Negative Weight Research Articles

Dual Electronic and Combustible Cigarette Use: Understanding the Relation of Cannabis Use with E-Cigarette Outcomes

Background: E-cigarette use is on the rise and many who use e-cigarettes also smoke combustible cigarettes. Dual use (i.e., use of both electronic and combustible cigarettes) is associated with greater rates of cannabis use and cannabis use among individuals who engage in dual use is related to more severe ecigarette-related problems. Yet, no known studies have tested whether cannabis use is related to more severe e-cigarette problems via negative affect and the expectation that e-cigarettes can help manage negative affect. Objectives: The current study tested this hypothesis among 400 adults who endorsed dual use, 33% of whom endorsed current (past three month) cannabis use. Results: Results indicated that participants with cannabis use reported more anxiety, depression, e-cigarette problems, and the following e-cigarette use expectancies: negative consequences, negative reinforcement, and weight concerns. Multiple mediator models found that the relation between cannabis use status and e-cigarette problem severity was mediated by anxiety (but not depression) and by negative reinforcement and weight concerns (but not negative consequences) expectancies. Serial mediator models indicated that the relation between cannabis use and e-cigarette problems occurred via the serial effects of anxiety and negative reinforcement (but not weight concerns) expectancies. Conclusions: These results highlight several clinical correlates of cannabis use among adults who smoke combustible and e-cigarettes, and suggest that anxiety and the expectation that e-cigarettes may help manage such negative emotions play important roles in e-cigarette-related problems among these individuals.

The auditory function in migraine model rats induced by postauricular nitroglycerin injection.

The mechanism by which migraines produce inner ear-related symptoms is not well understood. Previous studies have found that the latency of auditory brainstem response (ABR) in animal models of migraine has changed, but the threshold has not changed significantly. Therefore, it is necessary to establish a better animal model with both migraine and hearing loss to explore the relationship between migraine and auditory function deeply. In this study, the rat model of migraine was induced by postauricular injection of nitroglycerin (NTG), and the effect on the auditory function of the inner ear was explored by comparing with intraperitoneal injection of nitroglycerin. The rats were given the drug repeatedly on alternate days, a total of 5 dosing, with the body weight monitored during the drug administration. The tactile threshold of the rats' forepaw was measured using von-Frey filaments and auditory function was assessed by ABR. The results showed that the baseline tactile threshold of rats gradually decreased during the modeling process, and hyperalgesia appeared. Postauricular injection of NTG did not affect the weight gain of rats, while intraperitoneal injection of NTG showed slow or even negative weight gain. The ABR threshold of Click, 4 and 8 kHz of postauricular NTG injection rats increased, the latency was prolonged, and the ABR threshold in the right ear was higher than that in the left ear. We demonstrated that postauricular injection of nitroglycerin may be safer and more effective than intraperitoneal injection of nitroglycerin in the process of creating rat migraine model without affecting the weight gain. Postauricular injection of nitroglycerin has more damage to the auditory function of rats. Therefore, the migraine model rat induced by postauricular injection of nitroglycerin may be a new model of cochlear migraine.

Health Consequences of Familial Negative Weight Talk Across the Spectrum of Gender Diversity.

To synthesize differences in familial negative weight talk and health-related correlates across gender identities and to highlight gaps relevant to the unique experiences and health correlates of boys and transgender and gender diverse youth. Most of the studies included in this review observed no difference by gender in familial negative weight talk health correlates. Gender biases in existing measures, however, may have contributed to underreporting of health correlates in boys. Moreover, transgender and gender diverse youth are severely underrepresented in this research. Future research should consistently examine effect modification across gender identities and include measures that are specific to the weight-based concerns and experiences of boys and transgender and gender diverse youth.

Gestational weight loss and fetal growth in uncomplicated pregnancies among women with obesity: a population-based retrospective cohort study

ObjectiveThe impact of gestational weight loss (GWL) on fetal growth among women with obesity remains unclear. This study aimed to examine the association between weight loss during pregnancy among women with body mass index (BMI) ≥ 30 kg/m2 and the risk of small-for-gestational-age (SGA) and large-for-gestational-age (LGA) neonates.MethodsWe conducted a retrospective, population-based cohort study of women with pre-pregnancy obesity that resulted in a singleton live birth in 2012-2017, using birth registry data in Ontario, Canada. Women with pregnancy complications or health conditions which could cause weight loss were excluded. GWL is defined as negative gestational weight change (≤0 kg). The association between GWL and fetal growth was estimated using generalized estimating equation models and restricted cubic spline regression analysis. Stratified analysis was conducted by obesity class (I:30–34.9 kg/m2, II:35–39.9 kg/m2, and III + : ≥40 kg/m2).ResultsOf the 52,153 eligible women who entered pregnancy with a BMI ≥ 30 kg/m2, 5.3% had GWL. Compared to adequate gestational weight gain, GWL was associated with an increased risk of SGA neonates (aRR:1.45, 95% CI: 1.30–1.60) and a decreased risk of LGA neonates (aRR: 0.81, 95% CI:0.73–0.93). Non-linear L-shaped associations were observed between gestational weight change and SGA neonates, with an increased risk of SGA observed with increased GWL. On the contrary, non-linear S-shaped associations were observed between gestational weight change and LGA neonates, with a decreased risk of LGA observed with increased GWL. Similar findings were observed from the stratified analysis by obesity class.ConclusionThese findings highlight that GWL in women with obesity may increase the risk of SGA neonates but reduce the risk of LGA neonates. Recommendations of GWL for women with obesity should be interpreted with caution.

A NOVEL APPROACH TO MODELLING A DIAGNOSIS AND TREATMENT OF TRADITIONAL VIETNAMESE MEDICINE

Traditional Vietnamese Medicine (TVM) is based on the experiences of thousands of years of Vietnamese people in the struggle against diseases; therefore, TVM is very important in the medical system of Vietnam. In this paper, we propose a novel model of an expert system for diagnosing disease syndromes and treating traditional Vietnamese medicine. In this model, the knowledge base consists of IF-THEN rules, in which the antecedent of a rule is an elementary conjunction of propositions and negated propositions. The inference mechanism for the diagnosis of disease syndromes and treatment of traditional Vietnamese medicine applies Abelian group operations. A comparison of the inference of our model with the fuzzy max-min inferences shows that our model can have very similar rules whose contributions sum up to high weight. On the other hand, in our model, a rule with a negative weight may diminish an effect of a rule with a good weight. This feature is absent in the systems with fuzzy max-min inferences. We have built rule patterns for the diagnosis of about 50 disease syndromes and their treatment by Herbs and Acupuncture with the cooperation of practitioners of Oriental Traditional Medicine in Vietnam. Some examples of databases and the rules for disease syndrome differentiation and treatment by herbal medicine and Acupuncture are shown. Finally, some conclusions and future works are given.

Alaska Backcountry Expeditionary Hunting Promotes Sustained Muscle Protein Synthesis.

We have previously described negative energy balance (ie,-9.7±3.4 MJ/d) and weight loss (Δ-1.5 ± 0.7 kg) influenced by high levels of energy expenditure (ie, 17.4±2.6 MJ/d) during remote expeditionary hunting in Alaska. Despite negative energy balance, participants retained skeletal muscle. The purpose of this pilot study was to measure skeletal muscle protein synthesis and examine molecular markers of skeletal muscle protein metabolism under similar conditions of physical and nutrient stress. The "virtual biopsy method" was used to evaluate integrated fractional synthetic rates (FSRs) of muscle protein from blood samples in 4 participants. Muscle biopsies were taken to measure molecular markers of muscle protein kinetics (ie, FSTL1, MEF2, MYOD1, B2M, and miR-1-3p, -206, -208b, 23a, and 499a) using real-time polymerase chain reaction. Our findings in 4 participants (2 females [28 and 62 y of age; 66.2 and 71.8 kg body weight; 25.5 and 26.7 kg/m2 body mass index] and 2 males [47 and 56 y of age; 87.5 and 91.4 kg body weight; 26.1 and 28.3 kg/m2 body mass index]) describe mean muscle FSRs of serum carbonic anhydrase (2.4%) and creatine kinase M-type (4.0%) and positive increments in molecular regulation. Preservation of skeletal muscle under conditions of physical and nutrient stress seems to be supported by positive inflection of skeletal muscle FSR and molecular activation.

Are Negative Weights in Combining Forecasts So Bad?

Purpose of the study. In this paper, we consider the problem of negativity of weight coefficients when combining forecasts. Combining forecasts as a method has long ago proved itself in practice as a good way to improve forecast accuracy. However, in the literature little attention is paid to the issue of negative weights during aggregation, although the cases of obtaining such weights in practice are quite common. The reasons why this may happen are not considered or analyzed. Often, when obtaining weights less than zero, such weights are reset to zero, thus excluding the information contained in the particular forecasting method from the combination, which may reduce the accuracy of the combined forecast. In this regard, it is important to understand why when combining forecasts, negative weight can be obtained and determine options for how to avoid such situations in combining without losing accuracy.Materials and methods. It is proposed to consider various approaches to eliminate excluded weights when combining forecasts, including truncation of weight coefficients or imposing restrictions on them, including the option of sequential combining of forecasts. Results. The result is a list of reasons why negative weights can be obtained when combining forecasts, what risks they have and how to avoid them.Conclusion. Based on the results obtained, it can be concluded that the negative weights themselves when combining forecasts can be triggers for identifying problems when combining. However, it is dangerous to retain them, as they can lead to uncertain prediction results and degrade the accuracy of the resulting combined forecast. The proposed methods of work allow you to bypass the negativity of the weights without a strong deterioration in forecasting.

Chronic consumption of avocado seed (Persea americana) promotes a negative energy balance and body weight reduction in high-fat diet exposed mice: Implications for functional foods

Obesity is the main challenge for public health systems. Functional foods have emerged as an alternative to the ineffectiveness of pharmacological therapies. However, it is necessary to investigate to find sources of raw material for its preparation. The aim of this work was to evaluate the functional effects of residual avocado seed in diet-induced obese mice. Animals were fed a high-fat diet supplemented with avocado seed (1.25%) for 6 weeks. Body weight, food intake, satiety, physical activity, and energy expenditure-involved gene expression were measured. Supplementation with avocado seed led to reduced body weight, delayed satiety, increased physical activity, and induced Dio2 and Adrb1 expression in hypothalamus and white adipose tissue, respectively. No changes in markers of hepatic injury were observed. In conclusion, avocado seed exerts functional effects on obese mice, by promoting energy expenditure, without toxicity effects, making it possible to use this by-product in the development of functional foods.

Matrix weights and regularity for degenerate elliptic equations

We prove local boundedness, Harnack inequality and local regularity for weak solutions of quasilinear degenerate elliptic equations in divergence form. Degeneracy is via a non negative, symmetric, measurable matrix-valued function Q(x) and two suitable non negative weight functions. We setup an axiomatic approach in terms of suitable geometric conditions and local Sobolev–Poincaré inequalities. Data integrability is close to L1 and it is exploited in terms of suitable version of Stummel-Kato class that in some cases is also necessary to the regularity.

Unveiling Nilaparvata lugens Stål Genes Defining Compatible and Incompatible Interactions with Rice through Transcriptome Analysis and Gene Silencing.

The brown planthopper (Nilaparvata lugens Stål, BPH) is a major pest of rice (Oryza sativa L.), causing severe crop loss. Multiple biotypes and emerging populations of BPH pose a bigger challenge for the infestations control. Although several studies have been conducted to understand the molecular mechanisms of rice-BPH interactions, there are few studies dedicated to the Indian sub-continent BPH biotype (biotype 4). Here, we analyzed the transcriptomic, physiological, and gene-silencing responses of the BPH biotype 4 during the compatible (fed on susceptible Taichung Native 1, TN1 rice) and incompatible (fed on resistant PTB33 rice) rice-BPH interactions. In the incompatible interaction, a significant reduction in the honeydew production and negative weight gain were observed in the BPH. Similarly, the trehalose and glucose contents were found to be significantly high and low, respectively, during the incompatible rice-BPH interaction. The comparative BPH transcriptome analysis identified 1875 differentially expressive genes (DEGs) between the compatible and incompatible interactions from which many were annotated to be involved in vital BPH physiological processes, including cuticle development, sugar metabolism, detoxification, molting, and xenobiotics metabolism. The RNA interference-mediated independent silencing of three selected genes, including NlCP1, NlCYP320a1, and NlTret1, revealed that these genes are important for BPH physiology and survival. Moreover, the results of this study provide valuable insights into the rice-BPH interactions involving the BPH biotype 4.

Acute coronary syndrome as a current issue of pediatric cardiology. Outcomes and prognosis: Clinical case

Background. Acute coronary syndrome is widespread in the adult population and has clear diagnostic criteria. In pediatric practice, this pathology is rare, and often implies difficulties in diagnosis. Case description. A 16-year-old male with negative paternal history, hypercholesterolemia, dyslipidemia, and excessive body weight developed myocardial infarction on the background of acute tonsillitis. In the onset of the disease, the adolescent demonstrated clinical signs of acute respiratory infection and coronary spasm. Electrocardiogram revealed ST segment elevation above the baseline in leads I, II, III, aVF, V4–V6 and biochemical markers of myocardial necrosis. Echocardiography revealed signs of focal hypokinesis of the left ventricle, newly detected degree 2 mitral regurgitation. Percutaneous coronary angiography revealed no signs of coronary artery stenosis. The patient received conventional medical treatment of acute myocardial infarction as well as antibacterial therapy. He was discharged in satisfactory condition. After 1 year of follow-up after the myocardial infarction the patient showed no pathologic changes both on stress-echocardiography and electrocardiogram. Three-year catamnesis appeared to be favorable. Conclusion. The presented clinical case demonstrates the individual mechanism of acute coronary syndrome development in children. Pediatricians should be aware of the risk of developing acute coronary syndrome against the background of infectious pathology.

PROGESTERONE RECEPTOR GENE POLYMORPHISM AS A FACTOR IN PRETERM BIRTH (LITERATURE REVIEW)

The purpose of the work – to analyze data from the world literature regarding thedetermination of the probable role of the progesterone receptor gene polymorphism asa factor in the occurrence of premature birth.Conclusions. 1. Progesterone receptor gene polymorphism plays a significant role inthe mechanisms of development and course of miscarriage, negative pregnancy outcomeand low birth weight of newborns. 2. The probability of the threat of premature birthin different periods of gestation or termination of pregnancy with premature birth maydepend on the presence of one or another polymorphism. 3. Genetic variability thatcan lead to changes in the biological functions of the progesterone receptor, the geneticpolymorphism of the progesterone receptor is a major risk factor for complications ofpreterm birth.

Importance of nutrient balance in severe congenital diaphragmatic hernia: A retrospective case–control study

Growth retardation is a common morbidity in infants with severe congenital diaphragmatic hernia (CDH). This study aimed to investigate the appropriate amount of nutrition and nutrient balance in early infants with severe CDH. This was a retrospective case-control study. Isolated CDH patients with more than half of the chest wall devoid of diaphragmatic tissue and treated between 2006 and 2022 were included. The patients were divided into positive (n=16) or negative (n=8) weight gain velocity groups in early infancy (from 1 to 3 months of age). Clinical variables and amount of nutrition were compared between the two groups. The earlier start of enteral nutrition (EN) and higher replacement rate of the naso-duodenal (ND) tube were observed more frequently in the positive group than in the negative group. Regarding daily intake by both EN and parenteral nutrition (PN), total caloric intake and caloric intake of proteins and lipids were significantly higher in the positive group than in the negative group at 1 month of age. At 2 months, total caloric intake and caloric intake of lipids were significantly higher in the positive group than in the negative group. At 3 months of age, only caloric intake of lipid was significantly higher in the positive group than in the negative group. The early replacement of the ND tube may contribute to the early start of EN, which may subsequently lead to appropriate nutrient supplementation including adequate lipid administration, resulting in early catch-up growth.

A new tool to capture dimensions of family dinners in relation to adolescent health and risk-related outcomes: The ‘Family Dinner Index’

There is a strong association between family meals and child and adolescent health. To systematically understand the associations between family meals with a variety of health and risk outcomes, we developed and conducted a validation study of child- and parent-versions of the Family Dinner Index (FDI; FDI-C/FDI-P). We validated the measures with a national sample of 2,090 parent–child dyads. Using factor analysis, we reduced the initial FDIs each to eight items representing communication, enjoyment, and digital distractions; the FDI-C also included meal logistics and the FDI-P, family bonding. Using multivariable log-binomial regression models, we examined the relationships between FDI scores and substance use, violence, weight perception, weight control intention, and health indicators. Children who scored ≥21 on the FDI-C had a significantly lower average prevalence of a ‘negative outcome’ composite, as well as a lower prevalence of each of the individual behaviors. Children of parents who scored ≥24 on the FDI-P had a significantly lower average prevalence of the ‘negative outcome’ composite, as well as a lower prevalence of substance use indicators, negative weight perception and intentions to lose weight, less than daily fruit and vegetable consumption, and not meeting guidelines for physical activity. The FDI measures provide support for face and content validity, as well as concurrent criterion validity and construct validity. Further validation with these measures using a longitudinal design will allow for the establishment of predictive validity. Currently, the FDI measures may help researchers and practitioners identify points of emphasis for tailoring family-based prevention programs accordingly.

210-OR: Long-Acting GIPR Agonism Enhances Body Weight Regulation of Multiple Weight-Reducing Agents in Diet-Induced Obese Mice

The development of multi-agonists targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) has resulted in significant clinical improvements in body weight management, however the contribution of GIPR agonism to this effect is incompletely understood. Using a diet induced obese (DIO) mouse model, GIPR agonism (LAGIPRA) alone has demonstrated little to no efficacy in weight management, whereas the addition of LAGIPRA to long acting GLP-1R agonism decreased food intake and increased energy expenditure resulting in greater weight loss compared with GLP-1R agonism alone suggesting a synergistic benefit. To determine whether GIPR agonism would provide similar synergistic improvements in energy metabolism with additional pharmacologic drivers of weight loss, we treated DIO mice with various weight reducing agents plus and minus LAGIPRA in metabolic chambers. Interestingly, addition of LAGIPRA enhanced weight loss, fat mass reduction, energy expenditure, and lipid oxidation whether combined with T3, FGF21, or long-acting glucagon (IUB288); consistent with earlier experiments, it had little effect on its own. Assessment of adipose tissue engagement in these and subsequent studies suggest GIPR agonism in this tissue may enhance lipolysis, potentially enabling greater energy expenditure via release of stored lipids. These findings suggest a unique role for GIPR agonism to regulate energy expenditure when combined with molecules that reduce body weight generating a greater negative caloric balance and enhancing body weight reduction. Disclosure W.Roell: Employee; Eli Lilly and Company, Stock/Shareholder; Eli Lilly and Company. L.O'farrell: None. A.Regmi: Employee; Eli Lilly and Company. T.Coskun: Employee; Eli Lilly and Company, Stock/Shareholder; Eli Lilly and Company.

Negative Capabilities: Investigating Apophasis in AI Text-to-Image Models

Through a case study of images generated by Swedish artist Steph Maj Swanson using an AI text-to-image (T2I) model, this article explores the strategy of negative weight prompting in T2I models as a phenomenon of apophasis. Apophasis is a linguistic strategy commonly deployed in texts of mystical theology to express the ineffability of God through negative concepts. In this article, a comparison of apophatic strategies in mystical texts and T2I models is engaged to highlight the mutual benefit of theorising AI with the help of religious theory and concepts. With this, the article builds on previous work on the New Visibility of Religion, enchantment, and post-secularism—especially the research of Beth Singler on religious continuities in representations of AI. Recent work on AI prompt engineering, computational linguistics, and computational geometry is invoked to explain the linguistic processes of T2I models. Poststructuralist semiotics is then employed to theorise the search for the Transcendental Signified in apophatic theology. The article concludes that linguistic theology can help to elucidate technological use cases, subsequently arguing for further dialogue between scholars in artificial intelligence and religious studies, and for a revaluation of religion in the technological sphere.

Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice.

Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. In the present study we observed C57BL/6 mice to double their body weight from 4 to 48 weeks of age and become obese. We evaluated the efficacy of oral administration of recombinant-methioninase (rMETase)-producing E. coli (E. coli JM109-rMETase) or a methionine-deficient diet to reverse old-age-induced obesity in C57BL/6 mice. Fifteen C57BL/6 male mice aged 12-18 months with old-age-induced obesity were divided into three groups. Group 1 was given a normal diet supplemented with non-recombinant E. coli JM109 cells orally by gavage twice daily; Group 2 was given a normal diet supplemented with recombinant E. coli JM109-rMETase cells by gavage twice daily; and Group 3 was given a methionine-deficient diet without treatment. The administration of E. coli JM109-rMETase or a methionine-deficient diet reduced the blood methionine level and reversed old-age-induced obesity with significant weight loss by 14 days. There was a negative correlation between methionine levels and negative body weight change. Although the degree of efficacy was higher in the methionine-deficient diet group than in the E. coli JM109-rMETase group, the present findings suggested that oral administration of E. coli JM109-rMETase, as well as a methionine-deficient diet, are effective in reversing old-age-induced obesity. In conclusion, the present study provides evidence that restricting methionine by either a low-methionine diet or E. coli JM109-rMETase has clinical potential to treat old-age-induced obesity.

A Negative Weight Pseudotensor Formulation of Coupled Hemitropic Thermoelasticity

A Negative Weight Pseudotensor Formulation of Coupled Hemitropic Thermoelasticity

Circuit Design and Application of Discrete Cosine Transform Based on Memristor

Discrete Cosine Transformation(DCT) is an important method in image compression. With the advent of the era of big data, how to make efficient DCT calculation is the key to its application. Therefore, this paper proposes a one-step DCT calculation method from the point of view of analog circuit, which can greatly speed up the operation in the form of low energy consumption. Firstly, a new weight programming is proposed, and the negative weight problem is solved. On the basis of this analysis, One-dimensional DCT(1D-DCT) and One-dimensional IDCT(1D-IDCT) calculation circuit is proposed. After that, the One-dimensional circuit is designed into Two-dimensional circuit by using parallel processing. PSPICE simulation results show that the average calculation accuracy of the circuit is above 99%. Finally, the designed two-dimensional circuit is used in image compression, and it is found that the compression effect is significant in the case of high speed.

Nonexistence of negative weight derivations of the local k-th Hessian algebras associated to isolated singularities

Nonexistence of negative weight derivations of the local k-th Hessian algebras associated to isolated singularities