A methodology for assessing the possibility of ensuring salvage and rescue operations and oil and oil product spills response throughout the entire water area of the Northern Sea Route has been proposed. From 2024, it is planned to systematically develop year-round navigation along the Northern Sea Route, which will be associated with the need to ensure safety. At the moment, this possibility is severely limited due to the lack of multifunctional vessels of high ice class and technical means for spills response in ices. The methodological basis for determining the response time to marine oil spills in the Polar waters is laid down in the Polar Code, documents of the Maritime Safety Committee of the International Maritime Organization and documents of the Arctic Council, but their application is determined only by the hydrometeorological and geographical conditions at the place of the accident liquidation. Despite their broad and practical focus, the proposed approaches are only of a general methodological nature, which does not take into account the peculiarities of navigation in the waters of the Northern Sea Route, its length and zoning. The developed methodology largely overcomes these limitations and allows, at a qualitative level, to zone the waters of the Northern Sea Route according to three classification criteria. Two model examples are provided in the paper. The first example assumes that shipping occurs only in the western part of the Northern Sea Route, i. e. in the Kara Sea, the Ob Bay and the Yenisei Gulf, and in the eastern sector, shipping is completely absent; the second example assumes that navigation occurs throughout the entire water area. For each option under study, the entire water area is zoned according to the level of readiness, which is assessed as “high”, “medium” and “low” and depends on the presence of icebreakers and multifunctional vessels in the area. In the future, this methodology can be supplemented by an assessment of other factors, such as the influence of hydrometeorological conditions, ice conditions, navigation risks, forecasting the intensity of shipping and the selection of the necessary technical means for oil and petroleum product spills response.