Abstract
Two new eunicellin-based diterpenoids, cladieunicellins K (1) and L (2), were isolated from an octocoral Cladiella sp. The structures of 1 and 2 were elucidated by spectroscopic methods and 2 exhibited moderate cytotoxicity towards the MOLT-4 human leukemia.
Highlights
Eunicellin-based diterpenoids, such as eleutherobin, have been proven to be potential anticancer agents [1]
The normal phase HPLC (NP-HPLC) was performed using a system comprised of a Hitachi L-7110 pump (Hitachi Ltd., Tokyo, Japan) and a Rheodyne 7725 injection port (Rheodyne LLC, Rohnert Park, CA, USA)
N4 was repurified by NP-HPLC, using a mixture of n-hexane and acetone (10:1, flow rate: 2.0 mL/min) to yield seven subfractions N4A–N4G
Summary
Eunicellin-based diterpenoids, such as eleutherobin, have been proven to be potential anticancer agents [1]. In our continuing research on the chemical constituents of octocorals belonging to the genus Cladiella collected off the waters of Taiwan and Indonesia, various eunicellin-related analogues have been isolated [2–7]. Two new eunicellin-type diterpenoids, cladieunicellins K (1) and L (2). Were isolated from an octocoral identified as Cladiella sp. We describe the isolation, structure determination and cytotoxicity of eunicellins 1 and 2. The structures of cladieunicellins K (1) and L (2)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
