Opposite Direction Research Articles

An experimental study of a quasi-impulsive backwards wave force associated with the secondary load cycle on a vertical cylinder

Steep wave breaking on a vertical cylinder (a typical foundation supporting offshore wind turbines) will induce slam loads. Many questions on the important violent wave loading and the associated secondary load cycle remain unanswered. We use laboratory experiments with unidirectional waves to investigate the fluid loading on vertical cylinders. We use a novel three-phase decomposition approach that allows us to separate different types of nonlinearity. Our findings reveal the existence of an additional quasi-impulsive loading component that is associated with the secondary load cycle and occurs in the backwards direction against that of the incoming waves. This quasi-impulsive force occurs at the end of the secondary load cycle and close to the passage of the downward zero-crossing point of the undisturbed wave. Wavelet analysis showed that the impulsive force exhibits superficially similar behaviour to a typical wave-slamming event but in the reverse direction. To monitor the scattered wave field and extract run-up on the cylinder, we installed a four-camera synchronised video system and found a strong temporal correlation between the arrival time of the Type-II scattered wave onto the cylinder and the occurrence of this quasi-impulsive force. The temporal characteristics of this quasi-impulsive force can be approximated by the Goda wave impact model, taking the collision of the Type-II scattered waves at the rear stagnation point as the impact source.

MINFLUX reveals dynein stepping in live neurons

Dynein is the primary molecular motor responsible for retrograde intracellular transport of a variety of cargoes, performing successive nanometer-sized steps within milliseconds. Due to the limited spatiotemporal precision of established methods for molecular tracking, current knowledge of dynein stepping is essentially limited to slowed-down measurements in vitro. Here, we use MINFLUX fluorophore localization to directly track CRISPR/Cas9-tagged endogenous dynein with nanometer/millisecond precision in living primary neurons. We show that endogenous dynein primarily takes 8 nm steps, including frequent sideways steps but few backward steps. Strikingly, the majority of direction reversals between retrograde and anterograde movement occurred on the time scale of single steps (16 ms), suggesting a rapid regulatory reversal mechanism. Tug-of-war-like behavior during pauses or reversals was unexpectedly rare. By analyzing the dwell time between steps, we concluded that a single rate-limiting process underlies the dynein stepping mechanism, likely arising from just one adenosine 5'-triphosphate hydrolysis event being required during each step. Our study underscores the power of MINFLUX localization to elucidate the spatiotemporal changes underlying protein function in living cells.

Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

Maternal vitamin-D and omega-3 fatty acid (DHA) deficiencies during pregnancy have previously been associated with offspring neurodevelopmental traits. However, observational study designs cannot distinguish causal effects from confounding. First, we conducted Mendelian randomisation (MR) using genetic instruments for vitamin-D and DHA identified in independent genome-wide association studies (GWAS). Outcomes were (1) GWAS for traits related to autism and ADHD, generated in the Norwegian mother, father, and child cohort study (MoBa) from 3 to 8 years, (2) autism and ADHD diagnoses. Second, we used mother-father-child trio-MR in MoBa (1) to test causal effects through maternal nutrient levels, (2) to test effects of child nutrient levels, and (3) as a paternal negative control. Associations between higher maternal vitamin-D levels on lower ADHD related traits at age 5 did not remain after controlling for familial genetic predisposition using trio-MR. Furthermore, we did not find evidence for causal maternal effects of vitamin-D/DHA levels on other offspring traits or diagnoses. In the reverse direction, there was evidence for a causal effect of autism genetic predisposition on lower vitamin-D levels and of ADHD genetic predisposition on lower DHA levels. Triangulating across study designs, we did not find evidence for maternal effects. We add to a growing body of evidence that suggests that previous observational associations are likely biased by genetic confounding. Consequently, maternal supplementation is unlikely to influence these offspring neurodevelopmental traits. Notably, genetic predisposition to ADHD and autism was associated with lower DHA and vitamin-D levels respectively, suggesting previous associations might have been due to reverse causation.

High-Sensitivity Janus Sensor Enabled by Multilayered Metastructure Based on the Photonic Spin Hall Effect and Its Potential Applications in Bio-Sensing.

The refractive index (RI) of biological tissues is a fundamental material parameter that characterizes how light interacts with tissues, making accurate measurement of RI crucial for biomedical diagnostics and environmental monitoring. A Janus sensor (JBS) is designed in this paper, and the photonic spin Hall effect (PSHE) is used to detect subtle changes in RI in biological tissues. The asymmetric arrangement of the dielectric layers breaks spatial parity symmetry, resulting in significantly different PSHE displacements during the forward and backward propagation of electromagnetic waves, thereby realizing the Janus effect. The designed JBS can detect the RI range of 1.3~1.55 RIU when electromagnetic waves are incident along the +z-axis, with a sensitivity of 96.29°/refractive index unit (RIU). In the reverse direction, blood glucose concentrations are identified by the JBS, achieving a sensitivity of 18.30°/RIU. Detecting different RI range from forward and backward scales not only overcomes the limitation that single-scale sensors can only detect a single RI range, but also provides new insights and applications for optical biological detection through high-sensitivity, label-free and non-contact detection.

Impact of Socio-Demographic Attributes and Mutual Gaze of Virtual Humans on Users' Visual Attention and Collision Avoidance in VR.

This study investigated the extent that the non-verbal behaviors of virtual humans (VHs) and their socio-demographic attributes altered users' collision avoidance behaviors in Virtual Reality (VR). Users interacted with VHs representing different levels of ethnicities and gender, exhibiting different conditions of physical movement, and gaze behaviors. The VHs were depicted in three major ethnic conditions namely Asian, Caucasian, and Black. The physical movement states of the VHs were either static in the path of the user or walking toward the user in the opposite direction. The non-verbal gaze behavior of the VHs was either direct gaze or averted gaze. We used an HTC Vive tracking system to track users' performing real walking while we collected objective measures (i,e., continuous gaze, fixation gaze, clearance distance, and travel length), and subjective variables (i.e., game experiences and social presence). The results showed that the ethnicity of the VHs significantly impacted the gaze behavior of the users, and the gender of the VHs affected the user avoidance movement and their reciprocal gaze behavior. Our results revealed that users' physical movement, gaze behaviors, and collision avoidance were moderated by the VHs' perceived ethnicity, gender, and gaze behaviors. Understanding the impact of the socio-demographics attributes of VHs and their gaze behavior on users' collision avoidance is critical for applications in which users are navigating through virtual traffic, crowd, and other inter-personal simulations.

Stability Preparedness: The Not-So-Cold Case for Innovations in Vaccine Stability Modelling and Product Release.

The rapid development of equitably accessible vaccines is paramount in addressing emerging global health challenges. The safety and efficacy of vaccines hinge significantly on their ability to remain stable from manufacturing throughout the supply chain and up to administration. Furthermore, the release of vaccines requires sufficient understanding of the stability profile to allow for expiration dating. In the event of a public health crisis, the time to generate the necessary stability data and the need for rapid product release are in direct opposition. Developing manufacturing platforms with thermostable product formulations for rapid response is therefore key to meeting CEPI's 100 Days Mission goal. This Review aims to highlight the need for stability preparedness through developing thermostable vaccine platforms and exploring innovative stability monitoring strategies that leverage advanced technologies, predictive modelling, and adaptive methodologies. By doing so, we seek to enhance the efficiency and effectiveness of stability assessments, supporting rapid development, regulatory approval, and widespread, equal distribution of vaccines-especially in an outbreak scenario. Finally, enhanced thermostability will allow for simplification across the supply chain, which will reduce the financial burden of vaccination programmes and enhance equitable access.

Climate controls on longshore sediment transport and coastal morphology adjacent to engineered inlets

Coastal jetties are commonly used throughout the world to stabilize channels and improve navigation through inlets. These engineered structures form artificial boundaries to littoral cells by reducing wave-driven longshore sediment transport across inlet entrances. Consequently, beaches adjacent to engineered inlets are subject to large gradients in longshore transport rates and are highly sensitive to changes in wave climate. Here, we quantify annual beach and nearshore sediment volume changes over a 9-yr time period along 80 km of wave-dominated coastlines in the U.S. Pacific Northwest. Beach and nearshore monitoring during the study period (2014-2023) reveal spatially coherent, multi-annual patterns of erosion and deposition on opposing sides of two engineered inlets, indicating a regional reversal of longshore-transport direction. A numerical wave model coupled with a longshore transport predictor was calibrated and validated to explore the causes for the observed spatial and temporal patterns of erosion and deposition adjacent to the inlets. The model results indicate that subtle but important changes in wave direction on seasonal to multi-annual time scales were responsible for the reversal in the net longshore sediment transport direction and opposing patterns of morphology change. Changes in longshore transport direction coincided with a reversal in the Pacific Decadal Oscillation (PDO) climate index, suggesting large-scale, multi-decadal climate variability may influence patterns of waves and sediment dynamics at other sites throughout the Pacific basin.

A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients

Venoms are used by arthropods either to immobilise prey or as defence against predators. Our study focuses on the venom peptide, Ta3a, from the African ant species, Tetramorium africanum and its effects on voltage-gated sodium (NaV) channels, which are ion channels responsible for the generation of electrical signals in electrically excitable cells, such as neurons. Using the NaV1.7 isoform as our model NaV channel we show that Ta3a prolongs single channel active periods with increased open probability and induces non-inactivating whole-cell currents. Ta3a-affected NaV1.7 channels exhibit a leftward (hyperpolarising) shift in activation threshold, constitutive activity even in the absence of an activating voltage stimulus, and at cell membrane voltages where channels are normally silent. Current-voltage experiments show that Ta3a shifts the voltage at which NaV current changes direction (reversal potential) by altering the local ionic concentration of permeant ions (Na+) rather than changing the channel’s preference for ionic species. We propose a model where Ta3a maintains the positively charged voltage-sensing (S4) domains of the channel in the activated configuration where their electric field is exposed to the extracellular membrane surface to create an ionic bilayer comprising S4 domains and mobile anions (Cl−). This bilayer has a depolarising effect on the cell membrane, thus reducing the amount of externally applied voltage required for channel activation.

Platinum-based fluorescent nanozyme-driven “loong frolic pearls” multifunctional nanoplatform for tri-mode ultrasensitive detection and synergistic sterilization of Burkholderia gladioli

Rapid and accurate detection of Burkholderia gladioli (B. gladioli) and effective sterilization are crucial for ensuring food safety. Hence, a novel “loong frolic pearls” platform based on platinum-based fluorescent nanozymes (Pt-OCDs) and strand exchange amplification (SEA) was reported. Magnetic nanoparticles were modified on primer SEAF, while Pt-OCDs were covalently coupled with primer SEA-R. The highly efficient amplification capability of SEA permitted the accumulation of a large number of double-labeled amplicons. After magnetic adsorption, the supernatant was detected in reverse direction to collect colorimetric-fluorescence-photothermal signal values, enabling ultra-precise detection within 1 h. Furthermore, the Pt-based multifunctional nanoplatform generated abundant •OH and 1O2, which synergistically attacked B. gladioli and its biofilm, resulting in significant bactericidal efficacy within 30 min. This “triple-detection and double-sterilization” platform has been successfully applied in the field of food analysis with good recovery rates and immediate control over B. gladioli, thus demonstrating promising prospects for broad applications.

Confinement controls the directional cell responses to fluid forces

Our understanding of how fluid forces influence cell migration in confining environments remains limited. By integrating microfluidics with live-cell imaging, we demonstrate that cells in tightly-but not moderately-confined spaces reverse direction and move upstream upon exposure to fluid forces. This fluid force-induced directional change occurs less frequently when cells display diminished mechanosensitivity, experience elevated hydraulic resistance, or sense a chemical gradient. Cell reversal requires actin polymerization to the new cell front, as shown mathematically and experimentally. Actin polymerization is necessary for the fluid force-induced activation of NHE1, which cooperates with calcium to induce upstream migration. Calcium levels increase downstream, mirroring the subcellular distribution of myosin IIA, whose activation enhances upstream migration. Reduced lamin A/C levels promote downstream migration of metastatic tumor cells by preventing cell polarity establishment and intracellular calcium rise. This mechanism could allow cancer cells to evade high-pressure environments, such as the primary tumor.

Social sharing of emotion during the collective crisis of COVID-19.

We collected data from two sources - social media and online questionnaires - to investigate the emotional consequences of social sharing during the COVID-19 pandemic. Study 1 tracked and analysed sentiment of tweets posted over the course of a month in the crisis period and found that users who tweeted more frequently about COVID-19 expressed decreasing negative sentiment and increasing positive sentiment over time. Granger causality tests confirmed that this association was better interpreted in the forward direction (sharing levels predicting sentiment) than in the reverse direction (sentiment predicting sharing levels). Study 2 focused on immediate emotional consequences of sharing COVID-19-related events and found that participants reported improved overall affect about an event after sharing it, especially when that event was a personal experience rather than a news story. Reported positive feelings about both kinds of events were also significantly higher after sharing. Taken together, both studies suggested that social sharing is linked with emotional relief and may therefore help people to deal with their negative experiences during a persistent collective crisis.

Effect of hydrogen concentration, initial pressure and temperature on mechanisms of hydrogen explosion in confined spaces

Hydrogen as a renewable clean energy raises industrial safety and environmental issues. Studying the mechanism of hydrogen explosion in confined space is significant for guiding the risk assessment and efficient use of hydrogen energy. This paper used a 20 L explosion chamber to explore the effect of initial concentration changes on the hydrogen explosion and verify the model, the CHEMKIN simulation software was used to qualitatively and quantitatively evaluate the dynamic behavior characteristics of hydrogen explosion in confined space under different initial conditions, and the variation law of physical process of hydrogen explosion under different influencing factors in confined space was revealed from macro-micro perspectives. This study shows that the maximum explosion temperature and pressure under fuel-rich conditions are generally higher than those under fuel-lean conditions. The induction period of the hydrogen explosion reaction gradually shortens as the initial pressure increases, there is a negative temperature coefficient effect of ignition delay at the initial temperature of 800 K. In addition, compared with the initial pressure, higher explosion temperature and faster reactant mixing speed significantly affect the gas explosion reaction rate. The molar fractions of free radicals H, O, and OH show an inverted V-shaped relationship with the initial hydrogen concentration, and there is a hysteresis phenomenon in the final molar fraction peak of H free radicals; Sensitivity analysis indicates that free radicals are mainly responsive to the intermediate reaction R16 (forward direction) and R9 (reverse direction), thereby affecting parameters such as explosion pressure and temperature. These research findings can provide theoretical support for developing hydrogen explosion suppression technology.

Bidirectional Molecular Motors by Controlling Threading and Dethreading Pathways of a Linked Rotaxane.

Artificial molecular motors have been presented as models for biological molecular motors. In contrast to the conventional artificial molecular motors that rely on covalent bond rotation, molecular motors with mechanically interlocked molecules (MIM) have attracted considerable attention owing to their ability to generate significant rotational motion by dynamically shuttling macrocyclic components. The topology of MIM-type rotational molecular motors is currently limited to catenane structures, which require intricate synthetic procedures that typically produce a low synthetic yield. In this study, we develop a novel class of MIM-type molecular motors with a rotaxane-type topology. The switching of the threading/dethreading pathways of the linked rotaxane by protecting/deprotecting the bulky stopper group and changing the solvent polarity enables a net unidirectional rotation of the molecular motor. The threading/dethreading reaction rates were quantitatively evaluated through detailed spectroscopic investigations. Repeated net unidirectional rotation and switching of the direction of rotation were also achieved. Our findings demonstrate that linked rotaxanes can serve as MIM-type molecular motors with reversible rotational direction controlled by threading/dethreading reactions. These motors hold potential as components of molecular machinery.

Phase classification and transient effects of the start-up process of multi-functional pump station in pump mode

In the context of achieving the goal of carbon neutrality, multi-functional pump stations (MFPS) have been greatly developed as a new energy system in recent years. The MFPS can operate in forward direction in pump mode to pump water and in turbine mode in reverse direction to generate electricity. At present, the instability of the MFPS during start-up process (SUP) in pump mode has become the key to restricting the operating life and further development of MFPS. In this paper, based on the motion characteristics of the pump and the cut-off facility (COF), the SUP of the MFPS in pump mode is clearly classified. In order to reveal the transient effect during the SUP, the steady-state full characteristic experiment (SFCE) of the pump was carried out. The occurrence phase of the transient effect during the SUP is analyzed, and the deviation between the steady-state external characteristics and the transient characteristics is revealed. In this study, the evaluation formula of the start-up completion degree (SUCD) of the MFPS in pump mode is proposed for the first time, and the evaluation and identification of the start-up progress at different phases are completed. The results show that the water flow in the system is in a reverse flow state in the Phase I. The SUCD of Phase I is 17 %. In the Phase II, The high-speed jet flow in the pump flows to the inlet of the guide vane (GV), which gradually changes the mainstream direction in the GV. A certain vortex structure can be observed at the exit of the flap gate (FG). The SUCD of Phase II is 61 %. In the Phase I and II, the dimensionless head of transient simulation is much larger than that of SFCE. In the Phase III, the flow state in the impeller will gradually stabilize. The transient effect disappears and the pressure fluctuation intensity decreases. The SUCD of Phase III is 93 %. In the Phase IV, the separation vortex that persists from Phase I-III at the tail of the GV blades disappears. The diversion capacity at the gate increases, and significant annular flow can be observed near the FG.

Tagged particle behavior in a harmonic chain of direction-reversing active Brownian particles

Abstract We study the tagged particle dynamics in a harmonic chain of direction-reversing active Brownian particles, with the spring constant k, rotation diffusion coefficient D R , and directional reversal rate γ. We exactly compute the tagged particle position variance for quenched and annealed initial orientations of the particles. For well-separated time-scales, k − 1 , D R − 1 and γ −1, the strength of the spring constant k relative to D R and γ gives rise to different coupling limits, and for each coupling limit there are short, intermediate, and long-time regimes. In the thermodynamic limit, we show that, to the leading order, the tagged particle variance exhibits an algebraic growth t ν , where the value of the exponent ν depends on the specific regime. For a quenched initial orientation, the exponent ν crosses over from 3 to 1 / 2 , via intermediate values 5 / 2 or 1, depending on the specific coupling limits. However, for the annealed initial orientation, ν crosses over from 2 to 1 / 2 via an intermediate value 3 / 2 or 1 for the strong coupling limit and the weak coupling limit, respectively. An additional time-scale t N = N 2 / k emerges for a system with a finite number of oscillators N. We show that the behavior of the tagged particle variance across tN can be expressed in terms of a crossover scaling function, which we find exactly. Moreover, we study the velocity autocorrelation. Finally, we characterize the stationary state behavior of the separation between two consecutive particles by calculating the corresponding spatio-temporal correlation function.

Control of Flow and Acoustic Fields Around an Axial Fan Utilizing Plasma Actuators

Abstract Small axial fans, commonly employed for cooling electronic equipment, are frequently housed within narrow ducts, where intense tonal sound with duct resonance can occur, particularly when the blade passing frequency or its harmonic frequency aligns with the duct's resonance frequency. To mitigate resonant sound, this study proposes a flow control using dielectric barrier discharge plasma actuators, which induce a flow along the generation of plasma in air. The control effects on flow field, acoustic radiation, and aerodynamic characteristics are evaluated through direct aeroacoustic simulations and experiments conducted at different flow rates. The computational results reveal that swirling flow occurs in the inflow due to fan rotations at low flow coefficients. This swirling flow is weakened by utilizing plasma actuators, which are arranged to induce flows in the circumferentially reverse direction compared to fan rotations. This control method weakens the resonant sound at low and intermediate flow coefficients, while intensifying it at high flow coefficients, all at the same rotational speed. Moreover, the static pressure coefficient decreases and increases at low and high flow coefficients, respectively, with the latter attributed to an increase in the relative inflow angle induced by the control. Experimental findings demonstrate that the acoustic resonance was reduced by the control at both low and high flow rates, achieved by adjusting the rotational speed to maintain the same flowrate and static pressure rise as in the baseline case.

Simulating droplet distribution characteristics in sprinkler irrigation using a modified ballistic model under multifactor coupling

External factors affecting the processes of sprinkler irrigation water flow generation, flight, and landing have not been thoroughly considered in existing ballistic models. This result indicates that ballistic models with better prediction effects under specific conditions are not sufficient for extension to multi-factor coupled scenarios in large-scale farmlands. Therefore, wind, evaporation, surface slope, and tilted sprinkler riser factors were comprehensively considered in this study. Differential equations for jet and droplet motion under the influence of wind, differential equations of droplet evaporation, sprinkler riser deflection angle matrix, and surface slope angle matrix were constructed to establish a droplet distribution model for sprinkler irrigation considering multifactor coupling using MATLAB 2018a software. The results showed that, under different working conditions, the data points of the droplet landing diameter, velocity, and angle were distributed near the 1:1 line. The Nash efficiency coefficients (NSE) for the droplet landing diameter, velocity, and angle varied from 0.821 to 0.932, 0.616 to 0.931, and 0.770 to 0.911, respectively. The increase in slope resulted in droplets with diameters larger than 4.63 mm concentrating on the land in the reverse slope direction. When the ambient temperature increases from 10 to 45 °C and the total evaporation rate increases from 0.45 to 4.37 %, the larger droplets have a larger area of contact with the air, and the higher the temperature, the greater the energy loss to the larger droplet diameters. The higher the wind speed, the more droplets in the downwind direction fall to the ground at a smaller landing angle, which can easily increase the risk of soil shear damage. If the sprinkler riser was tilted east, the droplets on both the east and west sides tended to be distributed centrally; the maximum droplet landing velocity occurred on the east side (tilted side), and the maximum droplet landing angle occurred on the west side. This study considers various factors that may affect the motion of sprinkler irrigation water flow, extends the application scenarios of the theoretical model, and improves the applicability of the theoretical model for sprinkler irrigation droplet motion in more complex and practical agricultural environments.

Genetic overlap and Mendelian randomization analysis highlighted the causal relationship between psoriatic disease and migraine.

Despite observational studies suggesting a link between psoriatic disease (including psoriasis and psoriatic arthritis) and migraine, it is unclear whether there is a shared genetic etiology or a causal relationship between the two conditions. We aimed to reveal the genetic overlap and causality using the Mendelian randomization (MR) framework. The genetic analysis utilized summary data from the most extensive European genome-wide association study (GWAS) of migraine. Well-powered psoriatic disease GWAS data were obtained from two independent cohort studies, which served as discovery and validation datasets. Global and regional genetic correlations between psoriatic disease and migraine were assessed, and pleiotropic regions identified by pairwise GWAS analysis were further annotated. We further applied a two-sample MR multivariate MR to investigate the potential causal relationship between them. The global genetic correlation test indicated weak correlations between psoriatic disease and migraine, while regional correlation analyses delineated one significant shared locus between psoriasis and migraine. Pathway enrichment analysis revealed that shared genes were involved biological processes to the major histocompatibility and antigen processing and presentation. In terms of causality estimates, genetically predicted psoriasis (Pmeta = 0.003) and psoriatic arthritis (Pmeta = 0.028) were associated with an increased risk of migraine. Multivariate MR analysis indicated that psoriasis was an independent risk factor for migraine (P < 0.05). No significant associations were found in the reverse direction. Our study supported the causal role of psoriasis on migraine, and the central role for immunomodulatory etiology. These findings have significant implications for the management of migraine and clinical practice in patients with psoriasis.

Age at separation, residential mobility, and depressive symptoms among twins in late adolescence and young adulthood: a FinnTwin12 cohort study

BackgroundSeparating with close siblings and leaving the parental home at an early age represents a major life event for an adolescent (reflected by age at separation in a twin pair) and may predispose them to poor mental health. This study aims to examine the association of age at separation and residential mobility on depressive symptoms in late adolescence and young adulthood and to explore possible underlying genetic effects.MethodsResidential mobility consisted of the number and total distance of moves before age 17. Based on 3071 twins from the FinnTwin12 cohort, we used linear regression to assess the association of age at separation and residential mobility with General Behavior Inventory (GBI) scores at age 17 and in young adulthood. A higher GBI score indicated more depressive symptoms occurred. Then, the mixed model for repeated measures (MMRM) was used to visualize the scores’ trajectory and test the associations, controlling for "baseline" state. Twin analyses with a bivariate cross-lagged path model were performed between the difference in GBI scores, between cotwins, and separation status for the potential genetic influence.ResultsCompared to twins separated before age 17, twins who separated later had significantly lower GBI scores at age 17 and in young adulthood. In MMRM, separation at a later age and a higher number of moves were associated with a higher GBI score in young adulthood. A small genetic effect was detected wherein GBI within-pair differences at age 17 were associated with separation status before age 22 (coefficient: 0.01).ConclusionThe study provides valid evidence about the influence of siblings and family on depressive symptoms in later adolescence and young adulthood while finding some evidence for a reverse direction effect. This suggests more caution in the interpretation of results. A strong association between residential mobility and depressive symptoms was affirmed, although further detailed research is needed.

Observation of Topological Transition in Floquet Non-Hermitian Skin Effects in Silicon Photonics.

Non-Hermitian physics has greatly enriched our understanding of nonequilibrium phenomena and uncovered novel effects such as the non-Hermitian skin effect (NHSE) that has profoundly revolutionized the field. NHSE has been predicted in systems with nonreciprocal couplings which, however, are challenging to realize in experiments. Without nonreciprocal couplings, the NHSE can also emerge in systems with coexisting gauge fields and loss or gain (e.g., in Floquet non-Hermitian systems). However, such Floquet NHSE remains largely unexplored in experiments. Here, we realize the Floquet NHSEs in periodically modulated optical waveguides integrated on a silicon photonic platform. By engineering the artificial gauge fields induced by the periodical modulation, we observe various Floquet NHSE phases and unveil their rich topological transitions. Remarkably, we discover the transitions between the unipolar NHSE phases and an unconventional bipolar NHSE phase, which is accompanied by the directional reversal of the NHSEs. The underlying physics is revealed by the band winding in complex quasienergy space which undergoes a topology change from isolated loops with the same winding to linked loops with opposite windings. Our work unfolds a new route toward Floquet NHSEs originating from the interplay between gauge fields and dissipation effects, and thus offers fundamentally new ways for steering light and other waves.