Introduction: Adequate biomechanical preparation of root canals is the essence of successful endodontic therapy. Roots with curved canal framework led to endodontic complexity. The hassles in the preparation of such complex canals have prompted the inauguration of nickel–titanium (Ni-Ti) instruments with properties of shape memory and superelasticity. They benefit root canal preparation with causing less aberration, yet intracanal separation due to fatigue remains a concern. The study was intended to evaluate and compare the stresses developed during biomechanical preparation with Ni-Ti rotary file in straight, moderate, and severely curved root canals using finite element analysis (FEA). Materials and Methods: Six real sizes, three-dimensional root models were designed in SolidWorks software with varying angles of curvature (2°–45°), and using the same software, ProTaper Gold F2 rotary file was developed. All the designed root models with the rotary file inserted into each model were subjected to FEA. ANSYS Software (version 17.2 Company, Commonwealth of Pennsylvania, USA) 2015 was used to simulating root canal shaping, and the stresses generated in all the root canal models were observed. Results: Highest mean stress was observed with 45° models which was 235.95 MPa, followed by a 30° simulated model showed 220.36 MPa and least stress of 125.22 MPa was observed with 2° models (P > 0.05). Conclusions: Increased canal curvature has definitely resulted in generation of more amount of stress.
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