Nobel Prize Research Articles

Istoriya perevoda na russkij yazyk proizvedenij Mo Yanya

This article examines the history of the development of the translation into Russian of the works of Mo Yan - one of the most famous modern writers of China. In 2007, his works began to be translated in Russia, although a wide range of readers have known about Mo Yan in 2012, when he won the Nobel Prize in literature. Since that moment, an average of one work by the Chinese writer has been translated and published in Russia almost every year.

Physical reality

The principle of non-locality, or the existence of systems of particles with properties that relate them even at great distances, are called entangled systems and defy the intuition that requires all relationships to be described by means of energy exchange or by material links, quantum physics presents non-locality as a consequence of objects being described by a single wave function and as such unless they decohere (losses its nonphysical link), the relationship remains, and each cannot be understood separately. Recently, there have been many technological models that can produce entangled systems. In addition to the examples that submicroscopic physics can illustrate, the simplest is spontaneous parametric fluorescence, which requires a laser and a parametric crystal that has allowed very elaborate experiments to be carried out and shows the relevance of quantum physics and the limitations of our perception. The examples described here have emerged over the years as attempts to make this concept more acceptable and try to guide the imagination to situations where these types of phenomena can be plausible and point to human perception with the duality of bringing us closer to the appreciation of nature, but at the same time, it is the main limitation to appreciate and understand nature. The relevance of this concept was recognized with the Nobel Prize 2022 in physics, and it can be summarized as the Proof of the Bell inequality using anecdotes from a Nobel non-recipient.

Reymont as a Life. Voices and Glosses

The article offers an overview of the content of the present issue of „Tekstualia” and problematizesthe issue of Reymont’s status and meaning of his role as a writer in Polish and world literature sincehis Nobel Prize in Literature in 1924. The article also tries to offer an overview of the scientifi cpapers included in „Tekstualia” issue, but also (as an introduction) offers a kind of reconnaissancewhich focuses on different points of view and glosses about Reymont’s papers and works (especiallynovels, short stories, novellas, diaries, memoirs and adaptations of his great novel – The Peasants).

Discourse of Alternative Identity in Nobel Prize Lectures of Latin American Writers

Discourse of Alternative Identity in Nobel Prize Lectures of Latin American Writers

Daniel Kahneman: The psychologist who won a Nobel Prize in Economics for replacing Homo economicus with flesh-and-blood humans

Daniel Kahneman: The psychologist who won a Nobel Prize in Economics for replacing Homo economicus with flesh-and-blood humans

Newly discovered letter: why Muller failed to cite the negative mouse mutation findings of Snell, preserving his chances to receive the Nobel Prize.

A recently acquired letter between Hermann Muller and his wife (March 21, 1933) reveals that Muller had learned that he had been nominated for the Nobel Prize in 1932 with about 1/3 of the total votes being supportive. Muller was hopeful that over time sufficient votes would lead to receiving the award. The knowledge of Muller on this matter and its timing provide a likely explanation why Muller never cited the negative mouse mutation findings of George Snell, performed under Muller's direction during that time period. This action of Muller, along with the failure of Snell to promote his discovery, greatly reduced the chances that those findings would complicate his attempt to garner support for his LNT single-hit model and its application to hereditary and cancer risk assessment. It also helped Muller achieve the Nobel Prize, allowing him the necessary international visibility to promote his ideologically driven ionizing radiation-related LNT-based paradigm.

The Nobel Prize and the Formation of Contemporary World Literature - Book Review

Book Details - Title: The Nobel Prize and the Formation of Contemporary World Literature ; Author: Paul Tenngart; Publisher: Bloomsbury Academic, 249 pages; Year of publication: 2024; ISBN:978-1-5013-8212-3 (hardback), 978-1-5013-8213-0 (eBook), 978-1-5013-8214-7 (PDF)

Allvar Gullstrand: The Only Ophthalmologist Who Won the Nobel Prize.

Allvar Gullstrand, the Swedish ophthalmologistand Nobel laureate, was a self-taught mathematician who applied mathematics and higher-order equations to understand the optic system. His inventions, the slit lamp, and the ophthalmoscopeareused in clinical practice for the diagnosis of eye diseases. With his efforts, he explained the accommodation, the process of changing the shape of the lens to focus on near or distant objects.In 1911, he was awarded the Nobel Prize in Physiology or Medicine. In 1913, he was elected as the first president of the Swedish Ophthalmological Society. In 1927, he was awarded the Graefe Medal of the Deutsche Ophthalmologische Gesellschaft.

It is time to pay tribute to women in science: the women who won the Nobel prizes in Chemistry and Physiology or Medicine

In the 21st century, it is time to recognize the essential role of women in science. The study carried out by women-scientists makes it possible to combine brightness of mind, deep knowledge with humaneness and wisdom. Their approaches to the problems and the ways to solve them are largely determined by their maps of meaning and existential experience that can enrich and expand the scientific field and, as a result, can offer unexpected but most effective ways to solve the problem. However, women face obstacles in advancing their careers in science, and the situation is even more discouraging when it comes to winning science awards, the most prestigious of which is the Nobel Prize. Between 1901 and 2023, the Nobel Prizes were awarded 621 times to 965 individuals and 27 organizations, but only 64 of them were women-scientists. While we recognize and praise all women – Nobel laureates, this paper pays special attention to women who have received Nobel Prizes in Chemistry and Physiology or Medicine and briefly outlines their scientific achievements. A more detailed description of their life and scientific journey will be provided in subsequent articles. Keywords: the Nobel Prize in Chemistry and in Physiology or Medicine, women – Nobel Prize winners, women-scientists

Analysis of One-dimensional Double-potential Barrier Structures Resonant Tunnelling Based on Transmission Matrices

The comprehension of the tunnel effect, the passage of matter waves and particles across a high potential barrier, was the most astounding of all discoveries in quantum mechanics. Research on tunnelling in semiconductors and superconductors, as well as the development of scanning tunnelling microscopy, garnered five Nobel prizes in physics. In this study, the resonant tunnelling effect of electron tunnelling through a one-dimensional double-potential barrier was found and verified by solving the time-independent Schrödinger equation and calculating the transmittance rate of the electron tunnelling through the two potential barriers by using the transmission matrix technique performed by MATLAB. According to the analysis, the transmittance rate was one under certain specific conditions (under some specific incident energy values or some specific distance between two potential barriers), which was called as resonant tunnelling. However, in this study, square potential wells were analyzed, which can be considered merely as ideal models in real life, and therefore all results are idealized. For further investigations, researchers can use more realistic parameters to set up potential wells and analyze real-life problems.

„Miasto nigdy się nie kończy…”. Mroczne oblicze miasta w prozie Herty Müller

One of the recurring motifs in Herta Müllerʼs work is the experience of the city, which often becomes a space of threat, violence, uncertainty, and finally repression and death. The German Nobel Prize laureate describes urban spaces, where the fate of the city is intertwined with the fate of the protagonists, depicting a world of people who are downtrodden, lost, defeated, and yet not without hope. This article discusses selected works by Herta Müller, in which the multidimensional image of the city opens up new fields for reflection and allows us to gain insight into how a totalitarian state functions. The cities the author describes are reflective of all Romanian cities under the dictatorship of Nicolae Ceaușescu; they are places of depravity and terror. This article also explores the aesthetics of ugliness which affects the understanding of the role of cities in Herta Müllerʼs prose, and analyzes important urban symbols such as asphalt, apartment blocks, parks and the flora and fauna characteristic of communist cities. In many of Müllerʼs texts, cities form a dramatic backdrop for acts of violence and repression against ‘the Stranger’ – for instance, the German minority,the Roma community, and women. Thus, the experience of an individual becomes the experience of the whole community, which makes Herta Müllerʼs work enduringly relevant.

A railway modernity. Izmalkovo train station in Ivan Bunin’s work

The article discusses the everyday life of Izmalkovo, a train station in Imperial Russia’s Oryol governate. Among its frequent visitors and commuters was Ivan Bunin. The writer often resided in the area and used the station’s postal and passenger services. Housed in a small and inconspicuous railway station building of the fourth rank, Izmalkovo gradually became an important logistical hub for the writer. Izmalkovo’s postmark grew increasingly familiar to prominent figures of Russian modern art and literature. Following the devastating events of 1917, life in the Russian provinces becomes perilous for those living there. The political crisis forced Bunin to move from Izmalkovo to Yelets, where he had to seek a secret sanctuary at the local notary’s house. Next, the writer was forced to flee the country. Nostalgic memories of the humble station’s chronotope haunted Bunin for the rest of his life. Using an extensive body of examples, the scholar traces the changing perception of the station in the Nobel Prize winner’s writings, from the romantic impressions of his youth to the agonizing reflections on the ‘cursed days.’

Career or Family: A Woman’s Difficult Choice (On the Nobel Prize in Economics in 2023)

This article presents the achievements of the 2023 Nobel laureate in economics, Harvard University professor Claudia Goldin. The obstacles to women’s employment related to the fact that the initially established structure of jobs was focused on male labor are considered. The “quiet revolution” discovered by the laureate and consisting of a sharp increase in the age of first marriages and a switch in women’s motivation from earnings to careers is analyzed. The importance of flexible working conditions when women choose a place of work and increasing women’s participation in the economy was highlighted. As an example of maximum effort and approach to working conditions convenient for women, the laureate cites the pharmaceutical sector, both industry and trade. The problems of the existence of a “natural level” of women’s participation in the economy are touched upon. Finally, the impact of the 2021–2022 pandemic on women’s choice between career and family is examined.

Analisis Komparatif Pada Puisi “Stopping By Woods On The Snow Evening” Oleh Robert Frost

The poem "Stopping by Woods on a Snowy Evening" by Robert Frost is one of the world's most famous works of literature. The translation of this poem into Indonesian presents its own challenges for the translator, especially in maintaining the style, atmosphere, and message desired by the poet. This study aims to analyze stylistic changes that occur in the translation of this poem from English to Indonesian. Using a comparative approach, this study compares stylistic elements such as diction, metaphor, rhyme, and rhythm between the original text and the translation. Robert Frost's poems received many prestigious international awards, including the Nobel Prize. The poem is characterized by its depth, its mysterious nature, and its profound meaning. As mentioned earlier, many critics have varying perspectives when analyzing this poem. Regardless of his interpretation, Frost effectively provides readers and literary enthusiasts with various literary components that can be analyzed in the text. The many literary elements contained in this poem make it interesting to listen to.

Thematic Analysis of Non-Violence in the Select Excerpts of Svetlana Alexievich and Thiruvalluvar

The universal prominence attained by English language has paved way for translation and thereby, offers access to world literature and comparative studies. India has witnessed a growth in the field of comparative studies since it received an impetus from Rabindranath Tagore's lecture delivered on the subject when he was invited by National Council of Education in 1907. Tamil Literature has endorsed stalwarts like Thiruvalluvar whose couplets focus on valuable topics that have not only stood the test of time but also has its influence across cultural, political, ethical and topographical diversity. His magnum opus titled Thirukkural is a masterpiece of human thought, equivalent to the Bible, Milton’s Paradise Lost and works of Plato. Svetlana Alexievich is a Belarusian writer who writes in Russian language. He works have been translated into 35 languages and more that 20 documentary films have been produced based on her testimonies collected from victims, survivors, and firsthand witnesses of war and disaster. Alexievich received the Nobel Prize in Literature in 2015, for her polyphonic writing skill which fetched her veneration in the 21st century. This research article aims to compare and contrast how two literary stalwarts belonging to two different centuries and completely dissimilar ethnicities have unified thoughts on human existence. Thiruvalluvar’s views about ‘war’ and ‘killing’ and Nobel laureate Svetlana Alexievich’s perception of the futility of war are analyzed in a novel attempt to corroborate that peace and harmony are themes validated since the origin of species and will continue to be valued as long as human civilization exists.

Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation

Quantum dots, which won the Nobel Prize in Chemistry, have recently gained significant attention in precision medicine due to their unique properties, such as size-tunable emission, high photostability, efficient light absorption, and vibrant luminescence. Consequently, there is a growing demand to identify new types of quantum dots from various sources and explore their potential applications as stimuli-responsive biosensors, biomolecular imaging probes, and targeted drug delivery agents. Biomass-waste-derived carbon quantum dots (CQDs) are an attractive alternative to conventional QDs, which often require expensive and toxic precursors, as they offer several merits in eco-friendly synthesis, preparation from renewable sources, and cost-effective production. In this study, we evaluated three CQDs derived from biomass waste for their potential application as non-toxic bioimaging agents in various cell lines, including human dermal fibroblasts, HeLa, cardiomyocytes, induced pluripotent stem cells, and an in-vivo medaka fish (Oryzias latipes) model. Confocal microscopic studies revealed that CQDs could assist in visualizing inflammatory processes in the cells, as they were taken up more by cells treated with tumor necrosis factor-α than untreated cells. In addition, our quantitative real-time PCR gene expression analysis has revealed that citric acid-based CQDs can potentially reduce inflammatory markers such as Interleukin-6. Our studies suggest that CQDs have potential as theragnostic agents, which can simultaneously identify and modulate inflammatory markers and may lead to targeted therapy for immune system-associated diseases.

Surprising Wilkins’ error (Nature 1953, 172: 755–762)

The Nobel Prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Compton Crick, James Dewey Watson and Maurice Hugh Frederick Wilkins “for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material”. Building the scale atomic-molecular models and applying strong inference Watson and Crick (1953a,b) presented convincing evidences for the following features of the spatial structure of the DNA molecule: (i) this structure has two helical chains each coiled round the same axis; (ii) both chains follow right-handed helices; (iii) the sequences of the atoms in the two chains run in opposite directions; (iv) the two chains are held together by hydrogen-bonded purine and pyrimidine bases; (v) the planes of the bases are perpendicular to the fibre axis; (vi) only specific pairs of bases can bond together: adenine (purine) with thymine (pyrimidine), and guanine (purine) with cytosine (pyrimidine). X-ray evidence obtained at the same time by Wilkins et al. (1953a,b), and Franklin et al. (1953a,b) gave qualitative support to this structure and was incompatible with all previously proposed structures. Wilkins et al. (1953b) built molecular models of the type described by Watson and Crick (1953a) and adjusted them to conform with their experimental data. However, it appeared that the paper by Wilkins et al. (1953b) contains a curious and inexplicable error. Namely, in their Figure 3 DNA is schematically drawn as a left-handed helix, which, as Crick and Watson (1954) explained, is stereochemically impossible and must be right-handed. The fact stated here was mysteriously not noticed before and, fortunately, had no detrimental effect on the development of science.

Androgen Signaling in Prostate Cancer: When a Friend Turns Foe.

Androgen (AR) signaling is the main signaling for the development of the prostate and its normal functioning. AR is highly specific for testosterone and dihydrotestosterone, significantly contributing to prostate development, physiology, and cancer. All these receptors have emerged as crucial therapeutic targets for PCa. In the year 1966, the Noble prize was awarded to Huggins and Hodge for their groundbreaking discovery of AR. As it is a pioneer transcription factor, it belongs to the steroid hormone receptor family and consists of domains, including DNA binding domain (DBD), hormone response elements (HRE), C-terminal ligand binding domain (LBD), and N-terminal regulatory domains. Structural variations in AR, such as AR gene amplification, LBD mutations, alternative splicing of exons, hypermethylation of AR, and co- regulators, are major contributors to PCa. It's signaling is crucial for the development and functioning of the prostate gland, with the AR being the key player. The specificity of AR for testosterone and dihydrotestosterone is important in prostate physiology. However, when it is dysregulated, AR contributes significantly to PCa. However, the structural variations in AR, such as gene amplification, mutations, alternative splicing, and epigenetic modifications, drive the PCa progression. Therefore, understanding AR function and dysregulation is essential for developing effective therapeutic strategies. Thus, the aim of this review was to examine how AR was initially pivotal for prostate development and how it turned out to show both positive and detrimental implications for the prostate.

Behavioral economics and the nature of neoclassical paradigm

Psychological observations are by now well integrated into economics, especially in the theory of finance, as can also be seen in the Nobel Prize awarded to Thaler. On the contrary, Simon’s attempt to reforge economic theory on the paradigm of bounded rationality failed. Starting from the birth of the neoclassical paradigm, we’ll describe the attempt to give it psychological foundations with a direct measurement of utility, then the axiomatic turn of the paradigm and its first anomalies. We’ll then sum up the debate on rationality, taking place in the group of economists led by Simon, which brought to the rational expectations hypothesis. Finally, we’ll discuss the development of behavioral economics and its progressive acceptance in economic theory. This historical reconstruction allows us to understand the actual hard core of the neoclassical paradigm and the growing need of the paradigm for practical flexibility that determines how to choose arguments, methods and evidence that can be useful to its development, including psychological ones.

The History of Nerve Growth Factor: From Molecule to Drug.

Nerve growth factor (NGF), the first neurotrophin to be discovered, has a long and eventful research journey with a series of turning points, setbacks, and achievements. Since the groundbreaking investigations led by Nobel Prize winner Rita Levi-Montalcini, advancements in the comprehension of NGF's functions have revolutionized the field of neuroscience, offering new insights and opportunities for therapeutic innovation. However, the clinical application of NGF has historically been hindered by challenges in determining appropriate dosing, administration strategies, and complications related to the production process. Recent advances in the production and scientific knowledge of recombinant NGF have enabled its clinical development, and in 2018, the United States Food and Drug Administration approved cenegermin-bkbj, a recombinant human NGF, for the treatment of all stages of neurotrophic keratitis. This review traces the evolutionary path that transformed NGF from a biological molecule into a novel therapy with potential research applications beyond the eye. Special emphasis is put on the studies that advanced NGF from discovery to the first medicinal product approved to treat a human disease.