Nowadays, built heritage condition assessment is realized through on-site or photo-aided visual inspections, reporting pathologies manually on drawings, photographs, notes. The knowledge of the state of conservation goes through subjective and time or cost consuming procedures. This is even relevant for a historic building characterized by geometrical and morphological complexity and huge extension, or at risk of collapse. In this context, advancements in the field of Computer Vision and Artificial Intelligence provide an opportunity to address these criticalities. The proposed methodology is based on a Mask R-CNN model, for the detection of decay morphologies on built heritages, and, particularly on historic buildings. The experimentation has been carried out and validated on a highly heterogeneous dataset of images of historic buildings, representative of the regional Architectural Heritage, such as: castles, monasteries, noble buildings, rural buildings. The outcomes highlighted the significance of this remote, non-invasive inspection technique, in support of the technicians in the preliminary knowledge of the building state of conservation, and, most of all, in the decay mapping of some particular classes of alterations (moist area, biological colonization).