Application Of Nanotechnology Research Articles

Green nanoparticles as a Novel application of nanotechnology in medicine: study of zinc, copper and magnesium nanoparticles

Green nanoparticles as a Novel application of nanotechnology in medicine: study of zinc, copper and magnesium nanoparticles

The Impact of a Nanotechnology-Based Training Program on the Development of Digital Competencies among High School Biology Teachers

This study aimed to investigate the impact of a training program based on nanotechnology applications on the development of digital competencies among high school biology teachers. There is a gap between teachers' current digital competencies and the skills needed to effectively leverage nanotechnology in biology education. The study found statistically significant differences between pre-test and post-test scores on a digital competency assessment after teachers completed the nanotechnology training program. The program encompassed fundamental nanoscience knowledge, biology-specific applications, digital skills training, and hands-on activities. Results showed a large effect size, indicating the substantial impact of the intervention on enhancing teachers' digital competencies. Recommendations highlight integrating nanotechnology into science curricula and emphasize biology connections, problem-solving, content creation, and ethical considerations regarding advanced nanomaterials. Promoting teacher motivation and scientific inquiry is vital. The research addresses an urgent need to equip biology educators with digital skills aligned with rapidly evolving science and technology.

Redesigning Humans in the Nano-Age

The blurring boundaries between therapy and human enhancement raise a lot of ethical questions that need to be addressed. Therapy is healing and restoring the sick to health; enhancement is improving the normal functioning of the body. With nanomedicine, the boundary becomes even hazier. Nanomedicine refers to the application of nanotechnology to the prevention and treatment of diseases. The European Science Foundation defines it as the science and technology of diagnosing, treating, and preventing disease and traumatic injury, relieving pain, and preserving and improving human health using molecular tools and knowledge of the human body (ESF, 2005). While nanomedicine delivers numerous and unprecedented benefits to the health and general well-being of individuals, nano- enabled human enhancement technologies will be the gateway to the transhumanist vision of immortality. Transhumanism contends that through the advancements in science and technology, we can overcome our physical and cognitive limitations, extend human lifespan, and attain perpetual existence. The blurring boundaries between enhancement will have remarkable consequences on what it means to be a human being. The study will make use of New and Emerging Science and Technology (NEST) Ethics as a framework for addressing dichotomous approaches and polarizing perspectives on human enhancement.

STUDY ON NANOEMULSION AND MICROEMULSION OF ESSENTIAL OILS: A REVIEW

Over the years, the interest in nanotechnology and its applications has been increasing, providing numerous benefits to the industries. One such nanotechnology application being used in a majority of industries is the incorporation of nanoemulsion (NE) and microemulsion (ME) in industrial products which act as a carrier/delivery system for some of the active compounds in the product. The incorporation of such emulsion systems helps increase the bioavailability, stability, and interactions of the active compounds in the product. One of the commonly used active components in NE and ME are essential oils (EO)that have a wide range of biological properties used in several fields such as food, pharmaceutical, agriculture, etc. This review intends to provide details on the formulation, stability, and components for the preparation of nanoemulsion and microemulsion. It also deals with understanding the benefits of the incorporation of essential oils into NE/ME.

Anisotropic Cu2O nanostructures: A promising remediation for per- and polyfluoroalkyl substances

Copper oxide (Cu2O) exhibits exceptional optical properties and phase stability at the nanoscale level making it highly desirable in nanotechnology applications. Its unique and distinctive properties make it highly feasible for diverse applications, which include environmental remediation, energy conversion, and catalysis. In this study, we tailor the surface and facet orientation of Cu2O nanoparticles to enhance their efficacy in addressing environmental contaminants such as per- and polyfluorinated substances (PFAS). By adjusting the ratios of the precursor and capping agent, we have synthesized Cu2O nanocubes (NCs) and octahedra (Oh) with average sizes of 450 nm and 650 nm, respectively. The time-dependent UV–Vis interaction studies revealed significant redshifts in absorption spectra upon the addition of Cu2O NCs and Oh to the PFAS solutions, indicative of the changes in the surroundings upon the interaction. FT-IR spectra further confirmed the sorption of PFAS on Cu2O nanostructures with stronger adsorption observed for longer-chain PFAS due to enhanced hydrophobic interactions. XPS analysis further provided insights into the surface composition changes after post-interaction, indicating the presence of PFAS on Cu2O nanostructures. The zeta potential analysis supported the role of electrostatic interactions in PFAS removal. Our results demonstrate that Cu2O Oh exhibits superior PFAS adsorption compared to Cu2O NCs, which is attributed to the exposed facets of a copper atom having a positive surface charge and facilitating electrostatic interactions. Specifically, Cu-terminated (110) or (111) surfaces exhibit enhanced sorption capacity, while the reduced reactivity of Cu-terminated Cu2O (100) surfaces is linked to high energy barrier holes at the surface region. Overall, this study elucidates the interaction mechanisms between Cu2O nanostructures and PFAS which underscores the significance of surface engineering for optimizing their performance in environmental remediation strategies.

Stability and Elasticity of Ultrathin Sphere-Patterned Block Copolymer Films.

Sphere-patterned ultrathin block copolymer films are potentially interesting for a variety of applications in nanotechnology. We use self-consistent field theory to investigate the elastic response of sphere monolayer films with respect to in-plane shear, in-plane extension, compression deformations, and bending. The relations between the in-plane elastic moduli are roughly compatible with the expectations for two-dimensional elastic systems with hexagonal symmetry, with one notable exception: The pure shear and the simple shear moduli differ from each other by roughly 20%. Even more importantly, the bending constants are found to be negative, indicating that free-standing block copolymer membranes made of only a sphere monolayer are inherently unstable above the glass transition. Our results are discussed in view of the experimental findings.

Advancement in Carbon Nanoparticle Synthesis and Their Application: A Comprehensive Review

The global population gradually increase at an alarming state, which would increase demand for food globally. This increasing use of pesticides and fertilizers. In order to meet this demand, an overview of the numerous applications of nanotechnology for agriculture. Various nanomaterials like nanofertilizers and pesticides enhance soil fertility and crop productivity. However, excessive chemical fertilizer use as per FAO, 2017. Among these, the nanotechnology has wide range of applications in healthcare and medicines, diagnosis etc. Recently, carbon nanoparticles (CNPs) play a significant role in various fields. Carbon nanoparticles (CNPs) represent innovative nanostructures. These can be synthesized by different methods, green synthesis as well as chemical synthesis such as arch discharge method, laser ablation method, chemical vapour deposition method etc. The advancement of CNPs entails the exploration of diverse synthetic techniques and exploration of various application due to their chemical and physical properties in healthcare, agriculture (for delivery of agrochemicals) etc. These are also used in plant growth enhancement and resistance to stresses. However, challenges related to precisely defining CNP structures and ensuring property uniformity remain inadequately addressed and lack detailed study. In this review article we emphasize methodologies for the synthesis of CNPs by various chemical methods and also include their applications in therapeutics, pharmaceuticles, sensing and agriculture.

Nanotechnology for Pain Management.

Introduction: In the context of the current opioid crisis, non-pharmacologic approaches to pain management have been considered important alternatives to the use of opioids or analgesics. Advancements in nano and quantum technology have led to the development of several nanotransporters, including nanoparticles, micelles, quantum dots, liposomes, nanofibers, and nano-scaffolds. These modes of nanotransporters have led to the development of new drug formulations. In pain medicine, new liposome formulations led to the development of DepoFoam™ introduced by Pacira Pharmaceutical, Inc. (Parsippany, NJ, USA). This formulation is the base of DepoDur™, which comprises a combination of liposomes and extended-release morphine, and Exparel™, which comprises a combination of liposomes and extended-release bupivacaine. In 2021, Heron Therapeutics (San Diego, CA, USA) created Zynrelef™, a mixture of bupivacaine and meloxicam. Advancements in nanotechnology have led to the development of devices/patches containing millions of nanocapacitors. Data suggest that these nanotechnology-based devices/patches reduce acute and chronic pain. Methods: Google and PubMed searches were conducted to identify studies, case reports, and reviews of medical nanotechnology applications with a special focus on acute and chronic pain. This search was based on the use of keywords like nanotechnology, nano and quantum technology, nanoparticles, micelles, quantum dots, liposomes, nanofibers, nano-scaffolds, acute and chronic pain, and analgesics. This review focuses on the role of nanotechnology in acute and chronic pain. Results: (1) Nanotechnology-based transporters. DepoDur™, administered epidurally in 15, 20, or 25 mg single doses, has been demonstrated to produce significant analgesia lasting up to 48 h. Exparel™ is infiltrated at the surgical site at the recommended dose of 106 mg for bunionectomy, 266 mg for hemorrhoidectomy, 133 mg for shoulder surgery, and 266 mg for total knee arthroplasty (TKA). Exparel™ is also approved for peripheral nerve blocks, including interscalene, sciatic at the popliteal fossa, and adductor canal blocks. The injection of Exparel™ is usually preceded by an injection of plain bupivacaine to initiate analgesia before bupivacaine is released in enough quantity from the depofoarm to be pharmacodynamically effective. Finally, Zynrelef™ is applied at the surgical site during closure. It was initially approved for open inguinal hernia, abdominal surgery requiring a small-to-medium incision, foot surgery, and TKA. (2) Nanotechnology-based devices/patches. Two studies support the use of nanocapacitor-based devices/patches for the management of acute and chronic pain. A randomized study conducted on patients undergoing unilateral primary total knee (TKA) and total hip arthroplasty (THA) provided insight into the potential value of nanocapacitor-based technology for the control of postoperative acute pain. The results were based on 2 studies, one observational and one randomized. The observational study was conducted in 128 patients experiencing chronic pain for at least one year. This study suggested that compared to baseline, the application of a nanocapacitor-based Kailo™ pain relief patch on the pain site for 30 days led to a time-dependent decrease in pain and analgesic use and an increase in well-being. The randomized study compared the effects of standard of care treatment to those of the same standard of care approach plus the use of two nanocapacitor-based device/patches (NeuroCuple™ device) placed in the recovery room and kept in place for three days. The study demonstrated that the use of the two NeuroCuple™ devices was associated with a 41% reduction in pain at rest and a 52% decrease in the number of opioid refills requested by patients over the first 30 days after discharge from the hospital. Discussion: For the management of pain, the use of nano-based technology has led to the development of nano transporters, especially focus on the use of liposome and nanocapacitors. The use of liposome led to the development of DepoDur™, bupivacaine Exparel™ and a mixture of bupivacaine and meloxicam (Zynrelef™) and more recently lidocaine liposome formulation. In these cases, the technology is used to prolong the duration of action of drugs included in the preparation. Another indication of nanotechnology is the development of nanocapacitor device or patches. Although, data obtained with the use of nanocapacitors are still limited, evidence suggests that the use of nanocapacitors devices/patches may be interesting for the treatment of both acute and chronic pain, since the studies conducted with the NeuroCuple™ device and the based Kailo™ pain relief patch were not placebo-controlled, it is clear that additional placebo studies are required to confirm these preliminary results. Therefore, the development of a placebo devices/patches is necessary. Conclusions: Increasing evidence supports the concept that nanotechnology may represent a valuable tool as a drug transporter including liposomes and as a nanocapacitor-based device/patch to reduce or even eliminate the use of opioids in surgical patients. However, more studies are required to confirm this concept, especially with the use of nanotechnology incorporated in devices/patches.

Nanotechnology's Applications and Potential in Various Fields.

Since ancient times, several sorts of nanoparticles have been employed in the quickly expanding field of nanotechnology. These features include size, shape, and chemical as well as physical properties.Because of their small size and huge surface area, carbon-based nanoparticles, including fullerenes, carbon nanotubes, graphene, graphene oxide, and carbon-based quantum dots, have attracted a lot of attention in a variety of sectors, including biomedical applications. Lipid bilayers form the spherical vesicles known as liposomes. Magnetic resonance imaging (MRI) contrast agents are iron oxide nanoparticles. These materials are perfect for drug and delivery of genes, bioimaging, and bone repair because of their remarkable mechanical, electrical, visual, and chemical properties. However, concerns about potential asbestos-related diseases have arisen due to their length-to-width aspect ratio. Ceramic nanoparticles, on the other hand, are a common material in daily life and play a crucial role in bone repair, multiscale hybridisation, and aerospace structures. These nanoparticles can enhance osseointegration and bone development by mimicking the nanocomposition and nanoscale characteristics of bone tissue and enhance osteoconductive and osteoinductive capacities. Ceramic nanoparticles, however, have the potential to generate oxidative stress, which can result in irritation of the reticuloendothelial system, cytotoxicity to the heart, liver, and lungs, as well as toxicity to the cells that are attached. Additionally, oxidative stress, cell damage, and genotoxicity might result from the generation of free radicals by ceramic nanoparticles. Metal nanoparticles exhibit linear optical properties similar to molecular systems but arise from a different physical process. Semiconductor nanocrystals (NCs) are made from various compounds, such as silicon and germanium. Polyandry nanoparticles are particles approximately 10 and 10000 nanometers (nm) in size that can contain active substances. They have applications in vaccine delivery, gene therapy, and polymer nanoparticles (nanomedicine) for therapeutic applications.

Advanced developments in nanotechnology and nanomaterials for the oil and gas industry: A review

The utilization of nanotechnology to effectively extract oil and gas resources has garnered attention in response to the growing energy demand. This paper provides a comprehensive overview of several applications of nanotechnology in the oil and gas industry. These applications mostly involve the investigation of how nanoparticles flow through porous materials, the development of nanosensors, and the utilization of nanoparticles to enhance the effectiveness of drilling fluids and increase oil recovery. Nanotechnology is employed to investigate the transport mechanisms of hydrocarbons in nanoporous media and nanoparticles in porous media. This has emerged as a crucial method for assessing hydrocarbon resources. Nanoparticles (NPs) are employed to create temperature and magnetic sensors, as well as imaging techniques, for precise detection of reservoir characteristics and downhole conditions. Nanotechnology has proven to be highly effective in the field of drilling, showcasing its extensive range of possibilities. The addition of NPs improves the rheological properties of drilling fluids, ensures safe drilling, reduces fluid losses, seals nanopores and inhibits shale hydration, and stabilizes the wellbore. Drilling fluids containing NPs are particularly well-suited for situations with high pressure and high temperature. NPs can enhance the effectiveness of fracking fluids by improving their cleanliness, stability, and resistance to friction. Whether hot or cold, NPs show great potential for enhanced oil recovery in thermal and non-thermal chemical flooding. In conclusion, nanotechnology improves the efficiency of exploration, production as well as storage and transportation of oil and gas resources. This study aims to provide academics with a thorough comprehension of the most recent implementations of nanomaterials in the oil and gas industry, while also examining the obstacles and prospects for the future.

Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

AbstractAntibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic therapy (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for antibacterial treatment under the stimulation of light/ultrasound, which have the characteristics of broad‐spectrum antibacterial properties, low drug‐resistance, and effective targeting of infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers of sensitizers. They enhance the stability and permeability of sensitizers, improve targeting of sensitizers, strengthen photodynamic/sonodynamic properties of sensitizers (modification of sensitizers absorption efficiency and light/ultrasonic response stress by modulation of nanoparticle shape, size, and structure). Also, they improve modifiability of sensitizers (controlling the release rate and time of the sensitizer as needed to optimize the therapeutic effect), enhance programmability and multifunctionality of sensitizers (flexible application of nanotechnology for designing sensitizers with multiple functions, such as drug delivery, targeted therapy, and therapeutic monitoring), and expand possibilities for combination therapies (the nano‐carriers can be loaded with other therapeutic agents, enabling combination therapies). Nanomaterials are expected to further promote the development of aPDT/aSDT and achieve improved antibacterial effects. This review summarizes the progress in nanomaterials in aPDT/aSDT in recent years and based on the current development strategies to provide a theoretical reference for the application of nanomaterials in aPDT/aSDT.

Nanotechnology: Current Developments, Applications and Patents for Non-invasive Topical Cosmetics and Dermatological Therapeutic Delivery

Abstract:: Nanotechnology exhibits the advancement in the field of invention, by improving the potency of the formulation through the delivery of inventive solutions. To resolve several limita-tions related to conventional formulations, nanotechnology applications are increasing in the cosmetics and dermatological area. Cosmetic and dermatological preparations are considered a thriving branch of the body care arena and their usage has increased dramatically through the past years. Scientists are designing innovative delivery mechanisms and emerging innovations that are presently being utilized in the development of cosmetics. Inventive nanocarriers such as nio-somes, liposomes, microemulsions, nanoemulsions, solid-lipid nanoparticles, nanospheres, and nanostructured (lipid) carriers have substituted the use of traditional drug delivery. These innova-tive nanocarriers have the convenience of better skin permeation, sustained and controlled drug delivery, precise location, higher stability, and greater incorporated capability. Since the usage of cosmetics has increased, the usual delivery system has been substituted by modern delivery ap-proaches. The introduction of newer advancements and novel drug delivery systems make cos-metics and cosmeceuticals more popular with increased market share. This review article on nan-otechnology employed in cosmetics and dermatology emphasizes the numerous innovative nanocarriers designed for cosmetic and dermatologic drug delivery, their negative and positive aspects, and their toxicity.

Novel nonlinear quantum dust acoustic waves for modified variable coefficients Zakharove–Kusnetsov equation in dusty plasma

In this paper, the direct similarity reduction method is used to reduce the modified variable coefficient Zakharove–Kusnetsov equation (vcmZK), which represents the propagation of quantum dust acoustic waves (QDAWs) in an inhomogeneous magnetized dusty plasma field, into a nonlinear ordinary differential equation (NODE). Moreover, the Jacobi elliptic method is used to solve the NODE, where many novel double periodic, kink, and solitary wave solutions are obtained. Additionally, we have chosen to plot periodic, kink, and soliton QDAWs solutions according to some choices for the variable coefficients. According to the a chieved results, we can conclude that the choices of the functional forms of the variable coefficients can control the QDAWs propagation. Finally, the new discovered results may have many important applications in astrophysics, atmospheric science, nanotechnology, and industrial plasma physics.

Emerging Opportunities and Challenges of Nanoparticles in Nanomedicine

Nanomedicine encompasses a wide range of utilizations, including medical biological devices, nanoparticles (NPs), nanoelectronic biosensors, and possible future applications of molecular nanotechnologies, such as biological machines. Understanding toxicity and environmental impact problems is a current challenge in nanomedicine. The advancement of NPs in nanomedicine foresees emerging opportunities that may change healthcare by enhancing pharmaceutical effectiveness. This review may reveal novel and improved biomedical significance by delving deeper into advanced growth methodologies and NP applications in nanomedicine. NPs' outstanding physical and chemical characteristics have advanced medical, diagnostic, and screening techniques. The present review offers a current overview of organic and inorganic nanoparticles, highlighting recent advancements, obstacles, and potential applications for nanomedicine. Also, the focus of this review is on a fundamental concept that underlies the creation of novel and successful therapies using NPs in the field of nanomedicine for the human body's lungs, heart, brain, and kidneys. This extensive and insightful information source would be beneficial to the advancement of nanomedicine.

Nanotechnology applications in interior design of hospitals to enhance thermal comfort and decrease the infection spread for the occupants

Background In healthcare facilities, the significance of sensitive architecture cannot be overstated. In regions facing challenges such as Egypt, the healthcare sector is grappling with deteriorating conditions. The design of hospitals is crucial for addressing the needs of patients with varying illnesses and for creating an environment that fosters psychological well-being. The interior design process, especially the selection of materials, plays a pivotal role in ensuring a hygienic and safe environment within healthcare facilities. Walls, floors, ceilings, and furniture materials are key elements that contribute to the overall design. A study was conducted to investigate the application of nano materials in healthcare facility interior design in Egypt. Methods The study involved first a literature review on nano technology and its application in healthcare interior spaces. It culminated in a framework and guidelines for nano materials in different hospital zones. The analytical part of the study analysed successful international examples, leading to a checklist of nanomaterials categorized by hospital zones. The third part involved a base case study in Alexandria, Egypt, simulating the impact of nano coatings on air temperature, radiant temperature, and relative humidity using the DesignBuilder software. Results The results demonstrated a positive impact on patient health and thermal comfort with nano materials. The use of nano coatings in interior design finishes resulted in decreases in air temperature, radiant temperature, and relative humidity. There was an average decrease of 12.3%-16.7% in air temperature, 3%-4.2% in radiant temperature, and 7%-12% in relative humidity throughout the year. Conclusions The study highlighted the effectiveness of nano technology in enhancing the interior finishes of healthcare buildings, leading to improved patient health, thermal comfort, and decreased infection spread rate. We provide valuable recommendations for optimizing material selection in existing hospital buildings in emphasizing potential benefits of nano materials in healthcare facility design.

Biosynthesized metallic nanoparticles: A new era in cancer therapy.

Cancer remains a global health crisis, claiming countless lives throughout the years. Traditional cancer treatments like chemotherapy and radiation often bring about severe side effects, underscoring the pressing need for innovative, more efficient, and less toxic therapies. Nanotechnology has emerged as a promising technology capable of producing environmentally friendly anticancer nanoparticles. Among various nanoparticle types, metal-based nanoparticles stand out due to their exceptional performance and ease of use in methods of imaging. The widespread accessibility of biological precursors for synthesis based on plants of metal nanoparticles has made large-scale, eco-friendly production feasible. This evaluation provides a summary of the green strategy for synthesizing metal-based nanoparticles and explores their applications. Moreover, this review delves into the potential of phyto-based metal nanoparticles in combating cancer, shedding light on their probable mechanisms of action. These insights are invaluable for enhancing both biomedical and environmental applications. The study also touches on the numerous potential applications of nanotechnology in the field of medicine. Consequently, this research offers a concise and well-structured summary of nanotechnology, which should prove beneficial to researchers, engineers, and scientists embarking on future research endeavors.

Application of nanotechnology in forensic science - A Review

Application of nanotechnology in forensic science - A Review

A Review of Recent Advancements in Nanotechnology for Medical Drugs Delivery

In recent years, nanotechnology has played a crucial role in revolutionizing the delivery of drugs by allowing precise control of the release and targeting of the drugs. During this review, we will discuss some of the recent advances in nanotechnology for drug delivery systems, as well as strategies used for delivering targeted drugs, controlled release mechanisms, as well as the potential applications of nanotechnology for specific diseases. Among the strategies discussed for targeting drug delivery are ligand-targeted nanoparticles, size-dependent nanoparticles, magnetic nanoparticles, pH-responsive nanoparticles, antibody-targeted nanoparticles, active targeting using peptides that penetrate cells, and surface charge-based strategies. In addition to degradation-controlled release mechanisms, diffusion-controlled release mechanisms are also used as well as pH-controlled release mechanisms, magnetism-controlled release mechanisms, light-controlled release mechanisms, and temperature-controlled release mechanisms. The discussion also includes nanotechnology's potential to treat diseases, including cancer, heart disease, and neurological disorders. This is in addition to its potential applications in general. In order to improve patient outcomes, these advances in nanotechnology have the potential to revolutionize medicine in order to provide targeted and controlled release drug delivery systems that can revolutionize the way medicines are delivered to patients.

Real-time swelling-collapse kinetics of nanogels driven by XFEL pulses.

Stimuli-responsive polymers are an important class of materials with many applications in nanotechnology and drug delivery. The most prominent one is poly-N-isopropylacrylamide (PNIPAm). The characterization of the kinetics of its change after a temperature jump is still a lively research topic, especially at nanometer-length scales where it is not possible to rely on conventional microscopic techniques. Here, we measured in real time the collapse of a PNIPAm shell on silica nanoparticles with megahertz x-ray photon correlation spectroscopy at the European XFEL. We characterize the changes of the particles diffusion constant as a function of time and consequently local temperature on sub-microsecond timescales. We developed a phenomenological model to describe the observed data and extract the characteristic times associated to the swelling and collapse processes. Different from previous studies tracking the turbidity of PNIPAm dispersions and using laser heating, we find collapse times below microsecond timescales and two to three orders of magnitude slower swelling times.

Fluorocarbon Nanodroplets: Their Formation and Stability in Complex Solution Systems.

Perfluorocarbon (PFC) nanodroplets (NDs) are expanding in a wide range of applications in biotechnology and nanotechnology. Their efficacy in biological systems is significantly influenced by their size uniformity and stability within bioelectrolyte contexts. Presently, methods for creating monodisperse, highly concentrated, and well-stabilized PFC NDs under harsh conditions using low energy consumption methods have not been thoroughly developed, and their stability has not been sufficiently explored. This gap restricts their applicability for advanced medical interventions in tissues with high pH levels and various electrolytic conditions. To tackle these challenges and to circumvent potential toxicity from surface stabilizers, we have conducted an in-depth investigation into the formation and stability of uncoated perfluorohexane (PFH) NDs, which were synthesized by using a low-energy consumption solvent exchange technique, across complex electrolyte compositions or a broad spectrum of pH levels. The results indicated that low concentrations of low-valent electrolyte ions facilitate the nucleation of NDs and consistently accelerate Ostwald ripening over an extended period. Conversely, high concentrations of highly valent electrolyte ions inhibit nucleation and decelerate the ripening process over time. Given the similarities between the properties of NDs and nanobubbles, we propose a potential stabilization mechanism. Electrolytes influence the Ostwald ripening of NDs by adjusting the adsorption and distribution of ions on the NDs' surface, modifying the thickness of the electric double layer, and fine-tuning the energy barrier between droplets. These insights enable precise control over the stability of PFC NDs through the meticulous adjustment of the surrounding electrolyte composition. This offers an effective preparation method and a theoretical foundation for employing bare PFC NDs in physiological settings.