Non-tobacco Products Research Articles

Oral tobacco-free nicotine products: Quality and safety during storage

Oral non-tobacco nicotine products have gained enormous popularity in recent years. The countries of the Eurasian Economic Union also produce and sell this type of innovative but poorly studied goods. As a result, the safety profile and quality of such products as nicotine poaches require urgent comprehensive research. This study featured the changes in quality of nicotine poaches during storage, i.e. nicotine content, water activity, and microbiological index. The research featured nicotine poaches of several popular brands. The authors used standard research methods; the experiments were performed in the laboratory for chemistry and quality control, Institute of Tobacco, Makhorka, and Tobacco Products, Krasnodar, and at the Department of Bioorganic Chemistry and Technical Microbiology, Kuban State Technological University, Krasnodar. The water activity was 0.8911–0.9502 Aw at the initial stage and remained stable in most samples even after six months of storage. Velo Freeze was the only brand to show significant variations in water activity. The nicotine content was 10.115–12.950 mg/g at the initial stage. Only four samples maintained the initial values after six months of storage. The fluctuations of nicotine content were also mentioned by the manufacturer. The microbiological profile remained stable during the six months of storage and met the requirements for similar products, i.e., chewing gum and unglazed caramel. The project needs further research because the qualitative characteristics of nicotine poaches provided rather unambiguous results. Our study will help develop state standards for oral nicotine products. The results obtained will be used to formulate proposals to the organizations responsible for the future Technical Regulations of the Eurasian Economic Union for nicotine products.

Analysis of wastewater from 2013 to 2021 detected a recent increase in nicotine use in Queensland, Australia

Previous wastewater-based epidemiology (WBE) studies have reported decreasing trends of nicotine and tobacco use in Australia before 2017, but there is concern that increasing illicit use of nicotine in vaping products and illicit tobacco could reverse this progress. This study aimed to assess temporal trends of nicotine consumption and specifically tobacco consumption via wastewater analysis in a population in Australia between 2013 and 2021. One week of daily wastewater samples were analyzed every two months from February 2013 to December 2021 in a regional city serving ∼100,000 people. A total of 340 daily samples were analyzed for anabasine (tobacco specific biomarker) and nicotine metabolites, cotinine and hydroxycotinine, using direct injection method by liquid chromatography with tandem mass spectrometry. Daily consumption estimates were calculated from daily flow data, population estimates and previously reported excretion factors. Linear spline regression was performed to identify periods when significant change of slopes occurred and to evaluate the temporal trends. Tobacco use monitored using anabasine as a biomarker, showed a decreasing trend over the whole period with a higher rate of decrease during the first two years (2013-2014, 21 % decrease) compared to the later 7 years (2015-2021, 10 % decrease). Nicotine use, monitored using cotinine and hydroxycotinine, showed a downward trend between 2013 and 2018 (2013‐2014: 18 % decrease, p < 0.05; 2015‐2016: 6 % increase, p = 0.48; Feb-Dec 2017: 15 % decrease, p = 0.39) followed by a significant increase from 2018 to 2021 (40 % increase, p < 0.001). This finding suggests the increasing use of non-tobacco nicotine-based products. Additionally, the tobacco use estimate by wastewater analysis was higher than the tobacco sales data, which suggests the use of illicit tobacco in the catchment.

Tobacco products and electronic cigarettes’ legislation violations - observational study in 31 European countries, 2005–2022

BackgroundEuropean Union (EU) law regulates the manufacture, presentation, and sale of tobacco and related products in all member states. This study examined whether legislation non-compliant tobacco products and electronic cigarettes were available for sale in the European market. MethodsWe queried the EU Rapid Information System for dangerous non-food products, covering 28 current and former EU member states and 3 associated countries, also known as Rapex, for non-compliant tobacco and related products reported between 2005 and 2022. FindingsDuring the operation of the Rapex system, 183 violations were reported (six on tobacco, three on traditional cigarettes, and 174 on e-cigarettes). Insufficient product safety information was found in 86% of the reports on e-cigarettes and 74% of the refills. Violations regarding the volume of the liquid container were observed in 26% of the e-cigarette reports and 20% of the refill reports. Approximately 15% of the reported e-cigarettes and 17% of refill liquids exceeded permissible nicotine levels. More serious standard violations were recorded for refills than for e-cigarettes. Approximately one-third of Rapex system countries submitted no notifications. InterpretationE-cigarettes were the most frequently reported items in the European market of tobacco and non-tobacco nicotine products. The most common concerns were inadequate product safety information, incorrect liquid container volume, and excessive nicotine concentration. Identifying the most recognized legal infringements did not require laboratory tests and was based only on packaging and the manufacturer's declaration analysis. Further studies are necessary to corroborate whether products available in countries where no violations have been reported meet EU safety standards.

Use of tobacco, nicotine and cannabis products among students in Switzerland.

Most people who smoke cigarettes begin in their teens and teens may also be attracted to new tobacco, nicotine, and cannabis products. We describe use prevalence among upper-secondary school students in Switzerland, including daily use, of tobacco, nicotine, and cannabis products. We invited secondary school students (age 15 to 21) in two Swiss cantons to take an online survey between October 2021 and February 2022. The survey collected demographic information and asked how frequently they used tobacco products (cigarettes in commercial packages, self-rolled cigarettes, hookahs, pipes, cigars and cigarillos, tobacco heating systems, snus, snuff), non-tobacco nicotine products (nicotine pouches, e-cigarettes with and without nicotine), and cannabis products (smoking with and without tobacco, cannabis vaping). Answers were scored on a Likert scale (no use in past month, less than weekly, weekly but not daily, daily use, prefer not to say), then tabulated and reported as descriptive statistics. Of 32,614 students in the schools we contacted, 9,515 (29.2%) completed the survey; 49.5% identified as female and 48.4% as male; 9.5% were under 16, 47% were 16-17, 27.5% were 18-19, and 16% were over 19. Reported daily use was most frequent for tobacco cigarettes in commercial packages (14.2%), snus (4.1%) and cannabis smoking with tobacco (3.6%). Most participants (54.8%) reported they had used at least one product at least once within the last month. Students who used a product were most likely to smoke cigarettes, but many regularly used new tobacco, nicotine and cannabis products, though use frequency varies.

ANALYTICAL REVIEW OF THE METHODS FOR DETERMINING WATER ACTIVITY IN NON-SMOKING TOBACCO AND NON-SMOKING NICOTINE-CONTAINING ORAL PRODUCTS

The article presents an analytical review of the methods for determining the activity of water in food products. This is necessary in order to select among several methods the most suitable, which can be taken as a basis for further development of the methodology for determining water activity for non-smoking tobacco and nicotine-containing products. Water activity is an indirect indicator of microbiological contamination and is particularly important for tobacco and non-tobacco products consumed directly without burning. When water activity values are relatively high in Non-tobacco nicotine-containing products of oral type (NTNCPOT), microflora can develop. Non-tobacco nicotine-containing oral consumption products are actively marketed and are partially replacing traditional nicotine “consumption” methods. A distinctive feature of this product is its method of consumption, which is that as a result of consumption there is no process of inhaling tobacco smoke, which has a negative impact on the human body. On this basis, this product is a less dangerous alternative to smoking cigarettes. Since the products are so widespread, it is necessary to establish quality control. Water activity is not a standard indicator for controlling tobacco products, but since these products are intended for oral consumption, this indicator should begin to be defined as one of the most important for consumer safety. For non-smoking tobacco and nicotine-containing oral products, the CORESTA CRM88 method is the most appropriate. In order to develop a methodology for determining water activity and establishing the necessary values, further study of smokeless tobacco products and non-smokeless nicotine-containing oral products is needed.

CRITERIA FOR TOBACCO IDENTIFICATION FOR HOOKAH AND NON-TOBACCO MIXTURE FOR HEATING

Hookah tobacco is positioned as a “nicotine alternative” to traditional smoking, but the aerosol produced contains the same toxic components as cigarette smoke. Consumer properties and safety indicators of tobacco aerosol for hookah depend on the component composition of the tobacco mixture and the coal used. The main factor that has a physiological effect on the user of hookah tobacco or non-tobacco mixture for heating is the content of nicotine that passes into the aerosol. There is no single approach to the regulation of a segmental product, in addition, there are no standardized methods for generating and collecting aerosol. The smoking pattern on a laboratory smoking machine does not fully reflect the behavioral profile of a person, however, the quantitative composition of the aerosol obtained from machine testing can be used as input to determine the risk of the product. During the research, laboratory and analytical equipment was used: CERULEAN SM 405 linear smoking machine; "Expert-001-1(0.1)" ionomer, SF-16 spectrophotometer, Crystal 2000M / HP 5890 Series 11 chromatograph with FID. Experimental data have been obtained to evaluate consumer and physic-chemical parameters, including organoleptic evaluation, the content of nicotine, glycerin and propylene glycol in samples of tobacco for hookah / non-tobacco mixture for heating. The method of machine generation and collection of the solid-liquid phase of an aerosol has been standardized, which makes it possible to obtain reliable data on the quantitative content of nicotine in the produced aerosol. The content of nicotine in the samples is 0.1–1.9%, the transition of nicotine into the produced aerosol is insignificant. The microscopy method for determining the structure of the base (carrier) in combination with the determination of consumer properties (organoleptic evaluation, total content of glycerol and propylene glycol, pH and nicotine content) are tools for identifying tobacco or non-tobacco hookah products.

The differential categorization of novel products by institutional actors across places: The case of e-cigarettes in the US and the UK

Adopting a place-based approach to categorization, we explore how and why institutional actors in the US and the UK have categorized e-cigarettes differently, namely as tobacco products in the US and as non-tobacco consumer products in the UK. Our inquiry identified the historical contingencies generating two different perspectives informing these differential categorizations—precautionary in the US and harm-reduction in the UK. Embedded in these two perspectives are different future imaginaries to address the harm from cigarettes and e-cigarettes to the different population groups at risk (i.e. smokers versus youth and non-smokers). Data also show institutional actors across the two countries offering justifications for or against e-cigarettes by deploying facts from different scientific research. We theorize these findings and conclude the article by discussing the importance of adopting a place-based approach to categorization.

Shadow Market of Non-Smoking Nicotine Products in Russia (Assessment of the Consequences of State Regulation)

The subject of the study is the background and consequences of the adoption of the Federal Law «On Amendments to Certain Legislative Acts of the Russian Federation on Protecting the Health of Citizens from the Consequences of the Consumption of Nicotine-containing Products» № 303-FZ (July 31, 2020). This law introduced a complete ban on the wholesale and retail trade in Russia of tobacco-free nicotine products intended for chewing, sucking and sniffing. At the same time, the legislator did not impose bans on the production and import of relevant products into the territory of the Eurasian Economic Union. It is established that the corresponding ban was introduced without assessing the criminological, legal and economic consequences, as well as without empirical studies in Russia and other member states of the Eurasian Economic Union. The reason for the introduction of the ban was the facts of poisoning of teenagers with nicotine packs (nicpack) - products that look like sweets containing nicotine and sweeteners. The immediate consequence of the introduction of a ban on the sale of non-tobacco nicotine products was the termination of state control over the circulation of such products by Rospotrebnadzor because this authority does not exercise control functions in relation to products withdrawn from circulation. Contrary to expectations, the number of facts of illegal circulation of tobacco-free nicotine products revealed by the customs authorities and internal affairs authorities did not increase, and most of the EAEU member states did not introduce similar bans. At the same time, the opportunities for acquiring niсpacks (including by teenagers) using Internet resources and courier delivery were not restricted. The main negative consequence of the introduction of a complete ban on the sale of non-tobacco nicotine products, according to the authors of the article, was the creation of additional conditions for the growth of the corresponding shadow market and the criminalization of the illegal circulation of such products. To solve the problem, the authors propose a set of organizational and legal measures aimed at improving the efficiency of monitoring and preventing the illegal circulation of tobacco-free nicotine products, including the development of a number of national standards, amendments to the Code of Administrative Offenses of the Russian Federation and the Criminal Code of the Russian Federation.

Is tobacco a driver of footfall among small retailers? A geographical analysis of tobacco purchasing using electronic point of sale data

ObjectiveOpponents of policies designed to reduce tobacco retail availability argue that tobacco products are a vital driver of ‘footfall’ in small retailers. This study considers the changing contribution of tobacco...

Prevention of initiation of smokeless tobacco (SLT) consumption among rural children

Background: India Global Youth Tobacco Survey 2019 observed that 8.5% of the young age group (13-15 years) consume tobacco (9.6 % are boys and 7.4 % are girls). No interventional studies among adolescents were conducted before the initiation of the SLT use. Aims &amp; Objectives: To estimate the prevalence of consumption of tobacco and non-tobacco products and to provide school based interventions to bring behavioral changes. Materials and Methods: An interventional study was carried out in Primary Schools. For estimation of the prevalence of tobacco and non tobacco use all the students of 1st to 5th while for the interventions, 4th and 5th standard were selected. Baseline data and change in the behavior at the end of one year was collected. FGD with key informants were also conducted. Descriptive Statistics was conducted. Results: The prevalence of smokeless tobacco consumption and non-tobacco product was found to be 1.3% and 36.5% respectively. After intervention 40.5% students had quit non tobacco products. Findings of FGD suggested that children should not be sent to purchase tobacco products on behalf of their parents. Conclusion: School based intervention and sensitization of the field workers along with knowing their perceptions for the predictors of consumption could be useful.

Prevalence and determinants of oral potentially malignant lesions using mobile health in a rural block, northeast India.

In a rural block in North East India, community health workers (CHW) empowered with a mobile phone-based application screened a total of 2,686 participants for Oral Potentially Malignant Lesions (OPMLs), and an oral medicine specialist recommended treatment remotely. Independent risk factors were determined using independent multiple logistic regression models. Nearly 700 (26%) participants were identified with OPMLs. The sensitivity, specificity, positive predictive values, negative predictive values and accuracy of the CHW was 70.3, 88.4, 66.8, 89.9% and 83.7% respectively. Male gender, married status, smokeless tobacco, paan, areca-nut and alcohol consumption were independent predictors of OPMLs, the burden of which in North East India can be attributed to the high consumption of tobacco and non-tobacco products. Such programmes, with the recommendations from remote specialists, will facilitate early detection in remote settings.

Addiction-Related Outcomes of Nicotine and Alcohol Co-use: New Insights Following the Rise in Vaping.

Nicotine and alcohol-containing products are some of the most commonly used substances of abuse and are both leading causes of preventable death. These substances also have significant interactions that have additive and, in some cases, multiplicative effects on the health consequences of their use. Thus, to reduce these negative consequences, it is important to understand the abuse liability of nicotine and alcohol in combination, especially in the most relevant use cases among those who are most vulnerable. Specifically, as tobacco cigarette use is continually decreasing, vaping is quickly replacing cigarettes as the primary mode of nicotine use. This pattern is especially true in adolescent populations in which vaping has grown considerably. Particularly concerning is that adolescents are more vulnerable than adults to the negative consequences of substance use. It is therefore imperative to revisit the literature as it relates to the rising state of co-use of vaping products with alcohol. Here, we review the clinical outcomes of nicotine and alcohol co-use as they relate to the abuse liability of each individually. Special attention is paid to adolescent findings, where available, as well as investigations that use nontobacco nicotine products as these may more accurately reflect the more recent trends of co-use. Though nicotine alone has previously been considered a proxy for tobacco and tobacco cigarette use, combustible routes of administration have been decreasing. They are, instead, being replaced by e-cigarettes that do not involve other tobacco constituents and contain additional nonnicotine constituents of their own. Unfortunately, the literature remains limited with regard to e-cigarettes and their interactions with other substances, especially their prevalent co-use with alcohol. This review attempts to discuss the current literature on nicotine and alcohol co-use in the context of the vaping epidemic, predominantly focusing on addiction-related outcomes and why e-cigarette use may be unique.

Need for Regulation of Pan Masala Advertisements in Television Media

Tobacco industries have resorted to brand stretching to keep their brands visible through sale of non-tobacco products like elaichi (cardamom) and paan masala, as seen in television advertisements aired during Indian premier league matches. The direct and indirect forms of advertisements of tobacco products in digital media remains unchecked. Strict ban should be enforced as these advertisements lure children and the youth into consumption of tobacco products later in life. In addition to providing tobacco cessation services to patients, oral health professionals should be aware of the marketing strategies of tobacco companies so that we can advise governing authorities to enact new laws and enforce existing laws in order to curtail tobacco consumption in our country.

Identification characteristics of non-smoking tobacco products

Modern trends in the reduction of cigarette consumption have led to the spread of smokeless tobacco and non-tobacco nicotine-containing products [1]; their variety creates certain problems with the identification of products in this segment. Sucking tobacco (snus) has been banned in the Russian Federation for wholesale and retail trade since 2015, but it is a product similar to chew- ing tobacco in packaging, ingredient composition and physiological effects. Therefore, establishing the identification characteristics of chewing tobacco is an urgent task. The attitude towards chewing tobacco is controversial. The absence of the smoldering / burning process characteristic of cigarettes indicates a decrease in the harmful effect on the human body. At the same time, the physiological ef- fect on the consumer is based on the effect of nicotine extracted from tobacco through the oral mucosa. Consumer indicators of samples of smokeless tobacco / non-tobacco nicotine-containing products have been investigated: moisture content, fractional composition and nicotine content. The moisture content of samples of non-smoking products ranges from 19,0 % to 36,5 %. The nicotine content in the investigated tobacco / non-tobacco products is 0,3–2,4 % / 1,0–8,8 % respectively. To establish the identification signs of smokeless tobacco products the following methods have been used: product fractionation, optical microscopy, spectrophotometry, and liquid chromatography / tandem mass spectrometry (LCMS / MS). The main feature of the difference between smokeless tobacco products and non-tobacco nicotine-containing products has been determined – the presence of tobacco in the ingredient composition, confirmed by the structure of the product and the content of specific tobacco nitrosamines. As a result of the research, experimental data were obtained on the quantitative determination of the content of tobacco specific nitrosamines by the LCMS / MS method in smokeless tobacco products. The main identification feature of chewing tobacco has been established: the presence of raw tobacco in the ingredient composition with a coarse fraction content is at least 15 %.

Complex estimation system for smokeless nicotine containing products

Smokeless nicotine containing products are very diverse and offered in flavored tobacco/non tobacco forms, packed in portioned sachets of different mass, dimensions, and colors, with different nicotine content. In RF of chewing tobacco is regulated by Federal law № 268, sucking tobacco (snus) is prohibited for wholesale and retail trade according to FL № 456. Federal law № 303 equates consuming of non tobacco nicotine containing products for chewing and sucking to tobacco consumption. Absence of regulations for nicotine containing products with similar package, but different in composition and physiological effect requires elaboration methods for complex estimation of smokeless products with methods verification in order to their control. Monitoring of studies conducted in various scientific centers on the issue of toxicological assessment of smokeless tobacco / non-tobacco nicotine-containing products has been carried Analysis of consumer’s indicators of smokeless products includes organoleptic testing and measuring nicotine content as toxicity indicator. It is discovered that nicotine content in studied samples varies from 0.3 to 7.6 %. Quantity of absorbed nicotine during cigarette smoking is criterion of sufficient nicotine concentration in smokeless products, extracted through oral mucosa. Base (carrier) for non tobacco products is usually powdered microcrystal cellulose or grinded plant matter (peppermint) of different flavor and color. Structure of smokeless products is defined and their identification features are offered, including extra feature – tobacco presence in product, defined by presence of tobacco specific nitrosamines. As the result of the researches adoption of nicotine content limit of 20 – 30 mg per portion is offered. Complex estimation system for smokeless products is elaborated. It includes: organoleptic testing of consumer’s properties, spectrophotometric method for nicotine content measuring, thermogravimetric determination of the mass fraction of moisture, optical microscopy and luminiscence analysis for defining product structure in order to its identification, gas chromatography for defining humectants and LC-MS for measuring content of tobacco specific nitrosaminescontent.

The prevalence of waterpipe tobacco smoking among Polish youths.

IntroductionWaterpipe smoking is gaining popularity among the youth in Poland and is evaluated for the first time in this work. The authors address the social and demographic factors that motivate young people to smoke and attempt to determine which of them contribute to habit formation.Material and methodsThe data were collected among school and university students in Poland during a global survey on various forms of tobacco use. Multivariable regression models were applied for odds-ratio evaluation. The data concern waterpipe and cigarette smoking habits.ResultsThe survey was completed by 19,097 respondents. The survey included 144 schools and 32 universities from 16 voivodeships in Poland. Respondent gender exhibited the highest ORs (95% Cl), both in the case of current and ever WP users: 2.11 (2.10–2.12) and 2.16 (2.15–2.17), respectively. The other important factor was a place of living: 1.83 (1.82–1.84) and 2.17 (2.16–2.18), respectively. All ORs were statistically significant for p = 0.05.ConclusionsThe prevalence of tobacco smoking among Polish youths is high. Waterpipe tobacco smoking was found to be the second most popular habit after cigarette smoking. Moreover, young smokers use other non-tobacco products in waterpipes, and drink alcohol during smoking sessions. Many young people try waterpipe smoking without previous experience with cigarettes.

Patterns of Non-Cigarette Tobacco and Nicotine Use Among Current Cigarette Smokers and Recent Quitters: Findings From the 2020 ITC Four Country Smoking and Vaping Survey.

This study explores patterns of use of non-cigarette tobacco and nicotine products among adult cigarette smokers and recent ex-smokers. Along with cigarette smoking status we explore differences as a function of countries with different product regulations, gender, and age. Data came from the ITC Four Country Smoking and Vaping Wave 3 Survey conducted between February-June 2020. The analytic sample consisted of 9112 current cigarette smokers (at least monthly) and 1184 recent ex-smokers (quit cigarettes ≤ 2 years) from Australia, Canada, England, and the United States. Respondents were asked about their cigarette smoking and current use of the following non-cigarette products: combustible tobacco (cigars, cigarillos, pipe, waterpipe); noncombustible tobacco (smokeless tobacco, and heated tobacco products [HTPs]); and non-tobacco nicotine products (nicotine vaping products [NVPs], nicotine replacement therapy [NRT], and nicotine pouches). Overall, NVPs (13.7%) and NRT (10.9%) were the most reported nicotine products used, followed by cigars (5.3%), cigarillos (4.2%), and HTPs (3.5%). More than 21% current and recent ex-smokers of cigarettes reported using a non-tobacco nicotine product and noncombustible product, with respondents in England reporting the highest levels of use (>26%). Males, younger respondents, and current non-daily cigarette smokers were more likely to use non-cigarette nicotine products. Notably, 11.6% of ex-cigarette smokers were using other combustible tobacco. Considerable percentages of current cigarette smokers and ex-smokers use non-cigarette nicotine products, and there are unexpectedly high levels of use of other combustible products by those recent ex-smokers of cigarettes which is concerning and has important implications for definitions of smoking cessation. The tobacco product market has evolved to include new products which add to existing non-cigarette tobacco products creating a much more diverse nicotine market. This brief report provides a snapshot of use of various combustible and noncombustible nicotine-containing products among current cigarette smokers and recent ex-smokers in four western countries. Our results indicate that use of non-cigarette tobacco and nicotine products among these cigarette smokers and recent ex-smokers is not low, particularly among males, younger and non-daily cigarette smokers. Use of other combustible tobacco among respondents that recently quit cigarette smoking is concerning and has important implications for definitions of smoking cessation. Increased emphasis on researching non-cigarette nicotine product use is warranted in tobacco control generally and smoking cessation in particular.

Research of non-smoking products for oral consumption

A non-smoking, nicotine-containing, non-tobacco product is new to Russia. There are no normative legal documents regulating circulation, production, certification, control methods and ingredient composition. The composition of the product is not controlled. The absence of state regulation, technical requirements and regulatory documents for nontobacco nicotine-containing products, control methods and methods for its identification is a serious problem today, and the solution of the listed problems is extremely important and urgent. This situation has led to the appearance of a large number of products produced by semihandicraft methods. Technical conditions for their production are the property of a manufacturer, which allows unscrupulous manufacturers to manufacture a product that often represents a real threat to the health of consumers. The research began in 2018 in the Laboratory of technology for the manufacture of tobacco and tobacco products and aimed at solving the following problems: – monitoring of the Russian market of non-smoking nicotine-containing products for oral consumption; – research of consumer characteristics of brands of this type of products; – obtaining experimental data for an objective assessment of the toxic load of the test samples. The work was carried out according to the program developed in the laboratory using the following methods: – visual inspection (establishes the appearance of the consumer packaging and the labels on the packaging); – organoleptic and tasting assessment (establish consumer characteristics of the product); – establishment of individual characteristics (presence or absence of tobacco); – determination of physical, chemical and toxic indicators of the product: humidity, fractional composition, nicotine content.

Control methods for non-smoking nicotine-containing products

Non-smoking products for oral consumption are a growing segment of the nicotinecontaining products market and, therefore, the study of the component composition and toxicological load during its consumption is an urgent task. The toxic components of nicotine-containing products are the subject of research in scientific laboratories and are carried out by various methods. Studies have been monitored for potential toxicity determinations of tobacco and non-tobacco smokeless products. The article presents the results of monitoring methods for determining toxic components that determine the risk of nonsmoking products, carried out at the Federal State Budgetary Scientific Institution ARSRCTTP. As a result of the research, methods for the quantitative determination of nicotine content have been determined and the method for the determination of tobacco-specific nitrosamines (TSNA) using high-performance liquid chromatography in the product under study has been validated.

ASSESSMENT OF VAPING PRACTICES IN PATIENTS WITH CYSTIC FIBROSIS

SESSION TITLE: Diffuse Lung Disease Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: Smoking prevalence has decreased over the last several decades in the United States. However, new generations of tobacco and non-tobacco products such as electronic cigarettes (e-cigarettes) are being increasingly used, particularly in the young adult population. E-cigarettes are battery-powered devices that heat a liquid in order to develop vaporized products, including nicotine and marijuana. While originally thought to be less harmful than traditional cigarettes, e-cigarettes have been shown to have significant consequences including hospitalization and mechanical ventilation. Beginning in July 2019, there have been reports of previously healthy, young individuals developing respiratory failure, with e-cigarette use being identified as an antecedent factor. This new entity, E-cigarette or Vaping Associated Lung Injury (EVALI) has resulted in bans in several states. While the prevalence of e-cigarette use, and the rise of EVALI has been studied in the general population, to our knowledge there is no existing data about the prevalence of e-cigarette use among young adults with chronic lung disease. Individuals with Cystic Fibrosis (CF) offer a unique perspective on the impact of e-cigarette use on the young adult population with lung disease. METHODS: We administered a voluntary survey for patients with CF seen at the Rhode Island Cystic Fibrosis Center, as well as for adolescent and young adult primary care patients seen in the Medicine-Pediatrics Primary Care Clinic. The survey addressed patient experience with cigarettes and e-cigarettes, perceptions of substance use, validated quality of life scales (CFQR for CF patients, RAND-SF36 for non-CF patients), and an assessment of social desirability in order to assess risk of bias. RESULTS: Preliminary results from this observational study demonstrate avoidance of tobacco products and smoking amongst patients with CF compared to an age-matched cohort of the general population (Table 1). CONCLUSIONS: Patients with CF overwhelmingly described e-cigarette use as likely to cause significant lung damage within a brief period of time. A small portion of CF patients had tried smoking in the past, but no patients were identified as having a recent smoking history. Patients without CF averaged higher quality of life measures. While feelings of anxiety, sadness, and isolation were roughly comparable between the groups, physical symptoms were notably more bothersome in the CF patient group. CLINICAL IMPLICATIONS: This study demonstrates different social behaviors among CF and non-CF individuals in regards to cigarette and e-cigarette use. Adult CF patients were specifically able to verbalize risks associated with recreational inhalational products implying that a targeted educational program about EVALI is likely not necessary. DISCLOSURES: No relevant relationships by Roger Auth, source=Web Response no disclosure submitted for Debasree Banerjee; No relevant relationships by Michael Blundin, source=Web Response No relevant relationships by Sarah Rhoads, source=Web Response