Opposite Direction Research Articles

Internet-Delivered Exposure-Based Cognitive Behavior Therapy for Irritable Bowel Syndrome: A Clinical Effectiveness Study.

Irritable bowel syndrome (IBS) is a common and debilitating disorder. When dietary and pharmacological interventions are not satisfactory, psychological treatment may produce good results. However, the access to such treatment is scarce, and therefore, it is of importance to make use of technical solutions. In this study, we wanted to investigate the real-world effectiveness of an Internet-delivered exposure-based cognitive behavior therapy (ECBT) for IBS and to replicate an earlier finding regarding the working mechanism of the treatment. A total of 309 consecutively recruited patients from the Internet Psychiatry Clinic in Stockholm received ECBT for 12 weeks. The patients' IBS symptoms, quality of life, avoidance behaviors, and gastrointestinal symptom-specific anxiety were monitored, and we used a bivariate cross-lagged panel model to investigate time-related change in symptoms and avoidance behaviors. IBS symptoms, measured with the Gastrointestinal Symptom Rating Scale for IBS, were reduced from 48.06 (SD = 11.26) before treatment to 33.06 (SD = 10.81) 6 months after treatment ( P < 0.001). The effect size (calculated by Cohen d ) was 1.30 (1.08-1.51). There was a significant ( P < 0.001) cross-lagged effect from reduction in avoidance behavior to reduction in symptoms but not in the reverse direction, indicating that the treatment effect is mediated by behavioral change. We conclude that ECBT is effective under real-world conditions, also when delivered through the Internet, and that an important treatment mechanism is the reduction of avoidance behaviors.

Bidirectional Molecular Motors by Controlling Threading and Dethreading Pathways of a Linked Rotaxane.

Artificial molecular motors have been presented as models for biological molecular motors. In contrast to the conventional artificial molecular motors that rely on covalent bond rotation, molecular motors with mechanically interlocked molecules (MIM) have attracted considerable attention owing to their ability to generate significant rotational motion by dynamically shuttling macrocyclic components. The topology of MIM-type rotational molecular motors is currently limited to catenane structures, which require intricate synthetic procedures that typically produce a low synthetic yield. In this study, we develop a novel class of MIM-type molecular motors with a rotaxane-type topology. The switching of the threading/dethreading pathways of the linked rotaxane by protecting/deprotecting the bulky stopper group and changing the solvent polarity enables a net unidirectional rotation of the molecular motor. The threading/dethreading reaction rates were quantitatively evaluated through detailed spectroscopic investigations. Repeated net unidirectional rotation and switching of the direction of rotation were also achieved. Our findings demonstrate that linked rotaxanes can serve as MIM-type molecular motors with reversible rotational direction controlled by threading/dethreading reactions. These motors hold potential as components of molecular machinery.

Phase classification and transient effects of the start-up process of multi-functional pump station in pump mode

In the context of achieving the goal of carbon neutrality, multi-functional pump stations (MFPS) have been greatly developed as a new energy system in recent years. The MFPS can operate in forward direction in pump mode to pump water and in turbine mode in reverse direction to generate electricity. At present, the instability of the MFPS during start-up process (SUP) in pump mode has become the key to restricting the operating life and further development of MFPS. In this paper, based on the motion characteristics of the pump and the cut-off facility (COF), the SUP of the MFPS in pump mode is clearly classified. In order to reveal the transient effect during the SUP, the steady-state full characteristic experiment (SFCE) of the pump was carried out. The occurrence phase of the transient effect during the SUP is analyzed, and the deviation between the steady-state external characteristics and the transient characteristics is revealed. In this study, the evaluation formula of the start-up completion degree (SUCD) of the MFPS in pump mode is proposed for the first time, and the evaluation and identification of the start-up progress at different phases are completed. The results show that the water flow in the system is in a reverse flow state in the Phase I. The SUCD of Phase I is 17 %. In the Phase II, The high-speed jet flow in the pump flows to the inlet of the guide vane (GV), which gradually changes the mainstream direction in the GV. A certain vortex structure can be observed at the exit of the flap gate (FG). The SUCD of Phase II is 61 %. In the Phase I and II, the dimensionless head of transient simulation is much larger than that of SFCE. In the Phase III, the flow state in the impeller will gradually stabilize. The transient effect disappears and the pressure fluctuation intensity decreases. The SUCD of Phase III is 93 %. In the Phase IV, the separation vortex that persists from Phase I-III at the tail of the GV blades disappears. The diversion capacity at the gate increases, and significant annular flow can be observed near the FG.

Confinement controls the directional cell responses to fluid forces

Our understanding of how fluid forces influence cell migration in confining environments remains limited. By integrating microfluidics with live-cell imaging, we demonstrate that cells in tightly-but not moderately-confined spaces reverse direction and move upstream upon exposure to fluid forces. This fluid force-induced directional change occurs less frequently when cells display diminished mechanosensitivity, experience elevated hydraulic resistance, or sense a chemical gradient. Cell reversal requires actin polymerization to the new cell front, as shown mathematically and experimentally. Actin polymerization is necessary for the fluid force-induced activation of NHE1, which cooperates with calcium to induce upstream migration. Calcium levels increase downstream, mirroring the subcellular distribution of myosin IIA, whose activation enhances upstream migration. Reduced lamin A/C levels promote downstream migration of metastatic tumor cells by preventing cell polarity establishment and intracellular calcium rise. This mechanism could allow cancer cells to evade high-pressure environments, such as the primary tumor.

Tagged particle behavior in a harmonic chain of direction-reversing active Brownian particles

Abstract We study the tagged particle dynamics in a harmonic chain of direction-reversing active Brownian particles, with the spring constant k, rotation diffusion coefficient D R , and directional reversal rate γ. We exactly compute the tagged particle position variance for quenched and annealed initial orientations of the particles. For well-separated time-scales, k − 1 , D R − 1 and γ −1, the strength of the spring constant k relative to D R and γ gives rise to different coupling limits, and for each coupling limit there are short, intermediate, and long-time regimes. In the thermodynamic limit, we show that, to the leading order, the tagged particle variance exhibits an algebraic growth t ν , where the value of the exponent ν depends on the specific regime. For a quenched initial orientation, the exponent ν crosses over from 3 to 1 / 2 , via intermediate values 5 / 2 or 1, depending on the specific coupling limits. However, for the annealed initial orientation, ν crosses over from 2 to 1 / 2 via an intermediate value 3 / 2 or 1 for the strong coupling limit and the weak coupling limit, respectively. An additional time-scale t N = N 2 / k emerges for a system with a finite number of oscillators N. We show that the behavior of the tagged particle variance across tN can be expressed in terms of a crossover scaling function, which we find exactly. Moreover, we study the velocity autocorrelation. Finally, we characterize the stationary state behavior of the separation between two consecutive particles by calculating the corresponding spatio-temporal correlation function.

Control of Flow and Acoustic Fields Around an Axial Fan Utilizing Plasma Actuators

Abstract Small axial fans, commonly employed for cooling electronic equipment, are frequently housed within narrow ducts, where intense tonal sound with duct resonance can occur, particularly when the blade passing frequency or its harmonic frequency aligns with the duct's resonance frequency. To mitigate resonant sound, this study proposes a flow control using dielectric barrier discharge plasma actuators, which induce a flow along the generation of plasma in air. The control effects on flow field, acoustic radiation, and aerodynamic characteristics are evaluated through direct aeroacoustic simulations and experiments conducted at different flow rates. The computational results reveal that swirling flow occurs in the inflow due to fan rotations at low flow coefficients. This swirling flow is weakened by utilizing plasma actuators, which are arranged to induce flows in the circumferentially reverse direction compared to fan rotations. This control method weakens the resonant sound at low and intermediate flow coefficients, while intensifying it at high flow coefficients, all at the same rotational speed. Moreover, the static pressure coefficient decreases and increases at low and high flow coefficients, respectively, with the latter attributed to an increase in the relative inflow angle induced by the control. Experimental findings demonstrate that the acoustic resonance was reduced by the control at both low and high flow rates, achieved by adjusting the rotational speed to maintain the same flowrate and static pressure rise as in the baseline case.

Simulating droplet distribution characteristics in sprinkler irrigation using a modified ballistic model under multifactor coupling

External factors affecting the processes of sprinkler irrigation water flow generation, flight, and landing have not been thoroughly considered in existing ballistic models. This result indicates that ballistic models with better prediction effects under specific conditions are not sufficient for extension to multi-factor coupled scenarios in large-scale farmlands. Therefore, wind, evaporation, surface slope, and tilted sprinkler riser factors were comprehensively considered in this study. Differential equations for jet and droplet motion under the influence of wind, differential equations of droplet evaporation, sprinkler riser deflection angle matrix, and surface slope angle matrix were constructed to establish a droplet distribution model for sprinkler irrigation considering multifactor coupling using MATLAB 2018a software. The results showed that, under different working conditions, the data points of the droplet landing diameter, velocity, and angle were distributed near the 1:1 line. The Nash efficiency coefficients (NSE) for the droplet landing diameter, velocity, and angle varied from 0.821 to 0.932, 0.616 to 0.931, and 0.770 to 0.911, respectively. The increase in slope resulted in droplets with diameters larger than 4.63 mm concentrating on the land in the reverse slope direction. When the ambient temperature increases from 10 to 45 °C and the total evaporation rate increases from 0.45 to 4.37 %, the larger droplets have a larger area of contact with the air, and the higher the temperature, the greater the energy loss to the larger droplet diameters. The higher the wind speed, the more droplets in the downwind direction fall to the ground at a smaller landing angle, which can easily increase the risk of soil shear damage. If the sprinkler riser was tilted east, the droplets on both the east and west sides tended to be distributed centrally; the maximum droplet landing velocity occurred on the east side (tilted side), and the maximum droplet landing angle occurred on the west side. This study considers various factors that may affect the motion of sprinkler irrigation water flow, extends the application scenarios of the theoretical model, and improves the applicability of the theoretical model for sprinkler irrigation droplet motion in more complex and practical agricultural environments.

Genetic overlap and Mendelian randomization analysis highlighted the causal relationship between psoriatic disease and migraine.

Despite observational studies suggesting a link between psoriatic disease (including psoriasis and psoriatic arthritis) and migraine, it is unclear whether there is a shared genetic etiology or a causal relationship between the two conditions. We aimed to reveal the genetic overlap and causality using the Mendelian randomization (MR) framework. The genetic analysis utilized summary data from the most extensive European genome-wide association study (GWAS) of migraine. Well-powered psoriatic disease GWAS data were obtained from two independent cohort studies, which served as discovery and validation datasets. Global and regional genetic correlations between psoriatic disease and migraine were assessed, and pleiotropic regions identified by pairwise GWAS analysis were further annotated. We further applied a two-sample MR multivariate MR to investigate the potential causal relationship between them. The global genetic correlation test indicated weak correlations between psoriatic disease and migraine, while regional correlation analyses delineated one significant shared locus between psoriasis and migraine. Pathway enrichment analysis revealed that shared genes were involved biological processes to the major histocompatibility and antigen processing and presentation. In terms of causality estimates, genetically predicted psoriasis (Pmeta = 0.003) and psoriatic arthritis (Pmeta = 0.028) were associated with an increased risk of migraine. Multivariate MR analysis indicated that psoriasis was an independent risk factor for migraine (P < 0.05). No significant associations were found in the reverse direction. Our study supported the causal role of psoriasis on migraine, and the central role for immunomodulatory etiology. These findings have significant implications for the management of migraine and clinical practice in patients with psoriasis.

Age at separation, residential mobility, and depressive symptoms among twins in late adolescence and young adulthood: a FinnTwin12 cohort study

BackgroundSeparating with close siblings and leaving the parental home at an early age represents a major life event for an adolescent (reflected by age at separation in a twin pair) and may predispose them to poor mental health. This study aims to examine the association of age at separation and residential mobility on depressive symptoms in late adolescence and young adulthood and to explore possible underlying genetic effects.MethodsResidential mobility consisted of the number and total distance of moves before age 17. Based on 3071 twins from the FinnTwin12 cohort, we used linear regression to assess the association of age at separation and residential mobility with General Behavior Inventory (GBI) scores at age 17 and in young adulthood. A higher GBI score indicated more depressive symptoms occurred. Then, the mixed model for repeated measures (MMRM) was used to visualize the scores’ trajectory and test the associations, controlling for "baseline" state. Twin analyses with a bivariate cross-lagged path model were performed between the difference in GBI scores, between cotwins, and separation status for the potential genetic influence.ResultsCompared to twins separated before age 17, twins who separated later had significantly lower GBI scores at age 17 and in young adulthood. In MMRM, separation at a later age and a higher number of moves were associated with a higher GBI score in young adulthood. A small genetic effect was detected wherein GBI within-pair differences at age 17 were associated with separation status before age 22 (coefficient: 0.01).ConclusionThe study provides valid evidence about the influence of siblings and family on depressive symptoms in later adolescence and young adulthood while finding some evidence for a reverse direction effect. This suggests more caution in the interpretation of results. A strong association between residential mobility and depressive symptoms was affirmed, although further detailed research is needed.

Observation of Topological Transition in Floquet Non-Hermitian Skin Effects in Silicon Photonics.

Non-Hermitian physics has greatly enriched our understanding of nonequilibrium phenomena and uncovered novel effects such as the non-Hermitian skin effect (NHSE) that has profoundly revolutionized the field. NHSE has been predicted in systems with nonreciprocal couplings which, however, are challenging to realize in experiments. Without nonreciprocal couplings, the NHSE can also emerge in systems with coexisting gauge fields and loss or gain (e.g., in Floquet non-Hermitian systems). However, such Floquet NHSE remains largely unexplored in experiments. Here, we realize the Floquet NHSEs in periodically modulated optical waveguides integrated on a silicon photonic platform. By engineering the artificial gauge fields induced by the periodical modulation, we observe various Floquet NHSE phases and unveil their rich topological transitions. Remarkably, we discover the transitions between the unipolar NHSE phases and an unconventional bipolar NHSE phase, which is accompanied by the directional reversal of the NHSEs. The underlying physics is revealed by the band winding in complex quasienergy space which undergoes a topology change from isolated loops with the same winding to linked loops with opposite windings. Our work unfolds a new route toward Floquet NHSEs originating from the interplay between gauge fields and dissipation effects, and thus offers fundamentally new ways for steering light and other waves.

Multi-objective optimization and artificial neural network models for enhancing the overall performance of a microchannel heat sink with fins inspired Tesla valve profile

Microchannel heat sinks (MCHSs) are advanced cooling systems used in various applications such as electronics cooling, thermal management of high-power microprocessors, and microelectronic devices. These heat sinks are designed to efficiently dissipate heat generated by electronic components to maintain optimal operating temperatures and ensure device reliability. Employing appropriate fins within MCHSs is a crucial strategy to enhance heat removal efficiency. Since few investigations have been performed on the simultaneous thermo-hydraulic features in microchannels with Tesla valves, this research addresses this gap by suggesting that the microchannels of a heat sink be reinforced with novel Tesla valve-shaped fins. Tesla valves are designed to offer different levels of resistance depending on the flow direction. This characteristic allows for selective control of pressure drop and heat transfer efficiency by simply switching the flow direction. Utilizing Tesla valve-shaped fins is an almost new approach that differentiates the current research from conventional designs. The advantage of this structure is that under different circumstances, depending on whether more heat transfer is required or less pressure drop (ΔP), the flow direction can be changed, and the maximum efficiency of the MCHS can be accessed. The other innovative aspect of this study lies in the integration of artificial neural network (ANN) models to optimize the efficiency of MCHSs equipped with Tesla valve-shaped fins. The simulations were conducted to characterize the flow and thermal features of the MCHS. Then, these data were used as the benchmark for training the ANN models. Four ANN models were introduced to anticipate the Nusselt number (Nu) and ΔP in each forward and reverse direction. The divider's acute angle (α), the divider's obtuse angle (β), and the divider's radius (R) were selected as the input data. Multi-objective optimization and genetic algorithms were used to achieve the optimal conditions. In the optimal thermal design (Setting 2: MCHS with fin variables of α = 60 β = 180, and R = 80 μm in reverse flow direction), the overall performance had a significant enhancement of 57.1 % compared to the device lacking fins. Furthermore, in Setting 2, the overall performance of the MCHS and its diodicity experienced notable improvements of approximately 12.1 % and 38.5 %, respectively. Implementing the parameters of Setting 5 (MCHS with fin variables of α = 60, β = 152.32, and R = 73.10 μm in forward direction) during fin production resulted in a notable enhancement of about 41.1 % in the device's overall performance.

The role of body image dissatisfaction in the relationship between body size and disordered eating and self-harm: complimentary Mendelian randomization and mediation analyses.

Disordered eating and self-harm commonly co-occur in young people suggesting potential for shared underlying causes. Body image dissatisfaction (BID) has been recognised as a psychological correlate of body size, associated with both disordered eating and self-harm. However, the investigation into etiological pathways early in the lifecourse to provide detail on how body size and BID may foster disordered eating and self-harm remains largely unexplored. Employing data from two large population-based cohorts, the UK Biobank and the Avon Longitudinal Study of Parents And Children (ALSPAC), we conducted bidirectional Mendelian randomization (MR) to determine the causal direction of effect between genetically predicted prepubertal body size and two measures of BID indicating (i) desire to be smaller, and (ii) desire to be larger. We then used multivariable regression followed by counterfactual mediation analyses. Bidirectional MR indicated robust evidence that increased genetically predicted prepubertal body size increased desire to be smaller and decreased desire to be larger. Evidence for the reverse causal direction was negligible. These findings remained very similar across sensitivity analyses. In females and males, multivariable regression analyses demonstrated that being overweight increased the risk of disordered eating (risk ratio (RR), 95% confidence interval (CI): 1.19, 1.01 to 1.40 and 1.98, 1.28 to 3.05, respectively) and self-harm (RR, 95% CI: 1.35, 1.04 to 1.77 and 1.55, 0.86 to 2.81, respectively), while being underweight was protective against disordered eating (RR, 95% CI: 0.57, 0.40 to 0.81 and 0.81, 0.38 to 1.73, respectively). There was weak evidence of an increase in the risk of self-harm among underweight individuals. Mediation analyses indicated that the relationship between being overweight and subsequent disordered eating was largely mediated by the desire to be smaller. Our research carries important public health implications, suggesting distinct risk profiles for self-harm and disordered eating in relation to weight and body image. In addition, a better understanding of genetically predicted prepubertal BID may be valuable in the prevention and treatment of disordered eating and self-harm in adolescence.

Programming Fluid Motion Using Multi-Enzyme Micropump Systems.

In the presence of appropriate substrates, surface-anchored enzymes can act as pumps and propel fluid through microchambers. Understanding the dynamic interplay between catalytic reactions and fluid flow is vital to enhancing the accuracy and utility of flow technology. Through a combination of experimental observations and numerical modeling, we show that coupled enzyme pumps can exhibit flow enhancement, flow suppression, and changes in the directionality (reversal) of the fluid motion. The pumps' ability to regulate the flow path is due to the reaction selectivity of the enzymes; the resultant fluid motion is only triggered by the presence of certain reactants. Hence, the reactants and the sequence in which they are present in the solution and the layout of the enzyme-attached patches form an "instruction set" that guides the flowing solution to specific sites in the system. Such systems can operate as sensors that indicate concentrations of reactants through measurement of the trajectory along which the flow demonstrates a maximal speed. The performed simulations suggest that the solutal buoyancy mechanism causes fluid motion and is responsible for all of the observed effects. More broadly, our studies provide a new route for forming self-organizing flow systems that can yield fundamental insight into nonequilibrium, dynamical systems.

Platelet traits and sepsis risk and prognosis: a bidirectional two-sample Mendelian randomization study.

Sepsis is a critical medical condition characterized by a dysregulated host response to infection. Platelet abnormalities frequently manifest in sepsis patients, but the causal role of platelets in sepsis remains unclear. This study employed a bidirectional two-sample Mendelian randomization (MR) approach to investigate the causal direction between platelets and sepsis. MR analysis was used to investigate the causal effect of four platelet traits - platelet count (PLT), platelet crit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW)- on sepsis risk and prognosis. Additionally, the study explored the reverse causality, assessing the impact of sepsis on these platelet traits. Genetic variants from large-scale genome-wide association studies (GWAS) served as instrumental variables to infer causality. Sensitivity analyses and heterogeneity tests were conducted to ensure the validity and robustness of the results. Genetically predicted decreased PCT (OR = 0.938, p = 0.044) and MPV (OR = 0.410, p = 0.006) were associated with an increased risk of sepsis. In the reverse direction, 28-day sepsis mortality was significantly associated with decreased PLT (OR = 0.986, p = 0.034). No significant causal relationships were observed between sepsis and other platelet traits. This study suggests a causal association between low PCT and MPV levels and increased risk of sepsis. Additionally, sepsis with a poor prognosis was causally linked to decreased PLT. These findings provide novel evidence for the causal relationship between platelet traits and sepsis.

Genome-wide association study of susceptibility to Pseudomonas aeruginosa infection in cystic fibrosis.

Pseudomonas aeruginosa is a common pathogen that contributes to progressive lung disease in cystic fibrosis (CF). Genetic factors other than CF-causing CFTR (CF transmembrane conductance regulator) variations contribute ∼85% of the variation in chronic P. aeruginosa infection age in CF according to twin studies, but the susceptibility loci remain unknown. Our objective is to advance understanding of the genetic basis of host susceptibility to P. aeruginosa infection. We conducted a genome-wide association study of chronic P. aeruginosa infection age in 1037 Canadians with CF. We subsequently assessed the genetic correlation between chronic P. aeruginosa infection age and lung function through polygenic risk score (PRS) analysis and inferred their causal relationship through bidirectional Mendelian randomisation analysis. Two novel genome-wide significant loci with lead single nucleotide polymorphisms (SNPs) rs62369766 (chr5p12; p=1.98×10-8) and rs927553 (chr13q12.12; p=1.91×10-8) were associated with chronic P. aeruginosa infection age. The rs62369766 locus was validated using an independent French cohort (n=501). Furthermore, the PRS constructed from CF lung function-associated SNPs was significantly associated with chronic P. aeruginosa infection age (p=0.002). Finally, our analysis presented evidence for a causal effect of lung function on chronic P. aeruginosa infection age (β=0.782 years, p=4.24×10-4). In the reverse direction, we observed a moderate effect (β=0.002, p=0.012). We identified two novel loci that are associated with chronic P. aeruginosa infection age in individuals with CF. Additionally, we provided evidence of common genetic contributors and a potential causal relationship between P. aeruginosa infection susceptibility and lung function in CF. Therapeutics targeting these genetic factors may delay the onset of chronic infections, which account for significant remaining morbidity in CF.

Directionality Reversal and Shift of Rotational Axis in a Hemithioindigo Macrocyclic Molecular Motor.

Molecular motors are central driving units for nanomachinery, and control of their directional motions is of fundamental importance for their functions. Light-driven variants use easy to provide, easy to dose, and waste-free fuel with high energy content, making them particularly interesting for applications. Typically, light-driven molecular motors work via rotations around dedicated chemical bonds where the directionality of the rotation is dictated by the steric effects of asymmetry in close vicinity to the rotation axis. In this work, we show how unidirectional rotation around a virtual axis can be realized by reprogramming a molecular motor. To this end, a classical light-driven motor is restricted by macrocyclization, and its intrinsic directional rotation is transformed into a directional rotation of the macrocyclic chain in the opposite direction. Further, solvent polarity changes allow to toggle the function of this molecular machine between a directional motor and a nondirectional photoswitch. In this way, a new concept for the design of molecular motors is delivered together with elaborate control over their motions and functions by simple solvent changes. The possibility of sensing the environmental polarity and correspondingly adjusting the directionality of motions opens up a next level of control and responsiveness to light-driven nanoscopic motors.

OsLdh7, a rice lactate dehydrogenase, confers stress resilience in rice under cadmium stress through NAD+/NADH regulation

Lactate dehydrogenase (Ldh, EC 1.1.1.27), an oxidoreductase enzyme catalyses the interconversion of pyruvate to L-lactate and vice-versa with concomitant oxidation and reduction of NADH and NAD+. The enzyme functions as a ROS sensor and mitigates stress response by maintaining NAD+/NADH homeostasis. In this study, we delineated the role of the Ldh enzyme in imparting cadmium stress tolerance in rice. Previously, we identified a putatively active Ldh in rice (OsLdh7) through insilico modelling. Biochemical characterization of the OsLdh7 enzyme revealed it to be optimally active at pH 6.6 in the forward direction and pH 9 in the reverse direction. Overexpression of OsLdh7 in rice cv. IR64, increased tolerance of the transgenic lines to cadmium stress compared to the wild type (WT) at both seedling and reproductive stages. The transgenic lines showed increased enzyme activity in the reverse direction under cadmium stress, attributed to elevated cytosolic pH resulting from increased calcium concentration. This increased NADH content is highly essential for functioning of the ROS scavenging enzymes, RbohD and MPK6. qPCR analysis revealed that the overexpression lines had increased transcript abundance of these genes indicating an effective ROS scavenging mechanism. Additionally, the overexpression lines showed an efficient cadmium sequestration mechanism compared to the WT by increasing the transcript levels of the vacuolar transporters of cadmium as well as total phytochelatin content. Thus, our findings indicated OsLdh7 imparts cadmium stress tolerance in rice through a two-pronged approach by mitigating ROS and sequestering cadmium ions, highlighting its potential for crop improvement programs.

A rigid and compact piezoelectric motor with high output efficiency.

We introduce a novel piezoelectric stepper motor featuring high compactness, rigidity, and any direction operability. Here, not only is the structure of high novelty but also the working principle very simple. The piezo stacks unit is sandwiched between two spring finger pieces, with almost equal clamping forces applied between the top of the piezo stacks' unit and the spring finger piece. Applying individual driving signals to each of the five piezo stack pairs, causing deformation one by one in the same direction, followed by simultaneous recovery in the reverse direction, enables movement of the frame part. The optimized clamping force of the piezoelectric stack units and spring fingers ensures maximum output force. The motor's operational capability at low threshold voltages, specifically 8V for downward movement and 10V for upward movement, confirmed its efficacy in both vertical and horizontal directions. The motor's operational capability at a low threshold voltage of 10V confirmed its efficacy in both vertical and horizontal directions. At room temperature, step size ranges from 0.3 to 7.4 µm at 20Hz frequency and varying driving voltage from 10 to 180V. It has a maximum travel range of about 5mm and can lift a maximum load of 220g in an upward direction, so the maximum output force generated by this motor is 2.2 N. The compact and rigid design is capable of building an atomically resolved scanning probe microscope, and its working ability has the potential to use the cleavage of different types of samples in limited space environments, such as the small-bore superconducting magnet and low temperature.

On reversal of wave-generated longshore currents at tidal frequencies on dissipative beaches contiguous to a mesotidal estuary, S.E coast of Nigeria

Reversals in wave-generated longshore currents in surf zones occur at different temporal and spatial scales. Along coastlines with tidal channel openings with well-developed mouth bars or ebb-tidal deltas, the reversal mechanism is often attributed to the mouth bar – induced refraction of the shoaling waves. This reversal mechanism is characterized by convergence of longshore currents from the adjoining surf zones at the mouth of the tidal channel. Simultaneous half-hourly monitoring of wave-generated longshore currents over 50 successive (daylight) semi-diurnal tidal cycles in beach surf zones adjoining the Qua Iboe River estuary, S.E coast of Nigeria showed the above reversal pattern during flooding stage only. The converse pattern, where the surf zone longshore currents diverged away from the mouth of the estuary, was observed during ebbing stage. Both surf zones showed flow direction inversion with respect to each other, with velocity vector correlation coefficient r > − 0.8 in over 80 % of the data set. Instances of comparable flow direction (<10 %) were also recorded. Tidal processes are implicated in the documented results. Direction-averaged longshore current velocities, typically in the 15–60 cm/s range, attained highest values in both surf zones at about spring tide phase. Also, tidal cycle-residual longshore current maximum and minimum velocities occurred close to spring and neap tide, respectively. Only 30 % of the residual velocities were eastward directed in the up-drift surf zone as against 80 % in the down-drift counterpart. Given the prevailing southwesterly waves, the present results negate the assertion that reversal in longshore current direction in this offset shoreline setting is exclusively a consequence of wave refraction by mouth bar morphology. The reversing pattern of the longshore currents over a tidal cycle is well explained by incorporating interacting effects of shoaling waves with tide-induced oscillations in water level as well as the estuarine flow.

Dynamic evolution of amplitude and position of geomagnetic secular acceleration pulses since 2000

Recent studies on the behavior of geomagnetic secular acceleration (SA) pulses have provided a basis for understanding the dynamic processes in the Earth’s core. This analysis statistically evaluates the evolution of the SA pulse amplitude and position since 2000 by computing the three-year difference in SA with the CHAOS-7 geomagnetic field model (CHAOS-7.17 release). Furthermore, the study explores the correlation between the acceleration pulse amplitude and geomagnetic jerks and the dynamic processes of alternating variation and polarity reversal of pulse patches over time. Research findings indicate that the variation in pulse amplitude at the Core Mantle Boundary (CMB) closely resembles that observed at the Earth’s surface, with an average period of 3.2 years. The timing of peak pulse amplitude aligns with that of the geomagnetic jerk, suggesting its potential utility as a novel indicator for detecting geomagnetic jerk events. The acceleration pulses are the strongest near the equator (2°N) and more robust in the high-latitude region (68°S) of the Southern Hemisphere, indicating that the variation is more dramatic in the Southern Hemisphere. The acceleration pulses fluctuate unevenly in the west-east direction, with characteristics of local variation. In the Western Hemisphere, the pulse patches are distributed near the equator, exhibiting an evident westward drifting mode. The positive and negative patches alternate in time, displaying a polarity reversal in the west-east direction, with an average interval of approximately 32°. These characteristics can be attributed to the rapid magnetic field fluctuations disclosed by the model of stratification at the top of the Earth’s core. In the Eastern Hemisphere, the pulses are weaker between 10°E and 60°E, with the most active pulses occurring around 80°E to 105°E and near 150°E. The pulse patches exhibit a broader distribution in the north-south direction, with relatively strong patches still occurring near 40°N and 40°S. These local variation characteristics match the actual cases of zonal flows and geostrophic Alfvén waves in the Earth’s core.