The perspective on internal combustion engines (ICEs) has changed because of the step-by-step decrease in oil reserves, environmental concerns, and many other reasons. However, the use of these engines will continue in the coming years. The development of ICEs has accelerated in recent years. As a result, studies on systems that can improve performance and reduce pollution in engines are carried out by many researchers. The basis of the studies carried out in this context is the change in the combustion mode. In other words, the emergence of different combustion modes is given importance by researchers. Among these, many studies have been made on the implementation of the reactivity-controlled compression ignition (RCCI) combustion mode. RCCI engine uses two different fuels. These fuels are low-reactivity (alcohol, gasoline, etc.) and high-reactivity (diesel, biodiesel, etc.) fuels. In addition, the fact that different alternative fuel types can be employed in these engines has made them popular all over the world. This review presents the results of the effects of parameters such as fuel ratio, different injection strategies, exhaust gas recirculation (EGR) rate, compression ratio, and piston geometry on the performance, emissions, and combustion behavior of RCCI engines using both conventional and alternative fuels. This study has been compiled to provide an overview of the current status of the RCCI concept and to offer benefits to researchers.