Nonionic Emulsifier Research Articles

Enhancing Oil Based Drilling Fluids Parameters Using Secondary Synthetized Emulsifiers and Nanoparticles

Emulsion stability of oil based drilling fluids is a critical parameter for ultimate fluid performance, this property is controlled using a powerful emulsifiers. Good formulations of drilling fluid properties are required in the drilling operations which can be achieved by selection of adequate additives. The aim of this work is based on two parts; The first part is to enhance emulsion stability of oil based drilling fluids by series of nonionic secondary emulsifiers developed by esterification & amidation (MEAO, DEAO, DETAOA, DETADS, TEAOE and EGOE ) reactions from local materials. The chemical structure for the prepared secondary emulsifiers was elucidated using elemental analysis and FTIR. The second part is studying the mud stability by the secondary synthesized emulsifiers in presences of CuO nanoparticles. Besides, the rheological behavior, filtration loss and gel strength were investigated. The results revealed that, the maximum emulsion stability was achieved with the secondary emulsifiers (DEAO and DETAOA), the addition of CuO nanoparticles to the oil base mud pronounced extremely stability integrated with all mud properties as described in the text.

Facile synthesis toward self-dispersible waterborne comb-like Poly(hydroxyaminoethers)

Water-dispersible polymers represent an evolved category in the chemical industry in terms of an eco-friendly technology to meet the desired performance and to reduce the use of volatile solvents. One of the major challenges in the development of water dispersible resins deeply relies on the emulsification process that often requires the ionization process or the use of additional surfactants. In this study, an efficient method for the preparation of amphiphilic comb-like poly(hydroxyaminoethers), which consists of hydrophobic epoxy resins as the backbone and hydrophilic polyethers as the side chains, were realized in the absence of catalysts or initiators. Different from the conventional epoxy resin dispersions prepared in the presence of surfactants, or through ionization process, these amphiphilic comb-like polymers exhibited self-dispersed properties to achieve stable non-ionic emulsions in the water. The hydrophilic contents of these comb-like poly(hydroxyaminoethers) could be easily tailored in a wide range from less than 20 wt% to over 65 wt%, along with glass transition temperatures ranged from −45 °C to ~ 50 °C. In addition, the emulsifying ability was facilitated via the variations of the polymer architectures and compositions. Anti-corrosion properties were also evaluated for these self-dispersible poly(hydroxyaminoether) emulsions.

Systematic Investigation of the Effect of Non-Ionic Emulsifiers on Skin by Confocal Raman Spectroscopy-A Comprehensive Lipid Analysis.

Non-ionic emulsifiers are commonly found in existing pharmaceutical and cosmetic formulations and have been widely employed to enhance the penetration and permeation of active ingredients into the skin. With the potential of disrupting skin barrier function and increasing fluidity of stratum corneum (SC) lipids, we herein examined the effects of two kinds of non-ionic emulsifiers on intercellular lipids of skin, using confocal Raman spectroscopy (CRS) with lipid signals on skin CRS spectrum. Non-ionic emulsifiers of polyethylene glycol alkyl ethers and sorbitan fatty acid esters were studied to obtain a deep understanding of the mechanism between non-ionic emulsifiers and SC lipids. Emulsifier solutions and dispersions were prepared and applied onto excised porcine skin. Water and sodium laureth sulfate solution (SLS) served as controls. SC lipid signals were analysed by CRS regarding lipid content, conformation and lateral packing order. Polyethylene glycol (PEG) sorbitan esters revealed no alteration of intercellular lipid properties while PEG-20 ethers appeared to have the most significant effects on reducing lipid content and interrupting lipid organization. In general, the polyoxyethylene chain and alkyl chain of PEG derivative emulsifiers might indicate their ability of interaction with SC components. HLB values remained critical for complete explanation of emulsifier effects on skin lipids. With this study, it is possible to characterize the molecular effects of non-ionic emulsifiers on skin lipids and further deepen the understanding of enhancing substance penetration with reduced skin barrier properties and increased lipid fluidity.

Response Surface Modeling and Optimization of Polyphenols Extraction from Apple Pomace Based on Nonionic Emulsifiers

The factors affecting the efficiency of micelle-mediated extraction of phenolic compounds from apple pomace was investigated. Higher extraction efficiency by using as a solvent an aqueous solution of Tween 80 in comparison to Triton X-100, Span 20, Tween 20, 70% ethanol, and water was shown. Four independent variables (Tween 80 concentration, time, solvent-to material ratio, and pH) to enhance the recovery of polyphenols from apple pomace was investigated. Applying response surface methodology, the second order polynomial regression equation showing dependence of the yield of polyphenols on the extraction parameters was derived. The adjusted regression coefficient (R2 = 98.73%) and the lack-of-fit test (p > 0.05) showed a good accuracy of the developed model. The difference between observed and predicted values was no more than 3%. The optimal extraction conditions were found to be Tween 80 concentration of 1.14%, time of 65 min, solvent-to-material ratio of 104 mL g−1, pH of 3.8. Under optimal conditions the predicted total phenolic compounds content was 7.75 mg g−1. The obtained apple pomace extracts were characterized in terms of their antioxidant activity. The proposed extraction technology by using Tween 80 aqueous solution as a solvent allows obtaining the extracts with high content of polyphenols which are suitable for the applications in food, cosmetic, and pharmaceutical products requiring a surfactant to stabilize them.

Enhancement of physicochemical and encapsulation stability of O1/W/O2 multiple nanoemulsions loaded with coenzyme Q10 or conjugated linoleic acid by incorporating polyphenolic extract.

Multiple O1/W/O2 nanoemulsions and O1/W nanoemulsions fortified with CLA or CoQ10 were produced using extra virgin olive or olive pomace oil and were also incorporated with polyphenols extracted from olive kernel to enhance their kinetic and chemical stability. They were prepared using a high-speed ultrasonic homogenizer. Specifically, nanoemulsions with 6 wt% lipid phase and 6 wt% non-ionic emulsifier (Tween 40) were produced and they demonstrated a droplet diameter >200 nm and high encapsulation stability during 30 days of storage at 4 °C or 25 °C. The incorporation of CLA or CoQ10 and polyphenolic compounds facilitated the homogenization of emulsions, reducing the droplet size and enhancing their chemical stability, and their bioactive retention values were >79%. O1/W/O2 nanoemulsions were produced using a mixture of non-ionic emulsifiers (Span 20 and Tween 40) and the O1/W enriched nanoemulsion as the dispersed phase. All multiple emulsions showed a bimodal droplet size distribution and Newtonian behavior while polyphenols facilitated their homogenization. Both vegetable oils resulted in samples with high kinetic and chemical stability; the bioactive retention values were found to be >80% at the end of 30 days of storage at 4 °C or 25 °C. Extra virgin olive oil resulted in more stable nanoemulsions in regards to kinetic and chemical stability at 4 °C, showing limited creaming and sedimentation boundary. Multiple nanoemulsions with the lowest initial droplet size presented the lowest droplet diameter growth and phase separation and the highest retention values. By comparing O1/W nanoemulsions and O1/W/O2 nanoemulsions, we noted that the reduction in the total phenolic content and antioxidant activity during storage was higher in the O1/W type. However, both delivery systems protected CLA and CoQ10 presenting high retention during storage. FTIR spectra before and after ultrasonic homogenization indicated that the sonication process did not significantly affect the lipid phase of O1/W/O2 nanoemulsions.

Increased Electrical Conductivity of Polypyrrole Through Emulsion Polymerization Assisted Emulsifier Synthesis

A conductive Polypyrrole (PPy) has been successfully synthesized and characterized. The PPy was prepared through oxidative chemical polymerization using ammonium peroxydisulfate (APS) as an oxidizing agent in aqueous media. The reaction is prepared without heating. Anionic and non-ionic emulsifiers, sodium dodecyl sulfate (SDS), nonylphenol (NP) ethoxylate (EO) with 10 mole EO were respectively used during polymerization to increase the electrical conductivity. The FTIR spectrum of PPy indicates a change in the absorbance peaks of pyrrole monomer at 1530 cm−1 and those in the range region of 1100 - 1000 cm−1. With the SDS addition, the temperature of solution increased with reaction time reached the highest 35 °C within 2 minutes reaction. The pH value of an SDS added solution was 3.3 higher than that of SDS free solution (1.8). The addition of SDS was also to change the color changing during the polymerization reaction. The final characteristic of PPy by measuring the electrical conductivity (σ) value concluded that the presence of emulsifier anionic in a polymerization reaction increased the electrical conductivity of PPy 150 times higher compared with that obtained of emulsifier free solution.

Emulsification and oxidation stabilities of DAG-rich algae oil-in-water emulsions prepared with the selected emulsifiers.

Diacylglycerol (DAG) reduces body weight, suppresses body fat accumulation, and lowers the blood lipid concentration, and docosahexaenoic acid (DHA) can reduce the risk of occurrence of coronary artery diseases. DAG-rich algae oil with a high DHA content (55.9%) was synthesized via the lipase-catalyzed glycerolysis of algae oil, which consisted of triacylglycerol (43.9mol%), DAG (40.9mol%), and monoacylglycerol (15.2mol%). The DAG-rich algae oil-in-water emulsions were prepared using three emulsifiers [whey protein concentrate (WPC), Tween80, and Tween80 + Span80]. The WPC-emulsion formed a thicker serum layer (6.67% at day 51) and larger oil droplets (d32 , 0.37 μm at day 28) than the Tween80- and Tween80 + Span80-emulsions (3.33-4.17%; 0.26 μm), and an upper cream layer with excess oil droplets was observed in only the WPC-emulsion, indicating that WPC-emulsion possesses the lowest emulsification stability. The hydroperoxide value and reduction rate of the DHA content were higher in the WPC-emulsions than in the Tween80- and Tween80 + Span80-emulsions during storage, which suggested that the WPC-emulsion had the lowest oxidation stability. The DAG-rich algae oil-in-water emulsion prepared with suitable emulsifiers, such as non-ionic emulsifiers, would have excellent emulsification and oxidative stabilities and provides a health benefit for special purposes in the food processing industry. © 2019 Society of Chemical Industry.

Improving the Technology Synthesis and Properties of Biodiesel

Existing technologies for the synthesis of active additives to motor fuels are quite complicated. Therefore,improvement of the technology of biodiesel fuel synthesis in order to increase the cetane number and andimprovement of other diesel fuel characteristics with combustion activators is an urgent problem. Raw materialsfor the biodiesel production are vegetable oils methanol and ethanol with the alkaline or acid catalyst usage. Theuse of ethyl esters of long-chain fatty acids of rapeseed oil as biodiesel has a number of advantages comparedwith the methyl ester use [2]. Thus, biodiesel fuel was synthesized by transesterification of rapeseed oil withabsolute ethanol (99.9 %), which was dehydrated with calcium oxide (95 %) freshly prepared, using sodiumethoxide as a catalyst [3]. In order to achieve a high degree of mixing of a heterogeneous system, which consistsof natural oil and ethyl alcohol, a specially synthesized non-ionic emulsifier was used as a reagent. Thetechnological features of this type of a rapeseed oil transesterification process were studied and the maincharacteristics of the new diesel fuels such as fractional composition and molecular mass were estimated usingthe chromatographic method and mass spectrometry. The yield of biodiesel from rapeseed oil increases from 85 -90 % to 95 – 98 % without waste fraction of glycerol (10 – 15 %).

OIL-IN-WATER (O/W) EMULSIONABLE CONCENTRATE OF ISHPINK (Ocotea quixos) WITH THERMODYNAMIC STABILITY

ABSTRACT Ecuador has a vast number of native species with fungicidal, herbicidal, and insecticidal properties, of which several have been studied; however, few plant species have been applied for the development of commercial products. Ocotea quixos is an indigenous plant of the Ecuadorian Amazon that has fungicidal properties. In this work, we focus on developing an emulsifiable concentrate that is physically stable for use in the agricultural industry. The study aimed to determine the appropriate formulation to prepare an emulsifiable concentrate with thermodynamic stability. For the formulation, we used Ocotea quixos essential oil with cinnamaldehyde as an active ingredient, with solvesso 100 as the solvent, two non-ionic emulsifiers (Span-20 and Tween-20), and calcium phenyl sulfonate as an anionic emulsifier to obtain a stable product. The results showed that the OC5C emulsifiable concentrate has the best stability characteristics with the hydrophilic-lipophilic balance (HLB) within the range of 14 to 16 at room temperature as well as at high and low temperature with a drop size between 3 and 4 µm.

Role of Osmotic Pressure for the Formation of Sub-micrometer-Sized, Hollow Polystyrene Particles by Heat Treatment in Aqueous Dispersed Systems †.

In a previous article, it was reported that a rather amount of sulfate end-groups as initiator fragment were buried in the inside of polystyrene (PS) particles, which were synthesized by emulsion polymerization with potassium persulfate initiator and nonionic emulsifier and operated to absorb water from the aqueous medium, resulting in hollow particles, when the PS emulsion was treated at higher temperature than the glass transition temperature of PS. In this article, it was clarified that the water absorption is based on the osmotic pressure between the outside (aqueous medium) and inside of the PS particles due to the buried sulfate end-groups.

Formation of drug-loaded nanoemulsions in stirred media mills

The feasibility of stirred media mills for the production of nanoemulsions loaded with active pharmaceutical ingredients (API) using plant oils as disperse phase and different types of the non-ionic emulsifier polysorbate is demonstrated. The influence of the emulsion formulation, namely oil type, surfactant and surfactant-to-oil-weight-ratio (SOR) on the product droplet size at constant stressing conditions is studied in detail. At similar stressing conditions and SOR, the type of the used plant oil and surfactant did not influence the product droplet size and the smallest achievable median droplet size was 20 nm. The API saturated oil phases and the pure oil phases exhibit similar viscosities, emulsification kinetics and final product droplet sizes, i.e. no influence of the API on the emulsification process could be identified. However, a strong dependency of the emulsion droplet size on the SOR has been observed. Moreover, very good long-term stabilities could be achieved for the obtained emulsions. A release test with fenofibrate-loaded peanut oil-polysorbate 80-water nanoemulsions showed remarkably fast drug distribution as compared to a formulation containing the same amount of the non-dissolved micronized drug.

Polyoxyethylene Alkenyl Succinate Gemini Emulsifier for Diesel Fuel Nanoemulsions

Highly stable nanosized water droplets in diesel nanoemulsions were prepared in the presence of polyoxyethylene alkenyl succinate as a gemini emulsifier. This nonionic gemini emulsifier was prepared through three stages. The addition reaction of octadecene to the double bond of maleic anhydride was the prime step. The second step includes the ring-opening reaction between 2 mol of alkenylsuccinic anhydride with diethylene glycol as a spacer, and the third step was the esterification reaction between the said products with 2 mol of polyethylene glycol 200 to produce polyoxyethylene alkenyl succinate gemini emulsifier abbreviated as GE. FT-IR and 1H NMR spectroscopies were utilized to justify the chemical formula of the synthesized emulsifier. Four water-in-diesel nanoemulsions were formulated under 5 wt % water content and (2, 4, 6, and 8 wt %) surfactant concentrations of the overall nanoemulsion’s weight. The prepared emulsifier’s dynamic interfacial tension mensuration and also its thermodynamic paramet...

Synthesis and application of aqueous stomach aminoalkyl methacrylate copolymer

A series of stomach cationic aminoalkyl methacrylate copolymer emulsions containing large number of tertiary amino groups in molecular side chain were prepared throughl emulsion polymerization, which take dimethylaminoethyl methacrylate, methyl methacrylate and butyl methacrylate as main raw materials. The The properties of the emulsions were characterized by Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). And effects of monomer mass ratio and emulsifier system on the properties of emulsions polymerization were also discussed. The results showed that the emulsion performance was stable when the amount of emulsifier was 4.5wt% taking cationic and non-ionic composite emulsifier as emulsifying system. At the same time, it has excellent moisture resistance and stable performance when used in pharmaceutical coating materials.

Investigation of the Compatibility of the Skin PAMPA Model with Topical Formulation and Acceptor Media Additives Using Different Assay Setups.

The Skin Parallel Artificial Membrane Permeability Assay (PAMPA) is a 96-well plate-based skin model with an artificial membrane containing free fatty acid, cholesterol, and synthetic ceramide analogs to mimic the stratum corneum (SC) barrier. The current study evaluates the compatibility of lipophilic solvents/penetration enhancer, topical emulsions containing different emulsifier systems, and organic acceptor media additives with the artificial membrane of the assay. Additionally, different assay setups (standard setup: donor in bottom plate versus modified setup: donor in top plate) were compared. Methylparaben (MP), ethylparaben (EP), and propylparaben (PP) were used as model permeants and internal standards for proper assay execution. The permeation order of the parabens (MP > EP > PP) remained the same with different lipophilic solvents, and the ranking of lipophilic solvents was comparable under standard and modified conditions (isopropyl myristate, IPM > dimethyl isosorbide, DMI ≥ propylene glycol, PG > diisopropyl adipate, DIPA). Pre-incubation of the Skin PAMPA plates with IPM, DIPA, and DMI, as well as with formulations that contain non-ionic emulsifiers, and acceptor solutions containing DMSO or EtOH (≤ 50%) for 4h did not increase the percentage of permeated parabens in the main experiment, suggesting that those compounds do not make the artificial membrane more permeable. High-resolution mass spectrometry confirmed that acceptor solutions with ≤ 50% DMSO or EtOH do not extract stearic acid, cholesterol, and certramides at standard assay conditions. Hence, if certain constraints are considered, the Skin PAMPA model can be used as a pre-screening tool for topical formulation selection.

Optimized nonionic emulsifier for the efficient delivery of astaxanthin nanodispersions to retina: in vivo and ex vivo evaluations

Astaxanthin (AST) is a naturally occurring carotenoid with potent anti-oxidative and anti-inflammatory potency against chronic diseases. In this study, we suspended AST in different nonionic emulsifiers to produce nanodispersions. The basic physicochemical properties of the produced AST nanodispersions were verified to select the optimized nonionic emulsifier. Among the tested emulsifiers, Polysorbate 20 produced the AST nanoemulsions with smaller particle diameters, narrower size distributions, and higher AST contents among these emulsifiers. The N-methyl-N-nitrosourea (MNU) administered mouse is a chemically induced retinal degeneration (RD) model with rapid progress rate. AST suspended in Polysorbate 20 was demonstrated to ameliorate the dramatic consequences of MNU on retina architectures and function in several different tests encompassing from electrophysiology to histology and molecular tests. Furthermore, the multi-electrodes array (MEA) was used to detect the firing activities of retinal ganglion cells within the inner retinal circuits. We found that AST nanodispersions could restrain the spontaneous firing response, enhance the light induced firing response, and preserve the basic configurations of visual signal pathway in degenerative retinas. The MEA assay provided an appropriate example to evaluate the potency of pharmacological compounds on retinal plasticity. In summary, emulsifier type affects the basic physicochemical characteristic of AST nanodispersions. Polysorbate 20 acts as an optimized nonionic emulsifier for the efficient delivery of AST nanodispersions to retina. AST nanodispersions can alleviate the photoreceptor loss and rectify the abnormities in visual signal transmission.

Effect of fatty acid-based anionic surfactants on the emulsion properties of self-emulsifying poly(ethylene-co-acrylic acid) waxes

Self-emulsifying polyethylene waxes (SE-PEA) were prepared by saponification of KOH with poly(ethylene-co-acrylic acid) (PEA) wax in the presence of surfactants. The viscosity, softening point and penetration of SE-PEA were compared according to the structure of surfactants. After simple preparation of the emulsions, the storage stability, particle size and accelerated stability were evaluated. Using the mixture of nonionic and unsaturated fatty acid emulsifiers, excellent emulsion stabilities and drop emulsion size of <3μm were achieved. The emulsion of SE-PEA prepared using a fatty acid surfactant having unsaturated groups showed stable emulsion characteristics because of the double bond on hydrophobic chain.

Oil-in-water emulsion of a heterocyclic adduct as a novel inhibitor of API X52 steel corrosion in acidic solution

AbstractIn this study, an addition reaction occurred between epoxidized soybean oil and 4-(dimethylamino)benzenethiol to produce a thiol adduct (TA). The produced TA had been emulsified using a nonionic emulsifier blend (Tween 20, Span 20, and Span 80) to be a water-miscible emulsified thiol adduct (ETA). The ETA emulsion was investigated as a corrosion inhibitor for API X52 carbon steel in 1 m HCl using weight loss, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS) techniques. The surface morphologies of the carbon steel were characterized by scanning electron microscopy and energy dispersive X-ray. The effect of temperature was investigated. It was found that the emulsified adduct behaves as an excellent corrosion inhibitor with high inhibition efficiency of 94.7% with 0.005 m concentration. The polarization data indicate that the emulsified adduct acted as a mixed-type inhibitor. The adsorption of the emulsified adduct on the carbon steel surface has been found to follow the Langmuir isotherm.

Influence of Oxidants on the Stability of Tocopherol in Model Nanoemulsions: Role of Interfacial Membrane Organized by Nonionic Emulsifiers

Nanoemulsions were prepared by using emulsifiers with various sizes of hydrophilic and hydrophobic groups to determine the impact of interfacial characteristics on the stability of α-tocopherol incorporated into the nanoemulsions. The α-tocopherol concentration remaining after 3 weeks of storage at 25°C depended greatly on the type of oxidative stress, which indicated that the environment surrounding the oil droplets could determine the stability of α-tocopherol in nanoemulsions. α-Tocopherol was gradually degraded by radical-mediated oxidation over storage, and approximately 60% of its initial concentration remained after 3 weeks of storage. However, under acid- and iron-mediated oxidation, α-tocopherol concentration steeply decreases for the initial 3-day storage, but the degradation rate of α-tocopherol decreased after 3 days of storage and over 90% of the initial α-tocopherol remained after 3 weeks of storage. Interestingly, and contrary to our expectations, the thickness and/or density of the droplet interfacial membrane rarely affected the stability of α-tocopherol incorporated into nanoemulsions. Although it is difficult to generalize beyond α-tocopherol, we conclude that the properties of oil droplet surfaces had no influence on the storage stability of α-tocopherol encapsulated in the droplets.

Poly(tertiary amine) as a surface-active multifunctional macro-initiator in Cu2+–amine redox-initiated radical emulsion polymerization of methyl methacrylate

Redox-initiated radical polymerization of methyl methacrylate (MMA) using poly(2-(N,N-dimethylamino)ethyl methacrylate) (PDMAEMA) or poly(N-[3-(N,N-dimethylamino)]propyl methacrylamide) (PDMAPMA) as a surface-active multifunctional reducing agent, vis-a-vis low-molecular-weight (MW) analogs, was performed in aqueous emulsion at 70 °C using CuSO4 or FeCl3 complexes as an oxidizing agent and poly(ethylene glycol) as a nonionic emulsifier, to examine their effect on emulsification, rate of polymerization and the structure of final resultants. The kinetics was followed gravimetrically, while the MW of the resultants was monitored by gel permeation chromatography. CuSO4 complexes exhibited a higher activity than FeCl3 complexes in both cases, and the polymerization evolved at a faster rate than those with low-MW tertiary amines. The MW of the resultants increased by several folds with respect to pristine PDMAEMA or PDMAPMA initially, but adversely decreased with further reaction, owing to the formation of free PMMA chains. The control experiments suggested that the transition metal cation complexes promote the hydrolysis of ester/amide moieties. CuII-catalyzed hydrolysis of PDMAEMA or PDMAPMA occurred steadily during the CuII–PDMAEMA or PDMAPMA redox-initiated radical polymerization of MMA, leading to gradual accumulation of low-MW tertiary amines. During the later stage, the radical polymerization was primarily redox-initiated by pairs of CuII complexes and low-MW tertiary amines, giving rise to the formation of free PMMA chains.

Changes in characteristics of nanoemulsion of cinnamon oil and their relationships with instability mechanisms during storage

Development of nano-structured food delivery systems containing essential oils are finding growing interest due to their unique physicochemical and potential functional properties such as high stability, optical transparency, and improved bioactivity. Cinnamon oil of bark of Cinnamomum burmannii was formulated into nanoemulsion systems and their characteristics during storage were evaluated to obtain their relationships with possible destabilization mechanisms. Nanoemulsion was prepared using a phase inversion technique incorporating cinnamon oil (5% and 10%) and non-ionic emulsifier (75% of the oil). The emulsions were kept at 20, 30, 40°C and their physical characteristics were analyzed over time during 8 weeks storage. Average droplet sizes of 192.6 and 184.3 nm were produced at the beginning of storage and they tended to increase during storage. Droplet sizes and polydispersity index exhibited the same increase trends, while the absolute value of zeta potential and viscosity showed decrease trends in general. Creaming appeared to dominate the destabilization of nanoemulsion accompanied by Ostwald ripening and followed by oil sedimentation. Practical applications Consumers become more aware of the uses of natural ingredients in food formulation in-line with the increase trends in back-to-nature lifestyle. Cinnamon oil has been used for food flavoring and preservation but its incorporation into aqueous-based formulation is still difficult due to its hydrophobicity. Development of nanoemulsion is a prospective approach to the dispersity problem. This study provides valuable information in formulating nanoemulsion suitable for the food delivery system. Identification of changes in nanoemulsion characteristics during storage gives the feature of coarsening behavior useful in designing approaches to control their instability.