Development of Mouth Dissolving Films of Ondansetron Hydrochloride By Using Factorial Experimental Design

Abstract

The objective of this study was to develop a mouth dissolving film of ondansetron hydrochloride, an antiemetic drug that can not only serve in an active form but also provide rapid relief from motion sickness. Mouth dissolving oral film of ondansetron hydrochloride is a novel dosage form and was prepared by using HPMC E5, HPMC E15 and PVP K30 as a film-forming polymer in different concentrations. To study the effect of independent variables, i.e., concentration of HPMC E5, HPMC E15, and PVP K30 on various dependent variables like disintegration time and percentage drug content, 33 factorial designs was employed by using Design expert .11 After the application of 33 factorial experimental design, the process was optimized for the response variables R1-R2. The formulation showing disintegration time in the range (10-30 second), desired percentage drug release more than 85% is selected as optimized formulation. Formulation mouth dissolving films-5 (MDF-5), MDF-8, MDF-14, MDF-20, MDF-24, and MDF-25 shows desirable characteristics; all these formulations were taken as optimized formulation and subjected to in vitro dissolution study. MDF-25 containing 1% HPMC E5, 1% HPMC E15, and 1% PVP K30 show the promising faster disintegration time (19.66 seconds) followed by rapid and highest drug release (95.80%) within 120 seconds. How to cite this article: Thakur, S., Sethi, V.A., Siddiqui, A.W. and Tyagi, L.K. (2019). Development of Mouth Dissolving Films (MDFs) of Ondansetron Hydrochloride By Using Factorial Experimental Design. International Journal of Drug Delivery Technology, 9(4): 517-524.