Offset Response Research Articles

Amplitude Variation with Offset Responses Modeling Study of Walkaway Vertical Seismic Profile Data at CO2Geological Storage Site, Ketzin, Germany

Abstract:An important component of any CO2sequestration project is seismic monitoring for tracking changes in subsurface physical properties, such as velocity and density. Different reservoirs have different amplitude variation with offset (AVO) responses, which can define underground conditions. In the present paper we investigate walkaway vertical seismic profile (VSP) AVO response to CO2injection at the Ketzin site, the first European onshore CO2sequestration pilot study dealing with research on geological storage of CO2. First, we performed rock physics analysis to evaluate the effect of injected CO2on seismic velocity using the Biot‐Gassmann equation. On the basis of this model, the seismic response for different CO2injection saturation was studied using ray tracing modeling. We then created synthetic walkaway VSP data, which we then processed. In contrast, synthetic seismic traces were created from borehole data. Finally, we found that the amplitude of CO2injected sand layer with different gas saturations were increased with the offset when compared with the original brine target layer. This is the typical class III AVO anomaly for gas sand layer. The AVO responses matched the synthetic seismic traces very well. Therefore, walkaway VSP AVO response can monitor CO2distribution in the Ketzin area.

Amplitude Variation with Offset Responses Modeling Study of Walkaway Vertical Seismic Profile Data at CO2 Geological Storage Site, Ketzin, Germany

An important component of any CO(2) sequestration project is seismic monitoring for tracking changes in subsurface physical properties, such as velocity and density. Different reservoirs have diffe ...

The Sound of Silence: Ionic Mechanisms Encoding Sound Termination

Offset responses upon termination of a stimulus are crucial for perceptual grouping and gap detection. These gaps are key features of vocal communication, but an ionic mechanism capable of generating fast offsets from auditory stimuli has proven elusive. Offset firing arises in the brainstem superior paraolivary nucleus (SPN), which receives powerful inhibition during sound and converts this into precise action potential (AP) firing upon sound termination. Whole-cell patch recording invitro showed that offset firing was triggered by IPSPs rather than EPSPs. We show that AP firing can emerge from inhibition through integration of large IPSPs, driven by an extremely negative chloride reversal potential (E(Cl)), combined with a large hyperpolarization-activated nonspecific cationic current (I(H)), with a secondary contribution from a T-type calcium conductance (I(TCa)). On activation by the IPSP, I(H) potently accelerates the membrane time constant, so when the sound ceases, a rapid repolarization triggers multiple offset APs that match onset timing accuracy.

Vp‐Vs relationship and amplitude variation with offset modelling of glauconitic greensand‡

ABSTRACTThe relationship between Vp and Vs may be used to predict Vs where only Vp is known. Vp/Vs is also used to identify pore fluids from seismic data and amplitude variation with offset analysis. Theoretical, physical, as well as statistical empirical Vp‐Vs relationships have been proposed for reservoir characterization when shear‐wave data are not available. In published work, the focus is primarily on the Vp‐Vs relationship of quartzitic sandstone. In order to broaden the picture we present Vp‐Vs relationships of greensand composed of quartz and glauconite by using data from the Paleocene greensand Nini oil field in the North Sea. A Vp‐Vs relationship derived from modelling is compared with empirical Vp‐Vs regressions from laboratory data as well as from log data. The accuracy of Vs prediction is quantified in terms of root‐mean‐square error. We find that the Vp‐Vs relationship derived from modelling works well for greensand shear‐wave velocity prediction. We model the seismic response of glauconitic greensand by using laboratory data from the Nini field. Our studies here reveal that brine‐saturated glauconitic greensand can have a similar seismic response to that from oil‐saturated quartzitic sandstone and that oil‐saturated strongly cemented greensand can have a similar amplitude variation with offset response to that from brine‐saturated weakly cemented greensand.

External Capital Structures and Oil Price Volatility

This paper assesses the extent to which a country’s external capital structure can aid in mitigating the macroeconomic impact of oil price shocks. Two Caribbean economies highly vulnerable to oil price shocks are considered: an oil importer (Jamaica) and an oil exporter (Trinidad and Tobago). From a risk-sharing perspective, a desirable external capital structure is one that, through international capital gains and losses, helps offset responses of the current account balance to external shocks. It is found that both countries could alter their international portfolio to provide a better buffer against such shocks.

Brain Stem Responses to Speech in Younger and Older Adults

This experiment was designed to evaluate whether neural encoding of speech features at the brain stem level is altered in the aging auditory system. In addition, the effect of minimal peripheral hearing loss on the auditory brain stem response (ABR) evoked by speech stimuli and interactions with aging were examined. Speech-evoked ABRs (S-ABRs) were recorded using a synthetic 40-msec /da/ stimulus from both ears of participants in two groups: normal-hearing younger adults (n = 19) and normal-hearing older adults (n = 18). Latencies and amplitude for S-ABR peaks representing neural responses to the onset and offset of the speech syllable as well as a sustained frequency following response to the vowel content were analyzed. The role of hearing threshold differences between groups and the reduced overall stimulus level on the S-ABR were also examined. In addition, click-evoked ABRs (C-ABRs) were obtained from all participants, and age-group differences in the neural response to both types of stimuli at the brain stem level were compared. S-ABR latencies, amplitudes, and sustained response mean data were obtained for younger adults and older adults. Older adults were found to have significantly smaller C-ABRs with longer latencies, despite all latencies falling within normal limits. Older adults also had significantly smaller onset and offset responses for the S-ABR, with significantly delayed offset latencies in response to this synthetic consonant-vowel syllable. Many of the C-ABR and S-ABR variables were found to significantly correlate with high-frequency audiometric thresholds, and few of the group differences remained significant when this was taken into account. The remaining significant S-ABR effects were decreased amplitude at the onset and significantly delayed offset responses in the older group. These effects were different from those of simply decreasing the overall stimulus level, which caused significant shifts in latency across the entire S-ABR. Results of this study partially supported the hypothesis of age-related differences in neural processing of speech at the brain stem level. There were significant delays in the timing of the offset portion of the S-ABR in older listeners compared with their younger counterparts, even after accounting for the differences in peripheral hearing threshold between groups. There were also significant reductions in amplitude of the S-ABR at the onset. These results are consistent with a reduction in neural synchrony in older adults to transient components of both speech and nonspeech sounds. However, sustained components of the S-ABR, which follow the harmonic components of the syllable, showed group differences but were not significant after adjusting for peripheral hearing loss, suggesting that they may be more affected by hearing sensitivity and other peripheral changes. These results support further investigation into the ability of the aging auditory system to encode temporal cues at the brain stem level, particularly the response to speech stimulus offset and its relationship to speech perception and temporal processing abilities.

Synergistic Ca2+ Responses by Gαi- and Gαq-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβγ and Gαq

Synergistic Ca2+ Responses by Gαi- and Gαq-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβγ and Gαq

Offset response of the olfactory projection neurons in the moth antennal lobe

We investigated a population activity of central olfactory neurons after the termination of odor input. Olfactory response of projection neurons in the moth primary olfactory center was characterized using in vivo intracellular recording and staining techniques. The population activity changed rapidly to the different states after the stimulus offset. The response after stimulus offset represents information regarding odor identity. We analyzed the spatial distribution of offset-activated glomeruli in a virtual neuronal population that was reconstructed using accumulated individual recordings obtained from different specimens. The offset-activated glomeruli tended to be widely distributed, whereas the onset-activated glomeruli were relatively clustered. These results suggest the importance of lateral interaction in shaping the offset olfactory response.

Auditory cortex tracks the temporal regularity of sustained noisy sounds

Neuroimaging studies have revealed dramatic asymmetries between the responses to temporally regular and irregular sounds in the antero-lateral part of Heschl’s gyrus. For example, the magnetoencephalography (MEG) study of Krumbholz et al. [Cereb. Cortex 13, 765-772 (2003)] showed that the transition from a noise to a similar noise with sufficient temporal regularity to provoke a pitch evoked a pronounced temporal-regularity onset response (TRon response), whereas a comparable transition in the reverse direction revealed essentially no temporal-regularity offset response (TRoff response). The current paper presents a follow-up study in which the asymmetry is examined with much greater power, and the results suggest an intriguing reinterpretation of the onset/offset asymmetry. The TR-related activity in auditory cortex appears to be composed of a transient (TRon) and a TR-related sustained response (TRsus), with a highly variable TRon/TRsus amplitude ratio. The TRoff response is generally dominated by the break-down of the TRsus activity, which occurs so rapidly as to preclude the involvement of higher-level cortical processing. The time course of the TR-related activity suggests that TR processing might be involved in monitoring the environment and alerting the brain to the onset and offset of behaviourally relevant, animate sources.

Patterned sound therapy for the treatment of tinnitus

USING SOUND TO CURE TINNITUS Sound therapy, via either acoustic or electric stimulation, uses external sounds to provide short- and longterm relief from tinnitus. The interactions between external sounds and tinnitus are well established, as the external sounds can not only induce tinnitus, but can alter its perception as well. Excessive exposure to loud sounds is the single greatest risk associated with tinnitus onset, and for those with tinnitus, sound overexposure may exacerbate it. However, sounds used at safe levels can be highly beneficial to an individual with tinnitus. Sounds can not only distract a person’s attention away from tinnitus, but also affect the overall quality of the tinnitus. In some cases, people report noticeable changes in tinnitus pitch or quality following exposure to certain external sound sources. For example, a variety of sounds, ranging from constant, low-level background sounds mimicking running water to intermittent sounds mimicking fire crackling have been used to mask the overall perception of tin

Elastic full waveform inversion of multicomponent ocean-bottom cable seismic data: Application to Alba Field, U. K. North Sea

Elastic full waveform inversion of multichannel seismic data represents a data-driven form of analysis leading to direct quantification of the subsurface elastic parameters in the depth domain. Previous studies have focused on marine streamer data using acoustic or elastic inversion schemes for the inversion of P-wave data. In this paper, P- and S-wave velocities are inverted for using wide-angle multicomponent ocean-bottom cable (OBC) seismic data. Inversion is undertaken using a two-dimensional elastic algorithm operating in the time domain, which allows accurate modeling and inversion of the full elastic wavefield, including P- and mode-converted PS-waves and their respective amplitude variation with offset (AVO) responses. Results are presented from the application of this technique to an OBC seismic data set from the Alba Field, North Sea. After building an initial velocity model and extracting a seismic wavelet, the data are inverted instages. In the first stage, the intermediate wavelength P-wave velocity structure is recovered from the wide-angle data and then the short-scale detail from near-offset data using P-wave data on the [Formula: see text] (vertical geophone) component. In the second stage, intermediate wavelengths of S-wave velocity are inverted for, which exploits the information captured in the P-wave’s elastic AVO response. In the third stage, the earlier models are built on to invert mode-converted PS-wave events on the [Formula: see text] (horizontal geophone) component for S-wave velocity, targeting first shallow and then deeper structure. Inversion of [Formula: see text] alone has been able to delineate the Alba Field in P- and S-wave velocity, with the main field and outlier sands visible on the 2D results. Inversion of PS-wave data has demonstrated the potential of using converted waves to resolve shorter wavelength detail. Even at the low frequencies [Formula: see text] inverted here, improved spatial resolution was obtained by inverting S-wave data compared with P-wave data inversion results.

Fast glutamate uptake via EAAT2 shapes the cone-mediated light offset response in bipolar cells

Excitatory amino acid transporters (EAATs) are responsible for extracellular glutamate uptake within the retina, and are expressed by retinal neurons and Müller cells. Their role within glutamatergic synapses is not completely understood. In the salamander retina, five distinct EAAT-encoding genes have been cloned, making the amphibian retina an excellent system to study EAAT function. This study focused on sEAAT2, which is expressed in photoreceptor terminals and Off-bipolar cells in two isoforms, sEAAT2A and sEAAT2B. Using whole-cell patch-clamp recording, florescence imaging and antibody labelling methods, we systematically studied the functions of these two isoforms at the synapse between photoreceptors and bipolar cells, both in dark and with photic stimulation. Both sEAAT2A and sEAAT2B were sensitive to dihydrokainic acid (DHKA), a known EAAT2-specific inhibitor. Each isoform of sEAAT2 was found to play a role in tonic glutamate uptake at the cone synapse in darkness. Furthermore, presynaptic sEAAT2A strongly suppressed the rapid, transient glutamate signal from cones following light-offset. This was achieved by quickly binding exocytosed glutamate, which subsequently limited glutamate spillover to adjacent receptors at postsynaptic sites. Since the intensity and duration of photic stimulation determine the magnitude of these cone transient signals, we postulate that presynaptic cone EAATs contribute to the encoding of contrast sensitivity in cone vision.

Investigation on Harmonic Response of Pneumatic Vibration Isolation System with Single and Double-Frequency Excitations

In this paper, a nonlinear model of pneumatic vibration isolator was established, considering the volumetric compressibility of air. Based on this, simulation analyses were done using matlab/simulink software. The response to two different types of disturbances is studied: single-frequency excitation and double-frequency excitation. Single-frequency excitation can induce harmonic frequency response and offset response at the zero frequency. When the frequency is near to the the linearized natural frequency, the harmonic frequency response become stronger. Nonlinear characters have much to do with the drive amplitude. When the drive amplitude become large, the nonlinear characters are more obvious. Double-frequency excitation can induce combination resonance. When the two drive frequencys are close, combination resonance are more strong.

The Contributions of Transient and Sustained Response Codes to Audiovisual Integration

Multisensory events in our natural environment unfold at multiple temporal scales over extended periods of time. This functional magnetic resonance imaging study investigated whether the brain uses transient (onset, offset) or sustained temporal codes to effectively integrate incoming visual and auditory signals within the cortical hierarchy. Subjects were presented with 1) velocity-modulated radial motion, 2) amplitude-modulated sound, or 3) an in phase combination of both in blocks of variable durations to dissociate transient and sustained blood oxygen level-dependent responses. Audiovisual interactions emerged primarily for transient onset and offset responses highlighting the importance of rapid stimulus transitions for multisensory integration. Strikingly, audiovisual interactions for onset and offset transients were dissociable at the functional and anatomical level. Low-level sensory areas integrated audiovisual inputs at stimulus onset in a superadditive fashion to enhance stimulus salience. In contrast, higher order association areas showed subadditive integration profiles at stimulus offset possibly reflecting the formation of higher order representations. In conclusion, multisensory integration emerges at multiple levels of the cortical hierarchy using different temporal codes and integration profiles. From a methodological perspective, these results highlight the limitations of conventional event related or block designs that cannot characterize these rich dynamics of audiovisual integration.

Potential fMRI correlates of 40-Hz phase locking in primary auditory cortex, thalamus and midbrain

MEG and BOLD fMRI are both related to post-synaptic activity, but not all components of the MEG appear to be equally reflected by the BOLD response. To evaluate potential BOLD correlates of the auditory 40-Hz steady-state response (SSR), 40-Hz amplitude-modulated (AM) tones and pure-tones with 1000-Hz tone frequency and 32-s tone duration were presented to 12 listeners in fMRI and MEG. The SSR evoked by AM-tones is readily separated from the onset, offset and sustained fields in MEG by a high-pass filter. For fMRI, a contrast of AM- versus pure-tones was used to estimate activity related more specifically to the 40-Hz SSR, but excluding other activity that is evoked by AM and pure-tones alike. This contrast showed sustained BOLD activation confined to the medial part of Heschl's gyrus, the location of the primary auditory cortex, as well as activity in the medial geniculate body (MGB) and the inferior colliculus (IC). Transient BOLD onset and offset responses were prominent throughout the auditory cortex. In contrast, sustained BOLD activity for pure-tones was weak and did not match well with the time course of the sustained field, suggesting that there is no reliable BOLD correlate of the sustained field in MEG. The sustained BOLD activity in primary auditory cortex is therefore more likely linked to the phase-locked SSR. Enhanced BOLD for AM compared to pure-tones in the IC and MGB may similarly be related to phase locking.

Multiple sclerosis impairs ability to detect abrupt appearance of a subliminal stimulus

Objectives: The study was designed to find evidence that brain electrical activity associated with processing the abrupt appearance or disappearance of a sensory stimulus differed in the presence and absence of the neuropathological changes that are characteristic of multiple sclerosis (MS).Methods: A subliminal stimulus (electrical field) was applied, and the onset and offset responses from patients with MS were compared with the responses of study participants in two age- and gender-matched control groups, using a novel type of non-linear dynamical analysis that had been developed in earlier studies.Results: An onset response occurred in 27% of the patients with MS, compared with 85% in the control groups. Among the three patients who exhibited onset-induced changes in brain electrical activity, the average latency of the effect was less and the magnitude of the change was greater than the corresponding values in the control group.Discussion: Non-linear analysis of electroencephalograms recorded during the sudden presentation of a subliminal stimulus potentially could serve as the basis of a functional test to help diagnose MS. A larger cohort of patients with MS needs to be assessed to validate the results of this study.

Oscillatory response function: Towards a parametric model of rhythmic brain activity

Rhythmic brain activity, measured by magnetoencephalography (MEG), is modulated during stimulation and task performance. Here, we introduce an oscillatory response function (ORF) to predict the dynamic suppression-rebound modulation of brain rhythms during a stimulus sequence. We derived a class of parametric models for the ORF in a generalized convolution framework. The model parameters were estimated from MEG data acquired from 10 subjects during bilateral tactile stimulation of fingers (stimulus rates of 4 Hz and 10 Hz in blocks of 0.5, 1, 2, and 4 s). The envelopes of the 17-23 Hz rhythmic activity, computed for sensors above the rolandic region, correlated 25%-43% better with the envelopes predicted by the models than by the stimulus time course (boxcar). A linear model with separate convolution kernels for onset and offset responses gave the best prediction. We studied the generalizability of this model with data from 5 different subjects during a separate bilateral tactile sequence by first identifying neural sources of the 17-23 Hz activity using cortically constrained minimum norm estimates. Both the model and the boxcar predicted strongest modulation in the primary motor cortex. For short-duration stimulus blocks, the model predicted the envelope of the cortical currents 20% better than the boxcar did. These results suggest that ORFs could concisely describe brain rhythms during different stimuli, tasks, and pathologies.

Neural substrate of sound duration discrimination during an auditory sequence in the guinea pig primary auditory cortex

Mismatch negativity (MMN) is a negative component of event-related brain potentials elicited by stimulus transitions. Stimulus duration transition also elicits MMN (duration MMN), with a magnitude that is related to the degree of duration change and the discrimination ability. The neural substrates of duration MMN have not yet been investigated. We therefore studied how duration transitions in an auditory stimulus train are represented in neurons in the primary auditory cortex of anesthetized guinea pigs. Two types of neuronal responses to the context of changes in stimulus duration were found. One was a reduced response as the duration of the preceding stimulus was increased. Second was an enhancement of the late components of the response including sustained and offset responses at the duration transition. The former may be explained by the previously proposed two-tone suppression, which is dependent on the preceding stimulus duration. The latter is likely to be caused by stimulus-specific adaptation that could be a possible neural generator of duration MMN.

Multifocal visual evoked potential responses to pattern-reversal, pattern-onset, pattern-offset, and sparse pulse stimuli

The purpose of the present study was to compare standard multifocal visual evoked potential (mfVEP) pattern-reversal responses with those produced by pattern-onset, pattern-offset, and pulsed pattern stimuli. mfVEP recordings were obtained from five normal subjects using VERIS and a 4-electrode array. The standard reversal stimulus had 2(15) m-sequence steps (7.5-min duration). Pattern-onset and -offset responses were evaluated using sequences that all had 32 frames per m-step and 2(10) total steps (7.5 min); but the duration of the contrast step varied so that it was 1, 2, 4, 8, 12, or 16 of the 32 frames. The same series was also inverted so that adapting contrast was high and the stimulus step began with a contrast decrement. The effect of temporal sparseness was studied with positive contrast pulses (two-frame duration) within 16, 20, 24, 28, or 32 frames per m-step (all had 2(11) total steps). Four stimulus locations were isolated to study the effect of spatial sparseness. Standard mfVEP reversal responses were virtually identical to onset responses throughout the field, but ~3.5 times smaller. Responses to pattern onset were about twice as large as those for offset, especially in the lower hemifield, irrespective of adapting contrast level. Offset responses exhibited a different waveform compared with reversal, onset, or brief pulse responses. Though temporally sparse pattern-pulse responses were ~3.5 times larger than standard reversal responses, there was no improvement in signal-to-noise ratio (SNR). However, spatial isolation increased SNR by 22% for reversal responses and by 62% for temporally sparse pulses. Temporally sparse pattern-pulse stimuli do not improve mfVEP SNR unless they are also spatially sparse, suggesting that lateral inhibitory mechanisms have a greater impact than temporal contrast gain control mechanisms. The mfVEP response depends on the polarity of a contrast step, irrespective of the state of contrast adaptation.

Fetal sensitivity to properties of maternal speech and language

Fetal speech and language abilities were examined in 104 low-risk fetuses at 33–41 weeks gestational age using a familiarization/novelty paradigm. Fetuses were familiarized with a tape recording of either their mother or a female stranger reading the same passage and subsequently presented with a novel speaker or language: Studies (1) & (2) the alternate voice, (3) the father’s voice, and (4) a female stranger speaking in native English or a foreign language (Mandarin); heart rate was recorded continuously. Data analyses revealed a novelty response to the mother’s voice and a novel foreign language. An offset response was observed following termination of the father’s and a female stranger’s voice. These findings provide evidence of fetal attention, memory, and learning of voices and language, indicating that newborn speech/language abilities have their origins before birth. They suggest that neural networks sensitive to properties of the mother’s voice and native-language speech are being formed.