The objective of the research was to study the nootropic effects of photochromotherapy using narrow-band optical radiation (PCT NBOR) of 530 nm wavelength in combination with the standard medical and psychological therapy in cognitive impairments rehabilitation in patients with focal brain lesions.
 Materials and methods. The rehabilitation outcomes in 141 patients with cognitive impairments due to focal brain lesions were studied. Patients were subdivided into two groups: 90 patients of the control group were treated with the standard nootropic medications and neuropsychological procedures; 51 patients of the main group were additionally treated with PCT NBOR of 530 nm wavelength transorbitally and in the neck-collar zone. The dynamics of the score increase according to Rivermid, Karnovsky, Roshina, MMSE, mRS, HDRS, SF-36 scales were analyzed.
 Conclusion. PCT NBOR of 530 nm wavelength has advantages in restoring the functional state, attention, counting, reading, and speech intrinsic to the ischemic brain damage compared to the standard cognitive rehabilitation program. In the patients with hemorrhagic stroke PCT NBOR of 530 nm wavelength has no significant effect on cognitive functions; however it improves the general functional state.