Study on the prognosis of premature infants with recurrent apnea treated with nasal intermittent positive pressure ventilation

Abstract

Objective To investigate the effect of nasal intermittent positive pressure ventilation(NIPPV) on the prognosis of infants with recurrent apenea of premature(AOP) for 12 months of correcting gestational age, thus to provide reference for the treatment of AOP. Methods The premature infants with recurrent AOP of the neonatal intensive care unit were divided into observation group and control group according to the random number table method.The observation group was treated with NIPPV, the control group was treated with nasal continuous positive airway pressure(NCPAP). All living premature infants were followed up for early intervention, hearing, visual acuity, physical and mental development after hospital discharge.Neonatal behavioral neurological assessment(NBNA) was given to the premature infants at the corrected gestational age of 40 weeks and 42 weeks, CDCC was used to test of the corrected gestational age of 1 year old, and the mental retardation, cerebral palsy, hearing impairment, severe deafness, blindness were assessed and compared. Results 123 cases were selected, including 2 cases were abandoned in the treatment, 7 cases died(4 cases died during hospitalization, 3 cases died after hospital discharge), 5 cases were lost following up after hospital discharge, 12 cases were treated with poor compliance, the actual research subjects were 97 cases, 51 cases in NIPPV group, 46 cases in NCPAP group.In NIPPV group, the NBNA score more than 35 points of 40 weeks and 42 weeks were in 38 cases(74.5%), 47 cases(92.2%) respectively, which in NCPAP group were respectively in 28 cases(60.9%), 37 cases(80.4%). There were statistically significant differences between the two groups(t=14.786, 4.149, all P<0.05). In NIPPV group, MDI score<80 points, PDI score<80 points, mental retardation, cerebral palsy were respectively in 7 cases(13.7%), 6 cases(11.8%), 3 cases(5.9%), 1 case(2.0%), which in NCPAP group were respectively in 15 cases(32.6%), 14 cases(30.4%), 8 cases(17.4%), 5 cases(10.9%), there were statistically significant differences between the two groups(χ2=10.040, 9.765, 5.944, 6.663, all P<0.05). In NIPPV group, the hearing impairment, very severe deafness, blindness were respectively in 2 cases(3.9%), 0 cases(0.0%), 0 cases(0.0%), which in NCPAP group were respectively in 7 cases(15.2%), 2 cases(4.3%), 2 cases(4.3%), there were statistically significant differences between the two groups(χ2=7.037, 4.082, 4.082, all P<0.05). Conclusion NIPPV in the treatment of premature infants with recurrent AOP has a certain improvement in prognosis. Key words: Intermittent positive-pressure ventilationt; Infant, premature; Apnea; Prognosis