Octocoral Cladiella Research Articles

Coniferains A and B, new eunicellin-based diterpenoids from the octocoral Cladiella conifera (Tixier-Durivault, 1943)

Two new eunicellin-based diterpenoids, coniferains A ( 1 ) and B ( 2 ), have been isolated from the soft coral Cladiella conifera . Structures of eunicellins 1 and 2 were elucidated by spectroscopic analysis and the structure of a known eunicellin, australin G, was revised. • New eunicellin, coniferains A ( 1 ) and B ( 2 ), were obtained from an octocoral Cladiella conifera . • The structure of a known eunicellin, australin G, was revised. • Octocorallia belonging to genus Cladiella are proven to be rich sources of eunicellin-based diterpenoids.

A New Natural Butenolide, (5R)-3-Tetradecyl-5-methyl-2(5H)-furanone, from Octocoral Cladiella conifera

A New Natural Butenolide, (5R)-3-Tetradecyl-5-methyl-2(5H)-furanone, from Octocoral Cladiella conifera

Compositional variation between high and low prokaryotic diversity coral reef biotopes translates to different predicted metagenomic gene content.

In a previous study, we identified host species that housed high and low diversity prokaryotic communities. In the present study, we expand on this and assessed the prokaryotic communities associated with seawater, sediment and 11 host species from 7 different phyla in a Taiwanese coral reef setting. The host taxa sampled included hard, octo- and black corals, molluscs, bryozoans, flatworms, fish and sea urchins. There were highly significant differences in composition among host species and all host species housed distinct communities from those found in seawater and sediment. In a hierarchical clustering analysis, samples from all host species, with the exception of the coral Galaxea astreata, formed significantly supported clusters. In addition to this, the coral G. astreata and the bryozoan Triphyllozoon inornatum on the one hand and the coral Tubastraea coccinea, the hermit crab Calcinus laevimanus and the flatworm Thysanozoon nigropapillosum on the other formed significantly supported clusters. In addition to composition, there were highly pronounced differences in richness and evenness among host species from the most diverse species, the bryozoan T. inornatum at 2518 ± 240 OTUs per 10,000 sequences to the least diverse species, the octocoral Cladiella sp. at 142 ± 14 OTUs per 10,000 sequences. In line with the differences in composition, there were significant differences in predicted metagenomic gene counts among host species. Furthermore, there were pronounced compositional and predicted functional differences between high diversity hosts (Liolophura japonica, G. astreata, T. coccinea, C. laevimanus, T. inornatum) and low diversity hosts (Antipathes sp., Pomacentrus coelestis, Modiolus auriculatus, T. nigropapillosum, Cladiella sp. and Diadema savigny). In particular, we found that all tested low diversity hosts were predicted to be enriched for the phosphotransferase system compared to high diversity hosts.

Novel secoeunicellins produced by an octocoral Cladiella sp

Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds.

Cladieunicellins R and S, new eunicellins from the Formosan octocoral Cladiella tuberculosa

Two new eunicellin-type diterpenoids, cladieunicellins R (1) and S (2), were isolated from the octocoral Cladiella tuberculosa and their structures were elucidated by spectroscopic methods. Eunicellin 1 was proven to be the first 2,6-hemiketal eunicellin and 2 was found to exhibit moderate cytotoxicity toward the MOLT-4, K562, and SUP-T1 cells.

Cladieunicellin J, a New Hydroperoxyeunicellin from Cladiella sp

A new 6-hydroperoxyeunicellin diterpenoid, designated as cladieunicellin J (1), was isolated from an octocoral Cladiella sp., and its structure elucidated by spectroscopic methods. Compound 1 was found to exhibit cytotoxicity toward CCRF-CEM human T-cell acute lymphoblastic leukemia.

Cladieunicellins M–Q, New Eunicellins from Cladiella sp.

Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.

Cladieunicellins K and L, New Eunicellin-Based Diterpenoids from an Octocoral Cladiella sp.

Two new eunicellin-based diterpenoids, cladieunicellins K (1) and L (2), were isolated from an octocoral Cladiella sp. The structures of 1 and 2 were elucidated by spectroscopic methods and 2 exhibited moderate cytotoxicity towards the MOLT-4 human leukemia.

New 6-Hydroxyeunicellins from a Soft Coral Cladiella sp.

Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

ChemInform Abstract: Cladielloides C and D: Novel Eunicellin‐Based Diterpenoids from an Indonesian Octocoral Cladiella sp.

AbstractNew compounds, cladielloides C (I) and D (II), display moderate inhibitory effects on superoxide anion generation by human neutrophils.

Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp.

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.

Cladieunicellins A and B, two new eunicellin-based diterpenoids from an Indonesian octocoral Cladiella sp.

Cladieunicellins A and B, two new eunicellin-based diterpenoids from an Indonesian octocoral Cladiella sp.