NBNA Score Research Articles

Influence Evaluation of Human Immunoglobulin and Yinzhihuang on Bilirubin Level and NBNA Score of Newborn ABO Hemolytic Jaundice Children

Influence Evaluation of Human Immunoglobulin and Yinzhihuang on Bilirubin Level and NBNA Score of Newborn ABO Hemolytic Jaundice Children

Effects of Family Participatory Nursing on Clinical Outcomes of Premature Infants in NICU and Families' Psychological Status.

The purpose of this study was to explore the effects of family participatory nursing on the clinical outcomes of premature infants in the neonatal intensive care unit (NICU) and their families' psychological status. Total of 150 premature infants were admitted to the NICU of our hospital from December 2019 to December 2021, and their families were selected by convenience sampling method and divided into control group (n = 78, from December 2019 to December 2020) and observation group (n = 72, from January 2020 to December 2021) according to the admission time. The infants in the control group were given routine nursing, while those in the observation group received family participatory nursing. In the observation group, the length of stay and duration of oxygen therapy were shorter, the weight gain speed was higher, and the incidence rate of nosocomial infection was lower than those in control groups (P < 0.05). The time of reaching full gastrointestinal feeding was earlier, the daily milk intake and exclusive breastfeeding rate were higher, and the feeding intolerance rate was lower in observation group than those in control group (P < 0.05). Observation group exhibited significantly higher body weight, Z-value of body weight, NBNA score at 7 d after hospitalization, 15-month mental development index (MDI), and psychomotor development index (PDI) scores than control group (P < 0.05). In addition, the families' somatization, depression and anxiety factor scores, and total score of SCL-90 in the observation group were lower than those in the control group, while each dimension score and total score of MPOC-20 were higher than those in control groups (P < 0.05). Family participatory nursing is of great significance in ameliorating the clinical outcomes of premature infants in the NICU, which can shorten the length of stay, improve feeding conditions, facilitate infant growth and development, and enhance their families' psychological status and nursing satisfaction.

Optimized Clustering Algorithm for Comparative Analysis of Different Prenatal Corticosteroid Neurological Deficits in Premature Infants through Magnetic Reasoning Imaging (MRI).

Objective This study aimed to explore the application of different prenatal corticosteroids in the assessment of neurological deficits and prognosis in premature infants through Magnetic Reasoning Imaging (MRI) under optimized cluster algorithm. Methods 100 pregnant women with threatened preterm labor were retrospectively analyzed, in which 38 pregnant women with lasting threatened preterm labor (group A) were treated with multiple courses of antenatal corticosteroids (dexamethasone treatment) and 62 cases of pregnant women with threatened preterm labor (group B) were treated with single course of dexamethasone treatment. Craniocerebral MRI images based on optimal clustering algorithm were used to examine neonates. Neonatal hypoxic-ischemic encephalopathy (HIE) rate, serum neuron-specific enolase (NSE) concentration, neonatal behavioral neurological score (NBNA), respiratory distress syndrome (RDS) rate, perinatal mortality, neonatal birth weight, and maternal complications rate of two groups were compared. Results Compared with other traditional image segmentation algorithms, this algorithm had the best segmentation effect, the shortest running time (1.43 s), the least number of iterations (5 times), and the highest segmentation accuracy (97.98%). There was no significant difference in the HIE rate, serum NSE concentration, NBNA score, RDS score, and perinatal mortality in group A and group B (P > 0.05). Compared with group B, neonates' body weight in group A was decreased, while the maternal complication rate in group A was increased (P < 0.05). Conclusion MRI images based on optimized clustering algorithm can be used in the diagnosis of neonatal hypoxic-ischemic encephalopathy. There is no significant difference in the application of different antenatal corticosteroids affecting premature nerve function defect and prognosis, but multiple courses of antenatal corticosteroids can affect neonatal body mass and increased maternal complications to a certain extent; therefore, before threatened premature delivery treatment, the pros and cons of multiple courses of antenatal corticosteroids should fully be considered and in the treatment, measures should be actively taken to alleviate the side effect.

Analysis of Clinical Related Factors of Neonatal Hand-Foot-Mouth Disease Complicated With Encephalitis.

Objective: To explore the clinical related factors of neonatal hand-foot-mouth disease (HFMD) complicated with encephalitis.Method: The neonatal HFMD complicated with encephalitis treated in our hospital from July 2015 to July 2020 was taken as the object of study. According to the NBNA score at discharge, the patients were divided into normal group and abnormal group. The clinical symptoms, auxiliary examination and prognosis of the two groups were compared.Result: (1) General condition: there was no significant difference in sex, age, duration of fever, treatment time and etiological test between the two groups (P > 0.05). (2) Clinical symptoms and signs: there was significant difference in abnormal consciousness between the two groups (P < 0.05). However, there was no significant difference in skin rash, respiratory system symptoms, digestive system symptoms, signs of high intracranial pressure, increased muscle tone and weakening of primitive reflex (P > 0.05). (3) Auxiliary examination: the number of white blood cells and the level of cytokines (CK-BB, UCH-L1) in cerebrospinal fluid (CSF) in the group with abnormal NBNA score were significantly higher than those in the group with normal NBNA score (P < 0.05). The serum IgM level in the abnormal NBNA score group was higher than that in the normal NBNA score group, and the serum IgG level in the abnormal NBNA score group was lower than that in the normal NBNA score group, and the difference was statistically significant (P < 0.05). The abnormal rate of Craniocerebral MRI in abnormal NBNA score group was higher than that in normal NBNA score group, and there was significant difference between the two groups (P < 0.05). There was no significant difference in the levels of protein, sugar, chloride, lactate dehydrogenase, and MMP-9 in CSF and the abnormal rate of amplitude integrated EEG (aEEG) between the two groups (P > 0.05). (4) The prognoses of patients with normal and abnormal NBNA score are good, and there are not significantly differences in the prognosis between the two groups (P > 0.05).Conclusion: (1) Neonatal HFMD complicated with encephalitis occurs more than 10 days after birth, there is no obvious abnormality in male and female, the vast majority of newborns have febrile symptoms, rash is not its specific manifestation, and most of them are atypical. (2) The positive rate of HFMD-related virus detected in CSF of neonatal HFMD is high. For newborns with abnormal consciousness, CSF examination should be accomplished in time, which has certain clinical significance for early diagnosis and treatment of severe newborns. (3) The increase of white blood cell count and cytokines (CK-BB, UCH-L1) in CSF of neonatal HFMD complicated with encephalitis has a certain clinical reference value for early diagnosis and identification of severe newborns. (4) There is a certain humoral immune disorder in newborns with HFMD complicated with encephalitis, but the overall prognosis is better due to the protective effect of maternal IgG.

Application of case management in the continuous nursing care of low birth weight infants after discharge and its influence on growth and development

Objective To explore the application of case management in the continuous nursing of low birth weight infants after discharge and its influence on their growth and development. Methods A total of 94 infants with low birth weight admitted to this hospital from February 2015 to February 2017 were selected as the research objects.Children were divided into observation group and control group according to random number table method, with 47 cases each.The control group continued nursing after discharge, and the observation group implemented case management on the basis of the control group. Height, weight, head circumference and development quotient of the two groups at 6 and 12 months after birth and scores of neurological behavior at the corrected gestational age of 40 weeks(NBNA) were compared. Results There were statistically significant differences in weight and body length between the two groups at 6 months and 12 months (P 0.05). NBNA score in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). The scores of the observation group were significantly better than that of the control group in terms of macromotor, adaptability, fine motor, language and social interaction, and the differences were statistically significant(P<0.05). Conclusion The application of case management in the continuous care of low-birth-weight infants can significantly promote the physical and intellectual development of low-birth-weight infants. Key words: Case management; Continuous nursing; Low birth weight infants; Growth and development

Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy.

The effect of mild hypothermia on the expression of interleukin (IL)-10 and IL-18 in neonates with hypoxic ischemic encephalopathy was investigated. A retrospective analysis was performed on 97 neonates with hypoxic-ischemic encephalopathy (HIE) admitted to the neonatal intensive care unit of Xuzhou Children's Hospital, Xuzhou Medical University from September 2016 to August 2018. Of these patients, 54 with mild hypothermia were included in the experimental group (moderate + severe), and 43 patients who received conventional therapy were included in the control group (moderate + severe). The effect of mild hypothermia on IL-10 and IL-18 expression levels was analyzed, and the relationship between IL-10, IL-18 and disease severity in children with hypoxic ischemic encephalopathy was analyzed. The concentration of IL-10 in the experimental group was significantly lower than that in the control group at 1, 2, 3 and 5 days (P<0.05). The concentration of IL-18 in the experimental group was significantly lower than that in the control group at the 2, 3 and 5 days (P<0.05). NBNA scores of the experimental group were significantly higher than those of the control group at 14 and 28 days after birth (P<0.05). Before treatment, the expression levels of IL-10 and IL-18 in severe children were significantly higher than those in moderate children (P<0.05). IL-10 was positively correlated with the severity of the disease (r=0.521, P<0.05), and IL-18 was also positively correlated with the severity of the disease (r=0.616 P<0.05). Mild hypothermia treatment can effectively improve the neurological function of children with HIE, reduce the expression of IL-10 and IL-18 in serum, and inhibit the inflammatory response. Therefore, the expression of IL-10 and IL-18 was positively correlated with the severity of disease in children with HIE, and could be used as an indicator to judge the severity of HIE.

Clinical significance of detecting serum melatonin and SBDPs in brain injury in preterm infants

To investigate the clinical values of serum melatonin and αII spectrin cleavage products (SBDPs) in assessing the severity of brain injury in preterm infants. Sixty-four premature infants in total were selected and classified into the brain injury group (BI, n=30) and the non-brain injury group (CON, n=34) according to cranial imaging examination. The serum melatonin and SBDPs were detected by ELISA. All the preterm infants were received NBNA testing at 40 weeks of corrected gestational age. The levels of melatonin and SBDPs in the BI group were significantly higher than the CON group (p<0.05) and the levels in the infants with severe brain injury were significantly higher than those with mild brain injury (p<0.05), as well as exhibiting a negative correlation with the NBNA score at 40 weeks of corrected gestational age (p<0.05). Detecting melatonin and SBDPs has clinical value in diagnosing and assessing the severity of brain injury in preterm infants.

Application of family centered cognitive intervention in neonatal nursing

Objective To explore the role of family centered cognitive intervention in neonatal nursing. Methods According to the random number table method, 100 newborns were randomly divided into observation group and control group, 50 cases in each group.The two groups received routine health education, and the observation group received the family centered cognitive intervention.After the intervention, the neonatal physical development status (body weight, height, head circumference) and neonatal disease status of the two groups were analyzed.The active muscle tension, passive muscle tension, primitive reflexes, behavior ability, general evaluation and neonatal behavioral neurological assessment score(NBNA score) were evaluated and analyzed. Results The body weight[(4 753.88±434.59)g], length[(55.16±1.17)cm], head circumference[(37.34±0.51)cm]after 1 month discharge of the observation group were better than those of the control group[(4 295.78±344.63)g, (52.25±0.58)cm, (35.67±0.21)cm], the differences between the two groups were statistically significant(t=2.564, 6.235, 8.679, all P<0.05). The incidence rate of born disease of the observation group was 14.00%, which of the control group was 32.00%, there was statistically significant difference between the two groups(χ2=4.574, P<0.01). The active muscle tension, passive muscle tension, behavior ability, original reflection, the general evaluation and NBNA scores of the observation group were significantly higher than those of the control group, the differences were statistically significant(all P<0.01). Conclusion Family centered intervention can significantly improve the growth status of newborn infants, reduce the incidence of the disease, it is beneficial to improve the patients' neurological behavior, it is worthy of wide application. Key words: Home nursing; Cognition; Neonatal nursing; Child development

Effects of prenatal stress on the physical development of neonatal

Objective To observe the effect of adverse factors on neurodevelopmental development of neonates during pregnancy. Methods The prenatal stress mothers were selected by the Life Event Scale and their neonatal were as the prenatal stress group. The newborns of normal mothers were as the control group. Results The NBNA scores of the prenatal stress group were significantly lower than those in the control group (33.16±2.35 vs 38.36±2.13, t=-9.724, P<0.01), specialty in light and tone habit. Gender and mode of delivery had no effect on NBNA scoring. Conclusion Prenatal stress can result in a reduction in neonatal NBNA scores and is independent of the mode of delivery and gender. Key words: Newborn; Prenatal stress; Neonatal behavioral neurological assessment; Physical development

Study on the prognosis of premature infants with recurrent apnea treated with nasal intermittent positive pressure ventilation

Objective To investigate the effect of nasal intermittent positive pressure ventilation(NIPPV) on the prognosis of infants with recurrent apenea of premature(AOP) for 12 months of correcting gestational age, thus to provide reference for the treatment of AOP. Methods The premature infants with recurrent AOP of the neonatal intensive care unit were divided into observation group and control group according to the random number table method.The observation group was treated with NIPPV, the control group was treated with nasal continuous positive airway pressure(NCPAP). All living premature infants were followed up for early intervention, hearing, visual acuity, physical and mental development after hospital discharge.Neonatal behavioral neurological assessment(NBNA) was given to the premature infants at the corrected gestational age of 40 weeks and 42 weeks, CDCC was used to test of the corrected gestational age of 1 year old, and the mental retardation, cerebral palsy, hearing impairment, severe deafness, blindness were assessed and compared. Results 123 cases were selected, including 2 cases were abandoned in the treatment, 7 cases died(4 cases died during hospitalization, 3 cases died after hospital discharge), 5 cases were lost following up after hospital discharge, 12 cases were treated with poor compliance, the actual research subjects were 97 cases, 51 cases in NIPPV group, 46 cases in NCPAP group.In NIPPV group, the NBNA score more than 35 points of 40 weeks and 42 weeks were in 38 cases(74.5%), 47 cases(92.2%) respectively, which in NCPAP group were respectively in 28 cases(60.9%), 37 cases(80.4%). There were statistically significant differences between the two groups(t=14.786, 4.149, all P<0.05). In NIPPV group, MDI score<80 points, PDI score<80 points, mental retardation, cerebral palsy were respectively in 7 cases(13.7%), 6 cases(11.8%), 3 cases(5.9%), 1 case(2.0%), which in NCPAP group were respectively in 15 cases(32.6%), 14 cases(30.4%), 8 cases(17.4%), 5 cases(10.9%), there were statistically significant differences between the two groups(χ2=10.040, 9.765, 5.944, 6.663, all P<0.05). In NIPPV group, the hearing impairment, very severe deafness, blindness were respectively in 2 cases(3.9%), 0 cases(0.0%), 0 cases(0.0%), which in NCPAP group were respectively in 7 cases(15.2%), 2 cases(4.3%), 2 cases(4.3%), there were statistically significant differences between the two groups(χ2=7.037, 4.082, 4.082, all P<0.05). Conclusion NIPPV in the treatment of premature infants with recurrent AOP has a certain improvement in prognosis. Key words: Intermittent positive-pressure ventilationt; Infant, premature; Apnea; Prognosis

Maternal bedside care on early development of newborn and maternal depression and anxiety, lactation

Objective To investigate the influence of maternal and child care bedside on early development of newborns and maternal depression and anxiety, lactation. Methods From January 2013 to June 2015, 120 cases of healthy full-term newborns and maternal admitted in our hospital were randomly divided into control group and observation group, 60 cases in each group.The two groups of newborns and mothers were given routine care, including care and neonatal umbilical buttocks care, maternity care, including genital or abdominal incision dressing, newborns were routinely vaccinated.In the control group, the newborns were taken to a public bath chamber concentrated bath.The observation group was implemented maternal and child care bedside manner Based on this, at the bedside of the newborn bathing and massage, swimming daily with newborns.Anxiety score (SAS) and depression scale score (SDS) for depression and anxiety were evaluated before and after the two groups of mothers nursing, and maternal milk yield variation were observed at different time, measured neonatal neurological assessment score (NBNA) and height, body mass index, head circumference growth. Results After treatment, the SAS and SDS scores of mothers of the two groups were decreased compared with before treatment, which in the observation group decreased more significantly, the differences were statistically significant (t=3.46, 4.21, all P<0.05). After care, the maternal milk productions of the two groups started to grow, which of the observation group were always increased better than the control group, the differences were statistically significant (χ2=9.34, 4.53, 6.79, all P<0.05). The newborn NBNA scores, head circumference, height, improvement in the quality index of growth in the observer group were better than the control group, the differences were statistically significant (t=1.98, 1.65, 2.73, 3.63, all P<0.05). Conclusion Maternal and child bedside care can significantly improve maternal depression and anxiety scores, increase maternal lactation, and has a certain role in promoting early neonatal development, it is worth clinical application. Key words: Maternal-child nursing; Lactation; Infant, newborns; Depression and anxiety; Early development

Analysis of the effect of improved support nursing model applied in the intervention nursing of premature infants

Objective To analyze the construction and advantages of improved support nursing model applied in the nursing intervention of premature infants. Methods A total of 120 premature infants from NICU in our hospital from July 2012 to July 2014 were randomly divided into two groups according to the order out of the hospital, 60 cases in each group.The control group received traditional premature nursing model, while the experimental group adopted the modified support nursing intervention model.The NBNA score at 40 weeks of correct age and the score of CDCC at a year old of the two groups were retrospectively analyzed and evaluated. Results The NBNA scores of the behavior ability, passive muscle tension, active muscle tension, initial reflex and general reaction of the premature infants of the experimental group at 40 weeks of correct age were higher than that of the control group, and the differences were statistically significant (P<0.05). The intelligence and motor development score of the experimental group at 1 year old were (107.81±9.72) points and(109.32±10.17)points respectively, which was significantly higher than that of(100.98±16.89) points and (98.59±11.15) points of the control group .The difference was statistically significant (P<0.05). Conclusions The implementation of improved support nursing model applied in the intervention nursing of premature infants can effectively improve the infant's behavior, and promote the development of children's intelligence and sports development, and the short-term, long-term prognosis is significant, which is a safe, reliable and effective new nursing model. Key words: Improved support nursing model; Premature infant; Neurobehavior; Intelligent motor development

A meta-analysis of the protective effect of recombinant human erythropoietin (rhEPO) for neurodevelopment in preterm infants.

The purpose of this study is to assess the efficacy and safety of recombinant human erythropoietin (rhEPO) for improving neurodevelopment outcomes in preterm infants. According to the requirements of Cochrane systematic review, a literature search was performed among PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Wan Fang Data, and VIP INFORMATION from the establishment of the database from January 1999 to December 2011. Quality assessments of clinical trials were carried out. Randomized controlled trials (RCTs) or quasi-RCTs with rhEPO in preterm infants were enrolled, and RevMan5.0 software was used for meta-analysis. Data extraction, quality assessment, and meta-analysis for the results of homogeneous studies were done by two reviewers. The trials were analyzed using weighted mean difference (WMD) for continuous data and odds ratio (OR) for dichotomous data, both kinds of data were expressed by 95 % CI. For homogenous data (P ≥ 0.10), fixed effect model was calculated. Two RCTs and 3 quasi-RCTs including 233 preterm infants (119 of treatment group and 114 of control group) were included in the analysis. The results of quality assessment were that 1 study was A, 1 was B, and 3 were C. There was evidence of a significant effect of therapeutic rhEPO on the outcomes of MDI scores [WMD = 7.77, 95 % CI (3.49-12.06), P = 0.0004], PDI scores [WMD = 3.85, 95 % CI (0.62-7.09), P = 0.02] at 18-22 months and NBNA scores [WMD = 1.96, 95 % CI (1.56-2.37), P < 0.00001] at 40 weeks of corrected gestational age. However, rhEPO had no effect on MDI <70 (OR = 0.70, 95 % CI 0.31-1.61), PDI <70 (OR = 2. 46, 95 % CI 0.94-6.45), cerebral palsy (OR = 1.08, 95 % CI 0.39-2.99), blindness (OR = 0.34, 95 % CI 0.01-8.56), and hearing loss (OR = 1.04, 95 % CI 0.06-17.15). There were no differences between groups with respect to the percentage of preterm infants with severe retinopathy of prematurity of stage III or above (OR = 1.30, 95 % CI 0.50-3.43), severe intraventricular hemorrhage of stage III or above (OR = 2. 91, 95 % CI 0.64-13.23), necrotizing enterocolitis (OR = 0.57, 95 % CI 0.13-2.54), and borderline personality disorder (OR = 1. 06, 95 % CI 0.50-2.26). The rhEPO treatment has beneficial effect on the neurodevelopment outcomes without severe adverse side effect in preterm infants.

Effect of chiropractics combined with swimming therapy on neonatal neurobehavioral development

Objective To explore the effect of chiropractics combined with swimming therapy on neonatal neurobehavioral development.Methods 116 healthy full-term neonates born in our hospital were divided into a study group and a control group.The study group received chiropractics combined with swimming therapy after bathing,while the control group received bathing alone.All the neonates were assessed by the NBNA scale on days 1,5,and 42 after birth.Results The NBNA score was higher in the study group than in the control group on days 5 and42 (P＜0.05).Conclusions Chiropractics combined with swimming therapy plays a marked role in acceleration of neonatal neurobehavioral development,thus it is worth popularizing clinically. Key words: Neonates; Chiropractics; Swimming therapy; Neurobehavioral development

C1inical research of thetherapy of ganglioside combined with high-dose immunoglobulin for neonate with hypoxic-ischemic encephalopathy

Objective To investigate the clinical effect of ganglioside with high-dose immunoglobulin therapy treating on severe neonatal hypoxic-ischemic encephalopathy.Methods 80 severe hypoxic-ischemic encephalopathy neonate were selected and randomly divided into experimental group(42 cases) and control group(38 cases).Control group received conventional treatment,while experimental group received ganglioside with high-dose immunoglobulin therapy.Followed up 1 ～ 2 months,then compared recovery time and neonatal behavioral neurological assessment of two groups.Results The neurological symptoms after treatment,recovery time and NBNA scores of two groups had significant differences(P ＜ 0.05),and the curative effect of experimental group was better than that of control group.Gonclusion The application of ganglioside with high-dose immunoglobulin therapy treating on neonatal hypoxic-ischemic encephalopathy can effectively shorten the course of treatment. Key words: Ganglioside; Immunoglobulin; Moderately severe; Hypoxic-ischemic; Encephalopathy

Effect of early stage protein intake on growth and behavior of premature infants

Objective To explore effects of the early stage different dietary protein intake on behavior and growth condition of premature. Methods Premature infants were given different nutritional feeding, 65 selected subjects were divided into A group (high protein group, the average daily intake of protein ≥ 3g/kg.d), B group (usual protein, the daily intake of protein ＜3g/kg.d), and was corrected gestational age after 37 weeks, 40 weeks and 7 days, 14days, 28 days with NBNA score. Results With the growing age after birth, two sets of NBNA scores were gradually increased; NBNA scores at 5 time points of A group were higher than those in B group, the difference was statistically significant (P＜0.05); two groups had the fastest growth rate while corrected gestational age at 37-40 weeks when, but growth slowed down after the increase with age. Conclusion Early feeding with high protein content to preterm infants can promote their neurobehavioral development, helps to reduce neurological sequelae, and promote its growth. Key words: Premature infant; Protein; NBNA score; Behavioral development

Effects of ultra-early intervention on high-risk children behavioral neurological assessment and intellectual development

Objective To investigate the influence of the ultra-early intervention on high-risk children behavioral neurological assessment (NBNA) and intellectual development.Methods 82 cases of high risk-infants of NICU in our hospital, according to the wishes of parents were randomly divided into intervention group of 40 cases and control group of 42 cases. Both groups were given routine treatment and care. On this basis, the intervention group to implement early intervention, including basic nursing interventions, sensory stimulation intervention and exercise training intervention and so on. Comparison of the intervention group and the control group NBNA scores in 14th day and 28th day and DQ in the third month.Results The NBNA scores of the intervention group in 14th day and 28th day were all higher than those in the control group (P<0.05 or P<0.01), and the NBNA score compliance rate in 28th day was significantly higher than that in the control group (P<0.05). The mental development index (MDI), psychomotor development index (PDI) of the intervention group in the third month was significantly higher than those in the control group (P<0.05).Conclusions The ultra-early intervention can improve the high-risk children's neural capacity, to promote smart growth. Key words: High-risk children; Ultra-early intervention; NBNA score; Intellectual development

Effect of Superearly Period Rehabilitative Intervention on the High Risk Infants with Cerebral Palsy or Intellectual Obstruction

目的 探讨超早期干预对高危新生儿脑瘫及智能发育障碍的影响.方法 将163例高危新生儿分为两组,干预组83例,除常规治疗外,施行早期环境干预和康复功能训练,出院后依据0～3岁小儿智能发育规律及教育大纲,随访干预治疗至2岁;对照组(常规育儿)80例,只接受常规治疗及常规育儿指导和评估.结果 干预组神经行为评分第30天明显高于对照组(P＜0.001);两组在3、6、12、18、24个月的发育商(DQ),干预组明显高于对照组(P＜0.001);两组高危新生儿发育落后及后遗症发生率,干预组明显低于对照组(P＜0.05).结论 早期环境干预、系统的康复功能训练,以及足够的治疗疗程和随访可降低高危新生儿脑瘫和智能低下的发生率,提高高危新生儿的存活质量。