Abstract
Smokeless nicotine containing products are very diverse and offered in flavored tobacco/non tobacco forms, packed in portioned sachets of different mass, dimensions, and colors, with different nicotine content. In RF of chewing tobacco is regulated by Federal law № 268, sucking tobacco (snus) is prohibited for wholesale and retail trade according to FL № 456. Federal law № 303 equates consuming of non tobacco nicotine containing products for chewing and sucking to tobacco consumption. Absence of regulations for nicotine containing products with similar package, but different in composition and physiological effect requires elaboration methods for complex estimation of smokeless products with methods verification in order to their control. Monitoring of studies conducted in various scientific centers on the issue of toxicological assessment of smokeless tobacco / non-tobacco nicotine-containing products has been carried Analysis of consumer’s indicators of smokeless products includes organoleptic testing and measuring nicotine content as toxicity indicator. It is discovered that nicotine content in studied samples varies from 0.3 to 7.6 %. Quantity of absorbed nicotine during cigarette smoking is criterion of sufficient nicotine concentration in smokeless products, extracted through oral mucosa. Base (carrier) for non tobacco products is usually powdered microcrystal cellulose or grinded plant matter (peppermint) of different flavor and color. Structure of smokeless products is defined and their identification features are offered, including extra feature – tobacco presence in product, defined by presence of tobacco specific nitrosamines. As the result of the researches adoption of nicotine content limit of 20 – 30 mg per portion is offered. Complex estimation system for smokeless products is elaborated. It includes: organoleptic testing of consumer’s properties, spectrophotometric method for nicotine content measuring, thermogravimetric determination of the mass fraction of moisture, optical microscopy and luminiscence analysis for defining product structure in order to its identification, gas chromatography for defining humectants and LC-MS for measuring content of tobacco specific nitrosaminescontent.
Highlights
В РФ табак жевательный находятся в обороте на основании Федерального закона от 22.12.2008 г
In RF of chewing tobacco is regulated by Federal law No 268, sucking tobacco is prohibited for wholesale and retail trade according to FL No 456
Monitoring of studies conducted in various scientific centers on the issue of toxicological assessment of smokeless tobacco / non-tobacco nicotine-containing products has been carried Analysis of consumer’s indicators of smokeless products includes organoleptic testing and measuring nicotine content as toxicity indicator
Summary
Проводимых в различных научных центрах, по вопросу токсикологической оценки некурительных табачных/нетабачных никотинсодержащих продуктов. Анализ потребительских показателей некурительной продукции, включает органолептическую оценку и определение никотина, как показателя токсической нагрузки. Основой (носителем) некурительных нетабачных продуктов является, в основном, порошкообразная микрокристаллическая целлюлоза или мелкоизмельченное растительное сырье (мята перечная), различного ароматического профиля и цвета. Определена структура и предложены идентификационные признаки некурительной продукции, в т.ч. И дополнительный признак наличия табака в ингредиентном составе продукта - содержание табачных специфических нитрозаминов. В результате исследований, предложено введение ограничения содержания никотина в некурительных изделиях на уровне 20 - 30 мг на порцию и разработана комплексная оценка некурительной продукции, включающая: органолептический анализ потребительских показателей; спектрофотометрический метод определения никотина; термогравиметрический метод определения массовой доли влаги, метод оптической микроскопии и люминесцентный анализ для определения структуры продукта с целью идентификации; жидкостную хроматографию/масс-спектрометрию количественного определения табачных специфических нитрозаминов. Ключевые слова: нетабачная никотинсодержащая продукция, табак жевательный, ингредиентный состав, рецептура, никотин, биодоступность, дегустационная оценка, влажность, структура, токсичные компоненты, специфические нитрозамины, нитрозонорникотин
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