The work highlights the guidelines for the development of the industrial complex of Donbass, through alternative economic and organizational tools of technological progress, allowing, in the context of the restoration of industrial enterprises of the Donetsk People’s Republic (hereinafter referred to as the DPR), the development of progressive forms of production organization (PFOP) and advanced management methods. An analysis of the existing practice of the considered areas of the organizational, economic and technical level of the industrial potential of Donbass made it possible to outline the concept of a comprehensive solution for the synthesis of production structures at the stages of reconstruction and technical re-equipment of production. The methodological basis is generally accepted in economic science methods of scientific analysis and synthesis, induction and deduction, generalization, comparison. The paper presents the results of analytical studies of an important component of the scientific and technical potential of industrial sectors of Donbass, which have significant untapped internal potential for activating and restoring its economic and technological structure to a higher neo-industrial competitive level. The main strategic guidelines for the development of industrial enterprises in Donbass are outlined, including: a) the creation of the Unified Fund for the Development of Science and Technology (EDFST); b) development of mini-factories on unused production areas of MMK im. CM. Kirov and Azovstal Iron and Steel Works; c) optimization of business processes of iron-containing components for resource recycling; d) development of progressive forms of production organization and innovative technologies.