This paper first presents a CRTS III track structure (TS) model specifically designed for curved sections, highlighting its adjustable superelevations feature that enhances adaptability to various high-speed railway curve profiles. The model considers the distribution of steel bars within the TS, concrete damaged plasticity, as well as contact nonlinearity. Afterward, the intricate impacts of longitudinal uneven subgrade settlement (LUSS) position (7 positions), amplitude (5–30 mm), wavelength (5–30 m), and TS superelevation (15–175 mm) on structural damage, stress, deformation, and interlayer gap are studied. The findings reveal that: 1) Under different LUSS positions, the concrete base (CB) experiences the most severe damage, particularly on its thick side. For the TS with 175 mm superelevation, in the wavelength range of 10–20 m, the maximum damage value of CB exceeds 0.9 when LUSS amplitude reaches 20 mm. With the movement of LUSS position, the main damage position of CB changes obviously. When the concrete stress reaches the tensile strength, the steel bars located in adjacent positions progressively assume the primary role in load-bearing. 2) The influence of LUSS on TS deformation and interlayer gap is inevitably associated with the distance between settlement center and expansion joints. Interlayer gaps vary among structural components, which are primarily distributed near settlement center, expansion joints, and settlement edges. 3) As the amplitude increases, both CB and self-compacting concrete layer (SCCL) damage are aggravated. Increasing wavelength initially causes damage to increase, then decrease, and 10–20 m is the most unfavorable wavelength range for most cases. 4) The effect of superelevation on TS damage is complex, varying with structural components and settlement characteristics. In most cases, as superelevation increases, the damage to CB increases, whereas the deformation decreases.