Abstract
Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.
Highlights
During the course of our search for novel metabolites from marine invertebrates of Taiwanese waters, a series of eunicellin-type diterpenoids including cladieunicellins A–J, have been isolated from a soft coral identified as Cladiella sp. collected in Taiwan waters [1,2,3]
We reported the isolation of a natural eunicellin, litophynin I diacetate (9) [1,7]
HL 60 and Molt 4 (Human acute lymphoblastic leukemia) cells were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA)
Summary
During the course of our search for novel metabolites from marine invertebrates of Taiwanese waters, a series of eunicellin-type diterpenoids including cladieunicellins A–J, have been isolated from a soft coral identified as Cladiella sp. (family Alcyoniidae) collected in Taiwan waters [1,2,3]. During the course of our search for novel metabolites from marine invertebrates of Taiwanese waters, a series of eunicellin-type diterpenoids including cladieunicellins A–J, have been isolated from a soft coral identified as Cladiella sp. (family Alcyoniidae) collected in Taiwan waters [1,2,3]. Because of our interest in the chemistry of new natural products, the continuing investigation on the chemical constituents of the soft coral Cladiella sp. Was carried out and resulted in the isolation of five new eunicellin-based diterpenoids, cladieunicellins M–Q (1–5) (Chart 1). This paper deals with the isolation, structure elucidation and cytotoxicity of compounds 1–5. The structures of cladieunicellins M–Q (1–5), krempfielins C and L (6 and 7) and cladieunicellin L (8)
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