Application Of Nanotechnology Research Articles

Gold Nanoparticles and Antimicrobial Peptides: A Novel Combination

AbstractThis article examines the diverse conjugation forms of AMP‐AuNP nanostructures that arise from the amalgamation of antimicrobial peptides (AMPs) and gold nanoparticles (AuNPs), as well as their prospective utility in the field of biomedicine. AMPs are a class of naturally occurring microbicidal compounds that are recognized for their wide range of inhibitory effects and distinctive modes of operation. The utilization of AuNPs in diverse biomedical applications is facilitated through the application of nanotechnology. AMP‐AuNP nanostructures exhibit diverse features through the utilization of molecular linkage techniques. The aforementioned qualities encompass the ability to expedite the process of wound healing, facilitate precise targeting through the incorporation of DNA aptamers, serve as a means for bacterial imaging, enable the use of photothermal therapy, and contribute to the advancement of prospective treatments for fungal infections. The utilization of these synthesized antimicrobial gold nanostructures in many biomedical applications holds significant promise for advancing treatments and enhancing disease management.

Triangle-toothed gear occlude-guided universal nanotechnology constructs 3D symmetric DNA polyhedra with high assembly efficiency for precision cancer therapy

Chemotherapy is commonly used to treat malignant tumors. However, conventional chemotherapeutic drugs often cannot distinguish between tumor and healthy cells, resulting in adverse effects and reduced therapeutic efficacy. Therefore, zigzag-shaped gear-occlude-guided cymbal-closing (ZGC) DNA nanotechnology was developed based on the mirror-symmetry principle to efficiently construct symmetric DNA polyhedra. This nanotechnology employed simple mixing steps for efficient sequence design and assembly. A targeting aptamer was installed at a user-defined position using an octahedron as a model structure. Chemotherapeutic drug-loaded polyhedral objects were subsequently delivered into tumor cells. Furthermore, anticancer drug-loaded DNA octahedra were intravenously injected into a HeLa tumor-bearing mouse model. Assembly efficiency was almost 100 %, with no residual building blocks identified. Moreover, this nanotechnology required a few DNA oligonucleotides, even for complex polyhedrons. Symmetric DNA polyhedrons retained their structural integrity for 24 h in complex biological environments, guaranteeing prolonged circulation without drug leakage in the bloodstream and promoting efficient accumulation in tumor tissues. In addition, DNA octahedra were cleared relatively slowly from tumor tissues. Similarly, tumor growth was significantly inhibited in vivo, and a therapeutic outcome comparable to that of conventional gene-chemo combination therapy was observed. Moreover, no systemic toxicity was detected. These findings indicate the potential application of ZGC DNA nanotechnology in precision medicine.

Bioactive zinc nanomaterials synthesized from Crotalaria Pallida leaf extract using hydrothermal method

In the present-day nanotechnology is popular in all the fields of technology. The extended application of nanotechnology was utilized in drug delivery, dye absorption, wastewater removal, and in environmental pollutant eradication. However, it is important to follow green synthesis of nanomaterials for safety purposes. In the present study, the zinc nanomaterial was synthesized using a hydrothermal method from Crotalaria pallida leaf extract, which shows that the average size distribution of zinc nanomaterials that have been synthesized was 45 nm and cuboidal in shape. This is identified from the characterization studies that includes X-ray diffraction (XRD), UV–visible spectroscopy (UV–Vis), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, Field emission scanning electron microscopy (FESEM), and Dynamic Light Scattering (DLS). Thus, the study has identified that the hydrothermal synthesis of nanomaterials is easy to synthesize, feasible and efficient. Some biological assays such as alpha-amylase and alpha-glucosidase inhibition for anti-diabetic activity, cytotoxicity assays for anticancer activities and various other biological assays were carried out for different purposes. All these assays have proved that the nanomaterial extracted from Crotalaria pallida leaf extract has applicability in various fields. Interestingly most of the assays provide increased activity in increased concentration of nanomaterial and proved their therapeutic effect on medicine.

At the Limit of Interfacial Sharpness in Nanowire Axial Heterostructures.

As semiconductor devices approach dimensions at the atomic scale, controlling the compositional grading across heterointerfaces becomes paramount. Particularly in nanowire axial heterostructures, which are promising for a broad spectrum of nanotechnology applications, the achievement of sharp heterointerfaces has been challenging owing to peculiarities of the commonly used vapor-liquid-solid growth mode. Here, the grading of Al across GaAs/AlxGa1-xAs/GaAs heterostructures in self-catalyzed nanowires is studied, aiming at finding the limits of the interfacial sharpness for this technologically versatile material system. A pulsed growth mode ensures precise control of the growth mechanisms even at low temperatures, while a semiempirical thermodynamic model is derived to fit the experimental Al-content profiles and quantitatively describe the dependences of the interfacial sharpness on the growth temperature, the nanowire radius, and the Al content. Finally, symmetrical Al profiles with interfacial widths of 2-3 atomic planes, at the limit of the measurement accuracy, are obtained, outperforming even equivalent thin-film heterostructures. The proposed method enables the development of advanced heterostructure schemes for a more effective utilization of the nanowire platform; moreover, it is considered expandable to other material systems and nanostructure types.

Silk Revolution: Redefining Sericulture through Application of Precise Nanotechnologies

Human civilization has been intertwined with sericulture—the art and science of producing silk for centuries. The application of nanotechnology to sericulture techniques has created new opportunities to improve the quantity, quality and use of silk in recent decades. This abstract examines the numerous applications of nanotechnology in sericulture, with particular attention on how it affects the quality of silk fibers, the procedures involved in producing silk and the creation of cutting-edge materials derived from silk. By providing comprehensive control over the properties of silk at the molecular and atomic levels, nanotechnology, defined as the manipulation of matter at the nano scale, has completely transformed the silk industry. Improving the health and growth of silkworms is one of the main application areas. Silver nanoparticles, for example have been used to fight illnesses and strengthen silkworm’s immune systems, boosting the insect’s resilience against illness and optimizing silk yield. Furthermore, silk fiber quality has increased largely in substantial measure by nanotechnology. The mechanical, thermal and optical characteristics of silk fibers have been altered by researchers by adding nanoparticles during the spinning process. For example, adding nanoparticles to silk can increase its tensile strength, making it more durable and appropriate for a variety of industrial uses. Similarly, silk can be given antibacterial qualities by adding nanoscale compounds, increasing its shelf life and possible uses in medical textiles. Furthermore, the production of sophisticated silk-based materials with distinctive functions has been made easier by nanotechnology. Nanocomposites, which consist of nanoparticles embedded in silk matrices, have unique characteristics like improved electrical conductivity, controlled drug release, and greater biocompatibility. Silk-based materials have emerged as a result of these developments, finding use both in wearable electronics and biomedical devices.

REVIEW OF SILVER NANOPARTICLE SYNTHESIS USING LASER ABLATION; ITS CHARACTERIZATION, ANTIOXIDANT AND ANTIBACTERIAL FOR SKIN WOUNDS

This comprehensive review paper thoroughly investigates the synthesis of silver nanoparticles (AgNPs) through laser ablation and biosynthesis methods, exploring their potential applications in nanotechnology. The paper highlights the distinctive properties of AgNPs, including their notable antibacterial and anticancer attributes, wound healing capabilities, and therapeutic potential. The focus is specifically on the synthesis of small, spherical particles ranging from 2 to 5 nm. This investigation centers on key parameters crucial to the synthesis process, such as laser beam spot size, strength, ablation duration, and green synthesis factors like time, temperature, and concentration. In the realm of laser ablation optimization, the study scrutinizes the impact of various spot sizes on particle size distribution, variations in laser strength, and the intricate relationship between ablation duration and particle size. These analyses are strategically aligned to achieve the desired properties for the efficient production of AgNPs. Simultaneously, green synthesis techniques are employed to ensure an environmentally friendly approach, with careful consideration for factors like time, temperature, and concentration to attain targeted characteristics. The paper employs sophisticated characterization techniques, including dynamic light scattering (DLS), scanning electron microscopy (SEM), and UV-Vis spectral analysis, for a comprehensive analysis of the synthesized AgNPs. DLS offers insights into size distribution and stability, SEM facilitates morphology visualization, and UV-Vis spectral analysis definitively confirms the presence of silver nanoparticles through characteristic absorption peaks.

ENHANCED SULFATED EXOPOLYSACCHARIDE PRODUCTION IN PORPHYRIDIUM PURPUREUM FROM INDONESIA: IMPACT OF CULTURE MEDIUM AND DURATION

Objective: This study investigates the influence of culture medium (Walne and F/2) and culture duration (14 ds and 28 ds) on sulfated Exopolysaccharide (EPS) production in Porphyridium purpureum from Indonesia. EPS sulfate has significant biotechnological potential due to its versatile applications, including in nanotechnological applications and optimizing cultivation conditions is essential to maximize yields. Methods: Cultures of P. purpureum were subjected to two distinct culture media, Walne and F/2, and maintained for two different durations, 14 ds and 28 ds. The microalgal biomass was harvested, and sulfated EPS was extracted using established methods. Statistical analysis was employed to assess the significance of differences between the cultural conditions. The novelty of this study lies in the comprehensive examination of the interactive effects of culture medium composition and duration on sulfated EPS production in P. purpureum. The findings contribute to our understanding of the dynamic responses of P. purpureum to different culture environments. Results: The results of this research reveal a significant increase in sulfated EPS production in the 28 d culture compared to the 14 d culture. Conclusion: This outcome underscores the importance of prolonged culture durations for achieving higher yields of sulfated EPS in P. purpureum.

A New Technology for Industrial Strain Mapping Using Single-Wall Carbon Nanotube Sensors

Measurements of mechanical strain are widely used in heavy industry to design and test new structures and to ensure the safety of installed infrastructure. However, the few practical methods for strain measurement all have serious limitations. To complement these methods, we have developed a new strain technology, called S4 for “strain-sensing smart skin,” which uses single-wall carbon nanotubes (SWCNTs) as microscopic sensors. Nanotubes dilutely embedded in a polymer are applied as a thin film to specimen surfaces of interest. Subsequent strains in the specimen are transmitted by load transfer through the film to the nanotubes, inducing axial compression or extension. Those small structural deformations of the SWCNTs alter the semiconducting band gaps in predictable ways, causing proportional shifts in the peak wavelengths of their near-infrared fluorescence emission. Shifts are quantified by optically exciting the specimen surface and spectrally analyzing the resulting fluorescence to deduce strain values at the probed locations. The S4 method has recently been implemented using hyperspectral imaging. We demonstrate measurements in less than one minute of strain maps containing hundreds of thousands of pixels with 50 microstrain noise levels and 0.2 mm spatial resolution. This technology has promising potential to become a large-scale commercialized application of carbon nanotechnology.

19]Starphene: Combined In‐Solution and On‐Surface Synthesis Towards the Largest Starphene

Starphenes are structurally appealing three‐fold symmetric polycyclic aromatic compounds with potential interesting applications in molecular electronics and nanotechnology. This family of star‐shaped polyarenes can be regarded as three acenes that are connected through a single benzene ring. In fact, just like acenes, unsubstituted large starphenes are poorly soluble and highly reactive molecules under ambient conditions making their synthesis difficult to achieve. Herein, we report two different synthetic strategies to obtain a starphene formed by 19 cata‐fused benzene rings distributed within three hexacene branches. This molecule, which is the largest starphene that has been obtained to date, was prepared by combining solution‐phase and on‐surface synthesis. [19]Starphene was characterized by high‐resolution scanning tunneling microscopy (STM) and spectroscopy (STS) showing a remarkable small HOMO‐LUMO transport gap (0.9 eV).

19]Starphene: Combined In-Solution and On-Surface Synthesis Towards the Largest Starphene.

Starphenes are structurally appealing three-fold symmetric polycyclic aromatic compounds with potential interesting applications in molecular electronics and nanotechnology. This family of star-shaped polyarenes can be regarded as three acenes that are connected through a single benzene ring. In fact, just like acenes, unsubstituted large starphenes are poorly soluble and highly reactive molecules under ambient conditions making their synthesis difficult to achieve. Herein, we report two different synthetic strategies to obtain a starphene formed by 19 cata-fused benzene rings distributed within three hexacene branches. This molecule, which is the largest starphene that has been obtained to date, was prepared by combining solution-phase and on-surface synthesis. [19]Starphene was characterized by high-resolution scanning tunneling microscopy (STM) and spectroscopy (STS) showing a remarkable small HOMO-LUMO transport gap (0.9 eV).

High‐Performance Cooperative DNA Nanodevice Enables Sensitive Circular RNA Imaging and Precise Tumor Growth Suppression

The utility of circular RNAs (circRNAs) as emerging biomarkers and regulatory factors in medical diagnostics and therapeutics is hampered by the challenges associated with their sensitive detection and precise modulation. Herein, a high‐performance cooperative DNA nanodevice (HCDN) based on DNA tetrahedron‐confined catalytic DNA assembly reaction (DT‐CDA) that enables both imaging and regulation of circRNAs is developed. Activation of the DT‐CDA is contingent upon the presence of the target circRNA, which, together with a replicative fuel probe, catalyzes the sequential opening of additional DT‐CDAs. This cooperative exponential signal amplification with negligible background interference allows HCDN to effectively detect minute quantities of circRNAs. Employing circSATB2 as a model, the HCDN demonstrates substantial downregulation of Cyclin D1 (CCND1) mRNA and protein levels in cellular and in vivo models, thereby inhibiting tumor growth. The innovative design of HCDN sets the stage for a powerful methodology conducive to enhanced clinical diagnostics and biomolecule manipulation, thereby advancing the capabilities and applications of DNA nanotechnology.

An Exploratory Study on the Role of Technology in Respiratory Diagnostics

Advancements in healthcare have led to several developments; respiratory tools and techniques will help doctors detect and diagnose respiratory problems earlier and more accurately. This knowledge can lead to improved treatments and better outcomes for patients with respiratory issues. The technique used in this study is a text mining using the qualitative tool NVIVO 12. The purpose of conducting this research is to exploratory the role of technology in respiratory diagnostics. It is seen that the significant role of technology in respiratory diagnostic are Nanotechnology applications, Imaging techniques, Telemonitoring, Telemedicine, Artificial intelligence, Computed tomography, Magnetic resonance, Biosignature analysis, Personalized medicine, Wearable devices, Point-of-care testing, the Internet of Things and Remote Monitoring.

Nanomedicine: Innovative Strategies and Recent Advances in Targeted Cancer Therapy.

Nanomedicine's application of nanotechnology in medicine holds tremendous potential for diagnosing and treating life-threatening diseases such as cancer. Unlike conventional therapies, nanomedicine offers a promising strategy to enhance clinical outcomes while minimizing severe side effects. The principle of drug targeting enables specific delivery of therapeutic agents to their intended sites, making it a more precise and effective therapy. Combination strategies, such as the co-delivery of chemotherapeutic drugs with nucleic acids or receptor-specific molecules, are being employed to enhance therapeutic outcomes. Nanocarriers and drug delivery systems designed using these approaches offer resourceful co-delivery of therapeutic agents for anticancer therapy. Targeted drug delivery via nanotechnology-based techniques has become an urgent need and has shown significant improvements in therapeutic implications, pharmacokinetics, specificity, reduced toxicity, and biocompatibility. This review discusses the extrapolation of nanomaterials for developing innovative and novel drug delivery systems for effective anticancer therapy. Additionally, we explore the role of nanotechnology-based concepts in drug delivery research.

Theranostic scope of monometallic selenium and titanium dioxide nanoparticles in biomedicine: A review.

The nanoparticles (NPs) of metals and metal oxides constitute significant components of technology in terms of monometallic NPs (MNPs). Over the last decade, the most fascinating and in-depth uses of NPs have been found in the biomedical field, which has demonstrated the therapeutic potential of these particles. Significant strides have been made in the application of nanotechnology across various industries, including biomedical sciences. In biomedicine, two of the most important applications of NPs are in the diagnosis and treatment of disease. Given their ability to deliver specific drugs, these next-generation NPs provide safe and effective pharmacotherapies for a wide range of disorders. Selenium nanoparticles (SeNPs) and titanium dioxide (TiO2) NPs offer potential treatments for various applications, including hair care and cancer treatment. SeNPs help with abiotic stress, plant disease, and growth, while TiO2 NPs enhance bio-imaging and drug delivery. This comprehensive review focuses on MNPs like Se (metal-based) and TiO2 (metal-oxide based). It covers their synthesis methods, nanoscale physicochemical properties, and the definition of specific industrial applications in various fields of applied nanotechnology, including biomedicine.

Exploring Magnetic Attributes: Borospherene-Like and Buckminsterfullerene-Like Lattices in Monte Carlo Simulations

This study explores the magnetic properties of Borospherene-like and Buckminsterfullerene-like lattices using Monte Carlo simulation, revealing novel behaviors. The dependency of blocking temperature (T B ) on external magnetic field strength (H), linear coupling interaction (J), and biquadratic coupling interaction (K) was studied and compared between the two lattice types. Additionally, the evolution of coercive field (H C ) with J and K parameters for both lattice types was analyzed. This study highlights the unique magnetic responses of these lattices and their potential applications in magnetic research and nanotechnology.

A DNA-Modularized STING Agonist with Macrophage-Selectivity and Programmability for Enhanced Anti-Tumor Immunotherapy.

The activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) and its adaptor, stimulator of interferon genes (STING), is known to reprogram the immunosuppressive tumor microenvironment for promoting antitumor immunity. To enhance the efficiency of cGAS-STING pathway activation, macrophage-selective uptake, and programmable cytosolic release are crucial for the delivery of STING agonists. However, existing polymer- or lipid-based delivery systems encounter difficulty in integrating multiple functions meanwhile maintaining precise control and simple procedures. Herein, inspired by cGAS being a natural DNA sensor, a modularized DNA nanodevice agonist (DNDA) is designed that enable macrophage-selective uptake and programmable activation of the cGAS-STING pathway through precise self-assembly. The resulting DNA nanodevice acts as both a nanocarrier and agonist. Upon local administration, it demonstrates the ability of macrophage-selective uptake, endosomal escape, and cytosolic release of the cGAS-recognizing DNA segment, leading to robust activation of the cGAS-STING pathway and enhanced antitumor efficacy. Moreover, DNDA elicits a synergistic therapeutic effect when combined with immune checkpoint blockade. The study broadens the application of DNA nanotechnology as an immune stimulator for cGAS-STING activation.

Bio-Nano Synergy in Therapeutic Applications: Drug-Graphene Oxide Nanocomposites for Modulated Acetylcholinesterase Inhibition and Radical Scavenging.

The current study explores the synergistic application of biophysical chemistry and nanotechnology in therapeutic treatments, focusing specifically on the development of advanced biomaterials to repurpose FDA-approved Alzheimer's disease (AD) drugs as potent antioxidants. By integration of AD drugs into graphene oxide (GO) nanocomposites, an attempt to enhance the acetylcholinesterase (AChE) inhibition and increase radical scavenging activity is proposed. This bionano synergy is designed to leverage the unique properties of both the nanomaterial surface and the bioactive compounds, improving treatment effectiveness. The nanocomposites also promise targeted drug delivery, as GO can traverse the blood-brain barrier to inhibit AChE more effectively in AD patients. Furthermore, the drug-GO nanocomposite exhibits enhanced radical scavenging capabilities, offering additional therapeutic benefits. This study also elucidates a molecular level understanding on how the properties of the drugs are modified when integrated into nanocomposites with GO, enabling the development of more effective materials. The interdisciplinary approach presented in this study exploits the potential of nanotechnology to enhance drug delivery systems and achieve superior therapeutic outcomes through bionano synergy.

What does nanotechnology have to offer for lithium-ion batteries materials?

The need for renewable energy source for cheap, portable electronic devices like electric vehicles has promoted an attractive research and innovation in batteries, especially in lithium-ion batteries. Ever since the success commercialization of its application in Sony in 1990s, this kind of battery has proved its efficiency and expense in market as a result of years of research and discoveries, however being limited for various kinds of reasons. With the combination of nanotechnology, modifications have been made to improve the drawbacks of the batteries from the angle of materials. Despite the fact that many attempts of changes have not been well-rounded developed, the discoveries are of great help to future research. In this article, recent research about application of nanotechnology in the development of lithium-ion batteries will be discussed. Starting from the cathode materials to anode materials, the enhancements brought by nanoparticles in typical lithium-ion battery materials will be reviewed, along with their targets and working principles.

Correlation Between Computational Fluid Dynamics (CFD) and Nanotechnology

This research aims to find the relationship between Computational Fluid Dynamics (CFD) and nanotechnology and carry out bibliometric analysis to determine research trends in CFD and nanotechnology. This research used bibliometric analysis methods. The keywords used are "Computational Fluid Dynamics (CFD)" and "Nanotechnology". The data processing and analysis are carried out quantitatively based on the principles of bibliometric analysis. The search results show that the year range for research publication articles on CFD and Nanotechnology used is from 2001 - 2024 with a total of 193 documents. The results of this research show that the relationship between CFD and nanotechnology is very close. This is because CFD provides an important tool for understanding, designing, and optimizing various processes and devices at the nanoscale. Additionally, CFD enables faster and more efficient progress in various nanotechnology applications. Based on an analysis of research developments, the development of article publications on CFD and nanotechnology in Scopus has a tendency to increase from the beginning of 2001 to 2024. In this research, it is known that the topic of CFD has become a research trend in the period 2012 to 2019 with the highest trend in 2016. Meanwhile, the topic of nanotechnology became a research trend from 2010 to 2018 with the highest trend in 2014. This research development can be caused by significant technological and methodological advances since the Industrial Revolution 4.0 which began at the beginning of the 21st century until now. This research can be used as consideration and reference for further research which will discuss CFD and nanotechnology.

5 MeV Si ion irradiation effects on structural and morphological properties of multiwalled carbon nanotubes

Carbon based nanomaterials (CBNs) such as multi walled carbon nanotubes (MWCNTs), graphene etc have attracted huge interest due to their widespread applications in contemporary nanotechnology. The ion bombardment is an important method which can be used for tuning of the structural and morphological properties of the CBNs. In the present work, we have carried out ion irradiation on MWCNTs (prepared by chemical vapour deposition method) with 5 MeV Si ions at different fluences ranging from 1 × 1014 to 5 × 1016 ions/cm2. The resulting structural and morphological modifications on the pristine MWCNTs have been characterized by using X-ray diffraction, Raman spectroscopy and field emission scanning electron microscopy. Results observed after successful characterization are compared with pristine sample results and we observed that the irradiation creates defects in MWCNTs and causes amorphized carbon nanomaterials depending on the fluence and energy deposited by energetic ions inside the MWCNTs.