Nosignificant Difference Research Articles

Timing and intensity of humid interglacial and interstadial periods from the Eemian in the southwestern Mediterranean region: new chronological and stable isotope data from Aït Said ou Idder (Middle Atlas) and comparison with other regional tufa deposits (Morocco and southern Spain)

Abstract. In the last few decades, multidisciplinary research on calcareous tufas as palaeoenvironmental and palaeoclimatic records has intensively grown, which has provided an increasing number of well-documented sites. Consequently, inter-site comparisons and regional- to continental-scale reviews have developed, discussing the link between tufa distribution and climate or providing diachronic comparisons of climatic and environmental conditions prevailing during Quaternary interglacials (and interstadials). This paper proposes such a review for the southeastern Mediterranean area, including new dating and isotopic data from Aït Said ou Idder (northern Morocco) to be compared with available regional data, in order to discuss the intensity of some humid periods of the last 125 kyr. According to several radiocarbon and U–Th dates, three chronological phases are indeed identified at Aït Said ou Idder: the Holocene, the Dansgaard–Oeschger (D–O) interstadial 8 and the Marine Isotopic Stage (MIS) 5e. Similarly, other tufa deposits from both Morocco and southern Spain (mostly Andalusia) appear to have preferentially developed during interglacial or interstadial periods, marked by maximal developments of the Mediterranean forest as reported in the palynological records from regional marine cores. Furthermore, isotopic data (δ18O and δ13C) from Aït Said ou Idder (and from other southeastern Mediterranean tufa deposits where available) suggest no significant difference in terms of temperature or air mass circulation between the Holocene, D–O 8 and MIS 5e. In terms of humidity conditions, no evidence of strong aridity is recorded even if D–O 8 appears drier than both interglacials. Conditions seems slightly wetter during the Holocene than during MIS 5e, but δ13C values at Aït Said ou Idder could also reflect strong differences in the seasonality of these interglacials. We demonstrate that calcareous tufa deposits have promising potential for discussing, in both space and time, the climate variability in the southeastern Mediterranean area, but new investigations, including dating and stable isotopes, are required to accurately feed such discussions.

Influence offentanyl, ketamine orlidocaine infusion onthe intraocular pressure and pupil size inconscious dogs.

Fifty-five healthy conscious dogs were included inaprospective randomised double-blinded clinical study. The dogs allocated toone offour groups received intravenous bolus followed byinfusion offentanyl (FEN-group), orketamine (KET-group), orlidocaine (LID-group), orsaline (SAL-group). The intraocular pressure (IOP), pupil size (PS), heart rate (HR) and mean arterial pressure (MAP) were measured prior toand at2, 5, 10, 20 and 30min after initiation ofthe drug administration. The data were analysed using ananalysis ofvariance and theSteel-Dwass test. Nosignificant difference inthe IOP within orbetween the groups was detected. Inthe FEN-group, the PS decreased significantly atall the measured times. Inthe KET-group, the PS increased significantly at2, 5and 10minutes. The PS was significantly smaller inthe FEN-group compared tothe KET-group at2, 5, 10 and 20min, compared tothe SAL-group at5, 10, 20 and 30minutes. Inthe FEN-group the HR significantly decreased compared tothe baseline and was significantly lower compared tothe KET-group and LID-group. Fentanyl, ketamine orlidocaine administered atthe doses studied asabolus followed bya30-min infusion seem tocause noeffect onthe IOP inhealthy conscious non-painful dogs without ocular abnormalities. Fentanyl decreased and ketamine transiently increased the PS.

Long-term outcomes of hemostatic therapy for variceal bleeding and the challenge pending in the post-direct-acting antivirals era.

This study evaluated the longterm outcomes of mainly endoscopic hemostatic therapy for gastrointestinal variceal bleeding and of the transition of hemostatic therapy. Among 1,163 patients treated for gastrointestinal varices between April 2006 and June 2020, a total of 125 patients who underwent emergency hemostatic therapy were enrolled. Survival rates and secondary evaluation points were analyzed. Additionally, patients were classified into two groups: the previous and latter term. Patients' background, therapeutic method, and treatment results were compared between the groups. 94.4% had cirrhosis. The average Child-Pugh score was 8.90. Successful primary hemostasis rate was 98.4%, and 5.6% died within 2 weeks, all with a Child-Pugh score ≥9. The respective 1- and 5-year survival rates for Child-Pugh grade A/B were 81.3% and 55.4%, while those for Child-Pugh grade C were 58.1% and 17.8%. Child-Pugh grade C or hepatocellular carcinoma was significantly associated with poor prognosis. In total, 21.6% experienced variceal re-bleeding; 62.9% of these cases were triggered by continued alcohol consumption. There was no significant difference in survival between patients with and without variceal re-bleeding and in post-treatment survival between the previous and latter terms. In the latter term, the number of cases caused by continued alcohol consumption significantly increased. Multidisciplinary treatment and continuation of proper management after hemostatic therapy for variceal bleeding are crucial. Continued alcohol consumption leads to variceal bleeding and re-bleeding; its proper management, including alcohol abstinence, is one of the major challenges left in the post-directacting antivirals era.

Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia

Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing the escalation of care and improving clinical outcome in older patients hospitalized for COVID-19 pneumonia. A total of 90 subjects (47.7% women; mean age = 82.3 ± 6.7 years) were enrolled. ECT was administered to 33 out of 90 patients before the hospitalization. At admission, no difference was detected in median SOFA score (2, IQR:2 vs. 2, IQR: 2). We found a significant difference in mean PaO2/FiO2 ratio during the first week of hospitalization between ECT patients and controls (F = 5.49, p = 0.002) and in mean PaO2/FiO2 ratio over time (F = 6.94, p < 0.0001). We detected no-significant differences in terms of in-hospital mortality and transfer to ICU between ECT patients and controls (27.1% vs. 22.8%, respectively, p = 0.63). ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. These findings are crucial given the current pandemic, and further studies are needed to provide additional data on the optimal timing of initiating corticosteroid treatment.

Effect of Exercise Intervention on Social Ability of ADHD Children

The incidence rate of attention deficit hyperactivity disorder (ADHD) is 7.25% in China. The main symptoms are attention deficit laxation, behavior impulsivity, social disorder and so on. Children aged 3-6 are in the golden age of social ability development. Therefore, if ADHD children at this age do not get correct and effective interventions, it will have a far-reaching impact on their social ability. In order to explore new intervention measures for ADHD children and improve their social ability, this study will intervene ADHD children through sports intervention, so as to provide theoretical and experimental basis for improving their social ability. A total of 12 hyperactivity prone children aged 3-6 years were recruited in this study. The subjects were intervened through engaging in KDL sports game, parent-child homework and parent-child carnival for four months. We used Achenbach children's behavior scale (CBCL) to evaluate children's social ability from activity ability, social ability and learning. In order to reduce the experimental error, before using the CBCL scale, the researchers have been trained in learning and understanding the specific rules and scoring methods of the CBCL scale to ensure that evaluated data have good reliability and validity. After data collection, SPSS 23.0 was used to conduct statistical analysis on the data. The results showed that after the intervention, the ADHD children significantly improved their social ability from the baseline to the post-test (Tsocial = -1.39, psocial = 0.01 &lt; 0.05). However, the results showed that there was no significant difference in children's activity ability and learning over time (Tactivity = 0.42, pactivity = 0.533 &gt; 0.05; Tlearning = -0.12, plearning = 0.756 &gt; 0.05). Exercise intervention can effectively improve the social ability of ADHD children, which is more harmonious with their peers and more able to communicate with their families. We suggest to carry out exercise intervention for more children with ADHD and to integrate behavioral therapy with multi-directional intervention.

Experimental Study on Effects of Physical Exercise Function Training on Physical Health of Primary School Students

Recently, the physical health problems of children in China have attracted extensive attention. The education department has issued a notice on further strengthening the physical health management of primary and secondary schools. Many studies have shown that physical exercise function training has unique advantages in promoting the healthy development of students' physique and is unaffected by venues or weather. This study aims to explore and verify the intervention effect of physical exercise function training on students’ physical health indicators, including physical shape, function, and quality. It also intends to practically explore the improvement of students' physical health status and expand their physical education and health curriculum. Sixty-four elementary school students were selected to participate in the experiment: 32 were in the experimental group and 32 in the control group. The experiment was conducted three times a week for 10 weeks. The experimental group performed physical exercise function training teaching. The control group underwent routine PE teaching. Before and after the experiment, the compulsory indexes of Grade 4 in the national physical health standard for students (revised in 2014) were selected for the test, including height, weight, vital capacity, 50m running, sitting forward flexion, 1-minute rope skipping, and 1-minute sit-ups. Body shape, physical function, and physical quality of the two groups were measured and analyzed. Independent sample t-tests showed that there was no significant difference in body shape, physical function, and physical quality between the two groups before the experiment, and no statistically significant difference in body shape between the experimental and control groups after the experiment (p &gt; 0.05). The tests also showed that the physical function of the experimental group improved significantly compared to the control group after the experiment (t lung capacity = -2.346, p = 0.022). The experimental group improved significantly more than the control group in the 50m running, 1-minute rope skipping, and 1-minute sit-ups (t 50m running = -2.192, p = 0.032; t 1-minute rope skipping = 2.071, p = 0.043; t 1-minute sit ups = 2.035, p = 0.046). No statistically significant difference was found in sitting forward flexion between the experimental and control groups after the experiment (t sitting forward flexion = 1.555, p = 0.125). The exercise intervention has no effects on improving primary school students’ body shape. However, it has a significant effect on improving their physical function, and their vital capacity is significantly enhanced. The intervention effectively improved students’ 50m running, 1-minute rope skipping, and 1-minute sit-ups performance. In the control group, the physical health levels were slightly improved in routine physical education teaching. Therefore, designing a special physical exercise function training program is reasonable for improving the physical health of primary school students.

Optimal Dose of Erenumab for Preventive Treatment of Episodic Migraine: A Systematic Review and Meta-Analysis.

Background:Erenumab is a novel monoclonal calcitonin gene-related peptide receptor antibody that is used for the preventive treatment of migraine.Objectives: This study aimed to evaluate the overall safety, efficacy, and dose-response relationship of erenumab in patients with episodic migraine and patients with prior migraine treatment failures.Methods:We searched randomized clinical trials on PUBMED, EMBASE database, and Cochrane Library database. A pair-wise meta-analysis and Bayesian network analysis were performed.Results:For efficacy outcomes, the network meta-analysis suggests that in comparison to erenumab 70 mg, participants who received erenumab 140 mg reported a significant decrease in monthly acute Migraine-Specific Medication Days (MSMD) and 50% increase in response rate, and erenumab was most likely to be ranked first for Monthly Migraine Days (MMD), MSMD, and 50% response rate. For safety outcomes, the network meta-analysis has found no significant difference between the 70 mg group and the 140 mg group measured by adverse events and serious adverse events. In the 140 mg erenumab group, a significant decreased in MMD and MSMD and 50% and 75% increased in response rate were reported in patients with ≥ 2 treatment failures compared to placebo. For safety outcomes, no significant difference was found between the 140 mg erenumab group and the placebo group.Conclusion:Erenumab was effective in patients with episodic migraine. A total of 140 mg erenumab was associated with better efficacy outcomes without any increased risk for developing adverse events compared to 70 mg erenumab. Furthermore, 140 mg erenumab was effective in patients with prior migraine treatment failures.

Modelling commuting tours versus non-commuting tours for university students. A panel data analysis from different contexts

University students’ mobility represents a significant part of the mobility demand, since the right to mobility becomes yet more significant, as it directly translates into the right to education. At the same time, lifestyle evolution and changes has yield to a boost in the number of non-commuting tours, which are now recognized as a key component of any travel demand system. However, their analysis is often overlooked due to their randomness and difficult detectability.Motivated by this shortfall, the current study sought to explore the university students’ mobility by focusing on i) a comparison among commuting and non-commuting tour, ii) analysing non-commuting patterns and iii) identifying factors affecting the tour generation. A joint mixed logit model was specified and estimated using panel data collected in two Italian Universities (Cagliari and Rome).This study represents a pilot test conducted for the purpose of providing scientific justification for implementing Voluntary Travel Behaviour Change programmes and Travel Demand Management policies in Italian Universities. Our results indicate that the number of non-commuting tours, when compared with commuting tours, is not negligible (around 28% of tours are non-commuting tours) and we detected no-significant differences between Cagliari and Rome with respect to the tour characteristics. In Cagliari women, individuals who have a high number of household members, people living in areas characterized by high building densities and a small number of shops, and in Rome students living in small families and those who own a car, are more apt to travel for discretionary purposes.

Effect of pH extraction buffer on antioxidant enzymes activities in water lily’s leaves and petioles

Water lily (Nymphaea antares) is one of the most valuable aquatic ornamental plants which has bright potential in the floriculture industry. It may be useful as an urban ecosystem and as a source of medicinal compounds. Due to its potential to become a new value-added product in the food industry, water lily (N. antares) was investigated in this study. Therefore, the goal of this study was to determine the nutritional content and antioxidant activity in water lily leaves and petioles with different pH extraction buffers. Water lily extract was obtained using three different pH extraction buffers, Tris buffer at pH 6.8, pH 7.1 and pH 7.8. The heat capacity of the extract was analysed using differential scanning calorimetry (DSC) and different functional groups were identified using Fourier transform infrared spectroscopy (FTIR). Thermal denaturation of the leaves sample was detected at 81.84°C. The antioxidant enzymes activities including catalase (CAT), peroxidase (POX), polyphenol oxidase (PPO), and superoxide dismutase (SOD) were determined in the leaves and petioles of water lily. In leaves, PPO activity was found to be higher in samples with pH 7.1 of the extraction buffer while there were no significant differences for activities of CAT, POX and SOD in all samples. In petioles, PPO and POX activity were found to be higher in samples with pH 7.8 and 7.1 of extraction buffer, respectively. Thus, the study found that a pH range of 7 to 9 extraction buffers did not greatly affect most of the analysis performed.

Effect of 0.2% chitosan high molecule nanoparticle on the push-out bond strength of resin cement in post-restoration (An in-vitro study)

ABSTRACT Debonding between post and resin cement often occurs due to inadequate smear layer removal.Currently, the wide use of Chitosan as an alternative irrigating solution can remove the smear layer. This studyaimed to determine the effect of 0.2% chitosan high molecule nanoparticle (CHMN) on the push-out bond strength ofresin cement in post-restoration and types of adhesion failure using the different irrigating solutions. Endodontictreatment was performed on 24 mandibular premolars, which were divided into four groups, namely group 1: 0.2%CHMN, group 2: 2.5% sodium hypochlorite (NaOCl) and CHMN, group 3: 5.25% NaOCl and CHMN, group 4: 2.5%NaOCl and EDTA 17%. The final restoration was done using prefabricated glass fiber posts, and each sample wassliced into three segments transversally with a thickness of 2 mm. A push-out test was performed with a universaltesting machine, and failure modes were observed under a stereomicroscope. Data were analyzed with a one-wayanalysis of variance (ANOVA), LSD, and Kruskal-Wallis tests. The results showed a significant difference in pushoutbond strength of resin cement in post-restoration between all groups. The Kruskal-Wallis test showed nosignificant difference between types of adhesion failure. In conclusion, 0.2% CHMN affects the push-out bondstrength of resin cement in post-restoration regardless of or without a combination of NaOCl. However, there wereno effects on the types of adhesion failure. Keywords: bond strength, 0.2% chitosan solution, endodontic irrigation, fiber post

Combined Radiometric Analysis Related to Guava Leaf Phenology in Response to Soil Application of Paclobutrazol (PBZ)

The leaf-response to three-soil applied treatments of Paclobutrazol (PBZ; 1000, 2000 and 0 ppm-control) was studied in a high-density plantation of eight guava (Psidium guajava) genotypes trees. All materials were prunned in vase form, with two to three major branches, yearly prunning for triggering the annual production cycle, and average height of 2.0 m. The dataset comprises fourth radiometric indices highly related to plant physiological activities. The dataset model took into account data collection dates, guava genotypes, and the positional effect of sun radiation on leaves based on their proximity to the canopy level and downward to the base of the woody seasonal-branch. Unexpectedly, there were no significant differences (NS) in PBZ treatments for genotypes, leaf position and radiometric indices. Analysis of the radiometric indices data revealed that anthocyanin (ARI index) and chlorophyll (PRI index) have a strong inverse relationship. Significant differences (P ≤ 0.05) were found between guava genotypes, and anthocyanin content; these results show that guava genotypes have varied responses, which could derive in their classification based-on drought resistance or low water requirements, however, it is important to note that additional research is required to determine the scope of these indications.

Kinetic–spectrophotometric approach to the ampicillin hydrolytic degradation applied for the histidine determination

The objective of this research was to develop a kinetic-spectrophotometric method for the determination of microquantities of L-histidine in pure form and dietary supplements. The method was based on the kinetics of ampicillin degradation by Ni(II) ion as a catalyst in the presence of L-histidine in a strongly alkaline medium. The rate of this reaction was monitored spectrophotometrically by measuring the increase in absorbance at 265 nm as a function of time. The same approach was used for the investigation of the reaction rate in the absence of histidine. A differential variant of the tangent method was used to process the kinetic data. Beer?s law was obeyed in the interval of histidine concentration from 1.24 ?g/ml to 11.63 ?g/ml with the relative standard deviation ranging from 8.1% to 0.7%. The detection limit of 0.46 ?g/ml was estimated based on the 3S0 criterion. The interference effects of some metal ions, anions, and other molecules on the reaction rate were studied to assess method selectivity. Herein described method was applied for the quantification of histidine in dietary supplements. The point hypothesis test confirmed that there was no significant difference between the proposed and the reference method.

Training and fitness variability in elite youth soccer

Research within sport science disciplines seeks to enhance performance via the combination of factors that influences the team’s periodization. The current study aimed to investigate the variations in training load (TL), and the consequential changes in fitness variables, based on the use of match difficulty prediction model (MDP), level of opposition (LOP), days between matches, and match location during 12 weeks in the competitive period I. Seventeen elite soccer players (age = 17.57 ± 0.49 years; body height 1.79 ± 0.05 m; body weight 72.21 ± 6.96 kg), have completed a Yo-Yo intermittent recovery test, a running-based anaerobic sprint test, a soccer-specific repeated sprint ability, and a vertical jump test to identify changes in players fitness. TL was determined by multiplying the RPE of the session by its duration in minutes (s-RPE). Training monotony, strain, and acute:chronic workload ratio (ACWR) were also assessed. A simple regression model was conducted and the highest variances explained (R2) were used. The LOP score explained most of the variance in ACWR (r= 0.606, R2=0.37). TL declined significantly when compared the match-day by the first three days and the last three days of the week. No significant difference was found in s-RPE between the high and low MDP factor. Strong negative correlations were reported between ACWR and LOP (r=-0.714, p&amp;lt;.01). In addition, we found a significant improvement in repeated sprint ability, aerobic and anaerobic fitness variables between pre- and post-test in fatigue index (d=1.104), best testing time, ideal time, total time and mean-best (d=0.518-0.550), and aerobic and anaerobic fitness variables (p&amp;lt;.05), respectively. The MDP could facilitate the training prescription as well as the distribution of training intensities with high specificity, providing a long-term youth player’s development and allowing teams to maintain optimal fitness leading into more difficult matches.

Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery.

The effectiveness and side effects of dexmedetomidine (DEX) in combination with midazolam and propofol have not been comparatively studied in a single clinical trial as sedative agents to general anesthesia before. The objective of this study is to compare intra and post-operative sedation between DEX-Midazolam and DEX-Propofol in patients who underwent major abdominal surgery on the duration of general anesthesia, hemodynamic and sedation effect. This prospective, randomized, double-blinded clinical trial included 50 patients who were 20 to 60 years of age and admitted for major abdominal surgery. The patients were randomly assigned by a computer-generated random numbers table to sedation with DEX plus midazolam (DM group) (n=25) or DEX plus propofol (DP group) (n=25). In the DM group, patients received a bolus dose of 0.1 mg/kg of midazolam and immediately initiated the intravenous (i.v.) infusion of DEX 1 μg/kg over a 10 min and 0.5 μg/kg/hr by continuous i.v. infusion within operation period. In the DP group, patients received pre-anesthetic i.v. DEX 1 μg/kg over 15 min before anesthesia induction and 0.2-1 μg/kg/hr by continuous i.v. infusion during the operative period. After preoxygenation for at least 2 min, during the surgery, patients received propofol infusion dose of 250 μg/kg/min for 15 min then a basal infusion dose of 50 μg/kg/min. The bispectral index (BIS) value, as well as mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), oxygen saturation (SaO2), percutaneous arterial oxygen saturation (SpO2) and end-tidal carbon dioxide tension (ETCO2) were recorded before anesthesia (T0), during anesthesia (at 15-min intervals throughout the surgical procedure), by a blinded observer. Evidence of apnea, hypotension, hypertension and hypoxemia were recorded during surgery. The hemodynamic changes, including HR, MAP, BIS, VT, SaO2, and RR had a downward tendency with time, but no significant difference was observed between the groups (P>0.05). However, the two groups showed no significant differences in ETCO2 and SPO2 values in any of the assessed interval (P>0.05). In this study, the two groups showed no significant differences in the incidence of nausea, vomiting, coughing, apnea, hypotension, hypertension, bradycardia and hypoxemia (P>0.05). Respiratory depression and serious adverse events were not reported in either group. Extubation time after surgery was respectively 6.3 ± 1.7 and 5.8 ± 1.4 hr. in the DM and DP groups and the difference was not statistically significant (P= 0.46). Our study showed no significant differences between the groups in hemodynamic and respiratory changes in each of the time intervals. There were also no significant differences between the two groups in the incidence of complication intra and post-operative. Further investigations are required to specify the optimum doses of using drugs which provide safety in cardiovascular and respiratory system without adverse disturbance during surgery.

The pencil eraser swab technique to quantify Cutibacterium acnes on shoulder skin.

Introduction: Cutibacterium acnes is the most common cause of postoperative infections in orthopaedic shoulder surgery and is hard to eradicate with current measures. Newer strategies focus on reducing bacterial load on the skin before surgery. Several previous studies have used a large number of both described and undescribed sampling techniques. The purpose of this study was to compare three previously described swab techniques to obtain bacterial cultures: Levine's (L) technique, the Z technique and the pencil eraser swab (PES) technique. Methods: Three consecutive skin swabs were collected from the right shoulder, on 15 healthy male volunteers, using Levine's technique, Z technique and PES technique from each participant. To determine the number of living bacteria, serial dilutions were made, and after culturing for 5 d, viable count (VC) was expressed as CFU/mL (with CFU representing colony-forming unit). Results: The PES technique yielded significantly higher VC than the two others. PES: median 3700 CFU/mL, L: 200 CFU/mL and Z: 220 CFU/mL (). There was no significant difference between the methods regarding the number of positive cultures. PES: 14/15, L: 11/15 and Z: 12/15. Conclusions: There is a need to harmonise sampling techniques of C. acnes in order to compare the efficacy of different measures to reduce the bacterial load on the skin before and during surgery. Of the three tested methods, the PES technique is simple and produces the highest bacterial counts.

First Line and Second Line Chemotherapy in Advanced Cholangiocarcinoma and Impact of Dose Reduction of Chemotherapy: A Retrospective Analysis.

ObjectivePrognosis of patients with irresectable cholangiocarcinoma is still poor. The ABC-02 trial established the current first line (1L) standard systemic chemotherapy (CT) with gemcitabine/platinum derivate for advanced cholangiocarcinoma. However, the majority of patients needed therapy adaptions. Thus, the aim of this study was to evaluate 1L and second line (2L) therapy regimens and the impact of therapy adaptions in an unselected real-life cohort of patients with advanced cholangiocarcinoma.Materials and MethodsThis is a single institution retrospective analysis of patients with irresectable cholangiocarcinoma who were treated with gemcitabine/platinum derivate from 2010 to 2018. Overall survival (OS), progression-free survival (PFS) and toxicity were analyzed for all patients, especially with regard to CT de-escalation.ResultsFifty-eight patients receiving gemcitabine/platinum derivate were included in the analysis. Median OS and PFS were 12.2 and 6.9 months. Interestingly, 41 patients (71%) needed therapy de-escalation. However, despite reduced CT exposition, there was no-significant difference in OS (10.8 months vs. 15.6 months, p = 0.127), and patients suffered from less adverse events during CT. 21 (36%) patients reached 2L CT, most often with FOLFIRI (57%). Survival beyond the end of 1L CT was 7.1 months with 2L CT vs. 2.9 months with BSC.ConclusionIn our study, the combination of gemcitabine/platinum derivate showed similar OS and PFS as randomized prospective phase II/III trials. Therapy regimen adaptions were needed in the majority of patients. However, individualized modifications of the therapy regimen allowed better tolerance as well as continuation of therapy and did not significantly influence median OS. Furthermore, our study revealed a potential survival benefit with 2L CT for selected patients.

A Comparative Evaluation of Dental Erosion Caused by Tetrapacked and Aerated Beverages: An In-Vitro study

Introduction: Dental erosion is an evolving concern with the food market globalization. In a rapidlydeveloping nation as India, beverage consuming behavior has significantly increased. There is freeaccess to new foods and beverages even in the neighborhood grocery stores and they are perceived asmodern and healthy. Extrinsic erosion appears to be a growing problem as a result of overconsumptionof soft drinks or fruit juices or both. Materials and Methods: Freshly extracted premolars weretreated with H202 for 24 hours and weighed with ‘Essae FB-200’ with a readability of 0.001 gram. Thebeverages were grouped into 2 categories, 1- Natural or tetra-packed beverages, 2 - aerated beveragesand a control. 20ml of each beverage was taken and the pH was measured. The tooth was immersed ineach of the beverage and pH were noted 4th hourly for 48 hours accounting for sipping the beveragefor 5 minutes every day for 1.5 years. The weight of the tooth was rechecked after 48 hours. Results:The mean pre-treatment pH of category 1 was 5±1.33 and that of category 2 was 4.66±1.32. There isno significant difference in the mean loss of weight between the two groups (p-value 0.94) there is nosignificant difference in the mean change of pH between the two groups (p-value 0.26) Conclusion:The objective erosive liability of tetra-packed and aerated beverages on the dental enamel was foundto be similar. However, natural fruit juices showed nil to negligible objective signs of dental erosion.

P.212 Demographic Trends in Canadian Neurosurgery Training &amp; Academic Neurosurgery

Background: Exploring current trends in career outcomes can guide further expansion and diversity in neurosurgery demographics, as well as inform medical trainees of qualifications required for a career in neurosurgery. This study therefore aims to explore temporal trends and gender distribution in training, teaching, and leadership positions among currently practicing neurosurgeons. Methods: A list of practicing Canadian neurosurgeons and their certification year, degrees, fellowships, and teaching positions was created using publicly available information and phone/email confirmation by surgeons. Results: We identified 297 neurosurgeons currently practicing in Canada (F=32, M=265). There was a significant trend towards a greater number of neurosurgical staff having at least one advanced degree or fellowship over time (p=0.0012, p=0.0048 respectively), with no significant difference between proportions of males and females. Within academia, women represent 33% of adjunct professors, 8% of associate professors, and 15.2% of full professors. Two neurosurgical departments in Canada are led by women. Conclusions: Literature shows there is an underrepresentation of women in neurosurgery, particularly in higher-ranking teaching and leadership positions, yet our results suggest there is no significant differences in qualifications between males and females. Further exploration is needed to identify reasons underlying these trends and propose solutions to promote growth in the field.

Association of osteopontin with thyroid dysfunction in type П diabetes mellitus

Both thyroid diseases (TD) and diabetes mellitus are common endocrine disorders that often appear in clinical practice (DM). It is more common for persons with type 2 diabetes to have hypothyroidism or hyperthyroidism (T2DM). A considerable influence on blood glucose, lipid, and protein metabolism, as well as many other organs and tissues, is exerted by thyroid hormones in the blood (T2DM). It has been shown that in people with hyperthyroidism, the presence of osteopontin increases, and in those with hypothyroidism, it decreases, indicating that it may be a novel way to find thyroid illness. A total of one hundred twenty (120) subjects were included in current study. Variables like (gender, age, BMI, thyroid hormones, FBS, HbA1c, lipid profile and OPN) were recorded and documented from participant included in this study. The results of current study displayed there was a significant differences between osteopontin and body mass index in patients suffering from thyroid dysfunction with diabetes (-0.37) with (P≤0.05), T3 was (0.32) and FBS was (0.35) both of them recorded significant differences and (P≤0.05) in patients with diabetes type II. TSH, T3 and T4 findings were high significant differences with OPN in patients with thyroid dysfunction with diabetes with (-0.89), (0.9) and (0.89) respectively. While other parameters recorded no-significant differences.

P.134 Movement medicine: A systematic review on the effect of early aerobic exercise initiation on symptom recovery following concussion

Background: Mounting evidence supports aerobic exercise as a promising treatment option for individuals experiencing persistent post-concussion symptoms beyond four weeks. The purpose of this review was to determine whether initiating structured aerobic exercise within the early period (first two weeks) following concussion affects symptom recovery compared to standard care. Methods: A systematic literature search was performed using MEDLINE, Embase, PsycINFO and CENTRAL databases, combining keywords: (brain concussion, post-concussion syndrome, mild traumatic brain injury) AND (exercise, exercise therapy, physical activity, kinesiotherapy). Results were limited to Randomized Controlled Trials (RCTs). All selected articles underwent quality assessment. Results: The search generated 112 unique abstracts, of which 5 met inclusion criteria. Sample sizes ranged from 16 to 103 participants. Of the four studies that were able to analyze between-group differences, one showed significantly faster recovery in the early aerobic exercise group compared to control, while three showed no significant difference. Two studies demonstrated a trend toward faster initial symptom resolution in the early exercise group. Conclusions: Preliminary RCT evidence suggests that aerobic exercise initiated in the early postconcussion period does not exacerbate symptoms or prolong recovery time, and may potentially hasten recovery. Larger, more rigorous RCTs are required to define the optimal exercise parameters to facilitate symptom recovery.