This research focuses on assessing the environmental impact of heating and cooling systems in public housing projects, built between 2000 and 2020, in Tucuman, Argentina. It considers current and projected climate change scenarios. The study compares existing conditions with improvements suggested by IRAM 11603 for a thermo-energetic transition. Anticipating future energy consumption changes is vital for proposing sustainable retrofitting options to enhance affordability and energy efficiency, while ensuring occupants’ thermal comfort. A public housing prototype in Tucumán serves as the case study. The methodology combines energy simulation and Life Cycle Assessment (LCA) to analyze current and future energy demands. The results show climate change’s potential impact on housing thermal behavior and the necessity for improvements. In the base case, cooling demand exceeds 11 kWh/m2·year, while heating demand decreases by approximately 4 kWh/m2·year. Rehabilitation could reduce cooling demand by 57% and heating demand by 32.5%, considering future climate scenarios. Active architectural strategies are proposed for enhancing thermal performance and reducing energy consumption and carbon dioxide emissions. This study underscores the importance of analyzing future scenarios and implementing strategies for the thermo-energetic transition of existing social housing.