<abstract><p>This article is devoted to studying a new class of nonlinear coupled systems of fractional differential equations supplemented with nonlocal integro-coupled boundary conditions and affected by infinite delay. We first transform the boundary value problem into a fixed-point problem, and, with the aid of the theory of infinite delay, we assume an appropriate phase space to deal with the obtained problem. Then, the existence result of solutions to the given system is investigated by employing Schaefer's fixed-point theorem, while the uniqueness result is established in view of the Banach contraction mapping principle. The illustrative examples are constructed to ensure the availability of the main results.</p></abstract>