The mechanisms underlying damage in high-performance polymer nanocomposites are remarkably affected by hygrothermal conditions. In this study, we develop a phase-field formulation to investigate the influence of hygrothermal conditions on the nonlinear viscoelastic fracture behavior of epoxy resins and their nanocomposites at finite deformation. For this, the Helmholtz free energy, capturing the effect of temperature and moisture and nanoparticle contents, is defined based on an additive decomposition of the energy into an equilibrium, a non-equilibrium, and a volumetric contribution with different definitions under tensile and compressive loading. The coupled displacement phase-field problem is solved using a quasi-Newton monolithic algorithm and a staggered solution scheme. Numerical examples show that the monolithic algorithm is more efficient. Simulations are performed to investigate the effect of temperature, deformation rate, and moisture content on the force–displacement response of boehmite nanoparticle/epoxy samples in benchmark numerical problems. Comparing numerical predictions and experimental data for compact-tension tests shows good agreement at different nanoparticle contents. Also, the model’s capability to predict fracture patterns is evaluated using simulations of single-edge notched nanocomposite plates under tensile and shear loading.