Numerous Nerve Research Articles

Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies.

The skeleton is highly innervated by numerous nerve fibers. These nerve fibers, in addition to transmitting information within the bone and mediating bone sensations, play a crucial role in regulating bone tissue formation and regeneration. Traditional bone tissue engineering (BTE) often fails to achieve satisfactory outcomes when dealing with large-scale bone defects, which is frequently related to the lack of effective reconstruction of the neurovascular network. In recent years, increasing research has revealed the critical role of nerves in bone metabolism. Nerve fibers regulate bone cells through neurotransmitters, neuropeptides, and peripheral glial cells. Furthermore, nerves also coordinate with the vascular and immune systems to jointly construct a microenvironment favorable for bone regeneration. As a signaling driver of bone formation, neuroregulation spans the entire process of bone physiological activities from the embryonic formation to postmaturity remodeling and repair. However, there is currently a lack of comprehensive summaries of these regulatory mechanisms. Therefore, this review sketches out the function of nerves during bone formation and regeneration. Then, we elaborate on the mechanisms of neurovascular coupling and neuromodulation of bone immunity. Finally, we discuss several novel strategies for neuro-bone tissue engineering (NBTE) based on neuroregulation of bone, focusing on the coordinated regeneration of nerve and bone tissue.

Conjunctival Neuroma After Corneal Neurotization in a Patient With Neurotrophic Keratopathy: A Case Report.

To report a rare case of conjunctival neuroma after a successful corneal neurotization surgery. The clinical file and histopathology slides of this patient who underwent surgical corneal neurotization for a neurotrophic keratopathy in the right eye were reviewed. A 70-year-old man with a history of severe herpetic (varicella zoster) neurotrophic keratopathy and keratouveitis in the right eye developed a corneal perforation, which required tectonic keratoplasty (May 2020). Corneal neurotization was performed 1 year later without complication, using the ipsilateral supraorbital and supratrochlear nerves to reinnervate the right cornea (April 2021), followed by repeat penetrating keratoplasty (September 2021). Three months later, a superonasal conjunctival mass was observed with a contiguous corneal delle and melt at the corneal-host junction. In vivo confocal microscopy showed numerous nerve fibers within the conjunctival mass, suggesting a diagnosis of conjunctival neuroma. The mass was surgically debulked, and the diagnosis was confirmed by histopathology and immunohistochemistry. The delle and corneal melt were successfully treated with an amniotic membrane. To the best of our knowledge, this is the first case of confirmed conjunctival neuroma reported after corneal neurotization. Confocal microscopy, histopathology, and immunohistochemistry have proven to be highly useful tools for the prompt recognition and accurate diagnosis necessary for the proper management of this rare complication.

Innervation of the female internal genital organs in 12-week-old porcine foetuses.

This is the first study aimed to investigate the innervation of the internal genital organs in 12-week-old female pig foetuses using single and double-labelling immunofluorescence methods. Immunostaining for protein gene product 9.5 (PGP, general neural marker) revealed that the most numerous PGP-positive nerve fibres were found in the mesenchyme of the uterovaginal canal height. Numerous nerve fibres were distributed in the uterine segment, less in the tubal segment of paramesonephric ducts (PD), and they usually occurred at the edge of the mesenchyme. A low number of fibres was visible in the developing ovary cortex and medulla. Many fibres expressed dopamine β-hydroxylase (DβH) and/or vesicular acetylcholine transporter (VAChT) in the studied period. Most DβH-positive nerve fibres were observed in all segments of PD. VAChT-positive were mainly distributed in the uterovaginal canal of PD. DβH/VAChT-positive nerve fibres were observed in the mesenchyme of all segments of the PD, but they were most common in the uterovaginal canal and the uterine segment of PD. In the ovary, nerves were mainly DβH-positive and single nerve fibres containing VAChT. Few DβH/VAChT-positive nerve fibres were observed in the ovary.

Complete excision of a giant chondrosarcoma within the cavernous sinus: a case report and literature review

BackgroundPrimary skull base chondrosarcoma (SBC) is a rare malignant central nervous system tumor, often involving the cavernous sinus. Complete excision of tumors invading this region is exceptionally challenging due to the presence of the internal carotid artery and numerous nerves within the cavernous sinus, particularly in cases with substantial tumor volume.Case presentationThis report describes a rare case of a massive primary SBC pushing the lateral wall of the cavernous sinus, measuring approximately 6.6 cm × 4.5 cm × 4.4 cm. Utilizing neurophysiological monitoring and intraoperative navigation, we successfully achieved complete tumor resection along the membranous structure via a left modified pterional approach (pterional-zygomatic arch-subdural-infratemporal approach), employing tools such as a cavitron ultrasonic surgical aspirator (CUSA) and piezosurgery. During the excision, localized rupture and bleeding of the internal carotid artery occurred, but prompt repair and anastomosis were performed. Postoperatively, the patient’s symptoms markedly improved, and good reperfusion of the internal carotid artery was observed without new severe complications. The postoperative pathological diagnosis, according to the World Health Organization classification, was Grade 1 chondrosarcoma; therefore, radiotherapy was not administered. Magnetic resonance imaging at the 8-month follow-up showed no residual tumor or recurrence.ConclusionsThis case highlights that surgical complete excision of large intracavernous SBCs, while preserving vital neurovascular functions, is feasible and paramount for achieving favorable outcomes, particularly for Grade 1 and 2 SBCs, which comprise 82.4% of all subtypes. The use of a modified left pterional approach, intra-capsular tumor resection techniques, alongside CUSA and piezosurgery, provides valuable insights and serves as a reference for achieving complete excision of SBCs within the cavernous sinus.

Jugular Foramen, Foramen Magnum Meningiomas

The jugular foramen, also known as the foramen magnum, is a highly intricate region of the skull base through which numerous critical blood vessels and nerves traverse. Meningiomas, the most common tumors in neurosurgical pathology, can arise at any location where the meninges are present, posing significant challenges. Meningiomas involving the jugular foramen and sublingual neural tube are particularly notable for their potential to extend from intracranial to extracranial sites, necessitating familiarity with extracranial anatomy, which is not typically encountered in clinical practice. A comprehensive understanding of anatomical characteristics, along with an ample field of view and working space, is crucial for handling the cerebellum, brainstem, and nerves meticulously. The use of surgical support tools such as neuromonitoring and navigation is essential for enhancing the safety of the procedure. Furthermore, preparedness for treatment options, rehabilitation, and adjunctive therapies is vital in the event of neurological symptoms such as those affecting the glossopharyngeal, vagal, or hypoglossal nerves.

Padabhyanga: Kansa Thali Foot Rub

Ayurveda may be a treasure for all-encompassing well-being. It incorporates an arrangement for nearly all well-being issues that an individual may experience. Indian treatments are utilized for an encompassing mending approach… With a history of over 5,000 a long time, this old framework permits us to lead a mentally, sound and disease-free life. It has got a wide extent of mending procedures to attain physical, mental, and mental well-being benefits. Individuals title the issues and Ayurveda offers an arrangement for it. ...Foot Rub boosts your circulation, makes a difference with recuperating, and keeps your muscles and tissues solid. The accentuation is on the marma or acupressure focuses which are known to adjust the chakras. ‘Foot rub and reflexology’ is one of the most common strategies of complementary treatments. Run treatment and reflexology are manual restorative approaches utilized to encourage healing. Foot reflexology is a treatment that’s been practiced for centuries. It involves applying pressure to different points on the bottom of the foot. "Illness does not go close one who rubs his feet sometime recently resting, fair as snakes don't approach hawks." - A superb antiquated Indian saying Foot rub is called "Padabhyanga", and it encompasses an exceptionally uncommon put inside the Ayurvedic convention. The feet are an imperative portion of our body, as numerous nerves from numerous organs end within the feet. So kneading makes a difference in fortifying these nerves and reestablishing well-being in numerous parts of the body. The marma (imperative) focuses are kneaded which gives adjust to your doshas and is exceptionally supportive for individuals with sleep deprivation, weakness, and cramps.

Regulating Schwann cells and endothelial cells by YIGSR functionalized porous chitosan scaffolds for nerve regeneration

Numerous artificial nerve implants for repair of peripheral nerve injury has been developed while their performance still needs to be further improved. In this study, the Tyr-Ile-Gly-Ser-Arg (YIGSR, YR) functionalized porous chitosan scaffolds were prepared by freeze-drying technique and surface biomodification for simultaneous regulation of Schwann cells (SCs) and endothelial cells (ECs), which play important role in nerve regeneration. The physicochemical properties were characterized, including morphology, composition, wettability, mechanical properties, porosity, etc. The culture of SCs and ECs were used to evaluate the pro-neural and endothelial cell growth effects of the grafts, as well as the constitutive relationship between YR-regulated SCs and ECs. Then, the mechanisms involved were explored using molecular biology experiments. The results showed that the YR-grafted chitosan scaffolds could be successfully prepared with aggregated dopamine and YR particles on the surface of the scaffolds. The scaffolds showed a uniform porous structure, YR grafting decreased the porosity of the scaffolds but increased the mechanical properties of the scaffolds, and YR displayed a relatively stable release behavior. Further on, all YR-grafted scaffolds were proven no cytotoxicity and significantly promoted the proliferation and spreading of SCs and ECs, up-regulated the gene expression of Tumor Necrosis Factor-alpha (TNF-α) and Recombinant Contactin 2 (Cntn2), and facilitated the release of growth factors such as brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and vascular endothelial growth factor (VEGF). Thus, this YR-functionalized scaffold is expected to simultaneously promote both neuronal cell growth and vascularization in peripheral nerve regeneration. This study provides a strategy for the development of biofunctionalized nerve grafts.

Innervation density and types of nerves in prostate cancer.

Innervation of cancerous tissue represents an important pathway enabling the nervous system to influence the processes associated with the initiation, progression, and metastasis of a neoplastic process. In the context of prostate cancer, several papers report the presence of innervation and its modulating effect on the cancer prognosis. However, most of the data are experimental, with limited information on human prostate cancer innervation. Morphometric analysis of archival prostate specimen immunohistochemistry with neural markers PGP9.5 and S100 showed a significant decrease of nerve density in the prostate cancer (n=44) compared to the normal prostate tissue (n=18) and benign prostatic hyperplasia (n=28). Sympathetic nerves were detected with TH, parasympathetic with VAChT, and sensory nerves with SP and CGRP protein detection. Dual immunofluorescence revealed numerous sympathetic nerves in normal prostate and benign prostatic hyperplasia, especially in the peripheral parts. Only a few parasympathetic nerves were found between the glands and in the peripheral parts of the prostate and benign hyperplasia. Sporadic positivity for sensory innervation was present only in approximately 1/10 of nerve fibers, especially in the larger nerves. The pattern of innervation in prostate cancer was analogous to that in normal prostate gland and benign prostatic hyperplasia but there was a significantly lower amount of all nerve types, especially in high-grade carcinoma cases. Although not significant, there was a tendency of decreasing innervation density with increasing Gleason score. Regarding the low density of nerves in prostate carcinoma, the significantly lower PCNA counts in nerves of the cancer specimens cannot be ascribed to lower proliferation activity. Our data confirmed the lower nerve density in the prostate cancer compared to the benign prostate tissue. We could not approve an increased nerve proliferation activity in prostate cancer. All nerve types, most the sympathetic, less the parasympathetic, and the sensory nerves, are present in prostate cancer. The highest nerve density at the periphery of the cancer tissue implies this to be the result of an expansive tumor growth. It is evident that the results of experimental prostate cancer models can be applied to human pathology only to a certain extent. The relation between the range of innervation and the biology of prostate cancer is very complex and will require more detailed information to be applied in therapeutic solutions.

Relação entre sono e memória: Mais próximos do que você imagina

Hypnology (the study of sleep) is an area of medicine that permeates all others, because sleep is a fundamental part of everyone's life, since we spend a third of it asleep. This is due to its circadian rhythm. For this to happen, the action of modulating neurons is fundamental, each with different neuromediators that send out axons, establishing synapses in large areas of the cerebral cortex and regions that extend from the thalamus to the spinal cord. In addition, there is an interaction between the organism and the environment that regulates the sleep-wake cycle more effectively. This interaction characterizes the timer systems, which have cells capable of detecting environmental variations - sensory cells, especially light variations, and the so-called oscillator cells or pacemakers, which are responsible for the cycle regardless of external influences. In addition, there are hormonal interactions that influence both the sleep-wake cycle and organic functions. It is essential to study these relationships in order to understand the different states and stages of sleep, namely: slow-wave sleep, also known as non-REM sleep, and fast-wave sleep or REM sleep. Non-REM sleep is further subdivided into 4 stages, in which the human being starts from wakefulness and plunges into the various stages of depth. REM sleep is the deepest sleep, the stage of dreams, in which it is more difficult to wake the individual. Numerous nerve circuits are formed in this last stage of sleep, and it is this stage that is partly responsible for memory consolidation. There are various types of memory: those acquired throughout life, whether conscious or not, are essential for human beings to live well in society and form their individuality. The storage and recall of memories depends on the emotions experienced by each person. This changes the storage process and the places where memories are stored in each person's brain. There are regions that are essential and common to everyone, such as the hippocampus and amygdala, but the place where long-term memories are stored depends on each person's reaction to a given situation, and this will happen during the REM sleep phase. Becoming aware of this topic is fundamental to understanding the importance of good sleep hygiene, which is essential for achieving a substantial improvement in sleep quality and, consequently, quality of life, whether in terms of mood, health, cognition, memory and its consequences, or aspects related to work or academicism.

Histological patterns of the stomach of Yorkshire piglets in the age aspect

Pig breeding is currently a fairly promising industry that is able to ensure the food security of citizens in the Russian Federation with meat, bacon and bacon products. By nature, the stomach of pigs is classified as a mixed type (esophageal-intestinal), and therefore there is a special interest in studying the histological structure of the stomach in newborn piglets. The purpose of our study is to study the histological patterns of the stomach wall of Yorkshire piglets in the age aspect, to clarify morphometric indicators and to characterize histostructures. As a result of the study, two age groups of piglets were used: newborn one-day-old piglets and 28-30 days of the postnatal period of ontogenesis. The histological method was used for the study. According to the results of the study, it was found that the stomach wall of Yorkshire piglets of two age groups is represented by three membranes: the mucosa, which borders on the submucosal base; muscle and serous membranes. The mucous membrane is represented by simple weakly branching tubular glands formed by the main, lining and accessory cells. At the age of 30 days, mucus-producing cells in the cardiac department were detected mainly in the deep parts of the mucosa, in the fundal they showed weak secretory activity throughout the branching tubular glands, and in the pyloric, as in the cardiac department, they were most often found in deep areas of the mucous membrane. Numerous nerve plexuses and ganglia were observed between the circular and longitudinal layers of smooth musculature in the thickness of the muscle membranes, occurring both in a oneday-old animal and at the age of 30 days. The serous lining of the stomach had a typical structure, was represented by loose connective tissue covered with mesothelium.

Surgical skills and precautions of pelvic exenteration combined with pelvic wall resection

The treatment of locally advanced rectal cancer (LARC) or locally recurrent rectal cancer (LRRC) has been a difficulty and challenge in the field of advanced rectal cancer, while pelvic exenteration (PE), as an important way to potentially achieve radical treatment of LARC and LRRC, has been shown to significantly improve the long-term prognosis of patients. The implementation of PE surgery requires precise assessment of the extent of invasion of LARC or LRRC and adequate preoperative preparation through multidisciplinary consultation before surgery. The lateral pelvis involves numerous tissues, blood vessels, and nerves, and resection is most difficult, and the ureteral and Marcille triangle approaches are recommended; while the supine transabdominal approach combined with intraoperative change to the prone jacket position facilitates adequate exposure of the surgical field and enables precise overall resection of the bony pelvis and pelvic floor muscle groups invaded by the tumor. Empty pelvic syndrome has always been an major problem to be solved during PE. The application of extracellular matrix biological mesh to reconstruct pelvic floor defects and isolate the abdominopelvic cavity is expected to reduce postoperative pelvic floor related complications. Reconstruction of the urinary system and important vessels after PE is essential, and the selection of appropriate reconstruction methods helps to improve the patient's postoperative quality of life, while more new methods are also being continuously explored.

Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors.

Emodin, a compound isolated from Aspergillusterreus, was studied using chromatographic and spectroscopic methods and compound purity (96%) was assessed by TLC. Furthermore, high larvicidal activity against Aedes aegypti-AeA (LC50 6.156 and LC90 12.450mg/L), Culex quinquefasciatus-CuQ (8.216 and 14.816mg/L), and Anopheles stephensi-AnS larvae (6.895 and 15.24mg/L) was recorded. The first isolated fraction (emodin) showed higher pupicidal activity against AeA (15.449 and 20.752mg/L). Most emodin-treated larvae (ETL) showed variations in acetylcholine esterase, α and β-carboxylesterases, and phosphatase activities in the 4th instar, indicating the intrinsic differences in their biochemical changes. ETL had numerous altered tissues, including muscle, gastric caeca, hindgut, midgut, nerve ganglia, and midgut epithelium. Acute toxicity of emodin on brine shrimp Artemia nauplii (54.0 and 84.5mg/L) and the zebrafish Danio rerio (less toxicity observed) was recorded. In docking studies, Emodin interacted well with odorant-binding-proteins of AeA, AnS, and CuQ with docking scores of - 8.89, - 6.53, and - 8.09kcalmol-1, respectively. Therefore, A. terreus is likely to be effective against mosquito larvicides.

Cognition and reflection on the "lateral ligament of rectum"

As total mesorectal excision (TME) for rectal cancer is widely carried out in China, lateral ligament of rectum, as an important anatomical structure of the lateral rectum with certain anatomical value and clinical significance, has been the focus of attention. In this paper, by comparing and analyzing the characteristics about ligaments of the abdomen and pelvis, reviewing the membrane anatomy and the theory of primitive gut rotation, and combining clinical observations and histological studies, the author came to a conclusion that lateral ligament of rectum does not exist, but is only a relatively dense space on the rectal side accompanied by numerous tiny nerve plexuses and small blood vessels penetrating through it.

Outcome of using the spinal accessory nerve for functional muscle innervation in facial paralysis reconstruction: The first two cases in Vietnam and literature review

Abstract Facial nerve injuries with various causes, such as after trauma, tumor dissection, radiotherapy, etc., resulting the patient's functional, aesthetic, and psychological sequelae. For many decades, plastic surgeons have introduced numerous different nerve sources to overcome the above sequelae, such as contralateral facial nerve, the hypoglosal nerve, the masseter nerve, and the spinal accessory nerve (CN XI). There were various advantages and disadvantages of donor nerves sources. However, the use of ipsilateral donor nerve is said to have many benefits. In this report, we would like to present preliminary results of using the CN XI source in treatment of subacute and chronic VII nerve injury. These were the first two cases of successful surgery using this nerve source in Vietnam. Keywords: Facial nerve injury, facial paralysis, nerve transfer, spinal accessory nerve.

Stress Distribution Analysis of Threaded Implants for Digital Dentistry.

In this study, stability evaluation is performed through structural analysis based on digital dental implant design variables. The design variables include the implant length and thickness, cortical bone thickness, and elastic modulus of the cancellous bone. Subsequently, the stress in the external cortical bone, in which numerous nerves exist, is analyzed. Results show that stress increases as the implant length decreases. However, when the implant length is 10 mm, the stress decreases, owing to stress dispersion at the lower section of the implant. Moreover, as the implant thickness increases, the stress decreases. As the elastic modulus of the cancellous bone decreases, the stress exerted on the cancellous bone decreases; consequently, the stress exerted on the cortical bone increases. Finally, as the thickness of the cortical bone increases, the stress decreases when a vertical load is applied. However, when a load is applied in the oblique direction, the stress increases. Based on data obtained via digital radiography, which is a digital dental technology, a more precise implantation plan will be established by substituting the data via structural analysis.

Regions of the human renal artery: histomorphometric analysis.

The renal artery is frequently involved in the pathogenesis of vasculorenal diseases, and it is a target in kidney surgery and therapeutic techniques for refractory hypertension. However, few detailed structural studies on the human renal artery have been conducted. Using histocytochemistry, immunohistochemistry, and quantitative image analysis, the wall thickness, structure, smooth muscle cells, extracellular matrix, and proportion of elastic tissue in the tunica media of main human renal arteries were used estimated. Ninety-six tissue samples were collected from sections of the right and left main renal arteries. The results showed that the renal artery changed from an elastic vessel in its proximal segment to a muscular artery in its distal part. A critical characteristic of the renal artery was the presence of longitudinal smooth muscle cell formations in the tunica adventitia of middle and distal segments but not in the proximal part of the artery. In addition, the tunica adventitia of the renal artery showed a rich vascularization and the presence of numerous nerves profiles. The artery's regional structural and morphometric features explain that a particular arterial pathology is more frequent in a specific vessel sector than in others. In addition, those characteristics could determine a different therapeutic response attending to the arterial sector.

Localization of substance P (SP)-immunoreactivity in the myenteric plexus of the rat esophagus.

The present immunohistochemical study was performed to examine the number, distribution, and chemical coding of intrinsic substance P (SP) neurons and nerve fibers within the esophagus and discuss their functional roles. Many SP neurons and nerve fibers were found in the myenteric plexus, and the SP neurons gradually decreased from the oral side toward the aboral side of the esophagus. Double-immunolabeling showed that most SP neurons were cholinergic (positive for choline acetyltransferase), and few were nitrergic (positive for nitric oxide synthase). Some cholinergic SP nerve terminals surrounded cell bodies of several myenteric neurons. In the muscularis mucosa and lower esophageal sphincter, and around blood vessels, numerous SP nerve endings were present, and many of them were cholinergic. Also, SP nerve endings were found on only a few motor endplates of the striated muscles, and most of them were calcitonin gene-related peptide (CGRP)-positive. Retrograde tracing using Fast Blue (FB) showed that numerous sensory neurons in the dorsal root ganglia (DRGs) and nodose ganglion (NG) projected to the esophagus, and most FB-labeled SP neurons were CGRP-positive. These results suggest that the intrinsic SP neurons in the rat esophagus may play roles as, at least, motor neurons, interneurons, and vasomotor neurons, which are involved in local regulation of smooth muscle motility, neuronal transmission, and blood circulation, respectively. Moreover, SP nerve endings on only a minority of motor endplates may be extrinsic, derived from DRGs or NG, and possibly detect chemical circumstances within motor endplates to modulate esophageal motility.

Study of variations in the formation and branching pattern of lateral cord of brachial plexus- A detailed cadaveric study

As the formation of brachial plexus involves numerous nerve roots, it is more common than rare to find variations in the formation and its branching pattern. Innumerable variations in the formation of lateral cord of brachial plexus and the branches of the lateral cord of brachial plexus are reported. This study is done with an intension to specifically look into the possible variations in the formation and branches of the lateral cord of brachial plexus only. The present study was carried on cadavers during undergraduate dissection, in the Department of Anatomy, Velammal Medical College, Annupanadi, Madurai, Tamilnadu India. In the present study The cadavers were dissected out to find the branching pattern of the Lateral cord and the observations were analysed, many variations in the branching patterns were observed, significant one being the musculocutaneous nerve being absent, coracobrachialis being supplied by branch from lateral root of median nerve, in another musculocutaneous nerve ends by supplying only coracobrachialis and the rest are supplied by the branches from median nerve. The frequency of anomalies found in the arrangement and distribution of lateral cord and its branches makes this anatomic region complicated with regard to surgical approaches.

Bulbostylis itremoensis (Abildgaardieae, Cyperaceae), a new sedge species from Madagascar

SummaryAn endemic species of Bulbostylis (Abildgaardieae, Cyperaceae) from Madagascar is described as new to science. Bulbostylis itremoensis is only known from two localities: the Itremo and Isalo massifs in the province of Fianarantsoa. The species can be recognised by its habit with numerous crowded culms, leaves and thick, soft roots with an outer mycorrhizal layer. Its culm is hairy, angular with about 10 rounded longitudinal ridges without conspicuous surface cells. The leaf sheaths are light brown to straw-coloured with numerous longitudinal nerves, densely short-hairy on the nerves but with numerous flexuose whitish hairs at their oblique orifices. Its inflorescence is a dense hemispherical head of c. 15 crowded spikelets with many erect or spreading involucral bracts. Its glumes are ovate, densely scabrid of which medium-reddish brown with a prominent 1 – 3-nerved green midrib ending below the obtuse apex or excurrent into a short mucro. This species is described, illustrated and compared to the other species of Bulbostylis that occur in the Itremo Massif Protected Area.

Facial Nerve Palsy in COVID-19-Associated Mucormycosis Patients: A Case Series

Sinonasal mucormycosis is a deadly fungal illness that primarily affects diabetics who are uncontrolled. Numerous cranial nerves can be involved; however, facial nerve palsy has only been observed in a few cases. The main objective of this research is to highlight facial nerve involvement as a clinical sign of sinonasal mucormycosis. Nasal stuffiness, headaches, eye pain, orbital edema, ophthalmoplegia, and vision loss are common symptoms in these mucormycosis patients. The study was done in the Department of Otolaryngology & Head and Neck Surgery, All India Institute of Medical Sciences (AIIMS), Raipur, India. Nevertheless, 17 patients with facial nerve palsy (lower motor nerve palsy) and sinonasal mucormycosis arrived at our department. All patients were diabetic, and a majority of patients got Schirmer's test positive with severe stage. In the case of mucormycosis, facial nerve palsy is an unusual but noteworthy symptom. This could be misinterpreted as a cerebrovascular accident (CVA), causing the therapy to be delayed. This is critical as early identification, surgical debridement, and adequate therapy of the underlying metabolic imbalance, as well as amphotericin B, are critical for a successful treatment outcome in mucormycosis.