In practical engineering, uncertainties in thermoelectric power generation arise from various factors such as material properties, geometric dimensions, assembly processes, and operational fluctuations of the thermoelectric components. Addressing subjective and objective uncertainties in the design parameters of multi-stage thermoelectric generators (TEGs), this study establishes a robust TEG model incorporating non-equilibrium thermodynamics. Fuzzy and stochastic theories are employed for uncertainty representation, and a variance-based global sensitivity analysis is conducted. The results indicate that the uncertainties in the design variables have varying effects on the output responses of the three-stage TEG. Among them, the temperature of the hot and cold sources has the most significant impact on the output responses(STHP: 0.5018, STLP:0.2199, STHη: 0.5436, STLη: 0.3336), Parameters like Seebeck coefficient, thermal resistance, thermal conductivity, and operating current exhibit relatively minor effects. The coefficient of variation of the output response varies consistently with changes in the standard deviation or coefficient of variation of input variables, following a similar order as the sensitivity indicators. The variations in the distribution parameters of the key design variable, i.e., the temperature of the hot and cold sources, do not affect the sensitivity index rankings of the variables concerning the system output responses. As the distribution parameters of the hot and cold source temperatures gradually increase, the sensitivity indices of the design variables to the system output responses exhibit different trends, indicating a change in the degree of sensitivity to the variations in distribution parameters of the design variables. Optimization based on global sensitivity analysis enhances power output by 43.37 %, reaching a maximum of 11.37 W under constraints compared to the original 7.93 W. This research provides guidance for designing and optimizing thermoelectric power systems under mixed uncertainties.