Noni Fruit Research Articles

노니 열매가루 첨가가 돈육 패티의 냉장저장 중 이화학적 품질에 미치는 영향

This study examined the effects of noni (Morinda citrifolia L.) fruit powder on the physicochemical properties of pork patty during cold storage. Four samples were collected and grouped as follows: S0 (control, without noni fruit powder), S1 with 0.5% noni fruit powder, S2 with 1.0 noni fruit powder, and S3 with 1.5% noni fruit powder. The water holding capacity, cooking loss, color, pH, volatile basic nitrogen (VBN) content, thiobarbituric acid reactive substances (TBARS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity were determined for the pork patty as the physicochemical properties. The water holding capacity of S0 was significantly higher than that of S2 and S3 on day 7. The cooking losses of S0 and S1 were significantly lower than those of S2 and S3 on day 7. The L-value decreased according to the increased amount of the noni fruit powder during cold storage. The a-value decreased during storage, and S1 was highest on day 10. The b-value was not changed during storage days and increased according to the increased amount of the noni fruit powder. The pH decreased, and S3 was lowest during storage days. The VBN content and TBARS increased, and S0 was highest during storage days. The DPPH radical scavenging activity decreased, and S3 was highest during storage days. These results suggest that noni fruit powder can be used as a natural antioxidant to retard lipid and myoglobin oxidation in pork patty during cold storage.

Effects of pretreatment and air drying temperature on Noni fruit powder.

The plant Morinda citrifolia L. (Noni) has been the subject of several recent research due to its positive impact on the treatment and prevention of a variety of diseases. Noni fruits contain a variety of phytochemicals, including flavonoid, polyphenol, and triterpenoid saponin. This study aimed to determine the best pre-treatment (including blanching, soaking in ascorbic acid solution and metabisulfite solution) and air-drying temperature (50, 60, 70, and 80°C) to maximize the total polyphenol content (TPC), flavonoid content (TFC), and triterpenoid saponin contents (TSC) of the resultant Noni fruit powder. The results revealed that pre-soaked Noni fruit samples in ascorbic acid or metabisulfite solution before air-drying at 60°C were beneficial in preserving TPC, TFC, and TSC. TPC, TFC, and TSC losses increased as drying temperatures (70 and 80°C) rose. The optimum sample was held at five different relative humidity conditions until they attained weight equilibrium. The results indicated that the sorption isotherm curve of the Noni powder was the sigmoid shape and fitted with the BET and GAB models.

Kinetic Study of Subcritical Water Extraction of Scopoletin, Alizarin, and Rutin from Morinda citrifolia.

Noni fruits (Morinda citrifolia) are a source of phenolic bioactive compounds (scopoletin, alizarin, and rutin), which have antioxidant, antimicrobial, anticancer, and anti-inflammatory activities. In this study, subcritical water was applied to determine the extraction yields and kinetics of phenolic compounds from noni fruits. The scopoletin and alizarin yields increased with the increase in temperature from 100 to 140 °C, while that of rutin increased up to 120 °C and then decreased at 140 °C. The yields of all the compounds rapidly increased from 1 to 2 mL/min and then slightly up to 3 mL/min of water flow rate. The extraction kinetics were assessed using two mathematical models. The two-site kinetic desorption model had a better fit for all experimental conditions throughout the extraction cycle and best described the extraction kinetics of phenolic compounds from noni fruits. The diffusion coefficients of scopoletin and alizarin at 140 °C and 3 mL/min were 3.7- and 16.2-fold higher than those at 100 °C and 1 mL/min, respectively. The activation energies of alizarin were 2.9- to 8.5-fold higher than those of scopoletin at various flow rates. Thus, subcritical water could be an excellent solvent with higher extraction yields and shorter extraction times using an environmentally friendly solvent.

The effects of heat treatment and modified atmosphere packaging on the storage stability of noni (Morinda citrifolia L.) fruit

Noni fruit (Morinda citrifolia L.) is a herbal remedy known for its therapeutic and nutritional value. However, it is perishable and subject to rapid postharvest deterioration that shortens its shelf life during storage. Therefore, this study investigated whether hot water dipping (HWD; 60°C, 1 min) and Modified Atmosphere Packaging (MAP; carbon dioxide and nitrogen) could prolong noni's shelf life. The noni physicochemical properties such as colour, firmness, weight loss, total soluble solids, titratable acidity and scopoletin content were monitored during six days of storage at room temperature. During storage, the noni skin colour changed from greenish-yellow to translucent yellow, but HWD storage was stopped on day 2 due to black spots' formation. The reduction of weight loss was significantly lowest in both MAP treatments (1.39–1.74%). Among these, N2-based had a significantly higher scopoletin content (27.12 mg/g) and firmness (0.8 N) compared to CO2-based, suggesting that it was the most effective postharvest treatment to efficiently prolong the shelf life and retained the quality and stability of noni during storage.

Biocontrol Ability and Mechanism of a Broad-Spectrum Antifungal Strain Bacillus safensis sp. QN1NO-4 Against Strawberry Anthracnose Caused by Colletotrichum fragariae.

Strawberry is a very popular fruit with a special taste, color, and nutritional value. Anthracnose caused by Colletotrichum fragariae severely limits fruit shelf life during post-harvest storage. Use of traditional chemical fungicides leads to serious environment pollution and threatens food safety. Biocontrol is considered as a promising strategy to manage the post-harvest fruit diseases. Here, strain QN1NO-4 isolated from noni (Morinda citrifolia L.) fruit exhibited a high antifungal activity against C. fragariae. Based on its physicochemical profiles and phylogenetic tree of the 16S rRNA sequence, strain QN1NO-4 belonged to the genus Bacillus. The average nucleotide identity (ANI) calculated by comparing two standard strain genomes was below 95–96%, suggesting that the strain might be a novel species of the genus Bacillus and named as Bacillus safensis sp. QN1NO-4. Its extract effectively reduced the incidence of strawberry anthracnose of harvested fruit. Fruit weight and TSS contents were also maintained significantly. The antifungal mechanism assays indicated that the extract of the test antagonist inhibited mycelial growth and spore germination of C. fragariae in vitro. Cells of strain QN1NO-4 demonstrated the cytoplasmic heterogeneity, disappeared organelles, and ruptured ultrastructure. Notably, the strain extract also had a broad-spectrum antifungal activity. Compared with the whole genome of strain QN1NO-4, several functional gene clusters involved in the biosynthesis of active secondary metabolites were observed. Fifteen compounds were identified by gas chromatography–mass spectrometry (GC-MS). Hence, the fruit endophyte B. safensis sp. QN1NO-4 is a potential bio-agent identified for the management of post-harvest disease of strawberry fruit.

Drosophila sechellia: A Genetic Model for Behavioral Evolution and Neuroecology.

Defining the mechanisms by which animals adapt to their ecological niche is an important problem bridging evolution, genetics, and neurobiology. We review the establishment of a powerful genetic model for comparative behavioral analysis and neuroecology, Drosophila sechellia. This island-endemic fly species is closely related to several cosmopolitan generalists, including Drosophila melanogaster, but has evolved extreme specialism, feeding and reproducing exclusively on the noni fruit of the tropical shrub Morinda citrifolia. We first describe the development and use of genetic approaches to facilitate genotype/phenotype associations in these drosophilids. Next, we survey the behavioral, physiological, and morphological adaptations of D. sechellia throughout its life cycle and outline our current understanding of the genetic and cellular basis of these traits. Finally, we discuss the principles this knowledge begins to establish in the context of host specialization, speciation, and the neurobiology of behavioral evolution and consider open questions and challenges in the field.

Noni (Morinda citrifolia L.) Fruit Polysaccharides Regulated IBD Mice Via Targeting Gut Microbiota: Association of JNK/ERK/NF-κB Signaling Pathways.

Inflammatory bowel disease (IBD) is a disease characterized by intestinal inflammation with immune dysregulation and intestinal microecological imbalance. In a dextran sulfate sodium salt (DSS)-induced IBD mouse model, noni (Morinda citrifolia L.) fruit polysaccharides (NFP) with homogalacturonan and rhamnogalacturonan-I domain decreased the concentration of serum LPS, TNF-α, and IL-17 by 84, 42, and 65%, respectively. It was abolished when intestinal microbiota were depleted by antibiotics. Sequencing analysis of gut microbiota showed an attenuated disruption of the microbial composition in the DSS+NFP group. Targeted metabolomic analysis revealed that NFP upregulated the content of acetic acid, propionic acid, and butyric acid by onefold but reduced isobutyric acid and isovaleric acid contents. NFP also inhibited JNK, ERK, and NF-κB phosphorylation of IBD mice. Taken together, the mechanism of NFP alleviating IBD is related to the intestinal microecological balance to inhibit inflammatory signaling pathways. This study provides a basis for NFP as a cheap intervention for the prevention and treatment of IBD patients.

Pengaruh Komposisi Ekstrak Mengkudu (Morinda citrifilia L.) Sebagai Antibakteri Pada Shampo Herbal Berbasis Methyl Ester Sulfonat (MES)

Shampoo is a preparation that contains surfactants in a suitable form and is useful for removing dirt and grease attached to the hair and scalp so as not to harm the hair and scalp. In this study the ingredients used were noni fruit extracts and surfactants using Methyl Ester Sulfonate (MES). The purpose of this study was to analyze the effect of time when making herbal shampoo, the effect of adding noni fruit extract to the quality of shampoo. To obtain the noni fruit extract maceration process is used by using distilled water. Noni ripe fruit is cut and then blended and then added 2 liters of aquadest, evaporated in a rotary evaporator. The processing of herbal shampoo is done by the influence of the volume of noni fruit extract and time by comparison: 5 ml: (1,2,3,4) minutes, 10 ml: (1,2,3,4) minutes, 15 ml: (1, 2,3,4) minutes, 20 ml (1,2,3,4) minutes. Tests carried out pH testing, foam stability test (%), foam height test (cm), viscosity (cps) and anti-bacterial test (colony, cm2). Based on the research results obtained high foam with 88 mm, foam stability 92.04%, Viscosity 2.31, antibacterial 31.7 colonies / cm2, and pH 4.2. The research results are expected to meet Indonesian National Standards.

Sensory Quality Analysis and Business Feasibility Study of Coffee (Coffea) and Noni (Morinda citrofolia) Syrup as an Alternative to Functional Drinks

Coffee has enormous potential to be developed into a food product. In addition, noni fruit as a local Indonesian fruit also has the potential as a source of functional food. Research has been carried out with the aim of analyzing the sensory quality and business feasibility of coffee syrup substituted with noni fruit. The study used a factorial design with 1 (one) treatment factor, namely variations in the composition of coffee and noni ((100; 0); (95: 5); (90:10); (85:15); (80:20)). The analysis carried out included analysis of yield, viscosity, sensory test and business feasibility of noni coffee syrup. The results showed that the less coffee used, the lower the yield, viscosity and the panelists' preference for syrup, with the best treatment being 85 grams of coffee and 15 grams of noni, with the panelist's preference for color 3.46 (like) , aroma 3.40 (like) and taste 3.51 (like), and yield 78.05 and viscosity 114.70 cp. The feasibility analysis of the noni coffee syrup business shows that the noni coffee syrup with a treatment of 85 grams of coffee and 15 grams of noni produces an r / c ratio of 1.3, so this business is feasible to develop

Filthy fruit! Confirmation bias and novel food

Fruit and vegetable consumption is worldwide too low, resulting in poor diet quality and health-related problems. A cognitive factor that might contribute to this low consumption is confirmation bias. Confirmation bias has been established in anxiety research and comprises the tendency to search for reinforcing negative information, while ignoring counter attitudinal information. If applicable to food, asking for negative food information reinforces the negative attitude and decreases the willingness to try (novel) food. The aim of the current study was twofold. First, to examine if confirmation bias translates to food stimuli. Second, to investigate if this bias is exaggerated in persons with higher levels of food neophobia. To this end, 117 participants (age M = 21.45, SD = 4.48) carried out an online study. They filled in the food neophobia scale (FNS) and performed a search for additional information scale (SAIS) task. Four novel fruits were used, two looking tasteful (pomelo and rose apple) and two looking non-tasteful (black sapote and noni fruit). Participants rated their willingness to eat these fruits and subsequently could indicate how eager they were to receive positive or negative information regarding that fruit. The results indicated that the participants were more willing to try the tasteful looking fruits than the non-tasteful. Additionally, higher levels of food neophobia coincided with less willingness to eat all fruits. Confirmation bias was observed, more negative information was requested for the non-tasteful than for the tasteful fruits. This bias was not related to levels of food neophobia. These results are important as confirmation bias might make people even more negative towards novel foods and could contribute to even less fruit and vegetable consumption, especially when they look less appetizing.

MicroRNAs Involved in the Therapeutic Functions of Noni (Morinda citrifolia L.) Fruit Juice in the Treatment of Acute Gouty Arthritis in Mice Induced with Monosodium Urate.

We investigated the functions of microRNAs in the therapeutic effects of noni (Morinda citrifolia L.) fruit juice on mouse models of acute gouty arthritis induced with monosodium urate (MSU). Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-α). Based on the next-generation sequencing technology, a total of 3896 microRNAs (234 known and 3662 novel) were identified in mice treated with noni fruit juice. A large amount of differentially expressed miRNAs were identified in the noni fruit juice group, suggesting the significant effects of noni fruit juice on the mice with acute gouty arthritis, while the different patterns of change in the numbers of both upregulated and downregulated miRNAs in both noni fruit juice and positive control groups indicated that the mice of acute gouty arthritis may be regulated by differential mechanisms between the treatments of noni fruit juice and colchicine. The target genes of microRNAs involved in the pathogenesis and pathology of acute gouty arthritis in mice were identified and further annotated by both Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Our results revealed the therapeutic effects of noni fruit juice on acute gouty arthritis in mice with a group of microRNAs involved in the pharmacological mechanisms of noni fruit juice, providing scientific evidence to support both the agricultural cultivation and pharmacological significance of noni plants.

Antibacterial Effectiveness of Morinda Citrifolia L. Extract on Salmonella Typhi Bacteria Using Serial Dilution Method with 15 - 60 Minutes Contact Time

Noni fruit (Morinda citrifolia L.) contains phenol and flavonoid compounds which can function as natural antibacterials with the highest phenol content obtained from ripe Morinda citrifolia L. fruit. Phenolic compounds have been widely studied as disinfectants against broadspectrum antibacterials, namely Gram-positive and Gram-negative bacteria. This study aims to determine the effectiveness of the inhibitory power of ripe Morinda citrifolia L. extract against the growth of gastroenteritis-causing bacteria with the serial dilution method at concentrations of 40%, 60%, 80%, and 100% with variations in a contact time of 15 ', 30', 45 'and 60'. Then proceed with a concentration of 10%, 20%, 30%, and 40% with the same variation in contact time. The results showed that all concentrations of ripe Morinda citrifolia L. extract and the variation in contact time could inhibit the growth of S.Typhi bacteria with a minimum inhibitory concentration at a concentration of 10% with a contact time of 15 minutes. It needs to be continued with a toxicity test before it is used in the community.

NARRATIVE REVIEW TANAMAN YANG BERPOTENSI SEBAGAI IMMUNOMODULATOR

COVID-19 (Coronavirus Disease-2019) is an infectious disease caused by the acute respiratory syndrome SARS-CoV-2. Currently, the COVID-19 disease outbreak is experienced by various countries around the world, including Indonesia. In overcoming it, there are several ways of deterrence that can be done, such as by increasing the body's immunity. During the COVID-19 pandemic, maintaining immunity is something that needs to be considered. In addition to vitamins, herbal plants that have the potential as immunomodulators can also be consumed. Therefore, through efforts to improve theimmune system, this review aims to obtain plants that have the potential as immunomodulators to enhance the immune system during the COVID-19 pandemic. The research method in the review used journals available online at Google Scholar with Sinta or Garuda accredited journals. The main focus of this review is herbal plants that have a role as an immunomodulator that can improve the body's immune system. The journals used are journals published in 2011-2021 with inclusion criteria, namely using Indonesian or English about plants that have the potential as immunomodulators, then the journalsobtained are analyzed. The results obtained were 30 types of plants that have potential as immune system enhancers including Dayak Onion Tubers, Papaya Leaves, Kecombrang Fruits, Pineapple Fruits, Kesambi, Soursop Leaves, Purslane, Garlic, Dates, Celery Leaves, Andaliman, Mahkota Dewa Fruit. , Moringa, Meniran, Noni Fruit, Gotu Kola, Sambiloto, Kiseureuh, Javanese Chili, Tempuyung Leaves, Basil Leaves, Ceplukan, Seaweed, Neem Leaves, Red Betel Leaf, Salam Leaves, Guava, Turmeric, Lime and Red Ginger Rhizome with compounds that act as flavonoids, alkaloids, saponins, triterpenoids,xeronin, tannins, quersentin, -tocopherol, lycopene, catechins, diterpenoids, deoxyandrographolide, andrographolide, epicatechin isothiocyanate and curcumin.
 Keywords: COVID-19, Potency of Immumodulator Plants, Flavonoids

PENYULUHAN MANFAAT PERASAN BUAH MENGKUDU DALAM MENURUNKAN HIPERTENSI

Hypertension is a state of increasing blood pressure beyond normal limits. Hypertension is often accompanied by symptoms that cause discomfort to the sufferer. The symptoms experienced are headache, palpitations, difficulty breathing, fatigue and blurred vision. To lower blood pressure to reduce the symptoms felt can be done by using noni fruit. Iuni action is very practical, cheap and easy and can be done by everyone. This action is still rarely performed by patients in the community when experiencing increased blood pressure. The service was carried out on 15 people who had hypertension. The service implementation team provided training on how to process noni in the work area of ​​the Patumbak Health Center. The team made home visits as an evaluation of the service program. The outreach activities went smoothly. There were 5 patients who asked about the counseling material. The importance of conducting regular outreach activities to the community about other complaints they suffer to improve their health status.

Diversity and community structure of endophytic Bacillus with antagonistic and antioxidant activity in the fruits of Xisha Wild Noni (Morinda citrifolia L.)

Noni (Morinda citrifolia L.) is a tropical crop with strong antibacterial, antioxidant and other abilities, and its fruit has a strong potential for adjuvant treatment of diseases. This study aimed to explore the dynamic change of endophytic bacteria in Noni fruit at different stages and the correlation between the antagonistic and antioxidant activity of the Bacillus which was screened and the change of the host's growth stage. In this study, though the high-throughput sequencing technology (HTS), 106 endophytic bacteria species were found in A, B, C, D, E and F stages of Noni fruit, among which the dominant group were Pantoea (0.3%–20.9%), and Candidatus_Uzinura (2.3%–35.2%) etc. The endophytic bacteria were isolated by culture-dependent method. Through their antagonistic experiments on Staphylococcus aureus and Escherichia coli, the results of 16S polyphasic taxonomic identification showed that the 34 antagonistic strains belonged to Bacillus. Five species of these Bacillus were identified by gyrA polyphase taxonomy, including Bacillus subtilis (76% of all Bacillus), Bacillus licheniformis (9%), Bacillus amyloliquefaciens (6%), Bacillus velezensis (6%) and Bacillus mojavensi (3%), and the RAPD showed these Bacillus are no signs of stable passage. In C, D, E and F stages, the average total antioxidant activity of Bacillus endophytic antagonists against Noni was 7.812 U/mL, 8.144 U/mL, 7.817 U/mL and 7.144 U/mL, which was much higher than that of Noni fruit, and antioxidant activity of Noni juice and Bacillus bacterial liquid vary with host's growth period showed the same trend, both rose slowly at first, and reached the highest in period E, then declined slightly in period F, it showed that the antagonistic Bacillus of Noni had synergistic function with Noni fruit. This study clarified the relationship of function between Noni fruit and endophytic bacteria, and laid a foundation for future study on the dynamic change of endophytic flora succession and efficacy.

Utilization Of Medical Plants In Hypertension Patients In Amparita Puskesmas, Tellu Limpoe District, Sidrap District

Background: Hypertension is the main risk factor for cardiovascular disease which is the highest cause of death, especially in Indonesia, for the treatment of hypertension, apart from using modern medicine, traditional medicine can also be used. In recent years, traditional medicine has become increasingly popular among the people as is the case with modern medicine. The high public interest in traditional medicine is also due to the low cost and easy to use itself. Purpose: to determine the utilization or use of medicinal plants in patients with hypertension at the Amparita Health Center, Tellu Limpoe District, Sidenreng Rappang Regency. Method: This type of research is a descriptive research. The sampling technique in this study used the purposive sampling technique. This research was carried out at the Amparita Health Center, Tellu Limpoe District, Sidenreng Rappang Regency from July to August 2019. Results: Medicinal plants used by people with hypertension were taken once a day, twice a day and 3 times a day. Conclusion: Medicinal plants that are used or used by people with hypertension in the working area of ​​the Amparita Health Center are soursop leaves, bay leaves, celery leaves, cucumbers, garlic, sweet starfruit, wuluh starfruit and noni fruit. The processing method is by boiling, blending and chewing or eating directly from the paper

Molecular docking study to reveal Morinda citrifolia fruits as a novel EGFR inhibitor for anticancer therapy

Lung cancer is the leading cause of cancer death in the world and represents a major public health burden. Epidermal Growth factor Receptor (EGFR) as targets for hormonal cancer therapy shown to decrease cell proliferation and tumor growth. Indonesian People usually consumed Health tonic from Morinda citrifolia fruits known as Noni juice. Morinda citrifolia fruits have been known for a therapeutic benefit such as antidiabetic, anticancer and pain. This study aims to investigate molecular interaction between Morinda citrifolia fruits compound with the active site of ERb antagonist and EGFR tyrosine kinase inhibitor for lung cancer therapy. Morinda citrifolia fruit compounds were retrieved from Dr. Duke’s Phytochemical and Ethnobotanical Databases (https://phytochem.nal.usda.gov) meanwhile ligand was retrieved from PubChem and 3D protein from PDB. The first step was ligand and receptor preparation before docking process using VegaZZ. Molecular docking process was calculated using Autodock Vina in PyRx v.0.8. The Result of this study reveals 12 major compounds of Morinda citrifolia fruits Anthraquinone, Benzo acid, Beta carotene, Eugenol, Limonene, Quercetin, Rutin, Scopoletin. Based on the molecular binding analysis, Quercetin are best docking complex with EGFR. The result showed that Quercetin is the best antagonist for EGFR indicated by the highest affinity (-8.6 Kcal/mol). It can be concluded that Quercetin in Morinda citrifolia is main compound in noni fruits that act as anticancer agent.

Cytotoxicity and antioxidant activity of combination noni (Morinda citrifolia) and periwinkle (Catharanthus roseus) extracts as anticancer candidate

The research of herbal compounds and conventional anti-cancer compounds has been widely explored. Noni fruits are well known as an herbal medicine for cancer. In the meantime, periwinkle develops two strong alkaloids, vinblasts and vincristins. In this study, we evaluate the cytotoxicity and antioxidant activity of a combination of Noni fruits (Morinda citrifolia) and Periwinkle Madagaskar leaves (Catharanthus roseus), which in this study called Moriseus extract as an anticancer drug candidate. Noni fruit ethanol extracts and periwinkle leaf. DPPH tests were used to assess the antioxidant of the extracts. The cytotoxicity of the MCF-7 breast cancer extracts was performed using the MTT procedure. In a nutshell, cells were seeded in 96 well plates at various extract concentrations. Cells were incubated for 24 hours and tetrazolium salt solution measured their viability. After 2 h medium aspiration, DMSO was applied and the absorbance with an ELISA plate reader was estimated at 540 nm. Cytotoxicity was considered when a decrease in cell survival of more than 50 percent was observed. Combination Noni (M. citrifolia) and Periwinkle (C. roseus) extract significantly decreased the viability of MCF7 cells in a concentration-dependent manner and have IC value 53.84 ppm with the scavenging activity of combination extract are 69.91%. Combination M. citrifolia and C. roseus extract have strong cytotoxicity and antioxidant activity which could be high potential as a candidate of anticancer drug.

DECREASE HYPERTENTION THROUGHT GIVING NONI FRUIT JUICE

Hypertension in elderly people in Indonesia is included in the 10 countries with the highest prevalence in the world. This disease is controlled to prevent further complications. The juice of noni (morinda citrifolia) fruit can be used as a provision for lowering blood pressure in elderly people with hypertension in Durin Tonggal village, Pancur batu sub-district. Objective to determine the effect of noni juice on lowering blood pressure in patients with hypertension. A Quasy Experiment study design with a population of 60 elderly with hypertension. The sample was taken by purposive sampling technique of 60 people divided into 15 people. The research instrument was the observation sheet. Data were analyzed with ∝0.05. The results of the experimental group research showed that the average pre TDS was 150.00mmHg, pre-TDD 90.00mmHg and TDS 200.00mmHG, and TDD 150.00mmHg. The results of the analysis and statistical tests obtained a systolic BP of 0.000 and a diastolic of 0.002 with a P value of <0.05, so Ho is rejectedmeaning that noni juice is effective in reducing blood pressure in the elderly.

DECREASE HYPERTENTION THROUGHT GIVING NONI FRUIT JUICE

Hypertension in elderly people in Indonesia is included in the 10 countries with the highest prevalence in the world. This disease is controlled to prevent further complications. The juice of noni (morinda citrifolia) fruit can be used as a provision for lowering blood pressure in elderly people with hypertension in Durin Tonggal village, Pancur batu sub-district. Objective to determine the effect of noni juice on lowering blood pressure in patients with hypertension. A Quasy Experiment study design with a population of 60 elderly with hypertension. The sample was taken by purposive sampling technique of 60 people divided into 15 people. The research instrument was the observation sheet. Data were analyzed with ∝0.05. The results of the experimental group research showed that the average pre TDS was 150.00mmHg, pre-TDD 90.00mmHg and TDS 200.00mmHG, and TDD 150.00mmHg. The results of the analysis and statistical tests obtained a systolic BP of 0.000 and a diastolic of 0.002 with a P value of &lt;0.05, so Ho is rejectedmeaning that noni juice is effective in reducing blood pressure in the elderly.