate biopolymers to convert them into Gelatin-Sodium alginate-Zinc oxide (GSZnO) nanocomposite hydrogels. The UV–Visible spectroscopy showed maximum absorbance at 376 nm for ZnO Nanoparticles and 360 nm for GSZnO nanocomposite. Different functional groups in ZnO Nps and GSZnO nanocomposites are identified using FT-IR spectroscopy. The SEM analysis of ZnO Nps and GSZnO nanocomposites demonstrates the size in the range of 67–80 nm. DLS Particle size analysis shows 71 nm for ZnO.A NPs and 74 nm for GSZnO nanocomposites. XRD analysis proved the crystalline nature and sharp highest peak at 101) plane confirm the hexagonal shape. While the EDAX analysis confirmed the formation of zinc oxide in the nanoparticles. Antioxidant studies were carried out for ZnO.A Nps showed better antioxidant properties compared to plant extract. The antimicrobial activity of plant extract and ZnO.A Nanoparticles were done against Staphylococcus aureus, Proteus vulgaris, Aspergillus flavus, and Candida albicans. ZnO.A nanoparticles showed good photocatalytic activity of methylene red dye in the presence of visible light irradiation. GSZnO nanocomposite was studied for In-vitro cytotoxicity on Vero cells, The IC50 value for the GSZnO nanocomposite was 101.5 µg/ml.

Synthesis and catalytic evaluation of silver@nickel oxide and alginate biopolymer nanocomposite hydrogel beads

In this study, silver–nickel oxide/calcium alginate (Ag@NiO/Alg) hydrogel beads were synthesized by incorporating the nanomaterial into the polymer solution followed by their extrusion from a syringe to coagulating solution for crosslinking. The Ag@NiO/Alg beads formed through this procedure were characterized by different instrumental techniques. The catalytic efficiency of Ag@NiO/Alg was evaluated for the reduction of rhodamine B (RhB) and methyl orange (MO), in the presence of sodium borohydride. After applying various kinetic order equations to the experimental data, the reactions were found to follow pseudo-first order kinetics using the Ag@NiO/Alg catalyst. The apparent rate constant (kapp) was determined as 0.33358 min−1 and 0.20882 min−1 for the catalytic reduction of RhB and MO, respectively. Furthermore, reduction reactions were studied at varying dye concentration and catalyst dosages. The recovered catalyst was reused up to five cycles without significant drop in the activity.

Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery

Nanocomposite hydrogels are one of the most important types of biomaterials which can be used in many different applications such as drug delivery and tissue engineering. Placement of nanoparticles within a hydrogel matrix can provide unique characteristics like remote stimulate and mechanical strength improvement. In this study, the synthesis of graphene oxide and graphene oxide nanocomposite hydrogel has been studied. Nanocomposite hydrogel was synthesized with carboxymethyl cellulose as a natural base, acrylic acid as a monomer, graphene oxide as a filler, ammonium persulfate as an initiator, and iron nanoparticles as a crosslinking agent. The effect of reaction variables such as the iron nanoparticles, graphene oxide, ammonium persulfate, and acrylic acid were examined to achieve a hydrogel with maximum absorbency. Doxorubicin, as an anti-cancer chemotherapy drug, was loaded on this hydrogel and the release of drug in a phosphate buffer solution with different pH was carried out. The structure of the graphene oxide and optimized hydrogel were confirmed by Fourier-transform infrared spectroscopy, Raman spectroscopy, X-Ray diffraction, scanning electron microscopy, and atomic force microscopy.

Fabrication of chitosan-aminopropylsilane graphene oxide nanocomposite hydrogel embedded PES membrane for improved filtration performance and lead separation

In the present study chitosan-aminopropylsilane graphene oxide (CS-APSGO) nanocomposite hydrogel was synthesized and utilized as a hydrophilic additive in different dosages (0.5, 1, 2 and 5 wt%) in fabrication of porous polyethersulfone (PES) membranes via the phase inversion induced process by immersion precipitation method for heavy metal ion and dye removal. The modified membranes were characterized using ATR-FTIR, AFM, SEM, water contact angle, overall porosity and mean pore radius evaluations and zeta potential measurement. The addition of CS-APSGO nanocomposite hydrogel to PES doping solutions enhanced membranes hydrophilicity and consequently pure water flux permeability. Filtration performance of the CS-APSGO embedded membranes showed promising antifouling properties during BSA filtration test (FRR> 90%) and 1 wt% membranes showed the highest pure water flux of 123.8 L/m2 h with BSA rejection more than 98% and removal capability more than 82% for lead (II) ion, 90.5% and 98.5% for C.I. Reactive Blue 50 and C.I. Reactive Green 19, respectively. Therefore, the CS-APSGO nanocomposite hydrogel blending in order to modification of PES-based membranes have a noticeable potential in improving filtration performance of blended membranes.

Collagen/chitosan-functionalized graphene oxide hydrogel provide a 3D matrix for neural stem/precursor cells survival, adhesion, infiltration and migration

To have therapeutic promise of neural stem/precursor cells (NS/PCs) an appropriate scaffold is mostly essential. This study was conducted to fabricate collagen (Col)/chitosan-functionalized graphene oxide (CSGO) nanocomposite hydrogel and evaluated it as scaffold for NS/PCs. Graphene oxide was first functionalized with chitosan and the obtained CSGO was then added to Col solution and the solution underwent hydrogel formation. GO sheets were exfoliated after CS functionalization and the CSGO was homogenously dispersed in Col hydrogel. CSGO addition resulted in hydrogels with higher porosity and smaller Col fibers. Furthermore, CSGO increased the gelation time and water absorption capacity while the degradation was decreased. Cell studies demonstrated higher viability of NS/PCs on Col/CSGO hydrogel comparing with Col and poly-l-lysine as control (Cnt). NS/PCs were also penetrated into the Col/CSGO hydrogel and showed more cell spreading, neurite outgrowth and inter-cell connections in comparison with Col hydrogel. In addition, the cells traveled longer distance on Col/CSGO hydrogels than on Col and Cnt, indicating excellent migration capacity of NS/PCs on Col/CSGO hydrogel. Our results indicate the potential Col/CSGO hydrogels as an appropriate scaffold for NS/PCs.

Rheology and direct write printing of chitosan - graphene oxide nanocomposite hydrogels for differentiation of neuroblastoma cells

The direct write printing method has gained popularity in synthesizing scaffolds for tissue engineering. To achieve an excellent printability of scaffolds, a thorough evaluation of rheological properties is required. We report the synthesis, characterization, rheology, and direct-write printing of chitosan - graphene oxide (CH - GO) nanocomposite hydrogels at a varying concentration of GO in 3 and 4 wt% CH polymeric gels. Rheological characterization of CH - GO hydrogels shows that an addition of only 0.5 wt% of GO leads to a substantial increase in storage modulus (G′), viscosity, and yield stress of 3 and 4 wt% of CH hydrogels. A three-interval thixotropy test (3ITT) shows that 3 wt% CH with 0.5 wt% GO hydrogel has 94% recovery of G′ after 7 sequential stress cycles and is the best candidate for direct-write printing. Neuronal cell culture on 3 wt% CH with 0.5 wt% hydrogels reveals that GO promotes the differentiation of SH-SY5Y cells.

Poly(vinyl alcohol)/graphene oxide nanocomposite hydrogel with catalytic activity: the removal behavior and dual adsorption/catalytic degradation mechanism for dye wastewater

AbstractThe treatment of dye wastewater with traditional adsorption materials usually proceeds slowly with low removal efficiency and without completely eliminating dye molecules, leading to secondary pollution. In this work, poly(vinyl alcohol)/graphene oxide@tetraamino iron phthalocyanine (PVA/GO@TAFePc) nanocomposite hydrogels with catalytic activity were prepared via an in situ crosslinking method. Through interfacial covalent and π–π interactions, TAFePc was loaded onto GO layers with a high loading ratio, and GO@TAFePc was exfoliated and uniformly dispersed in the matrix. With increasing GO@TAFePc hybrid content, the pore size increased and a loose network structure was formed for the hydrogels, while the specific surface area rose significantly by using the hydrogel in a dye removal process, the removal rate of methylene blue (MB) increased sharply with contact time, reaching 98% in the presence of H2O2 with good reusability, and high removal efficiency was achieved for different dyes. The large surface area of the hydrogel was beneficial for MB adsorption. Meanwhile, under catalysis of TAFePc, a large amount of high activity ·OH was produced by H2O2 so as to degrade the MB molecules rapidly. Therefore, the MB degradation process for the composite hydrogel was ascribed to a dual adsorption/catalytic degradation mechanism. © 2020 Society of Industrial Chemistry

One-pot synthesis of magnetic chitosan/iron oxide bio-nanocomposite hydrogel beads as drug delivery systems

ABSTRACT In this research, a novel dual-responsive supermagnetic chitosan/iron oxide nanocomposite hydrogel beads (CH/MION) was prepared using sodium tripolyphosphate (STPP) as cross linking agent. The prepared CH/MION hydrogel was systematically characterized by Fourier transforminfrared spectroscopy (FT-IR), scanning electron microscopy (SEM) X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). In addition, the CH/MION hydrogel exhibits favorable swelling properties that are sensitive to pH, and external magnetic field (EMF). The drug release behavior of the prepared hydrogel under EMF, and different pHs was also studied. The obtained hydrogel showed considerable temperature, pH, and EMF sensitivity for the in vitro release of Doxorubicin (DOX).These results suggested that the CH/MION hydrogel beads could be a promising candidate for drug delivery applications.

Rheological, Microstructural and Thermal Properties of Magnetic Poly(Ethylene Oxide)/Iron Oxide Nanocomposite Hydrogels Synthesized Using a One-Step Gamma-Irradiation Method.

Magnetic polymer gels are a new promising class of nanocomposite gels. In this work, magnetic PEO/iron oxide nanocomposite hydrogels were synthesized using the one-step γ-irradiation method starting from poly(ethylene oxide) (PEO) and iron(III) precursor alkaline aqueous suspensions followed by simultaneous crosslinking of PEO chains and reduction of Fe(III) precursor. γ-irradiation dose and concentrations of Fe3+, 2-propanol and PEO in the initial suspensions were varied and optimized. With 2-propanol and at high doses magnetic gels with embedded magnetite nanoparticles were obtained, as confirmed by XRD, SEM and Mössbauer spectrometry. The quantitative determination of γ-irradiation generated Fe2+ was performed using the 1,10-phenanthroline method. The maximal Fe2+ molar fraction of 0.55 was achieved at 300 kGy, pH = 12 and initial 5% of Fe3+. The DSC and rheological measurements confirmed the formation of a well-structured network. The thermal and rheological properties of gels depended on the dose, PEO concentration and initial Fe3+ content (amount of nanoparticles synthesized inside gels). More amorphous and stronger gels were formed at higher dose and higher nanoparticle content. The properties of synthesized gels were determined by the presence of magnetic iron oxide nanoparticles, which acted as reinforcing agents and additional crosslinkers of PEO chains thus facilitating the one-step gel formation.

Catalytic potential of cobalt oxide and agar nanocomposite hydrogel for the chemical reduction of organic pollutants

In this study, cobalt oxide nanoparticles (Co3O4 NPs) were synthesized by precipitation method from cobalt sulphate solution with basic pH, followed by calcination. The ex-situ synthesized Co3O4 NPs were mixed with hot agar (AG) aqueous solution. The preparation of AG- Co3O4 nanocomposite hydrogel was carried out by self-association method promoted by thermal denaturation. The quenching of hot suspension from 80 °C to room temperature resulted in the formation of AG-Co3O4 nanocomposite hydrogel. The as-synthesized AG-Co3O4 was characterized by FTIR, XRD and SEM techniques. In order to test the catalytic activity, AG-Co3O4 was used as a heterogeneous catalyst for the reduction of methylene blue (MB), congo red (CR) and 4-nitrophenol (4-NP). The excellent performance of the AG-Co3O4 was shown by the reaction rate constant (kapp) values of 0.3623, 0.2114 and 0.2893 for MB, 4-NP and CR, respectively. All these results were obtained with R2 above 94 and utilization of an AG-Co3O4 catalyst. Furthermore, the catalytic reduction was studied with varying dye concentration and catalyst dose. This study showed that AG-Co3O4 catalyst has high potential for remediation of environmental pollutants in wastewaters.

Effect of graphene oxide content on the tensile properties and swelling ratio of chitosan/xanthan gum/graphene oxide hydrogel films

In this study, chitosan (CS)/xanthan gum (XA)/graphene oxide (GO) nanocomposite hydrogels were prepared to enhance mechanical properties of CS/XA hydrogels. The hydrogels were characterized by Fourier-transform infrared spectroscopy (FT-IR) spectra, wide-angle X-ray diffraction (WXAD) patterns, thermogravimetric analysis, and universal testing machine. The swelling ratio of dried CS/XA and CS/XA/GO films were also measured in deionized water at 37 °C. The effect of GO content on the tensile properties and swelling ratio of CS/XA/GO hydrogel films were investigated. With addition of GO, tensile strength and modulus of CS/XA hydrogel films were improved without significant decrease of elongation at break, while the swelling ratio of CS/XA/GO films decreased with increasing GO contents.