Conducting adequate therapy for iridocyclitis (uveitis) remains an urgent problem in patients with ulcerative colitis (UC) due to the development of this complication in almost every fifth of them. Purpose. To present a clinical case of acute iridocyclitis (AI) in a patient with UC after suffering an acute respiratory disease (ARI) accompanied by a recurrence of Herpes labialis. Material and methods. Examination of a patient at the stage of remission of UC, who applied on the 5th day of the disease with a clinic of acute iridocyclitis and Herpes labialis after acute respiratory infections, suggested an etiological or trigger role of the herpes simplex virus in the development of inflammation in the choroid. Results. Conducting complex therapy with the inclusion of the drug valaciclovir led to the relief of clinical symptoms of OI already on the 16th day of the disease and increased visual acuity. Conclusion. Supplementing the treatment of acute iridocyclitis, which developed against the background of a relapse of a latent herpes infection in a patient with chronic UC in remission, with an antiherpetic drug is etiopathogenetically substantiated to achieve good visual results. Key words: acute iridocyclitis, nonspecific ulcerative colitis, herpes infection