Abstract
Nanocomposite hydrogels are one of the most important types of biomaterials which can be used in many different applications such as drug delivery and tissue engineering. Placement of nanoparticles within a hydrogel matrix can provide unique characteristics like remote stimulate and mechanical strength improvement. In this study, the synthesis of graphene oxide and graphene oxide nanocomposite hydrogel has been studied. Nanocomposite hydrogel was synthesized with carboxymethyl cellulose as a natural base, acrylic acid as a monomer, graphene oxide as a filler, ammonium persulfate as an initiator, and iron nanoparticles as a crosslinking agent. The effect of reaction variables such as the iron nanoparticles, graphene oxide, ammonium persulfate, and acrylic acid were examined to achieve a hydrogel with maximum absorbency. Doxorubicin, as an anti-cancer chemotherapy drug, was loaded on this hydrogel and the release of drug in a phosphate buffer solution with different pH was carried out. The structure of the graphene oxide and optimized hydrogel were confirmed by Fourier-transform infrared spectroscopy, Raman spectroscopy, X-Ray diffraction, scanning electron microscopy, and atomic force microscopy.
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