Ondansetron Research Articles

Application of the HPLC Method in Parenteral Nutrition Assessment: Stability Studies of Ondansetron

Ondansetron (OND) is a serotonin type 3 receptor antagonist that exhibits antiemetic activity. From the clinical point of view, vomiting and nausea prevention is an important task. Anticancer treatment and recovery impact the patient’s overall state by affecting appetite, well-being, and physical activity, and consequently, nutrition quality. Depending on the patient’s indication and condition, parenteral nutrition is administered to meet full nutritional requirements. In addition, antiemetic drugs can be added to the parenteral nutrition (PN) admixture to treat chemo- or radio-therapy-induced nausea and vomiting. However, adding any medication to the PN admixture can result in the instability of the composition in the overall admixture. This study aimed to develop the HPLC method of determination of OND in Lipoflex special, one of the most popular, ready-to-use PN admixtures. The proposed HPLC method and the sample preparation procedure were suitable for analyzing OND in PN admixture stored under various conditions, such as exposure to sunlight and temperature. It was found that the decomposition of OND during the seven-day storage did not exceed 5% and did not depend on external factors. Based on the conducted research, it is recommended to add OND to Lipoflex special, and it is possible to store such an admixture for seven days.

Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice

Opioid usage for pain therapy is limited by its undesirable clinical effects, including paradoxical hyperalgesia, also known as opioid-induced hyperalgesia (OIH). However, the mechanisms associated with the development and maintenance of OIH remain unclear. Here, we investigated the effect of serotonin inhibition by the 5-HT3 receptor antagonist, ondansetron (OND), as well as serotonin deprivation via its synthesis inhibitor para-chlorophenylalanine, on mouse OIH models, with particular focus on astrocyte activation. Co-administering of OND and morphine, in combination with serotonin depletion, inhibited mechanical hyperalgesia and astrocyte activation in the spinal dorsal horn of mouse OIH models. Although previous studies have suggested that activation of astrocytes in the spinal dorsal horn is essential for the development and maintenance of OIH, herein, treatment with carbenoxolone (CBX), a gap junction inhibitor that suppresses astrocyte activation, did not ameliorate mechanical hyperalgesia in mouse OIH models. These results indicate that serotonin in the spinal dorsal horn, and activation of the 5-HT3 receptor play essential roles in OIH induced by chronic morphine, while astrocyte activation in the spinal dorsal horn serves as a secondary effect of OIH. Our findings further suggest that serotonergic regulation in the spinal dorsal horn may be a therapeutic target of OIH. PerspectiveThe current study revealed that the descending serotonergic pain-facilitatory system in the spinal dorsal horn is crucial in OIH, and that activation of astrocytes is a secondary phenotype of OIH. Our study offers new therapeutic targets for OIH and may help reduce inappropriate opioid use.

Reply to Black and Ford.

Reply to Black and Ford.

Ondansetron should never be used in pregnancy: Against: Ondansetron in pregnancy revisited.

Ondansetron should never be used in pregnancy: Against: Ondansetron in pregnancy revisited.

Ondansetron should never be used in pregnancy.

Ondansetron should never be used in pregnancy.

5-HT3 blockade does not attenuate postspinal blood pressure change in cesarean section: A case-control study.

Spinal anesthesia (SpA) for elective caesarean section (CS) is often accompanied by clinically relevant arterial hypotension. The Bezold-Jarisch reflex, causing postspinal hypotension, has been shown to be antagonized by serotonin type 3 (5-HT3) blockade. Our aim was to assess if routine prophylactic administration of the 5-HT3 antagonist ondansetron (ODS) attenuates postspinal change in maternal blood pressure.Elective CS under SpA were retrospectively analyzed. Eighty parturients having routinely received 8 mg ODS prior to SpA were compared with 80 patients having not (control group).Mean arterial blood pressure significantly decreased from baseline to the postspinal period (P < .0001) without differences in blood pressure decreases between the 2 groups. This also applied to the heart rate. Overall use of cafedrine/theodrenaline was higher in the ODS group (0.8 (0.4–1.6) mL vs 0.8 (0–1.0) mL in the control group, P = .01). APGAR values showed a presumably clinically irrelevant decrease in control group compared with the ODS group.Our results suggest that routine administration of ODS in a dosage of 8 mg does not effectively attenuate postspinal change in maternal blood pressure during CS in our setting. Given the wide variability of anesthetic techniques, only large prospective and randomized multicenter trials will ultimately serve to elucidate this issue.

Comparison of ondansetron versus chewing gum for prevention of post operative nausea and vomiting in patients undergoing elective LSCS: A randomised control trial

Pregnant women are always considered full stomach with high incidence of nausea and vomiting. Anti-emetic efficacy of Ondansetron has been proved in various studies. The aim of this present study is to evaluate efficacy and safety of chewing gum as an alternative to Ondansetron in prevention of postoperative nausea and vomiting (PONV) in parturients undergoing elective LSCS under spinal anesthesia. One hundred pregnant women who were found eligible as per inclusion and exclusion criteria were randomized into two equal groups by simple randomization into Group A (n=50) who were given sugar free chewing gum which was to be chewed for 30 minutes three times a day starting immediately after cesarean section and Group B (n=50) who received Inj. Ondanse tron 4mg twice a day post operatively. The outcome measures were episodes of post-operative nausea and vomiting at 6, 12, 18 and 24 hours in both groups, relief of PONV and acceptability of treatment. The secondary outcome measures time to first flatus. Statistical analysis was done through relevant tests using SPSS 16.0. There was no statistically significant difference between the two groups in terms of demographic characteristics such as age, gravidity parity, duration of surgery and type of cesarean section. The incidence of nausea and vomiting was significantly less in Group A compared with Group B at 6 and 12 hours post operatively (p &amp;#60; 0.001). There was no significant difference of this variable at 18 and 24 hours in both groups. The mean average of the first passage of flatus in group A was 20.3±2.01 hours versus 29.6±2.51 hours in Group B (P&amp;#60;0.0001) was significantly shorter compared to the group B. Gum chewing after cesarean section is safe, well tolerated, and acceptable for prevention of post-operative nausea and vomiting and rapid resumption of intestinal motility and has potential impact on reducing the overall healthcare costs in case of routine implementation.

Design, Characterization and Evaluation of Quick Dissolving Matrix BARETab® ODT Tablet In Ondansetron Formulation

Design, Characterization and Evaluation of Quick Dissolving Matrix BARETab® ODT Tablet In Ondansetron Formulation

Quantitative Nuclear Magnetic Resonance Spectroscopic Analysis of Two Commonly Used Gastrointestinal Tract Drugs.

Two fast and precise quantitative nuclear magnetic resonance spectroscopic methods (qNMR) were established and evaluated for the determination of ondansetron (OND) and omeprazole (OMP) in bulk drugs and their pharmaceutical dosage forms. NMR spectra were established using dimethylsulfoxide (DMSO-d6) as a solvent and phloroglucinol as the internal standard. Proton NMR signals at 3.743, 3.811, and 5.670 ppm were used for quantitative monitoring purposes corresponding to OND, OMP, and phloroglucinol, respectively. In this study, the methods linearity, accuracy, limit of quantification, limit of detection, stability, and precision were validated as per International Conference on Harmonization (ICH) guidelines. Linearity ranges were 0.3-10 mg for OND and 1-10 mg for OMP. The student t-test and F-test were used for statistical evaluation. Herein, the proposed methods are useful and can be a successful practical appliance for OND and OMP determination in drug substances and their dosage forms.

Efficacy and mechanism of Xiaobanxia Decoction and categorized formula in preventing and treating delayed chemotherapeutic vomiting

Objective To observe the pharmacodynamic effect of Xiaobanxia Decoction (XBXD) and categorized formula on cisplatin-induced delayed chemotherapeutic vomiting in rats, and to explore its prevention and treatment mechanism. Methods Sixty Wistar rats were randomly divided into blank group, model group, ondansetron group, XBXD group, Ginger Pinellia Decoction group and Pinellia and Dried Ginger Powder group, with 10 rats in each group. The ondansetron group was given 2.6 mg/(kg•d) ondansetron, the XBXD group was given XBXD 22 g/(kg•d), the Ginger Pinellia Decoction group was given 31.5 ml/(kg•d) Ginger Pinellia Decoction, and Pinellia and Dried Ginger Powder group was given 0.63 g/(kg•d) Dried Ginger Powder. The blank group and the model group were intragastrically administered with normal saline. All the treattmens were last for three days and twice per day. After the first administration, except the blank group, the rats in all groups were intraperitoneally injected with 6 mg/kg cisplatin to establish chemotherapy-induced vomiting model. The kaolin intake of the chemotherapical rats were weighed every 24 h, and the ileum and medulla 5-HT, 5-HIAA, TPH and MAOA levels were detected by ELISA. Results Compared with the model group, the kaolin intake of the chemotherapy rats in each treatment group significantly decreased (P<0.05). The levels of ileum 5-HT (308.04 ± 29.90 ng/L, 355.97 ± 19.16 ng/L, 389.97 ± 24.86 ng/L vs. 498.95 ± 13.92 ng/L) and medulla 5-HT (375.32 ± 19.33 ng/L, 395.18 ± 16.12 ng/L, 406.68 ± 12.09 ng/L vs. 478.52 ± 13.88 ng/L) in the XBXD group, Ginger Pinellia Decoction group and Pinellia and Dried Ginger Powder significantly decreased (P<0.05). The levels of ileum TPH (35.14 ± 2.68 ng/L vs. 47.31 ± 0.83 ng/L) in the XBXD group significantly decreased (P<0.05). The levels of medulla TPH (33.68 ± 2.79 ng/L, 38.19 ± 1.74 ng/L vs. 43.68 ± 1.53 ng/L) in the Ginger Pinellia Decoction group and Pinellia and Dried Ginger Powder significantly decreased (P<0.05). The levels of MAOA, 5-HIAA in the ileum and medulla of the XBXD group, Ginger Pinellia Decoction group and Pinellia and Dried Ginger Powder significantly decreased (P<0.05). Conclusions XBXD and categorized formula can effectively prevent and treat delayed chemotherapy-induced vomiting in rats, and its mechanism may be related to decrease the TPH level and inhibiting 5-HT synthesis. Key words: Xiao Ban Xia Tang; Chemotherapy-induced vomiting; 5-hydroxytryptamine; Tryptophan hydroxylase; Rats

Development of Mouth Dissolving Films of Ondansetron Hydrochloride By Using Factorial Experimental Design

The objective of this study was to develop a mouth dissolving film of ondansetron hydrochloride, an antiemetic drug that can not only serve in an active form but also provide rapid relief from motion sickness. Mouth dissolving oral film of ondansetron hydrochloride is a novel dosage form and was prepared by using HPMC E5, HPMC E15 and PVP K30 as a film-forming polymer in different concentrations. To study the effect of independent variables, i.e., concentration of HPMC E5, HPMC E15, and PVP K30 on various dependent variables like disintegration time and percentage drug content, 33 factorial designs was employed by using Design expert .11 After the application of 33 factorial experimental design, the process was optimized for the response variables R1-R2. The formulation showing disintegration time in the range (10-30 second), desired percentage drug release more than 85% is selected as optimized formulation. Formulation mouth dissolving films-5 (MDF-5), MDF-8, MDF-14, MDF-20, MDF-24, and MDF-25 shows desirable characteristics; all these formulations were taken as optimized formulation and subjected to in vitro dissolution study. MDF-25 containing 1% HPMC E5, 1% HPMC E15, and 1% PVP K30 show the promising faster disintegration time (19.66 seconds) followed by rapid and highest drug release (95.80%) within 120 seconds. How to cite this article: Thakur, S., Sethi, V.A., Siddiqui, A.W. and Tyagi, L.K. (2019). Development of Mouth Dissolving Films (MDFs) of Ondansetron Hydrochloride By Using Factorial Experimental Design. International Journal of Drug Delivery Technology, 9(4): 517-524.

Pharmacological Approach for the Prevention of Postoperative Shivering: A Systematic Review of Prospective Randomized Controlled Trials

Shivering is a common postoperative complication that occurs after both general and regional anesthesia even in the cases when hypothermia during surgery has been averted. Patients describe it as a highly unpleasant experience, while clinicians are concerned due to its adverse effects such as increased oxygen consumption. In this article, we present a summary of the pathophysiological mechanisms involved in postoperative shivering (POS), risk factors, and inadvertent effects. The major objective of this article was to review the existing literature on the effi ciency of various drug interventions as a prophylactic measure against POS. Since α2-adrenergic, opioid, anticholinergic, and serotonergic pathways are thought to play a role in the pathogenesis of POS, a wide variety of drugs has been investigated in this regard. Although the methodological diversity of the study designs and regimens does not support drawing defi nite conclusions, there is evidence indicating a benefi cial effect of dexmedetomidine, ketamine, tramadol, meperidine, dexamethasone, nefopam, granisetron, and ondansetron in the prevention of POS. The purpose of this review is to provide a thorough insight on various drug options and to serve as an aid for clinicians for careful analysis of the advantages and disadvantages of each regimen to decide which regimen will be ideally suited for the medical profi le of each patient.

More Evidence That Ondansetron Is Safe During Pregnancy

Ondansetron is commonly prescribed for nausea during early pregnancy; however, a prior study raised the possibility of excess risk for cardiac

Effects of PCIA with nalbuphine on postoperative cellular immune function in patients undergoing liver cancer resection

Objective To evaluate the effects of patient-controlled intravenous analgesia (PCIA) with nalbuphine on postoperative cellular immune function in the patients undergoing liver cancer resection. Methods Eighty hepatoma patients of both sexes, aged 40-64 yr, with body mass index 19-25 kg/m2, of American Society of Anesthesiologists physical status Ⅱ or Ⅲ, undergoing elective liver cancer resection, were divided into 2 groups (n=40 each) using a random number table method: sufentanil PCIA group (S group) and nalbuphine PCIA group (N group). Transverse abdominal plane block was performed in two groups.In group S, sufentanil 0.1 μg/kg was intravenously injected at 30 min before the end of surgery, PCIA was performed with sufentanil 2 μg/kg plus ondansetron 16 mg (diluted to 100 ml in normal saline) at the end of surgery, and PCA pump was set up with a 1 ml bolus dose, a 10-min lockout interval and background infusion at a rate of 2 ml/h.In group N, nalbuphine 0.1 mg/kg was intravenously injected at 30 min before the end of surgery, PCA was performed with nalbuphine 2 mg/kg plus ondansetron 16 mg (diluted to 100 ml in normal saline) at the end of surgery, and PCIA pump was set up with a 1 ml bolus dose, a 10-min lockout interval and background infusion at a rate of 2 ml/h, maintaining visual analog scale score <4 within 48 h after surgery.Blood samples were collected from the right internal jugular vein on admission to operating room (T1) and 24 and 72 h after surgery (T2, 3) for measurement of levels of T lymphocyte subsets CD3+ , CD4+ and CD8+ , B cells and NK cells.CD4+ /CD8+ ratio was calculated. Results Compared with S group, levels of CD3+ and CD4+ cells at T2 and levels of CD4+ and NK cells at T3 were significantly increased in N group (P<0.05). Compared with the baseline at T1, the levels of CD3+ , CD4+ , NK and B cells at T2 and NK cells at T3 were significantly decreased in two groups, and CD4+ /CD8+ ratio was decreased at T2 in group S (P<0.05). Conclusion PCIA with nabuphine can improve the postoperative cellular immune function in the patients undergoing liver cancer resection. Key words: Nalbuphine; Analgesia, patient-controlled; Immunity, cellular

Ondansetron versus palonosetron as a marker of non-adherence to antiemetic prophylaxis guidelines in highly emetogenic chemotherapy.

e23108 Background: ASCO antiemetic guidelines recommend upfront triple prophylaxis (NK1 receptor antagonist (RA) + 5HT3 RA + dexamethasone) for patients receiving highly emetogenic chemotherapy (HEC). Physicians exhibit high variation in HEC guideline adherence, principally involving inclusion of NK1 RA. Whether adherence is associated with selection of the specific 5HT3 RA agent remains inadequately studied. Methods: In the IBM Explorys electronic health record database, we used procedure and diagnosis codes to identify HEC courses and related nausea/vomiting (NV) from 2012 to 2018. We defined HEC guideline adherence as triple prophylaxis at chemotherapy initiation. We assigned HEC courses for ≥ 7 day cycles of cisplatin or anthracycline + cyclophosphamide (AC), or carboplatin (≥ 14 day cycles as a proxy for AUC ≥ 4) to prescribing oncologists based on encounter frequency. We categorized 5HT3 RA use of each physician treating ≥ 5 HEC courses based on their most commonly used 5HT3 and performed descriptive statistics. Results: Of 12,262 HEC courses, 57% involved physicians having greater use of ondansetron (OND) (mean OND to palonosetron (PALO) ratio of 3.9:1). These courses had lower guideline adherence (due to NK1 RA omission) and higher rates of NV for combined HEC, AC, and carboplatin. NV rates for cisplatin did not vary by 5HT3 agent used. Courses involving physicians with greater PALO use (mean OND:PALO ratio of 0.2:1) had superior adherence and NV rates, despite involving a slightly higher risk population (younger and/or female). Conclusions: According to HEC antiemetic guidelines, NK1 RA use should occur independent of 5HT3 RA agent selection. However, we observed less NK1 RA use where OND was preferred, which may have caused the observed higher rates of NV with OND. Further evaluation should assess whether pharmacy cost minimization is a driver of both OND preference and NK1 omission in HEC. [Table: see text]

Simultaneous high-performance thin-layer chromatographic determination of ondansetron and pantoprazole in their pure forms and spiked human plasma

The therapeutic combination of ondansetron (OND) and pantoprazole (PAN) is widely prescribed for the treatment of many gastrointestinal tract (GIT) disorders. For this reason, a new, simple, very sensitive, accurate and precise HPTLC method was proposed for the determination of OND and PAN in pure forms, normal saline infusion solution, and spiked human plasma. Merck HPTLC aluminum plates pre-coated with silica gel 60 F254 were used as the stationary phase, and the mobile phase consisted of chloroform-methanolethyl acetate (6:2:2 v/v). Using this system resulted in compact , symmetric peaks with the best resolution between peaks. The RF values were 0.50 ± 0.12 for OND and 0.73 ± 0.09 for PAN. The densitometric scanner was set at 302 nm using a deuterium lamp as the source of radiation. The detection and quantification limits were 7.50 and 22.50 ng per spot for OND and 15.81 and 47.42 ng per spot for PAN. The proposed method was successively applied for the analysis of the studied drugs in their pharmaceutical dosage forms, normal saline solution, and spiked human plasma. It gives excellent percent of recovery. Excellent agreement between the proposed method and the reported methods was achieved when the results were matched with respect to accuracy and precision.

5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway.

Apolipoprotein E (apoE) is linked to the risk for Alzheimer’s disease (AD) and thus has been suggested to be an important therapeutic target. In our drug screening effort, we identified Ondansetron (OS), an FDA-approved 5-HT3 antagonist, as an apoE-modulating drug. OS at low micromolar concentrations significantly increased apoE secretion from immortalized astrocytes and primary astrocytes derived from apoE3 and apoE4-targeted replacement mice without generating cellular toxicity. Other 5-HT3 antagonists also had similar effects as OS, though their effects were milder and required higher concentrations. Antagonists for other 5-HT receptors did not increase apoE secretion. OS also increased mRNA and protein levels of the ATB-binding cassette protein A1 (ABCA1), which is involved in lipidation and secretion of apoE. Accordingly, OS increased high molecular weight apoE. Moreover, the liver X receptor (LXR) and ABCA1 antagonists blocked the OS-induced increase of apoE secretion, indicating that the LXR-ABCA1 pathway is involved in the OS-mediated facilitation of apoE secretion from astrocytes. The effects of OS on apoE and ABCA1 were also observed in human astrocytes derived from induced pluripotent stem cells (iPSC) carrying the APOE ε3/ε3 and APOE ε4/ε4 genotypes. Oral administration of OS at clinically-relevant doses affected apoE levels in the liver, though the effects in the brain were not observed. Collectively, though further studies are needed to probe its effects in vivo, OS could be a potential therapeutic drug for AD by modulating poE metabolism through the LXR-ABCA1 pathway.

Effect of flurbiprofen axetil combined with lung-protective ventilation on postoperative cellular immune function in patients undergoing thoracoscopic radical resection of lung cancer

Objective To investigate the effect of flurbiprofen axetil combined with lung-protective ventilation on postoperative cellular immune function in the patients undergoing thoracoscopic radical resection of lung cancer. Methods Eighty American Society of Anesthesiologists physical status Ⅰor Ⅱ patients of both sexes, with no abnormal lung function during the preoperative examination, aged 35-64 yr, with body mass index of 18-28 kg/m2, scheduled for elective thoracoscopic radical resection of lung cancer under general anesthesia, were divided into 4 groups(n=20 each)using a random number table method: conventional mechanical ventilation group(group C), flurbiprofen axetil combined with conventional mechanical ventilation group(group F+ C), lung-protective ventilation group(group P)and flurbiprofen axetil combined with lung-protective ventilation group(group F+ P). Flurbiprofen axetil 2 mg/kg was intravenously injected at 5 min before induction of anaesthesia in F+ C and F+ P groups.Patients were mechanically ventilated in volume-controlled mode in four groups.Conventional ventilator settings were adjusted with tidal volume(VT)10 ml/kg and respiratory rate 10-20 breaths/min during two-lung ventilation and with VT 8 ml/kg and respiratory rate 13-16 breaths/min during one-lung ventilation.Lung-protective ventilator settings were adjusted with VT 8 ml/kg and respiratory rate 12-14 breaths/min during two-lung ventilation and with positive end-expiratory pressure 5 cmH2O, VT 6 ml/kg and respiratory rate 14-16 breaths/min during one-lung ventilation.All patients received patient-controlled intravenous analgesia(PCIA)at the end of surgery until 24 h after surgery.PCIA solution contained sufentanil 100 μg and ondansetron 16 mg in 100 ml of normal saline in group C and group P. PCIA solution contained sufentanil 100 μg, flurbiprofen axetil 2 mg/kg and ondansetron 16 mg in 100 ml of normal saline in group F+ C and group F+ P.The PCIA pump was set up with a 0.5 ml bolus dose, a 15-min lockout interval and background infusion at a rate of 2 ml/h.Visual analog scale score was maintained ≤3.When visual analog scale score >3, tramadol 2 mg/kg was intravenously injected.Before induction of anesthesia(T0), at the end of surgery(T1), at 24 and 72 h after surgery(T2, 3)and at 1 week after surgery(T4), blood samples were collected from the central vein for measurement of the levels of T lymphocyte subsets CD3+ , CD4+ , CD8+ and NK cells.The CD4+ /CD8+ ratio was calculated. Results Compared with the baseline at T0, the levels of CD3+ , CD4+ and NK cells and CD4+ /CD8+ ratio were significantly decreased at T1-3 in C, F+ C and P groups and at T1, 2 in group F+ P(P<0.05). Compared with group C, the levels of CD3+ , CD4+ and NK cells and CD4+ /CD8+ ratio were significantly increased at T1-3 in the other three groups(P<0.05). Compared with group F+ C or group P, the levels of CD3+ , CD4+ and NK cells and CD4+ /CD8+ ratio were significantly increased at T1-3 in group F+ P(P<0.05). Conclusion Flurbiprofen axetil combined with lung-protective ventilation improves postoperative cellular immune function and provides better efficacy than either alone in the patients undergoing thoracoscopic radical resection of lung cancer. Key words: Cyclooxygenase inhibitors; Respiration, artificial; Immunity, cellular; Thoracoscopy

Determination of Ondansetron by Spectrofluorimetry: Application to Forced Degradation Study, Pharmaceuticals and Human Plasma.

The current manuscript describes a validated, responsive and rapid spectrofluorimetric method for quantifying ondansetron (OND) in authentic form, spiked human plasma and dosage forms. This is the first reported fluorescence study of Ondansetron in Triton X 100 system. Various variables affecting fluorescence response were studied precisely and optimised. The described method involved the fluorescence measurement in Triton X 100 system at λem/λex 354/317nm. The calibration plot attained linearity over concentration range of 0.2 - 2μg/mL. The developed method has been extensively applied to degradation studies of OND as per International Conference on Harmonisation (ICH) guidelines by exposing to oxidative, thermal, photo, acidic and alkaline conditions and also the degradation pathway has been proposed.

A Facile Strategy for Construction of Sensor for Detection of Ondansetron and Investigation of its Redox Behavior and Thermodynamic Parameters

AbstractA sodium dodecylsulfate‐doped polypyrrole (SDS‐PPy) film was elaborated on glassy carbon electrode (GCE) by an electrodeposition method in phosphate buffer solution (pH 2.0) containing pyrrole (Py) and sodium dodecyl sulfate (SDS). SDS‐PPy/GCE was used for the construction of sensor, which showed excellent electrochemical response for the detection of ondansetron (OND) compared to conventional PPy. The application of the square wave (SW), with the adsorptive accumulation, indicates a maximum response at 1.33 V in H2SO4 (0.5 M). The influence of experimental parameters on determination of OND is discussed. The adsorptive stripping technique showed to be more sensitive, giving responses twice as big as those of non‐accumulated OND. The substantial improvement of response permits the development of an electroanalytical technique with a linear concentration in the range (1.0–80 μM), low detection (0.09 μM), and quantification limits (0.3 μM), and acceptable relative standard deviations of repeatability (0.59 %), and reproducibility (1.51 %). Consequently, this electrode is promising candidate for an accurate electroanalytical determination of OND in pharmaceutical samples with high sensitivity and selectivity, good accuracy and precision. The electrooxidation of OND at SDS‐PPy/GCE at various temperatures were studied by cyclic voltammetry to evaluate both the kinetic (ks and Ea) and thermodynamic (ΔG*, ΔH* and ΔS*) parameters.