Singapore was once a strategic location that played a role in the development of the treasures of Islamic civilization in Southeast Asia. This great role cannot be separated from the dense international trade activities on the Strait of Melaka. This trade is accompanied by da'wah activities and Islamic scientific studies. British colonization had a major impact on the position of Malays and Muslims, making them a minority in Singapore. This journal article aims to explain the history and role of Singapore in the heyday of Islamic civilization in Southeast Asia in the 15-20th century. The research method used is the historical research method, with data collection techniques, namely literature study. The data sources that have been collected are then selected to fit the research theme, analyzed, then conclusions are drawn which are written in the form of historical research. The results showed that Singapore became a small region but had a major impact on the progress of Islamic civilization in Southeast Asia. From the development of da'wah, to the center of information channels and publishing Islamic studies literature, as well as the information center of the reform of the Islamic world in the Middle East for Southeast Asian Muslims. The movement of Islamic civilization in Singapore is dominated by Arab and Indian immigrant Muslims, while the Malays are struggling at the bottom because of the weakness of quality.