Stem cell research holds immense promise in regenerative medicine. However, the successful utilization of stem cells relies on their inherent properties and the appropriate support matrix that provides an optimal environment for growth and differentiation. Optimizing their delivery and retention at the target site is crucial to enhance stem cell-based therapies' effectiveness. In recent years, hydrogels have emerged as a popular choice for culturing and delivering stem cells due to their unique properties, including biocompatibility, tunable physical and chemical characteristics, and mimicking the native extracellular matrix. Among the various hydrogels available, Pluronic F-127 (PF-127) has gained significant attention in stem cell research. This paper aims to study the publication trends of research that discuss the utilization of PF-127 hydrogel for stem cell research. The analysis is based on data extracted from the Scopus database using bibliometric methods. The results revealed the publication trends, collaboration patterns among authors and institutions, research areas, influential journals, funding agencies, and thematic connections in this field. By understanding the current state of research and identifying key areas of focus, this analysis provides valuable insights for researchers and practitioners interested in harnessing the potential of PF-127 hydrogel in regenerative medicine and tissue engineering.