Nasal Temperature Research Articles

A Noninvasive Method for Monitoring Breathing Patterns in Nonhuman Primates Using a Nasal Thermosensor.

Respiration is strongly linked to internal states such as arousal, emotion, and even cognitive processes and provides objective biological information to estimate these states in humans and animals. However, the measurement of respiration has not been established in macaque monkeys, which have been widely used as model animals for understanding various higher brain functions. In the present study, we developed a method to monitor the respiration of behaving monkeys. We first measured the temperature of their nasal breathing, which changes between inspiration and expiration phases, in an anesthetized condition and estimated the respiration pattern. We compared the estimated pattern with that obtained by a conventional chest band method that has been used in humans and applied to anesthetized, but not behaving, monkeys. These respiration patterns matched well, suggesting that the measurement of nasal air temperature can be used to monitor the respiration of monkeys. Furthermore, we confirmed that the respiration frequency in behaving monkeys monitored by the measurement of nasal air temperature was not affected by the orofacial movement of licking to obtain the liquid reward. We next examined the frequency of respiration when they listened to music or white noise. The respiratory frequency was higher when the monkeys listened to music than the noise. This result is consistent with a phenomenon in humans and indicates the accuracy of our monitoring method. These data suggest that the measurement of nasal air temperature enables us to monitor the respiration of behaving monkeys and thereby estimate their internal states.

Design and evaluation of rufinamide nanocrystals loaded thermoresponsive nasal in situ gelling system for improved drug distribution to brain.

Rufinamide (Rufi) is an antiepileptic drug used to manage Lennox-Gastaut Syndrome and partial seizures. The oral bioavailability of Rufi is less due to its poor solubility and low dissolution rate in the gastrointestinal fluids. This results in less amount of drug reaching the brain following the oral administration of drug. Oral formulations of Rufi are prescribed at a high dose and dosing frequency to increase its distribution to the brain. A Rufi loaded thermoresponsive nasal in situ gel which showed significantly high brain concentrations compared to aqueous suspension of Rufi administered through nasal route was developed by our research group and published. In the current work, we have formulated nanocrystals of Rufi and suspended them in a xyloglucan based thermoresponsive gel to improve the nose-to-brain distribution. The particle size, polydispersity index, and yield (%) of the optimized Rufi nanocrystals were 261.2 ± 2.1 nm, 0.28 ± 0.08, and 89.6 ± 2.0 respectively. The narrow PDI indicates that the manufacturing process is reproducible and reliable. Higher % yield suggested that the method of preparation is efficient. The sol-to-gel transition of in situ gel loaded with Rufi nanocrystals was at 32°C which suggested that the formulation transforms into gel at nasal epithelial temperatures. The nasal pharmacokinetic studies showed that Rufi nanocrystals loaded in situ gel produced higher concentration of the drug in brain (higher brain Cmax) and maintained the drug concentrations for longer duration (higher mean residence time) compared to aqueous suspension of Rufi nanocrystals as well aqueous suspension of Rufi and Rufi loaded in situ gel, reported previously. Nanometric size of the Rufi nanocrystals combined with the in situ gelling properties helped the optimized formulation achieve higher brain distribution and also sustain the drug concentrations in brain for longer duration compared to any of the formulations studied by our research group.

Fabrication and Characterization of Clozapine Nanoemulsion Sol-Gel for Intranasal Administration.

Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes. Nose-to-brain (N2B) drug delivery offers a promising approach to reduce peripheral ADRs by minimizing systemic drug exposure. The aim of the present study was to develop and characterize clozapine-loaded nanoemulsion sol-gel (CLZ-NESG) for intranasal administration using high energy sonication method. A range of oils, surfactants, and cosurfactants were screened with the highest clozapine solubility selected for the development of nanoemulsion. Pseudoternary phase diagrams were constructed using a low-energy (spontaneous) method to identify the microemulsion regions (i.e., where mixtures were transparent). The final formulation, CLZ-NESG (pH 5.5 ± 0.2), comprising 1% w/w clozapine, 1% w/w oleic acid, 10% w/w polysorbate 80/propylene glycol (3:1), and 20% w/w poloxamer 407 (P407) solution, had an average globule size of ≤30 nm with PDI 0.2 and zeta potential of -39.7 ± 1.5 mV. The in vitro cumulative drug release of clozapine from the nanoemulsion gel at 34 °C (temperature of nasal cavity) after 72 h was 38.9 ± 4.6% compared to 84.2 ± 3.9% with the control solution. The permeation study using sheep nasal mucosa as diffusion barriers confirmed a sustained release of clozapine with 56.2 ± 2.3% cumulative drug permeated after 8 h. Additionally, the histopathological examination found no severe nasal ciliotoxicity on the mucosal tissues. The thermodynamic stability studies showed that the gel strength and viscosity of CLZ-NESG decreased after temperature cycling but was still seen to be in "gel" form at nasal temperature. However, the accelerated storage stability study showed a decrease in drug concentration after 3 months, which can be expected at elevated stress conditions. The formulation developed in this study showed desirable physicochemical properties for intranasal administration, highlighting the potential value of a nanoemulsion gel for improving drug bioavailability of clozapine for N2B delivery.

Thermal imaging reveals social monitoring during social feeding in wild chimpanzees.

Understanding the affective lives of animals has been a long-standing challenge in science. Recent technological progress in infrared thermal imaging has enabled researchers to monitor animals' physiological states in real-time when exposed to ecologically relevant situations, such as feeding in the company of others. During social feeding, an individual's physiological states are likely to vary with the nature of the resource and perceptions of competition. Previous findings in chimpanzees have indicated that events perceived as competitive cause decreases in nasal temperatures, whereas the opposite was observed for cooperative interactions. Here, we tested how food resources and audience structure impacted on how social feeding events were perceived by wild chimpanzees. Overall, we found that nasal temperatures were lower when meat was consumed as compared to figs, consistent with the idea that social feeding on more contested resources is perceived as more dangerous and stressful. Nasal temperatures were significant affected by interactions between food type and audience composition, in particular the number of males, their dominance status, and their social bond status relative to the subject, while no effects for the presence of females were observed. Our findings suggest that male chimpanzees closely monitor and assess their social environment during competitive situations, and that infrared imaging provides an important complement to access psychological processes beyond observable social behaviours.This article is part of the theme issue ‘Cognition, communication and social bonds in primates’.

Correlation of Nasal Mucosal Temperature and Nasal Patency-A Computational Fluid Dynamics Study.

Recent evidence suggests that detection of nasal mucosal temperature, rather than direct airflow detection, is the primary determinant of subjective nasal patency. This study examines the role of nasal mucosal temperature in the perception of nasal patency using in vivo and computational fluid dynamics (CFD) measurements. Healthy adult participants completed Nasal Obstruction Symptom Evaluation (NOSE) and Visual Analogue Scale (VAS) questionnaires. A temperature probe measured nasal mucosal temperature at the vestibule, inferior turbinate, middle turbinate, and nasopharynx bilaterally. Participants underwent a CT scan, used to create a 3D nasal anatomy model to perform CFD analysis of nasal mucosal and inspired air temperature and heat flux along with mucosal surface area where heat flux >50 W/m2 (SAHF50). Eleven participants with a median age of 27 (IQR 24; 48) were recruited. Probe-measured temperature values correlated strongly with CFD-derived values (r= 0.87, p< 0.05). Correlations were seen anteriorly in the vestibule and inferior turbinate regions between nasal mucosal temperature and unilateral VAS (r=0.42-0.46; p < 0.05), between SAHF50 and unilateral VAS (r=-0.31 to -0.36; p < 0.05) and between nasal mucosal temperature and SAHF50 (r=-0.37 to -0.41; p < 0.05). Subjects with high patency (VAS ≤10) had increased heat flux anteriorly compared with lower patency subjects (VAS >10; p < 0.05). Lower nasal mucosal temperature and higher heat flux within the anterior nasal cavity correlates with a perception of improved unilateral nasal patency in healthy individuals. 4 Laryngoscope, 133:1328-1335, 2023.

Technical note: a nose ring sensor system to monitor dairy cow cardiovascular and respiratory metrics.

Monitoring cardiovascular and respiratory measurements corresponds to the precision livestock farming (PLF) objective to continuously monitor and assess dairy cows' welfare and health. Changes in heart rate, breathing rate, and oxygen saturation (SpO2) are valuable metrics in human and veterinary medicine to assess stress, pain, illness, and detect critical conditions. The common way to measure heart rate is either manually or with a stethoscope. Under research conditions, heart rate is usually measured with a sports watch chest belt. Breathing rate is obtained by counting the cow's flank movements which is a time-consuming and labor-intensive method that requires training and is prone to human error. No devices are available on the market that enable practical and easy pulse oximetry in farm animals. This study presents a wireless nose ring sensor system (NoRS) composed of thermal and photoplothysmography sensors that attach to the nostrils of four Holstein dairy cows. The NoRS's thermocouple measured the cow's nasal cavity air temperature; an optic sensor measured the IR (660 nm) and RED (660 nm) signals reflected from the cow's nasal septum. Breathing was calculated from the thermocouple signal's center frequency with a fast Fourier transformation or the signal peak count (i.e., oscillations). The breathing rate was compared to breathing observed by concurrently counting the flank movements. Heart rate and SpO2 were measured by integrated pulse oximetry and heart rate monitor module (MAX30101 TinyCircuit) assembled on the NoRS circuit. Heart rate was also measured with FFT and by counting the number of peaks from the optic sensor's raw IR and RED signals. These measures were compared to an off-the-shelf hand-held pulse oximeter's heart rate and SpO2 readings during the same time. The comparisons revealed highly significant correlations for the heart rate readings where the strength of the correlation was sensitive to the method. The correlation between breathing rate and the veterinarian's visual observations was low, albeit significant. Thus, inhale-exhale cycle counting constitutes a more precise approach than flank movement counts. The hand-held device's 96% SpO2 is compatible with near-saturation values expected in healthy cows. The mean NoRS SpO2 reading was 3% less. After further piloting under field conditions, the NoRS will require no animal restraining to automatically and continuously record cows' breathing rate, heart rate, and SpO2.

Interspecies comparison of heat and mass transfer characteristics in monkey and human nasal cavities

Air conditioning in the nasal airways plays an important role in regulating ambient atmospheric temperature and humidity conditions of the inhaled air. Inevitably, it may alter the behaviour and fate of inhaled ambient aerosols within the human respiratory airways due to hygroscopic growth and droplet evaporation, which is a phenomena of variations in particle sizes due to physical and chemical reactions on particle surfaces in different temperature and humidity fields. Although laboratory animals have been widely used to predict health effects of human exposure to ambient substances, the nasal temperature and humidity responses in animal surrogates and human nasal cavities are still less-investigated. This paper provides a comparative study between two monkey and two human nasal subjects under the same ambient temperature and humidity conditions, where nasal models were reconstructed from CT images and the heat and mass transfer process incorporating with the intricate nose anatomy were modelled by the computational fluid dynamics (CFD) approach. Present model comparison revealed that the monkey nasal models can reach equilibrium temperature and moisture state for inhaled ambient air in a much shorter distance compared to the human models. This indicate that heat transfer in the monkey models is more effective compared to the human models due to having a higher complexity coefficient and a smaller hydraulic radius. Hence, in order to achieve comparable or similar inhalation exposure patterns in animal surrogates, corresponding adjustments such as changing the size of released particles, or the inhalation flow rates, to achieve comparable particle Stokes number are needed. The outcomes of this study would provide informative insights for future inhalation toxicology studies related to hygroscopic materials and targeted drug delivery through nasal airways.

Correlation between nasal mucosal temperature change and nasal airflow perception

The mechanism of nasal airflow perception remains little known. It is currently believed that the main mechanism for perceiving nasal patency is to activate transient receptor potential melastatin subtype 8. Computer fluent dynamics show that increased airflow and heat flux are associated with higher subjective scores. Similarly, physical measurements of the nasal cavity using a temperature probe show a correlation between the lower nasal mucosa temperature and better results. Trigeminal function detection also indirectly confirms this. This literature review aimed to explore the role of nasal mucosal temperature change in the subjective perception of nasal patency and the secondary aim was to appraise the relevant evidence about the mechanism.

The influence of unpleasant emotional arousal on military performance: An experimental study using auditory stimuli during a shooting task

Due to the intrinsic difficulties associated with simulating extreme events, it remains unclear how unpleasant emotional arousal might affect shooting performance among well-trained high-risk operators. To address this issue, an infantry rifle squad performed two simulated shooting exercises of different complexity (low vs. high) while exposed to unpleasant emotionally charged sound clips. A control group underwent the same experimental procedure without the presence of any sound clips. To externally validate our method of emotional arousal inoculation, we collected infantrymen's salivary cortisol and perceived arousal and valence levels over the experimental phases (i.e., baseline, shooting, and recovery). The dependent variables were their shooting performance (shot-to-hit ratio and instructor's evaluation) and the perceived degree of task complexity. Furthermore, we explored the variations of participants' nasal skin temperature during the shooting exercises. Salivary cortisol concentrations varied over time only for the squad exposed to emotionally charged stimuli. While emotional arousal had an effect on overall infantrymen performance (e.g., precision of movements while shooting), shooting accuracy was not affected. Emotional arousal did not influence nasal skin temperature. Overall, our results suggest that arousal inoculation based on emotionally charged sound clips could serve as a complementary (reliable and ethically appropriate) method to train high-risk operators to deal with emotional arousal. These findings may also contribute to a better understanding of the role of emotional arousal in operational effectiveness.

Prediction of Acute Kidney Injury for Acute Type A Aortic Dissection Patients Who Underwent Sun’s Procedure by a Perioperative Nomogram

Introduction: Postoperative acute kidney injury (AKI) occurs in 20–40% of acute type A aortic dissection (ATAAD) patients undergoing cardiac surgery. A predictive model could be developed to assess the probability of AKI in patients with ATAAD before and after cardiac surgery in a timely manner. Methods: This retrospective study enrolled a total of 224 patients with ATAAD. Patients were subjected to total arch replacement using a tetrafurcate graft with stented elephant trunk implantation according to Sun’s procedure. Statistical comparison for the collected data was done with Student’s t test or Mann-Whitney U test (continuous variables) and χ² test (categorical variables). The independent predictors were screened by multivariate logistic regression analysis and then incorporated into a nomogram. The reliability of cardiac surgery-associated AKI (CSA-AKI) models was evaluated using the area under the receiver operating characteristic curve (AUC). Results: This study enrolled 224 ATAAD patients, including 53 patients with AKI and 171 patients without AKI. The incidence of ATAAD-induced AKI in the cohort was 23.66%. The screened predictors for AKI include iliac artery involvement, creatinine, D-dimer, autotransfusion, platelet-rich plasma reinfusion, nasal temperature, red blood cells, fresh frozen plasma, drainage, and mechanical ventilation. The calculated AUC values for model 1, model 2, model 3, and model 4 were 0.710, 0.777, 0.827, and 0.848, respectively. Model 4 was optimum for AKI risk scoring compared with model 1, model 2, and model 3. Conclusions: AKI prediction models were established for ATAAD patients using preoperative, intraoperative, and postoperative information. Particularly, model 4 shows superiority in risk prediction for CSA-AKI.

The Utility of Perioperative Products for the Prevention of Surgical Site Infections in Total Knee Arthroplasty and Lower Extremity Arthroplasty: A Systematic Review.

Surgical site infections (SSIs) are among the most prevalent and devastating complications following lower extremity total joint arthroplasty (TJA). Strategies to reduce the rates can be divided into preoperative, perioperatives, and postoperative measures. A multicenter trial is underway to evaluate the efficacy of implementing a bundled care program for SSI prevention in lower extremity TJA including: (1) nasal decolonization; (2) surgical skin antisepsis; (3) antimicrobial incise draping; (4) temperature management; and (5) negative-pressure wound therapy for selected high-risk patients. The purposes of this systematic review were to provide a background and then to summarize the available evidence pertaining to each of these SSI-reduction strategies with special emphasis on total knee arthroplasty. A systematic review of the literature was conducted in accordance with the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines. Five individual literature searches were performed to identify studies evaluating nasal decolonization temperature management, surgical skin antisepsis, antimicrobial incise draping, and negative-pressure wound therapy. The highest level of evidence reports was used in each product review, and if there were insufficient arthroplasty papers on the particular topic, then papers were further culled from the surgical specialties to form the basis for the review. There was sufficient literature to assess all of the various prophylactic and preventative techniques. All five products used in the bundled program were supported for use as prophylactic agents or for the direct reduction of SSIs in both level I and II studies. This systematic review showed that various pre-, intra-, and postoperative strategies are efficacious in decreasing the risks of SSIs following lower extremity TJA procedures. Thus, including them in the armamentarium for SSI-reduction strategies for hip and knee arthroplasty surgeons should decrease the incidence of infections. We expect that the combined use of these products in an upcoming study will support these findings and may further enhance the reduction of total knee arthroplasty SSIs in a synergistic manner.

Evaluation of the effects of food intake on task engagement based on psychophysiological states

The objective of this study was to evaluate the effects of food intake on performance and task engagement based on psychophysiological states. The experiment was conducted under two conditions: taking a break with his eyes opened between the repeated tracking tasks (Control), and taking a break with food intake (Intake). We found the rate of deterioration of the distance between target pointer and the mouse cursor, a performance index, showed significant differences between the two conditions. Significant differences were also found between the two conditions in all assessment items of subjective feelings. Considering the hemodynamic parameters and nasal skin temperature responses, it was found that the approach to the second task was different in the two conditions. Therefore, due to food intake between repeated tasks, psychological responses such as “Awareness” and “Refreshment” were maintained. Hence, it was confirmed that food intake stimulated positive task engagement in the task and maintained performance.

An evaluation of thermal imaging as a welfare monitoring tool for captive chimpanzees.

Among the growing list of novel tools with which to assess animal welfare is the use of thermal (infrared) imaging. The technology has already been utilized to identify emotional arousal in several nonhuman primate species, though most of these approaches have necessitated the use of relatively controlled settings. Here, we were interested to determine the feasibility of such techniques in a sanctuary setting in which chimpanzees were unrestrained and able to move freely around their enclosures. Furthermore, we sought to evaluate how such thermal images could be paired with corresponding long-term behavioral data and contribute to a multifactorial welfare monitoring system. Over a 6-month period, we simultaneously collected both behavioral and thermographic data on 29 chimpanzees living in four social groups. While we took a thermal image with every behavioral data point, we found that only a small proportion (6.38%) of the thermal images we captured were of sufficient quality to analyze. Most of these usable thermal images (55%) corresponded with a behavioral observation scored as "inactive," and thus other, less frequent behaviors are not so well represented in our final data set. From our data set, we were able to determine that nasal temperatures were relatively lower when chimpanzees were categorized in active behaviors compared to inactive behaviors, providing some validity measures to our approach. While there are other potential applications for thermal imaging in the behavioral management of chimpanzees, managers should consider the practical limitations of developing long-term welfare monitoring programs that rely on thermographic data.

A Preliminary Report on the Correlation Between Nasal Function and the Different Phases of the Nasal Cycle.

To explore whether the different phases of the nasal cycle have a significant effect on nasal temperature, the nasal mucosal clearance rate, and levels of nasal nitric oxide (nNO) and to investigate the correlation between these nasal conditions. The study participants were divided into 2 groups: the control group and the rhinitis group. The participants' nasal temperature, cilia clearance rate, and nNO levels were measured during different phases of the nasal cycle (the congestion phase and decongestion phase) in the control group and before and after undergoing inferior turbinate ablation in the rhinitis group. The temperature of the nasal cavity in the control group was significantly higher in the congestion phase than in the decongestion phase (P = .0025), while in the rhinitis group, the temperature of the nasal cavity decreased significantly after inferior turbinate ablation (P = .001). In the control group, the nasal mucosa clearance time was significantly shorter in the congestion phase than in the decongestion phase (P = .001), and in the rhinitis group, the clearance time of the nasal mucosa was significantly shortened after the operation (P = .0025). In the control group, the levels of nNO were significantly higher in the congestion phase than in the decongestion phase (P = .025), while in the rhinitis group, nNO levels decreased significantly after the operation (P = .005). The function of the nasal cavity changes in different phases of the nasal cycle. Therefore, when evaluating the impact of various factors on nasal function, factors associated with the nasal cycle should also be considered. Inferior turbinate plasma ablation can improve the ciliary function of the nasal mucosa, reduce the temperature of the nasal cavity, and reduce nNO levels.

Association Between 2-Hz Electroacupuncture Stimulation Near the Cervical Sympathetic Trunk and Nasal Skin Temperature: A Randomized Crossover Study.

Objective: Human nasal vessels are innervated by sympathetic vasoconstrictors. This study examined the effect of electroacupuncture (EA) stimulation near the cervical sympathetic ganglion on human nasal skin temperature. Materials and Methods: This prospective, single center study was conducted at Teikyo Heisei University, in Tokyo, Japan, with 20 healthy adults (17 men and 3 women). The subjects were assigned randomly to an untreated group or an EA group in a crossover trial. The washout period was 2 weeks. In both groups, after 5 minutes of rest, a 5-minute additional rest or an EA stimulus was delivered, followed by 5 minutes more of rest. The EA was delivered near the cervical ganglia at the level of the sixth cervical vertebra on the left side. The EA stimulus was set to 2 Hz, and the stimulation intensity was set to a level at which no pain was felt by the subjects. Results: The EA group had significant decreases in nasal skin temperature during the intervention, compared with that temperature before the intervention. Additionally, the EA group had significant decreases in nasal skin temperature, compared with those in the untreated group. Conclusions: Stimulation with 2-Hz EA in the vicinity of the cervical sympathetic trunk decreases nasal skin temperature and activates sympathetic nerves. Future studies should assess EA's effectiveness for conditions such as allergic rhinitis.

Use of Cryotherapy for Managing Epistaxis in the First Aid Setting: A Scoping Review.

Epistaxis, or nosebleed, is bleeding from the nostril(s), nasal cavity, or nasopharynx. Anterior nasal bleeding is the most common location for spontaneous nontraumatic epistaxis and is commonly treated with manual compression to the nasal alae. Cryotherapy is also routinely recommended in conjunction with manual compression in the first aid and ED setting.We performed a scoping review on behalf of the International Liaison Committee on Resuscitation First Aid Task Force guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). We searched Embase, Cochrane, and PubMed databases for published studies, without date restrictions, and we searched the gray literature using Google.com and Google Scholar. The websites of selected resuscitation councils were searched for guidelines relating to the management of epistaxis. References from included studies were hand-searched. Our published and gray literature search identified 1255 and 61,315 records, respectively. After removing duplicates and following selection criteria, we included 21 records from the published literature and 11 records from the gray literature.Our scoping review found that most of the published studies and website documents focused on managing nontraumatic epistaxis in the first aid setting. They provide recommendations for the use of cryotherapy based on expert opinion or indirect evidence extrapolated from cryotherapy-associated changes in nasal submucosal temperature, nasal blood flow, and nasal blood volume in healthy subjects (three studies). We did not identify any prospective, randomized trials comparing the efficacy of cryotherapy as an intervention for nontraumatic epistaxis in the first aid setting. The limited literature identified in this scoping review does not support the development of a systematic review but highlights the need for future research to better understand the role of cryotherapy in the first aid setting.

Pain Caused by Ear Tagging in Kids of Native Black Goats

There is no study about changes in behaviour and peripheral temperature of kid goats undergoing ear tagging procedure. This study was designed to elucidate that pain caused by ear tagging affects peripheral temperatures and behavioural observations in Karadi kid goats. Nineteen native black goat kids, aged 10 – 14 days, were used in this study. Eye and nasal temperatures were recorded before the ear tagging process, and after ear tagging 5 periods in 30 minutes. Besides, the researchers observed each kid's behaviour for 30 minutes before ear tagging and 30 minutes after it, using focal sampling method and the data recorded with instantaneous time sampling to measure the duration and frequency of each behaviour of the kids. Results revealed that peripheral temperatures were significantly decreased for both eye (P≤0.01) and ear (P≤0.01) after ear tagging. The temperatures of both eye and ear decreased after tagging significantly (P≤0.01) for 30 minutes. The proportion of time kid goats spent normal standing and suckling the dam’s teat decreased whereas the proportion of time spent head-shaking increased after tagging. Significant differences were found between abnormal standing (P≤0.01) and vocalization (P≤0.01). It is concluded that ear tagging causes a considerable pain in kid goats and using surface temperatures and behaviour are useful indicators to approve it.

Pain Caused by Ear Tagging in Kids of Native Black Goats

Purpose: The normal behavior of goat kids is influenced by painful husbandry procedures such as ear tagging, with kids reducing peripheral temperature and increase restlessness. The present study was designed to elucidate that pain caused by ear tagging affects peripheral temperatures and behavioral observations in Karadi kid goats. Study Design: Experimental Study Design. Subjects and Methods: Nineteen native black goat kids, aged 10-14 days, were used in this study as a sample. Eye and nasal temperatures were recorded before ear tagging process (control) and after ear tagging 5 times in 30 minutes. In addition, the behavior of each kid was observed for 30 minutes before and 30 minutes after ear tagging using focal sampling recorded with instantaneous time sampling to measure the duration and frequency of each behavior of the kids. Results: It was revealed that peripheral temperatures were significantly decreased for both eye (P&lt;0.01) and ear (P&lt;0.01) after ear tagging. The temperatures of both eye and ear increased directly after tagging and then decreased significantly (P&lt;0.01) for 30 minutes. The proportion of time kid goats spent normal standing and suckling the dam’s teat decreased whereas the proportion of time spent head-shaking increased after tagging. In addition, abnormal standing was seen after ear tagging which was absent before the process of tagging. Significant differences were found between abnormal standing (P&lt;0.01) and vocalization (P&lt;0.01). While the differences between suckling, normal standing and head shaking were not significant. Conclusions: It is concluded that ear tagging causes considerable pain in kid goats.

Effects of the Flow State on Nasal Skin Temperature during Occupational Tasks

The flow state is an ideal state of work performance. A previous study concluded that the flow state might, in fact, be accompanied by increased parasympathetic modulation of sympathetic activity. However, there is little knowledge about the relationship between the flow state and thermal physiological indices. Nasal skin temperature is a remotely measurable index of autonomic nervous system activity marked by emotional stress. The objective of this study was to explore the relationship between the flow state and nasal skin temperature. As a result, it was found that there is a relationship between the deep flow state by psychological evaluation and nasal skin temperature variability. © 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.

Objective measurement and patient-reported evaluation of the nasal airway: Is correlation dependent on symptoms or on nasal airflow?

Evidence has shown that the sensation of nasal breathing is related to variations in nasal mucosa temperature produced by airflow. An appropriate nasal airflow is necessary for changing mucosal temperature. Therefore, the correlation between objective measurements of nasal airflow and patient-reported evaluation of nasal breathing should be dependent on the level of nasal airflow. To find if the correlation between patient-reported assessment of nasal breathing and objective measurement of nasal airflow is dependent on the severity of symptoms of nasal obstruction or on the level of nasal airflow. The airway of 79 patients was evaluated using NOSE score and peak nasal inspiratory flow (PNIF). Three subgroups were created based on NOSE and three subgroups were created based on PNIF level to find if correlation was dependent on nasal symptoms or airflow. The mean value of PNIF for the 79 patients was 92.6L/min (SD 28.1L/min). The mean NOSE score was 48.4 (SD 24.4). The correlation between PNIF and NOSE was statistically significant (P=.03), but with a weak association between the two variables (r=-.248). Evaluation of correlation based on symptoms demonstrated a weak or very weak association in each subgroup (r=-.250, r=-.007, r=-.104). Evaluation of correlation based on nasal airflow demonstrated a very weak association for the subgroups with middle-level and high PNIF values (r=-.190, r=-.014), but a moderate association for the subgroup with low PNIF values (r=-.404). This study demonstrated a weak correlation between NOSE scores and PNIF values in patients non-selected according to symptoms of nasal obstruction or to airflow. It demonstrated that patients with symptoms of nasal obstruction have different levels of nasal airflow and that low nasal airflow prevents the sensation of good nasal breathing. Therefore, patients with symptoms of nasal obstruction may require improving nasal airflow to improve nasal breathing sensation.