Multiple sclerosis impairs ability to detect abrupt appearance of a subliminal stimulus

Abstract

Objectives: The study was designed to find evidence that brain electrical activity associated with processing the abrupt appearance or disappearance of a sensory stimulus differed in the presence and absence of the neuropathological changes that are characteristic of multiple sclerosis (MS).Methods: A subliminal stimulus (electrical field) was applied, and the onset and offset responses from patients with MS were compared with the responses of study participants in two age- and gender-matched control groups, using a novel type of non-linear dynamical analysis that had been developed in earlier studies.Results: An onset response occurred in 27% of the patients with MS, compared with 85% in the control groups. Among the three patients who exhibited onset-induced changes in brain electrical activity, the average latency of the effect was less and the magnitude of the change was greater than the corresponding values in the control group.Discussion: Non-linear analysis of electroencephalograms recorded during the sudden presentation of a subliminal stimulus potentially could serve as the basis of a functional test to help diagnose MS. A larger cohort of patients with MS needs to be assessed to validate the results of this study.