Negative Weight Research Articles

The distance decay effect and spatial reach of spillovers

This paper quantifies and graphically illustrates the distance decay effect and spatial reach of spillover effects derived from a spatial Durbin (SD) model with parameterized spatial weight matrices. Building on attributes of the concept of spatial autocorrelation developed by Arthur Getis, we adopt a distance-based negative exponential spatial weight matrix and parameterize it by a decay parameter that is different for each spatial lag in this model, both of the regressand and of all regressors. The quantification and illustration are applied to the spatially augmented neoclassical growth framework, which we estimate using data for 266 NUTS-2 regions in the EU over the period 2000–2018. We find distance decay parameters ranging from 0.233 to 2.224 and spatial reaches ranging from 700 to more than 1500 km for the different growth determinants in this model. These wide ranges highlight the restrictiveness of the conventional SD model based on one common spatial weight matrix for all spatial lags.

Hepatic mRNA expression of innate and adaptive immune genes in beef steers with divergent residual body weight gain

Immune function plays a pivotal role in dictating the overall health and productivity of cattle. In a proficient immune system, the liver assumes an integral function in detoxification and metabolic processes and contributes substantially to overall production and immunity. In this study, we evaluated the hepatic mRNA expression of genes involved in innate and adaptive immunity in crossbred beef steers with positive or negative residual body weight gain (RADG). Positive-RADG beef steers (n = 8; RADG = 0.73 kg/d) and negative-RADG beef steers (n = 8; RADG = -0.69 kg/d) were identified from a group of 108 growing crossbred beef steers (average BW = 556 ± 38 kg) after a 56-d performance testing period. At the end of the 56-d period, liver tissue samples were collected from the beef steers for RNA extraction and cDNA synthesis. The mRNA expression of 84 genes involved in innate and adaptive immunity were analyzed using pathway-focused PCR-based arrays. The mRNA expression of genes with false discovery rate-adjusted P-values (FDR) ≤ 0.05 and absolute fold change (FC) ≥ 1.2 were determined to be differentially expressed. Out of the 84 genes analyzed, four genes (IL-2, MYD88, CD-80, NFkB-1) were differentially expressed and were all upregulated in positive compared with negative-RADG beef steers. IL-2 is a cytokine that plays a critical role in the immune response by activating and proliferating T-cells, which are important for fighting infections. MYD88 is an adaptor protein that is essential for signaling by toll-like receptors, which are involved in pathogen recognition. CD80 is a protein that is expressed on the surface of antigen-presenting cells and plays a critical role in the initiation of an immune response. The activation of NF-κB leads to the production of cytokines and chemokines that help to recruit immune cells to the site of infection. The upregulation of the aforementioned genes in positive-RADG beef steers suggests that they had a better ability than negative-RADG beef steers to quickly recognize pathogens and initiate appropriate responses to effectively fight off infections without causing inflammatory reactions, potentially contributing to their better feed efficiency.

The effect of different surface treatments of 310S austenitic stainless steel on the corrosion behavior in supercritical water using slow positron methods

AbstractThe corrosion behavior of 310S austenitic stainless steel, subjected to different surface treatments machined (MA), sandblasting (SB), and polishing (PO), was exposed to a 550°C supercritical water (SCW) environment. The aged samples were analyzed using variable‐energy slow positron beam techniques. The obtained results revealed that the plastic deformation of the near‐surface region of the MA and SB samples was substantially recovered in the SCW conditions. At least two distinct oxide layers formed, and the oxidation process created a Fe/Cr depletion zone in the inner layer. Various surface treatments, however, led to different corrosion profiles. The depth profile of slow positron beam characterization suggests that significant residual stress and deformation zones on the surfaces of the sandblasted samples probably provided a diffusion path for the oxidation of the 310S. Only the SB samples exhibited a negative weight change after SCW exposure. At the same time, the SB samples showed the highest concentration of the positron traps in this region, which was explained by open‐volume defects associated with the microcracks introduced by sandblasting.

Negative familial weight talk and weight bias internalization in a US sample of children and adolescents.

Negative familial weight talk may contribute to higher weight bias internalization in pre- and early adolescents (hereafter referred to as children) and may differ by gender, weight status, and race and ethnicity. Examine the relationship between negative familial weight talk and weight bias internalization and examine differences by gender, weight status, and race and ethnicity. We cross-sectionally analysed 5th-7th graders (10-15 years old) living in Massachusetts (n = 375, 52.3% girls, 21.3% BMI ≥85th percentile, 54.8% non-Hispanic White). Negative familial weight talk frequency during the past 3 months was self-reported and discretized as 'never,' 'occasionally' (1-9 times) and 'often' (>9 times); the Modified Weight Bias Internalization Scale assessed weight bias internalization. Generalized linear models estimated the relationship between negative familial weight talk and weight bias internalization and sub-analyses estimated the relationship across gender, weight status, and race and ethnicity. Results are summarized as ratios of means (RoM). Children experiencing negative familial weight talk occasionally (RoM = 1.12, p = 0.024) and often (RoM = 1.48, p < 0.001) had significantly higher weight bias internalization than children who never experienced it. In sub-analyses, experiencing negative familial weight talk often was associated with higher weight bias internalization among girls (RoM = 1.66, p < 0.001), boys (RoM = 1.32, p = 0.007), children with BMI <85th percentile (RoM = 1.44, p = 0.007) and BMI ≥85th percentile (RoM = 1.39, p = 0.001), and non-Hispanic White children (RoM = 1.78, p < 0.001), but not Hispanic (RoM = 1.25, p = 0.085) or non-Hispanic Black children (RoM = 1.20; p = 0.31). Frequent negative familial weight talk was associated with higher weight bias internalization across gender and weight status and in non-Hispanic White children only.

Has the opening of high-speed railway in China promoted urban low-carbon transformation along the route: re-estimation based on staggered DID robust estimators.

Considering the opening of high-speed railway (HSR) as a quasi-natural experiment, this paper explores the emission reduction effect of HSR opening and its mechanisms and heterogeneity characteristics based on the panel data of 272 cities in China from 2006 to 2019 by staggered DID model and the mediating effect model. It is found that (1) the opening of HSR significantly reduces the carbon emission level of cities, and the conclusion still holds after controlling the endogeneity issue and a series of robustness tests; (2) Bancon decomposition and negative weight diagnostics both show that the estimated average treatment effect bias is small and the robust estimators are more robust; (3) by reducing production costs and promoting inter-regional industrial division of labor, the opening of HSR promotes intra-industrial structural transformation and inter-industrial structural transformation, respectively, thus reducing urban carbon emissions. At the same time, HSR achieves urban carbon emission reduction by promoting free movement of population and human capital agglomeration; and (4) further study finds that there is regional heterogeneity in the emission reduction effect of HSR opening, and the carbon reduction effect is mainly reflected in large and medium-sized cities, near provincial capitals, non-resource-based cities, and cities with rich educational resources, which indicates that the location of future HSR should be combined with the city's own characteristics and be tailored to the city.

K-Medoids Clustering dan Mean-Value at Risk untuk Optimasi Portofolio Saham Jakarta Islamic Index

&lt;p&gt;The problem of the portfolio is how to choose stocks and determine their weights in order to generate maximum returns with minimal risk. Portfolios are formed by selecting stocks that have different characteristics. K-Medoids Clustering can be used to group data sets that contain outliers. Validate cluster results using the Davies Bouldin Index to determine the best number of clusters. Portfolio weighting is determined using the Mean-VaR method by taking into account the expected return value and minimizing the VaR risk value. Stocks are grouped based on Return on Assets, Return on Equity, Debt to Asset Ratio, and Debt to Equity Ratio. The results of cluster formation on the Jakarta Islamic Index stocks obtained six portfolio constituent stocks based on the highest expected return value from each cluster, consisting of PTBA, ADRO, AKRA, EXCL, PTPP, and UNVR. The results of calculating the weight of the optimal portfolio with Mean-VaR obtained a weight for PTBA of 0.46536; AKRA of 0.24018; EXCL of 0.25421; and UNVR of 0.25392. ADRO and PTPP stocks have a negative weight value of -0,07775 and -0,13593 this indicates the occurrence of short selling in the weighting. At the 95% confidence level, the VaR portfolio value is 5.06%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Keywords: &lt;/strong&gt;Clustering; K-Medoids; Daveis Bouldin Index; Portfolio; Mean-VaR&lt;/p&gt;

Caffeine Use and Attentional Engagement in Everyday Life

Caffeine is a common component of various beverages and foods with approximately 80% of the world's population consuming caffeinated products daily. Here we examined how caffeine consumption and different motivations for consuming caffeine (e.g., cognitive enhancement, negative affect relief, reinforcing effects, and weight control) relate to self-reported inattention, mind-wandering, and deep, effortless concentration (i.e., flow) in everyday life in a university student population via two online surveys (N = 224 and N = 234). Our results indicated that, contrary to what one might expect, the amount of caffeine consumed in a typical day (estimated in milligrams) was not related to attention-related experiences in everyday life. However, we found that those who are more likely to ingest caffeine to potentially enhance their cognition, or to experience the reinforcing effects of caffeine, or to help relieve negative affect showed higher levels of inattention in everyday life.

Wählen mit Kübeln und Kaskaden: Wie sich das Personenstimmen- paradox bei Wahlen in Bremen, Hamburg und Niedersachsen auf einfache Weise vermeiden lässt

In state elections in Bremen and Hamburg and local elections in Lower Saxony, voters have the opportunity to vote directly for one or more candidates or to confirm the order of the lists proposed by the parties . The ratio of votes cast for the candidates and the list deter- mines how many seats are filled according to the order of the list and how many seats are filled according to the order of the votes cast for the candidates . It may be the case that an additional vote for a candidate leads to him not receiving a seat at all . This phenomenon, which is reminiscent of the negative weight of votes in Bundestag elections, is a nuisance from the point of view of democratic theory because it violates the fundamental require- ment that a vote for a candidate always leads to an increase in his chances of getting elected . Probst and Schröder speak of the personal vote paradox or external-utilization paradox . The aim of this article is to present three simple procedures that avoid the personal vote paradox without fundamentally changing the logic of the current electoral system . The effects of the proposed procedures are illustrated using the election results of the Bremen state election in 2023 . [

Overweight people’s perceptions of their own appearance and the risks of negative weight development

Overweight people’s perceptions of their own appearance and the risks of negative weight development

Ab. No. 180 Association between Balance Confidence and Activities of Daily Living in Community Dwelling Elderly

Introduction: Balance confidence and FOF are essential psychological factors to consider when developing fall intervention strategies to enhance ability of elderly to remain active at home and within the community, and avoid injurious falls. Psychological factors like balance confidence and fear of falling (FOF) are related to balance impairment and falling. Ability to perform activities without falling may have positive effect on confidence in balancing. Study was aimed at obtaining better understanding of association of level activity of daily living (ADL) with individual’s estimation ability to avoid fall or maintain their balance. Methods: 315 ambulatory community dwelling elderly ageing 60 to 85 years were recruited by personal interview from parks, and housings of various areas of city. Elderly with MMSE score &lt; 18, neurological disorders (e.g. Stroke, Parkinson’s disease), any acute injury, hearing/communication problems, nonstable medical conditions, painful osteoarthritis with weight bearing, vestibulopathy were excluded. In this cross-sectional study, all individuals were screened for cognition using MMSE along with demographic details. The participants were assessed using Activities-specific balance confidence (ABC) scale, Katz Index of Independence in ADL and Lawton IADL Scale. Result: Mean sample age was 69.2±6.33 with 46.2% females. ABC score showed significant correlation with the criterion (p&lt;0.000). The multiple regression model with all four predictors produced R²=0.454, F=64.316, p&lt;0.000. MMSE, Lawton and Katz scale had significant positive regression (B=1.232,0.329,3.402 respectively). Age had significant negative weight (B=-0.786). Conclusion: Katz Index was the best predictor of balance confidence followed by MMSE, age and Lawton IADL Scale. Implications: Result provides better understanding of factors predicting balance confidence.

Fish consumption and omega-3 polyunsaturated fatty acids from diet are positively associated with cognitive function in older adults even in the presence of exposure to lead, cadmium, selenium, and methylmercury: a cross-sectional study using NHANES 2011–2014 data

BackgroundLong-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are reported to be beneficial for cognition, but limited consumption of some fish is recommended due to high concentrations of heavy metals and persistent organics. ObjectiveWe aimed to determine whether dietary ω-3 PUFAs from fish consumption are associated with higher cognitive scores in older adults and explored the associations of mixtures of ω-3 PUFAs and blood concentrations of lead, cadmium, selenium, and methylmercury on cognitive performance. MethodsWe conducted a cross-sectional study with data from the NHANES 2011–2014, assessing cognitive scores of immediate recall, delayed recall, and executive function in adults ≥60 y (n = 3123). We performed multivariate linear regressions and mixture models utilizing the quantile-based g-computation method to identify associations between monthly fish consumption or dietary ω-3 PUFAs with blood concentrations of lead, cadmium, methyl mercury, and selenium on cognitive scores. ResultsFish consumption had significant positive associations with all 3 cognitive scores, whereas dietary ω-3 PUFAs were only significantly associated with the Digit Symbol Substitution Test (DSST) scores. Mixture analysis showed significant positive associations with DSST scores for fish consumption (β: 0.88; 95% CI: 0.48, 1.29) and dietary ω-3 PUFAs (β: 0.41; 95% CI: 0.03, 0.78) with positive component weights for fish consumption, dietary ω-3 PUFAs, and blood selenium and negative component weight for blood cadmium concentrations. ConclusionsOur findings support dietary recommendations for older adults to consume fish to maintain cognitive function, likely due to biomolecular actions of ω-3 PUFAs that increase neuronal membrane fluidity, have antioxidation activity, and restore cell damage. The combination of selenium and fish consumption or ω-3 PUFAs was associated with reduced decline in cognitive scores and less negative associations from exposures to lead, cadmium, and mercury compounds.

On Frontier Portfolio in Shanghai Stock Exchange Based on Mean Variance Model

In security markets, how to achieve optimal allocation of asset has become the focus of investors. The mean-variance model is a method to achieve revenue maximization and risk minimization on investing stock portfolio. This paper will research on investment problem in Shanghai Stock Exchange. It involves research result about mean variance model since 1952. To take the experiment, 10 stocks are chosen from Shanghai Stock Exchange. Organizing rates of return for 360 days and using the average daily rate of return as the expected rate of return. Applying mean variance model, selecting data, the curve of frontier portfolio is obtained by experiment. Based on the result, the investment advice is given. It shows that higher expected rate of return accompanies by higher risk. To achieve higher returns, investor could analyse the variation of each asset along with the rise of the expected rate of change. When negative weight appears, there exists short selling. If short selling is not allowed, investor could shrink the interval of the expected rate of return.

Does place-based green policy improve air pollution? Evidence from China's National Eco-Industrial Demonstration Park Policy.

Air pollution is one of the serious environmental problems facing the world. This paper systematically investigates the impact and transmission mechanism of the construction of national eco-industrial parks (NEDPs) on urban air pollution based on Chinese city-level panel data from 2003 to 2021 using a staggered difference-in-differences (staggered DID) model. It is found that the construction of NEDP significantly reduces urban air pollution, a conclusion supported by the negative weight diagnostic test and two types of robust DID estimators. Mechanism analyses indicate that NEDP construction reduces urban air pollution mainly by improving regional environmental regulation, promoting green technology innovation and improving energy structure. In addition, the mitigation effect of NEDP construction on urban air pollution is heterogeneous by policy intensity, city resource endowment, city size and administrative status. Further tests show that the institutional environment enhances the air pollution mitigation effect of NEDP construction and that the better the degree of marketization, property rights system, legal system and market development in the place where the policy is implemented, the more conducive it is to amplify the air pollution suppression effect brought about by NEDP construction. Developing economies should take complete account of the characteristics of different regions when implementing place-based green policies to achieve synergistic development of the environment and the economy.

Hybrid Integrated Computing Algorithm for Sustainable Tourism

To avoid destroying the natural environment, we can create tourist paths without disrupting ecological systems or rare places such as rainforests that contain endangered species. Likewise, in sustainable tourism, we should consider visiting national parks or national museums as a way to understand the core values and the meaning of that culture and environment more clearly. In this paper, we consider which points tourists need to avoid or visit for sustainable tourism. We designed an algorithm that can give a path to avoid certain points or to go to a preferred point. If this algorithm does not give any weight, it will give the shortest path from the start to the end, and it can decide which vertices to avoid or travel to. Moreover, it can be used to vary the weights of different positive or negative values to obtain a path to avoid a point or to reach a point. Compared to Dijkstra’s algorithm, we can add a negative weight to the graph and still find the shortest path. In application, it can be used for path schedule decisions. We did not wave the large resources to calculate the walk length. In the usage scenario, users only need to provide the starting node, end node, avoidance point, and facing point to calculate the best path. This algorithm will give a good path for users. At the same time, users can use this algorithm to implement sustainable travel route planning, such as going to museums, avoiding rare environments, etc. So, this algorithm provides a new way to decide the best path. Finally, the experimental results show that the classic algorithms cannot avoid points. In real tourism, tourists can use this algorithm for travel planning to achieve sustainable tourism.

Latinas’ internalization of U.S. beauty ideals as a moderator of the relations between appearance-related messages from family members and Latinas’ depressive symptoms

Depression is a prevalent concern in Latinas; thus, it is critical that we examine the associations between negative eating and weight messages from mothers, fathers, and sisters, and depressive symptoms in Latinas. We utilized a sample of 195 Latina/Hispanic young women ( Mage = 23.25 years; range = 18–25; SD = 1.93; 67.4% Mexican-origin) to explore the moderating role of Latinas' internalization of U.S. beauty ideals on the associations between negative eating and weight messages from mothers, fathers, and sisters, and Latinas' depressive symptoms. We conducted three hierarchical regression analyses and found that negative messages from each family member (i.e., mothers, fathers, and sisters) and Latinas' internalization of U.S. beauty ideals were significantly and positively associated with Latinas' depressive symptoms. Further, we found that under both high and low internalization of U.S. beauty ideals, there was a positive association between negative messages from sisters and depressive symptoms. However, this association was stronger for those with high internalization of U.S. beauty ideals. Findings from this study further solidify the importance of family members' negative eating and weight messages for Latinas' well-being. Additionally, our study demonstrates that internalizing U.S. beauty ideals is associated with Latinas’ mental health.

PSIII-10 Hepatic Mrna Expression of Genes Related to Innate and Adaptive Immune Genes in Beef Steers with Divergent Residual Body Weight Gain

Abstract Immune function plays an important role in overall animal health and productivity. In this study, we evaluated the hepatic mRNA expression of genes involved in innate and adaptive immunity in crossbred beef steers with positive or negative residual body weight gain (RADG). Positive-RADG beef steers (n = 8; RADG = 0.34 kg/d) and negative-RADG beef steers (n = 8; RADG = -0.27 kg/d) were selected from a group of 108 growing crossbred beef steers (average BW = 556 ± 38 kg) after a 42-d performance testing period. At the end of the 42-d period, liver biopsies were collected from the beef steers for RNA extraction and cDNA synthesis. The mRNA expression of 84 genes involved in innate and adaptive immunity were analyzed using pathway-focused PCR-based arrays. The mRNA expression of genes with false discovery rate-adjusted P-values (FDR) ≤ 0.05 were considered to be differentially expressed. Out of the 84 genes analyzed, four genes (IL-2, MYD88, CD-80, NFkB-1) were differentially expressed and were all upregulated in positive-RADG, compared with negative-RADG beef steers. IL-2 is a cytokine that plays a critical role in the immune response by activating and proliferating T-cells, which are important for fighting infections. MYD88 is an adaptor protein that is essential for signaling by toll-like receptors, which are involved in pathogen recognition. CD80 is a protein that is expressed on the surface of antigen-presenting cells and plays a critical role in the initiation of an immune response. The activation of NF-κB leads to the production of cytokines and chemokines that help to recruit immune cells to the site of infection. The upregulation of the aforementioned genes in positive-RADG beef steers suggests that they had a better ability than negative-RADG beef steers to quickly recognize pathogens and initiate appropriate responses to effectively fight off infections without causing inflammatory reactions. This is essential to optimize immune function and minimize the impact of immune activation on growth and production. As a result, more energy and nutrients are available to support improved growth rate and feed efficiency.

Comparison Analysis of Graph Theory Algorithms for Shortest Path Problem

The Sumba region, Indonesia, is known for its extraordinary natural beauty and unique cultural richness. There are 19 interesting tourist attractions spread throughout the area, but tourists often face difficulties in planning efficient visiting routes. From this case, it can be solved by applying graph theory in terms of searching for the shortest distance which is completed using the shortest path search algorithm. Then these 19 tourist objects are used to build a weighted graph, where the nodes represent the tourist objects and the edges of the graph describe the distance or travel time between these objects. Therefore, this research aims to compare the shortest path search algorithm with parameters to compare the shortest distance results, algorithm complexity and execution time for tourism in the Sumba area. The results of this research involve a comparison of several shortest path search algorithms, with the aim of finding the shortest distance results, algorithm complexity, and execution time for tourism in the Sumba area. Based on the test results of the five algorithms with the parameters that have been prepared, and the findings show that each algorithm has its own characteristics, the results are as follows: Dijkstra's algorithm can be used to calculate the shortest route for single-source and single-destination types. This resembles the Bellman-Ford algorithm, only the Bellman-Ford algorithm can be used simultaneously on graphs that have negative weight values. Meanwhile, the Floyd-Warshall algorithm is suitable for use on the all-pairs type. Then, the Johnson Algorithm can be used to determine the shortest path from all pairs of paths where the destination node is located in the graph. Finally, the Ant Colony algorithm to compute from a node to each pair of destination nodes.

Parent-Adolescent Weight Communication: Parental Psychosocial Correlates Among a Diverse National Sample

Parental communication about body weight with their children is common across diverse families. The current study investigates how parents’ feelings about their own bodies, beliefs about body weight, history of weight stigma, and weight-related characteristics contribute to the degree to which they talk about weight – both negatively and positively – with their adolescent children. The study sample was comprised of U.S. parents (N = 1936) from diverse racial/ethnic backgrounds with children aged 10–17 years old. Parents completed an online survey with measures assessing their frequency of engaging in negative and positive weight communication with their children, along with several relevant psychosocial factors (i.e. body satisfaction, experienced weight stigma, associative stigma, body appreciation, beliefs about weight controllability, weight bias internalization). Study findings paint a complex picture, including some psychosocial factors (e.g. weight bias internalization) that are related to both more frequent negative and positive weight communication. Notably, higher levels of associative stigma were related to more frequent negative parental weight comments, and less frequent positive weight socialization. Findings can inform healthcare professionals in raising parents’ awareness about how their personal beliefs and feelings about their own weight and their child’s weight can contribute to how they engage in communication about weight with their children.

Variability across time in implicit weight-related bias: Random noise or meaningful fluctuations?

Social psychologists have struggled with the vexing problem of variability over time in implicit bias. While many treat such variability as unexplainable error, we posit that some temporal variability, whether within persons or across society at large, reflects meaningful and predictable fluctuation based on shifts in the social-cultural context. We first examined fluctuations at the group-level in a Project Implicit data set of female participants who completed the Weight Implicit Association Test between 2004 and 2018 (N = 259,613). Extending our prior work showing that mass media celebrity fat-shaming increased women's implicit antifat bias, we show that celebrity body positivity events reduced such bias (Study 1a). We then focused on a specific form of body positivity-that is, celebrity "push-back" in response to fat-shaming. Whereas fat-shaming without antibias push-back was associated with spikes in negative weight attitudes, fat-shaming with push-back showed no change in such bias (Study 1b). Critically, however, closer analysis revealed that this apparent stability was due to the canceling out of opposing negative (fat-shaming) and subsequent positive (body positivity) influences-an effect that was obscured when the window of observation was expanded. Finally, in Study 2, we examined parallel effects at the individual level in a daily diary study. Consistent with the group-level, between-subjects data, women's intraindividual fluctuations in implicit attitudes were reliably predicted based on prior-day exposure to fat-shaming and/or body positivity influences. Taken together, our work highlights how both group- and individual-level variability across time can be meaningfully explained rather than treated as unexplainable or left as unexplained. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Therapeutic Hypothermia Is Limited in Preventing Developmental Impairments after Neonatal Hypoxia-Ischemia

The only current treatment for neonatal hypoxia-ischemia (HI) is therapeutic hypothermia (TH), which still shows some limitations. Specific effects of TH in the several processes involved in brain injury progression remain unclear. In this study, the effects of TH treatment on developmental parameters, behavioral outcomes, and peripheral leukocytes were evaluated in neonatal male and female rats. In P7, animals were submitted to right common carotid artery occlusion followed by hypoxia (8% oxygen). TH was performed by reducing the animal scalp temperature to 32°C for 5 h. Behavioral parameters and developmental landmarks were evaluated. Animals were euthanized at P9 or P21, and cerebral hemispheres, spleen, and thymus were weighed. White blood cells (WBCs) were counted in blood smears. There was a reduction in the weight of the brain hemisphere ipsilateral to the carotid occlusion in HI and TH groups, as well as a reduction in body weight gain and a delay in the opening of the ipsilateral eye. Latency in negative geotaxis was increased by HI at P12. TH did not prevent brain weight loss, developmental impairments, or WBC number changes but prevented negative geotaxis impairment and spleen weight reduction. These data reinforce that a better understanding of the events that occur after HI and TH in both males and females is necessary and would allow the development of more adequate and sex-specific therapeutic approaches.