Overview Of Literature Research Articles

Role of tumor-infiltrating lymphocytes in melanoma prognosis and treatment strategies: A systematic review and meta-analysis

PurposeNumerous studies underscore the relevance of tumor-infiltrating-lymphocytes (TILs) as important prognostic factors for melanoma. This meta-analysis aims to provide a comprehensive literature overview elucidating their role in predicting patient outcomes, specifically investigating the association between TIL density and prognosis. MethodsFrom an initial pool of 6094 records, 16 met the eligibility criteria, encompassing a collective cohort of 16021 patients. Data on TIL counts, clinical characteristics, and survival metrics (5-year overall survival [5yOS], 10-year overall survival [10yOS], and 5-year melanoma-specific survival [5yMSS]) were extracted from each study and expressed as proportions. Results were graphically presented using forest plots, reporting the estimates from individual studies, summary estimates, and corresponding 95 % confidence intervals (CI). ResultsAnalysis revealed a statistically significant difference in 5yOS concerning subgroup differences However, 10yOS and 5yMSS did not exhibit statistical significance. Nonetheless, a consistent trend emerged indicating a higher survival rate corresponding to increased immune cell density, ranging from absent TILs to brisk levels. ConclusionsTILs present potential as a readily applicable prognostic factor. Yet, further investigations into their density and phenotypic subpopulation characteristics could enhance our understanding of their predictive value in tailoring optimal patient-specific therapies.

Spinal cord ischemia - from diagnosis to treatment.

The aim of the article is to outline the frequency of the occurrence, course, diagnosis and possible treatment of spinal cord ischemia (SCI) on the basis of a literature overview and to raise awareness of this rare yet devastating condition. SCI, when compared to cerebral stroke, is a relatively rare disease, being diagnosed 100 times less often. Our knowledge as to its root causes, proper treatment for it and long-term prognosis is still inconclusive. Magnetic resonance imaging with diffusion- weighted contrast is a main tool with which to confirm SCI and rule out a broad spectrum of possible alternative diagnoses. SCI is a condition in which prompt recognition, accurate diagnostic steps, and reperfusion therapy are essential to ensure a desirable functional outcome and reduce mortality and disability. Although there are no specific guidelines regarding treatment, the administration of rt-PA might be an effective therapy for acute ischemic stroke, preventing permanent spinal dysfunction. In surgical causes close cooperation between a neurologist and a neurosurgeon is necessary to provide combined appropriate management promptly. Due to the relative rarity of SCI, multi-center studies of ischemia of the spinal cord and its treatment would be advisable in neurological practice to enhance current knowledge. A rapid diagnosis is crucial for appropriate care and desirable long-term outcomes.

Academic insight for approaching the sustainability of the textile industry

Objective: Sustainability is gaining importance in the textile sector, but there is a lack of literature reviews using bibliometric techniques to provide a quantitative and comprehensive assessment of scientific output. This article aims to provide a current and systematic overview of previous literature on sustainability in the textile sector. To achieve this, a literature review on this topic is done and a model of analysis of the issues studied is presented.Methodology: A mixed-method approach combining bibliometric analysis and qualitative reflection was employed on a sample of 580 papers. Co-word analysis identified thematic clusters in the literature.Results: A general analytical model has been presented to provide a comprehensive and up-to-date review creating five key thematic research domains: Sustainable Development, Value Chain - Cellulose and Textile, Design Process, Circular Economy, and Sustainability. The model has also made it possible to evaluate the relationship of these areas with each other and identify other emerging themes.Limitations: The main limitations come from the methodology used. Future studies can complement the results obtained using additional techniques such as event analysis or case studies.Practical implications: This approach allows companies to focus their strategic decisionson sustainability practices. The findings provide insights for industry stakeholders to prioritise sustainability-related investments and initiatives and enhance operational efficiency.

Immigrant Consumption Behaviors: A Systematic Integrative Review and Future Research Agenda

This article explores the concept of “immigrant consumption behavior (ICB)” in the context of its holistic surroundings. The study investigated the current dynamics and scientometrics of the research field regarding immigrant consumption behaviors. Using an integrative approach employing bibliometric and content analysis, it scrutinized a collection of 224 studies from the Web of Science and Scopus databases to detect the field evolution, disciplinary distribution thematic map, and emerging trends in the ICB literature, as well as to forecast research directions. The results showed that ICB is a multi- and inter-disciplinary research area that experienced three phases of growth between 1989 and 2023: initiation (1989–2006), development (2007–2012), and consolidation (2013–now). The thematic analysis revealed five current trends, i.e., (1) the immigrant consumption behavior domain, (2) the demographic sub-groups of immigrants and related consuming products, (3) country-, region-, and cultural-focused studies, (4) the effects of culture and the acculturation process, and (5) the impact of urbanization. Each theme contains a number of sub-themes. Based on the current thematic evolution and keyword burst analysis, this paper suggests a number of critical research directions, comprising (1) observatory studies including remittances, China, ethnic minorities, lifestyle, inequality, urbanization, and food consumption; (2) context-based studies focused on socioeconomic, cultural, legal, and environmental factors; (3) studies based on compensatory and compromissory consumption behavior; (4) studies focused on sustainable and green consumption behaviors; and (5) studies regarding the behavior of specific demographic co-ethnic communities. The results have great implications for developing interventions and programs that can support immigrant populations in making appropriate consumption patterns and adapting to new cultural environments. The paper pushes forward the ICB investigation from individual empirical studies to synthesis-based research, which (1) provides an ample overview of the ICB literature, (2) identifies research priorities, emerging trends, and gaps, (3) proposes new research avenues for investigation, and (4) outlines expected contributions. The research contributes to a variety of disciplines through the provision of new knowledge, since ICB studies are multidisciplinary in nature. It also has numerous implications for policymakers and practitioners.

A Comprehensive Review of Fragile X Syndrome and Fragile X Premutation Associated Conditions in Africa.

Fragile X syndrome (FXS) is a genetic disorder caused by a mutation in the fragile X messenger ribonucleoprotein 1 (FMR1) gene and known to be a leading cause of inherited intellectual disability globally. It results in a range of intellectual, developmental, and behavioral problems. Fragile X premutation-associated conditions (FXPAC), caused by a smaller CGG expansion (55 to 200 CGG repeats) in the FMR1 gene, are linked to other conditions that increase morbidity and mortality for affected persons. Limited research has been conducted on the burden, characteristics, diagnosis, and management of these conditions in Africa. This comprehensive review provides an overview of the current literature on FXS and FXPAC in Africa. The issues addressed include epidemiology, clinical features, discrimination against affected persons, limited awareness and research, and poor access to resources, including genetic services and treatment programs. This paper provides an in-depth analysis of the existing worldwide data for the diagnosis and treatment of fragile X disorders. This review will improve the understanding of FXS and FXPAC in Africa by incorporating existing knowledge, identifying research gaps, and potential topics for future research to enhance the well-being of individuals and families affected by FXS and FXPAC.

Maintenance of peri-implant health in general dental practice

The long-term maintenance or restoration of peri-implant tissues‘ health depends on the strategic implementation of preventive measures and interventions. These measures should be initiated before implant placement and continued throughout a patient's lifetime, as part of a tailored and comprehensive supportive peri-implant care (SPIC) programme. Central to the clinical efforts of maintaining and rehabilitating peri-implant tissues are several key factors, including the ongoing assessment and frequent monitoring of tissue health and stability, proactive oral health promotion, the control of risk factors and indicators and the provision of professional plaque biofilm removal. It is of paramount importance to underline that SPIC should not limit its scope exclusively to patients already in a state of peri-implant health; in fact, it is imperative that it should extend its protective effect to individuals who have been previously diagnosed and treated for peri-implant diseases, focusing on preventing its recurrence and progression, thereby avoiding further complications, such as implant loss.This narrative review presents an overview of the current literature on the maintenance of peri-implant tissues‘ health and the steps of SPIC providing insights into the critical factors to be considered when managing dental implant patients in the general dental practice.

سید سلیمان ندوی بحیثیت سیرت نگار: ایک تحقیقی جائزہ

The greatest tutor of all time is widely regarded as being the Prophet Muhammad (SAW). In the field of Seerah literature, several study researchers have so far conducted a great deal of work with a combination of passion and devotion. One of the most amazing aspects of the noblest personality of the Prophet Mohammad (SAW) is that people of all religions, regardless of their affiliation, have produced masterworks of literature. In this regard, each contributor has made an effort to absorb and share nuggets of wisdom, love, and sacred attachment with the Prophet of Islam (SAW) to the best of their abilities. One of the most notable figures in Seerah Writing is Allam Sayad Sulaman Nadvi, who is regarded as a significant pioneer in the field. He published a few works on Seerah, including Seeraat-un-Nabi (SAW), Khutbat Madras, Rahmat Alam, and Muhammad the Ideal Prophet. He also gathered a wealth of information on Seerah. The main goals of this article are to provide an overview of the scholarly literature on Seeraat un-Nabi and to emphasise Allama Sayad Sulaman Nadvi's biography.

INDOOR AND OUTDOOR PATIENT SATISFACTION IN FORTIS ESCORT HOSPITAL JAIPUR

This studies paper explores the factors influencing indoor and outside affected person satisfaction at Fortis Escort Hospital in Jaipur, India. The take a look at ambitions to recognize the perceptions and stories of sufferers regarding the fine of healthcare services, patient engagement, and standard sanatorium environment. Drawing from a complete overview of literature and empirical information accrued through surveys and interviews with sufferers, the paper delves into the important factors of patient pleasure, which include the effectiveness of communication, the responsiveness of staff, the cleanliness and comfort of the sanatorium premises, and the accessibility of services. The findings reveal vast differences in satisfaction tiers among indoor and outdoor patients, highlighting the significance of environmental factors and affected person engagement techniques in enhancing basic satisfaction. The paper concludes with hints for Fortis Escort Hospital to improve patient pleasure with the aid of addressing identified gaps and leveraging great practices in healthcare service shipping. KEYWORDS: Research Paper, Overall Patient Satisfaction Metrics. Outdoor Patient Satisfaction. Indoor Patient Satisfaction.

Virtual reality training for intraoperative imaging in orthopaedic surgery: an overview of current progress and future direction

Trauma and orthopedic surgery commonly rely on intraoperative radiography or fluoroscopy, which are essential for visualizing patient anatomy and safely completing surgical procedures. However, these imaging methods generate ionizing radiation, which in high doses carries a potential health risk to patients and operating personnel. There is an established need for formal training in obtaining precise intraoperative imaging while minimizing radiation exposure. Virtual reality (VR) simulation serves as a promising tool for orthopaedic trainees to develop skills in safe intraoperative imaging, without posing harm to patients, operating room staff, or themselves. This paper aims to provide a brief overview of literature surrounding VR training for intraoperative imaging in orthopaedic surgery. In addition, we discuss areas for improvement and future directions for development in the field.

Trifarotene: a new chapter in the treatment of acne. An overview of the data on efficacy and safety profile of a fourth-generation retinoid

Vulgar acne is a chronic inflammatory skin disease that has a significant impact on patients' quality of life. The search for new highly effective and treatments with favorable safety profile remains relevant due to the high incidence in the population. The launch of a 4th generation retinoid, trifarotene, which has a selective mechanism of action on RAR-γ (γ-retinoic acid receptors agonist), represents a new era in topical therapy of acne vulgaris and is of particular interest to practical healthcare. A systematic literature overview in PubMed, Google Scholar, and ClinicalTrials.Gov databases was conducted to evaluate the mechanism of action, efficacy, and safety profile of the selective 4th generation retinoid, trifarotene 50 µg/g (0,005%) in dosage form topical cream. In a systematic overview, 12 contemporary studies (2015–2023) were selected confirming the high efficacy of trifarotene in protocols for the treatment of acne vulgaris with localization on both facial and truncal skin. The drug demonstrates a unique ability to modulate cell adhesion, optimize transepidermal water loss and reduce the activity of membrane metalloendopeptidases, which determines its proven efficacy. Trifarotene, an innovative 4th generation topical retinoid approved by the FDA in 2019 for the treatment of acne in patients over 9 years of age, opens new possibilities in the treatment of acne vulgaris. Its selective activity to RAR-γ receptors, proven efficacy and favorable safety profile make it a promising agent in therapeutic practice.

Reviewing Successful Dual LAD Disease Intervention: A Radiological Diagnostic Approach and Literature Overview

Reviewing Successful Dual LAD Disease Intervention: A Radiological Diagnostic Approach and Literature Overview

A pediatric and young adult case of unclassified renal cell carcinoma with medullary phenotype (RCCU-MP): Clinical course and treatment

Renal cell carcinoma (RCC) is the most common kidney tumor in adults. RCC is rare in children, although its incidence increases in the second decade of life. Renal medullary carcinoma (RMC) is a rare and often aggressive RCC subtype characterized by complete loss of SMARCB1/INI1, predominantly diagnosed in patients with sickle cell disease or -trait. Here, we describe a pediatric and a young adult patient with clinicopathological characteristics similar to RMC but without hemoglobinopathies. These tumors are currently classified as “RCC unclassified with medullary phenotype” (RCCU-MP). Both our patients had an infiltrating, rather small kidney tumor with SMARCB1/INI1 deficiency. Remarkably, the aggressiveness and clinical course and treatment differed greatly between these two cases. So far, only nine patients, predominantly adults, have been reported. In a literature overview, most cases were metastatic and progressed or relapsed after varying treatment approaches, with low survival. Whereas the classification of these tumors remains a topic of debate, case reports add to the current knowledge of RMCs without hemoglobinopathies, stressing the importance of sharing experience concerning rare renal neoplasms with often poor outcomes, also concerning younger age categories.

Amyloid, Crohn's disease, and Alzheimer's disease - are they linked?

Crohn's disease (CD) is a chronic inflammatory disease that most frequently affects part of the distal ileum, but it may affect any part of the gastrointestinal tract. CD may also be related to systemic inflammation and extraintestinal manifestations. Alzheimer's disease (AD) is the most common neurodegenerative disease, gradually worsening behavioral and cognitive functions. Despite the meaningful progress, both diseases are still incurable and have a not fully explained, heterogeneous pathomechanism that includes immunological, microbiological, genetic, and environmental factors. Recently, emerging evidence indicates that chronic inflammatory condition corresponds to an increased risk of neurodegenerative diseases, and intestinal inflammation, including CD, increases the risk of AD. Even though it is now known that CD increases the risk of AD, the exact pathways connecting these two seemingly unrelated diseases remain still unclear. One of the key postulates is the gut-brain axis. There is increasing evidence that the gut microbiota with its proteins, DNA, and metabolites influence several processes related to the etiology of AD, including β-amyloid abnormality, Tau phosphorylation, and neuroinflammation. Considering the role of microbiota in both CD and AD pathology, in this review, we want to shed light on bacterial amyloids and their potential to influence cerebral amyloid aggregation and neuroinflammation and provide an overview of the current literature on amyloids as a potential linker between AD and CD.

Temporal logics for compartmental models

Abstract This paper introduces two logic frameworks for the study of SIR (Susceptible-Infected-Recovered) and SIRS compartmental epidemic models, one based on Linear Temporal Logic and the other on Computation Tree Logic. We provide a short literature overview on compartmental models and other related works using logics, and then define our logics with their respective axiomatizations, and demonstrate their soundness and completeness proofs.

Trauma and memory-A contribution to the current debate in law and psychotherapy

The recall of memories of past events, experiences and emotions is acomplex process. When experiencing traumatic events, as is the case with sexual violence, ahost of additional complexities and difficulties arise. This becomes especially important in court cases which rely mostly or exclusively on the testimony of the victim, where the problem of the fallibility of memory takes center stage. Some research studies emphasize the possibility of inducing, altering or suppressing memories, especially in the context of psychotherapy. This has led to the unfortunate reality that the testimony of victims who have undergone psychotherapy is often considered to be unreliable. This in turn can lead to the impression that adecision has to be made between treatment of the adverse effects of traumatic events and maximizing the chances for aconviction of the perpetrator in court. This article introduces some central concepts of our current understanding of memory and gives an overview of the relevant scientific literature and debate. Following this, it examines the dilemma as it pertains to the different groups of all involved parties (i.e., victims, members of the judiciary and psychotherapists). Lastly, it proposes aframework of how to approach asolution to this problem by focusing on research in critical areas, expansion of therapy guidelines and documentation procedures as well as communication of these efforts to all parties involved.

Blocked out: reflections on the potential of intensive modes of teaching to enhance post-COVID-19 graduate employability in large-scale educational settings

PurposeThis paper explores the potential that block teaching offers to enhance employability in the context of large-scale classes. It suggests that block teaching, with its condensed structure, necessitates curriculum innovation, fosters participatory learning and peer-to-peer networking, and has been shown to increase student focus and enhance engagement and attainment, especially amongst diverse learners. As these are the same challenges that large-scale teaching faces, it is proposed that intensive modes of delivery could be scaled up in a way that may help to mitigate such problems as cohorts in business schools continue to increase in size.Design/methodology/approachThe paper is based on secondary research and provides an overview of literature that looks at block teaching, followed by that which explores the challenges of large-scale teaching contexts. It compares and contrasts the gaps in both to suggest a way that they could be combined.FindingsThe paper provides key insights into changes in the contemporary landscape of teaching within UK business schools, which have seen increasingly large cohorts and draws out the key strengths of intensive modes of delivery, which include helping students to time manage effectively, encouraging curriculum innovation and the creation of participatory learning opportunities as well as providing closer personal relationships between students and staff. Outlining some of the well-documented issues that can arise when teaching larger cohorts, the paper suggests that scaling up blocked delivery may offer a new way help to overcome them.Research limitations/implicationsBecause of the chosen research approach, the research results are subject to generalisation. Therefore, researchers are encouraged to test the proposed propositions in large-scale teaching scenarios.Practical implicationsThis paper includes implications for the development of innovative modes of teaching in the context of large cohorts, an experience that is increasingly common amongst British business schools and beyond.Originality/valueThis paper brings together two bodies of literature for the first time – that of intensive modes of teaching and that focuses on large-scale teaching contexts – for the first time to show how the former may help to overcome some of the key issues arising in the latter.

Precision Medicine in Congenital Heart Disease, Rheumatic Heart Disease, and Kawasaki Disease of Children: An Overview of Literature

Congenital heart disease and common acquired heart diseases like Kawasaki disease and rheumatic heart disease are prevalent cardiovascular conditions in children worldwide. Despite the availability of treatment options, they continue to be significant contributors to morbidity and mortality. Advancements in early diagnosis, improvements in treatment approaches, and overcoming resistance to available treatments are crucial to reduce morbidity. Researchers have turned to precision medicine to tackle these challenges. We aimed to analyze the existing literature concerning the utilization of precision medicine in congenital heart disease, rheumatic heart disease, and Kawasaki disease. The emphasis is placed on comprehending the key themes explored in these studies and evaluating the present state of their clinical integration. The central theme of most studies revolves around the examination of genetic factors. Despite promising research outcomes, limitations in these studies indicate that the clinical implementation of precision medicine in these conditions remains a distant prospect, necessitating additional exploration and attention to confounding factors.

Recent Advancements in Multicomponent Reactions of Substituted 2- Aminopyridines Synthesis: A Decade Review

Abstract: One-step synthesis of multifaceted heterocycles employing multicomponent reactions (MCRs) corresponds to a viable, innovative, and prospective strategy. In recognition of their noteworthy physiological, biological, and pharmacological behavior, 2-aminopyridines secure an exceptional spot among heterocycles. The current analysis comprises an overview of the scientific literature concerning the multicomponent reactions of substituted 2-aminopyridine synthesis. The stipulated outcomes have been thoroughly categorized according to the number and nature of the components. The past 11 years of literary work (2011–2022) are specifically incorporated. This review article will assist in advancing the development of cutting-edge and enhanced approaches towards the synthesis of 2-aminopyridines and their counterparts.

Metabolomic pathways in food allergy.

Food allergy (FA) is a widespread issue, affecting as many as 10% of the population. Over the past two to three decades, the prevalence of FA has been on the rise, particularly in industrialized and westernized countries. FA is a complex, multifactorial disease mediated by type 2 immune responses and involving environmental and genetic factors. However, the precise mechanisms remain inadequately understood. Metabolomics has the potential to identify disease endotypes, which could beneficially promote personalized prevention and treatment. A metabolome approach would facilitate the identification of surrogate metabolite markers reflecting the disease activity and prognosis. Here, we present a literature overview of recent metabolomic studies conducted on children with FA.

Literature overview of basic characteristics and flotation laws of flocs

Literature overview of basic characteristics and flotation laws of flocs