Abstract
Betahistine and Piracetam are routine drugs in neurological practice, which are used to correct cerebral circulation disorders. The clinical efficacy of these drugs can be caused not only by neuro-, but also by endotheliotropic action. In this review, the main information on the potential mechanisms for the implementation of vasoprotection, including metabolic, NO-ergic, anti-inflammatory and other components of the action are discussed. Betahistine as histamine receptors type 3 antagonist and histamine receptors type 1 and 2 agonist has a positive effect on cerebral and systemic hemodynamics, and due to anorexigenic action and the ability to stimulate lipolysis can ameliorate dyslipidemia. Piracetam, along with a nootropic effect, contributes to the correction of mitochondrial dysfunction, increases the fluidity of membranes and has antiplatelet properties. Both drugs suppress the synthesis of pro-inflammatory cytokines and increase the expression of endothelial NO synthase.
Highlights
PIRACETAM AND BETAHISTINE: POSSIBLE MECHANISMS OF ENDOTHELIOPROTECTION Solgalova A.S., Soldatov V.O., Pershina M.A., Pokrovskaya T.G
Along with a nootropic effect, contributes to the correction of mitochondrial dysfunction, increases the fluidity of membranes and has antiplatelet properties. Both drugs suppress the synthesis of pro-inflammatory cytokines and increase the expression of endothelial NO synthase
Накопленный клинический опыт свидетельствует о наличии у пирацетама и бетагистина положительного действия в отношении церебрального кровотока, но их воздействие на периферическую гемодинамику и процессы атеротромбогенеза могут служить предметом дальнейшего изучения
Summary
PIRACETAM AND BETAHISTINE: POSSIBLE MECHANISMS OF ENDOTHELIOPROTECTION Solgalova A.S., Soldatov V.O., Pershina M.A., Pokrovskaya T.G. Betahistine and Piracetam are routine drugs in neurological practice, which are used to correct cerebral circulation disorders. Поиск привел к обнаружению гистамина и описанию таких его фенотипических эффектов, как вазодилатация, повышение тонуса гладкой мускулатуры внутренних органов, а также положительное хроно- и инотропное действие [15].
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