The multi-horizontal section hot dry rock (HDR) heat extraction system is proposed for efficient deep geothermal resources mining in this study. The thermal-hydraulic numerical model of the multi-horizontal section geothermal exploitation system is set up, the space-time evolution of temperature field is analyzed. The sensitivity factors including completion schemes, horizontal well diameter, quantity of horizontal sections and spacing of horizontal sections are investigated. The simulation results show that the production temperature and heating power of the multi-horizontal HDR production system decrease with the development of mining, and the decreasing speed gradually slows down. The open hole completion can be preferred when the formation conditions permit. The variation of horizontal well diameter has little effect on heat production when other conditions remain unchanged. The quantity of horizontal sections to be 3 or 4 for better heat extraction performance under the spacing of horizontal section remains 300m and the spacing of the horizontal section to be 150m is recommended within the scoped of this study. The results of this study can provide guidance for HDR mining research.