Objectives This study confirms the effectiveness of a virtual reality simulation and blended education program based on Head Mounted Displays on newborn nursing for nursing college students.
 Methods The participants were 48 nursing students. The experimental group(n=24)received a blended simulation, combining a HMD based virtual reality simulation and a high-fidelity simulation, while the control group(n=24) received only a HMD based virtual reality simulation. Data were collected from January 9 to 12, 2023, and analyzed using SPSS version 25 for Windows.
 Results A blended education program was applied that includes an HMD-based VR and high-fidelity simulation education for neonatal nursing. There was a significant difference in problem-solving ability(t=3.47, p=.009)and clinical performance confidence(U=-3.68, p<.001)of the experimental group that received blended simulation training. Critical thinking disposition(t=2.86, p=.004),problem-solving ability(t=3.47, p<.001), and clinical performance confidence(U=-3.68, p=<.001) were significantly affected before and after training between the experimental and control groups. The difference in scores was statistically significant.
 Conclusions A blended simulation that integrates an HMD based virtual reality simulation program and high-fidelity simulation education for neonatal nursing was found to be effective in education. The goal is to provide basic data for children's nursing simulation education to operate more efficiently. Therefore, since the HMD based virtual reality simulation program can be integrated into the existing simulation program and used as an effective education method, it is believed that alternative practical education design research that applies various simulation education methods is necessary.